Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | Starlite/ChEMBL | References |
Homo sapiens | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | Starlite/ChEMBL | References |
Homo sapiens | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | 471 aa | 434 aa | 26.3 % |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 500 aa | 429 aa | 24.9 % |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 449 aa | 439 aa | 26.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0125 | 0.0742 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.2603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.2527 | 0.9604 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0208 | 0.2527 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0211 | 0.2603 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0556 | 1 | 1 |
Onchocerca volvulus | 0.0211 | 0.2603 | 0.5 | |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0125 | 0.0742 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0211 | 0.2603 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0211 | 0.2603 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0125 | 0.0742 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0125 | 0.0742 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0208 | 0.2527 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0211 | 0.2603 | 1 |
Giardia lamblia | Hypothetical protein | 0.0125 | 0.0742 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0208 | 0.2527 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0208 | 0.2527 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0211 | 0.2603 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.003 uM | Inhibition of recombinant human PFKFB3 using fructose 6 phosphate as substrate assessed as ADP generation after 1 hr by ADP Glo assay | ChEMBL. | 25849762 |
IC50 (binding) | = 0.025 uM | Inhibition of recombinant human PFKFB2 using fructose 6 phosphate as substrate assessed as ADP generation after 1 hr by ADP Glo assay | ChEMBL. | 25849762 |
IC50 (binding) | = 0.067 uM | Inhibition of PFKFB3 in human A549 cells assessed as reduction of fructose-1,6-bisphosphate formation after 4 hrs by MS/MS analysis | ChEMBL. | 25849762 |
IC50 (binding) | = 0.191 uM | Inhibition of recombinant human PFKFB1 using fructose 6 phosphate as substrate assessed as ADP generation after 1 hr by ADP Glo assay | ChEMBL. | 25849762 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.