Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tyrosyl-DNA phosphodiesterase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0143 | 0.7477 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0143 | 0.7477 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0124 | 0.5922 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0124 | 0.5922 | 0.7921 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0124 | 0.5922 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0143 | 0.7477 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0174 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.7477 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0143 | 0.7477 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0174 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0124 | 0.5922 | 0.7921 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.2364 | 0.3161 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0174 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.005 | 0 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.2364 | 0.1807 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.7477 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0174 | 1 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.008 | 0.2364 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0059 | 0.068 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.2364 | 0.1807 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0059 | 0.068 | 0.1148 |
Loa Loa (eye worm) | thymidylate synthase | 0.0124 | 0.5922 | 0.7921 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.008 | 0.2364 | 0.3161 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.2364 | 0.3161 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0174 | 1 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0124 | 0.5922 | 1 |
Brugia malayi | hypothetical protein | 0.0059 | 0.068 | 0.1148 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.008 | 0.2364 | 0.3161 |
Onchocerca volvulus | 0.0124 | 0.5922 | 0.5 | |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.008 | 0.2364 | 0.3991 |
Echinococcus multilocularis | thymidylate synthase | 0.0124 | 0.5922 | 0.7921 |
Mycobacterium ulcerans | thymidylate synthase | 0.0124 | 0.5922 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 24.4 uM | Cytotoxicity against human HepG2 cells assessed as reduction In cell number after 72 hrs by MTT assay | ChEMBL. | 25819333 |
IC50 (binding) | = 1.28 uM | Inhibition of recombinant TDP1 (unknown origin) assessed as increase in fluorescence | ChEMBL. | 25819333 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.