Detailed information for compound 1934782

Basic information

Technical information
  • TDR Targets ID: 1934782
  • Name: (E)-3-(7-methoxy-1,3-benzodioxol-5-yl)prop-2- enoic acid
  • MW: 222.194 | Formula: C11H10O5
  • H donors: 1 H acceptors: 2 LogP: 1.66 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=C/C(=O)O)cc2c1OCO2
  • InChi: 1S/C11H10O5/c1-14-8-4-7(2-3-10(12)13)5-9-11(8)16-6-15-9/h2-5H,6H2,1H3,(H,12,13)/b3-2+
  • InChiKey: TWUVAPFWYKZLOT-NSCUHMNNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(7-methoxy-1,3-benzodioxol-5-yl)acrylic acid
  • ZERO/009384

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.0155 0.242
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0119 0.0196
Leishmania major beta tubulin 0.0016 0.0047 0.068
Brugia malayi follicle stimulating hormone receptor 0.003 0.0119 0.1855
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0119 0.0196
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0029 0.0112 0.0102
Brugia malayi hypothetical protein 0.003 0.0119 0.1855
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.197 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0015 0.0039 0.0035
Brugia malayi Tubulin beta-1 chain 0.0016 0.0047 0.0718
Brugia malayi Dopamine receptor protein 1 0.003 0.0119 0.1855
Loa Loa (eye worm) beta-tubulin 0.0016 0.0047 0.0718
Schistosoma mansoni tubulin subunit beta 0.0016 0.0047 0.0721
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0119 0.1855
Brugia malayi Melatonin receptor type 1A 0.003 0.0119 0.1855
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0018
Echinococcus granulosus Tubulin beta 2C chain 0.0016 0.0047 0.0078
Echinococcus multilocularis tubulin subunit beta 0.0016 0.0047 0.0076
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0029 0.0111 1
Schistosoma mansoni hypothetical protein 0.003 0.0119 0.1857
Echinococcus granulosus g protein coupled receptor 0.003 0.0119 0.0198
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0007 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Brugia malayi hypothetical protein 0.003 0.0119 0.1855
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0008 0.0004 0.0167
Echinococcus granulosus thioredoxin glutathione reductase 0.0011 0.0023 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0119 0.1857
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0119 0.1857
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0008 0.0004 0.0043
Onchocerca volvulus 0.0037 0.0155 0.6041
Onchocerca volvulus 0.0008 0.0004 0.0101
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0029 0.0111 0.0107
Echinococcus multilocularis neuropeptide receptor 0.003 0.0119 0.0196
Echinococcus granulosus Tubulin beta 2C chain 0.0016 0.0047 0.0078
Echinococcus multilocularis neuropeptide receptor 0.003 0.0119 0.0196
Trypanosoma brucei trypanothione reductase 0.0011 0.0023 0.0298
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0027 0.01 0.009
Echinococcus multilocularis tubulin beta 1 chain 0.0016 0.0047 0.0076
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0119 0.1855
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0119 0.1857
Onchocerca volvulus 0.003 0.0119 0.4632
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0119 0.0198
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0011 0.002 0.001
Onchocerca volvulus 0.003 0.0119 0.4632
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Onchocerca volvulus 0.003 0.0119 0.4632
Giardia lamblia Beta tubulin 0.0016 0.0047 0.068
Treponema pallidum sodium- and chloride- dependent transporter 0.0037 0.0155 0.2118
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0026 0.0097 0.0087
Leishmania major cysteinyl-tRNA synthetase, putative 0.0029 0.0111 0.1688
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0015 0.0039 0.0065
Brugia malayi hypothetical protein 0.003 0.0119 0.1855
Echinococcus multilocularis neuroglian 0.0007 0.0002 0.0002
Toxoplasma gondii aspartyl protease ASP1 0.0022 0.0077 0.488
Mycobacterium tuberculosis Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG 0.0031 0.0123 0.0113
Giardia lamblia Beta tubulin 0.0016 0.0047 0.068
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0015 0.0039 0.0063
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0037 0.0156 1
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0119 0.1857
Onchocerca volvulus 0.0029 0.0111 0.4298
Trichomonas vaginalis STE family protein kinase 0.0132 0.0638 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0119 0.1857
Schistosoma mansoni myosin xvIII 0.003 0.0119 0.1857
Chlamydia trachomatis UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 0.0042 0.0181 0.535
Brugia malayi AKH receptor 0.003 0.0119 0.1855
Schistosoma mansoni nephrin 0.0007 0.0002 0.0021
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0119 0.0198
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.0008 0.0004 0.0007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0119 0.1857
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0033 0.0135 0.0225
Echinococcus multilocularis Tubulin beta 2C chain 0.0016 0.0047 0.0076
Echinococcus granulosus serotonin transporter 0.0037 0.0155 0.0258
Plasmodium vivax cysteine--tRNA ligase, putative 0.0029 0.0111 0.7106
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.0119 0.0196
Toxoplasma gondii beta-tubulin, putative 0.0016 0.0047 0.2963
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0029 0.0111 0.1688
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0119 0.1857
Trichomonas vaginalis tubulin beta chain, putative 0.0016 0.0047 0.068
Toxoplasma gondii beta tubulin 0.0016 0.0047 0.2963
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0119 0.1857
Schistosoma mansoni vesicular amine transporter 0.0007 0.0002 0.0021
