Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0208 | 0.9706 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0208 | 0.9706 | 0.9706 |
Mycobacterium ulcerans | hypothetical protein | 0.0125 | 0.2852 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.9706 | 0.9604 |
Giardia lamblia | Hypothetical protein | 0.0125 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0208 | 0.9706 | 0.9706 |
Onchocerca volvulus | 0.0211 | 1 | 0.5 | |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0211 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0211 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0125 | 0.2852 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0211 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0208 | 0.9706 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0211 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0211 | 1 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0211 | 1 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0125 | 0.2852 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0125 | 0.2852 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 30 uM | Inhibition of PFKFB3 in human A549 cells assessed as decrease in lactate secretion after 4 hrs | ChEMBL. | 25849762 |
IC50 (binding) | = 70.9 uM | Inhibition of recombinant human PFKFB3 using fructose 6 phosphate as substrate assessed as ADP generation after 1 hr by ADP Glo assay | ChEMBL. | 25849762 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human PFKFB1 using fructose 6 phosphate as substrate assessed as ADP generation after 1 hr by ADP Glo assay | ChEMBL. | 25849762 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human PFKFB2 using fructose 6 phosphate as substrate assessed as ADP generation after 1 hr by ADP Glo assay | ChEMBL. | 25849762 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.