Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 10A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | cAMP-specific phosphodiesterase | phosphodiesterase 10A | 789 aa | 666 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.7916 | 0.8413 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0257 | 0.7916 | 0.7916 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0257 | 0.7916 | 0.7916 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0257 | 0.7916 | 0.7916 |
Brugia malayi | steroid hormone receptor | 0.0257 | 0.7916 | 0.7916 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0257 | 0.7916 | 0.8413 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0257 | 0.7916 | 0.7916 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0257 | 0.7916 | 0.7916 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0257 | 0.7916 | 0.8413 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0257 | 0.7916 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0257 | 0.7916 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0257 | 0.7916 | 0.7916 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0257 | 0.7916 | 0.7916 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0257 | 0.7916 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0257 | 0.7916 | 0.7916 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0257 | 0.7916 | 0.8413 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0289 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0257 | 0.7916 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0257 | 0.7916 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0257 | 0.7916 | 0.7916 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0257 | 0.7916 | 0.7916 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.9409 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0257 | 0.7916 | 0.7916 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0289 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.7916 | 0.8413 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.7916 | 0.8413 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0257 | 0.7916 | 0.7916 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0257 | 0.7916 | 0.7916 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0257 | 0.7916 | 0.7916 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0257 | 0.7916 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0257 | 0.7916 | 0.7916 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0257 | 0.7916 | 0.7916 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0257 | 0.7916 | 0.7916 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0257 | 0.7916 | 0.8413 |
Schistosoma mansoni | thyroid hormone receptor | 0.0257 | 0.7916 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0257 | 0.7916 | 0.7916 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0257 | 0.7916 | 0.7916 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.7916 | 0.8413 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0257 | 0.7916 | 0.7916 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0257 | 0.7916 | 0.7916 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0257 | 0.7916 | 0.7916 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0257 | 0.7916 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.7916 | 0.8413 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0257 | 0.7916 | 0.7916 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0257 | 0.7916 | 0.7916 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0257 | 0.7916 | 0.7916 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0257 | 0.7916 | 0.8413 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0257 | 0.7916 | 0.8413 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0257 | 0.7916 | 0.7916 |
Brugia malayi | nuclear hormone receptor | 0.0257 | 0.7916 | 0.7916 |
Onchocerca volvulus | 0.0257 | 0.7916 | 0.5 | |
Schistosoma mansoni | nuclear hormone receptor | 0.0257 | 0.7916 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0257 | 0.7916 | 0.7916 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0257 | 0.7916 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0257 | 0.7916 | 0.7916 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0257 | 0.7916 | 0.8413 |
Brugia malayi | ecdysteroid receptor | 0.0257 | 0.7916 | 0.7916 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.7876 | 0.8371 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0257 | 0.7916 | 0.7916 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0257 | 0.7916 | 0.7916 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.7916 | 0.8413 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0257 | 0.7916 | 0.7916 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0257 | 0.7916 | 0.7916 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0257 | 0.7916 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0257 | 0.7916 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0257 | 0.7916 | 0.7916 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0257 | 0.7916 | 0.8413 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0257 | 0.7916 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0257 | 0.7916 | 0.7916 |
Schistosoma mansoni | thyroid hormone receptor | 0.0257 | 0.7916 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0257 | 0.7916 | 0.7916 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.7916 | 0.8413 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0257 | 0.7916 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0257 | 0.7916 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.7916 | 0.8413 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 200 nM | Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assay | ChEMBL. | 26378882 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.