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0119 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Mycobacterium ulcerans undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 0.0042 0.0181 0.0177
Brugia malayi ORL1-like opioid receptor 0.003 0.0119 0.1855
Schistosoma mansoni hypothetical protein 0.0033 0.0135 0.2104
Schistosoma mansoni sodium/chloride dependent transporter 0.0037 0.0155 0.2422
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Echinococcus granulosus beta tubulin 0.0016 0.0047 0.0078
Onchocerca volvulus Neuropeptide F receptor homolog 0.003 0.0119 0.4632
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0119 0.0198
Onchocerca volvulus 0.003 0.0119 0.4632
Loa Loa (eye worm) tubulin beta-1 chain 0.0016 0.0047 0.0718
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0119 0.1857
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Echinococcus multilocularis serotonin receptor 0.003 0.0119 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0022 0.0077 0.1146
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0007 0.0001 0.0003
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0119 0.1857
Leishmania major beta tubulin 0.0016 0.0047 0.068
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0119 0.0196
Brugia malayi sulfakinin receptor protein 0.003 0.0119 0.1855
Schistosoma mansoni cathepsin D (A01 family) 0.0065 0.0295 0.4612
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0026 0.0097 0.0087
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0119 0.0198
Echinococcus granulosus neuropeptide receptor 0.003 0.0119 0.0198
Loa Loa (eye worm) thymidylate synthase 0.0027 0.01 0.1553
Echinococcus granulosus neuropeptide receptor A26 0.003 0.0119 0.0198
Loa Loa (eye worm) hypothetical protein 0.0033 0.0135 0.2101
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022 0.0077 0.1185
Plasmodium falciparum plasmepsin VI 0.0022 0.0077 0.4793
Schistosoma mansoni biogenic amine receptor 0.003 0.0119 0.1857
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0119 0.0196
Trypanosoma brucei beta tubulin 0.0016 0.0047 0.068
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0119 0.0196
Mycobacterium tuberculosis Probable reductase 0.0026 0.0097 0.0087
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.0119 0.0196
Echinococcus granulosus somatostatin receptor 0.003 0.0119 0.0198
Schistosoma mansoni biogenic amine receptor 0.003 0.0119 0.1857
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.003 0.0119 0.4632
Giardia lamblia Cysteinyl-tRNA synthetase 0.0029 0.0111 0.1688
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0008 0.0004 0.0167
Leishmania major beta tubulin 0.0016 0.0047 0.068
Mycobacterium leprae Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0184 0.0902 0.0892
Trichomonas vaginalis tubulin epsilon chain, putative 0.0016 0.0047 0.068
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0119 0.1855
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0119 0.1855
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0119 0.0198
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0119 0.0196
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0018
Toxoplasma gondii thioredoxin reductase 0.0011 0.0023 0.1392
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0029 0.0111 0.1721
Brugia malayi Pre-SET motif family protein 0.005 0.0221 0.3449
Loa Loa (eye worm) solute carrier family 6 member 4 0.0037 0.0155 0.242
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0119 0.1857
Leishmania major beta tubulin 0.0016 0.0047 0.068
Plasmodium vivax aspartyl proteinase, putative 0.0022 0.0077 0.488
Brugia malayi dihydrofolate reductase family protein 0.0011 0.002 0.0291
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0119 0.1855
Echinococcus multilocularis orexin receptor type 2 0.003 0.0119 0.0196
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.004
Brugia malayi GnHR receptor homolog 0.003 0.0119 0.1855
Schistosoma mansoni cathepsin D (A01 family) 0.0065 0.0295 0.4612
Brugia malayi Thioredoxin reductase 0.0011 0.0023 0.0337
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0037 0.0155 0.2422
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0033 0.0135 0.2104
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0029 0.0111 0.0182
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0026 0.0097 0.0087
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0029 0.0111 0.1688
Echinococcus multilocularis dual specificity mitogen activated protein 0.0132 0.0638 0.1058
Leishmania major beta tubulin 0.0016 0.0047 0.068
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0119 0.0196
Brugia malayi glutathione reductase 0.0011 0.0023 0.0337
Echinococcus granulosus neuropeptide s receptor 0.003 0.0119 0.0198
Trichomonas vaginalis STE family protein kinase 0.0132 0.0638 1
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0011 0.002 0.0016
Echinococcus granulosus histone lysine methyltransferase setb 0.0007 0.0001 0.0002
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0029 0.0111 0.1721
Echinococcus multilocularis Immunoglobulin 0.0007 0.0002 0.0002
Brugia malayi Fibronectin type III domain containing protein 0.0007 0.0002 0.0018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0015 0.0039 0.0035
Loa Loa (eye worm) norepinephrine transporter 0.0037 0.0155 0.242
Toxoplasma gondii aldehyde dehydrogenase 0.0015 0.0039 0.2465
Schistosoma mansoni aldehyde dehydrogenase 0.0015 0.0039 0.06
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0029 0.0111 0.1724
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0011 0.002 0.001
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0027 0.01 0.009
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Giardia lamblia Kinase, STE STE20 0.0132 0.0638 1
Trypanosoma brucei RNA helicase, putative 0.0111 0.053 0.8292
Brugia malayi putative neuropeptide receptor 0.003 0.0119 0.1855
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0029 0.0112 0.0102
Treponema pallidum undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 0.0042 0.0181 0.3333
Echinococcus multilocularis g protein coupled receptor 0.003 0.0119 0.0196
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0015 0.0039 0.0559
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0184 0.0902 0.0892
Echinococcus multilocularis Immunoglobulin 0.0007 0.0002 0.0002
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0119 0.0198
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0119 0.1855
Onchocerca volvulus 0.003 0.0119 0.4632
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0029 0.0112 0.0102
Leishmania major beta tubulin 0.0016 0.0047 0.068
Onchocerca volvulus 0.0027 0.01 0.3879
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0007 0.0002 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Mycobacterium tuberculosis Hypothetical protein 0.0013 0.0029 0.0019
Schistosoma mansoni hypothetical protein 0.003 0.0119 0.1857
Plasmodium falciparum tubulin beta chain 0.0016 0.0047 0.2843
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0184 0.0902 0.0898
Trichomonas vaginalis tubulin gamma chain, putative 0.0016 0.0047 0.068
Echinococcus multilocularis sex peptide receptor 0.003 0.0119 0.0196
Schistosoma mansoni neuropeptide receptor 0.003 0.0119 0.1857
Echinococcus granulosus Immunoglobulin 0.0007 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0018
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0022 0.0077 0.0125
Leishmania major beta tubulin 0.0016 0.0047 0.068
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0119 0.0198
Schistosoma mansoni protein kinase 0.0132 0.0638 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Trypanosoma cruzi trypanothione reductase, putative 0.0011 0.0023 0.0298
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0119 0.0198
Onchocerca volvulus 0.003 0.0119 0.4632
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0119 0.0196
Plasmodium vivax glutathione reductase, putative 0.0011 0.0023 0.1392
Schistosoma mansoni inhibitor of apoptosis protein 0.0033 0.0135 0.2104
Plasmodium falciparum cysteine--tRNA ligase 0.0029 0.0111 0.7057
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0119 0.0196
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0119 0.1857
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0119 0.1857
Brugia malayi G protein-coupled receptor 0.003 0.0119 0.1855
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0029 0.0111 0.7106
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.005 0.0221 0.3449
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.007 0.0321 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0015 0.0039 0.0029
Brugia malayi Dihydrofolate reductase 0.0011 0.002 0.0291
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0011 0.0023 0.0012
Echinococcus multilocularis fmrfamide receptor 0.003 0.0119 0.0196
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0132 0.0638 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.003 0.0119 0.1855
Loa Loa (eye worm) BEN-1 protein 0.0016 0.0047 0.0718
Brugia malayi hypothetical protein 0.003 0.0119 0.1855
Schistosoma mansoni tubulin subunit beta 0.0016 0.0047 0.0721
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Echinococcus granulosus dual specificity mitogen activated protein 0.0132 0.0638 0.106
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0026 0.0097 0.0087
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0119 0.0196
Leishmania major beta tubulin 0.0016 0.0047 0.068
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.1721
Giardia lamblia Beta tubulin 0.0016 0.0047 0.068
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0027 0.01 0.1556
Mycobacterium ulcerans glycosyltransferase 0.0009 0.001 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0119 0.1857
Echinococcus granulosus serotonin receptor 0.003 0.0119 0.0198
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0119 0.0198
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0013 0.0029 0.0397
Schistosoma mansoni cell adhesion molecule 0.0007 0.0002 0.0021
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0119 0.0198
Schistosoma mansoni hypothetical protein 0.0111 0.053 0.83
Brugia malayi hypothetical protein 0.003 0.0119 0.1855
Onchocerca volvulus 0.003 0.0119 0.4632
Leishmania major beta tubulin 0.0016 0.0047 0.068
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0037 0.0156 0.2392
Onchocerca volvulus Deterin homolog 0.0033 0.0135 0.5247
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0132 0.0638 1
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0033 0.0135 0.2101
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0033 0.0135 0.0222
Onchocerca volvulus 0.003 0.0119 0.4632
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0029 0.0111 0.1688
Schistosoma mansoni biogenic amine receptor 0.003 0.0119 0.1857
Mycobacterium ulcerans aldehyde dehydrogenase 0.0015 0.0039 0.0035
Plasmodium vivax thioredoxin reductase, putative 0.0011 0.0023 0.1392
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0119 0.0198
Echinococcus granulosus dihydrofolate reductase 0.0011 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Brugia malayi hypothetical protein 0.003 0.0119 0.1855
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Echinococcus multilocularis fmrfamide receptor 0.003 0.0119 0.0196
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0119 0.1857
Plasmodium falciparum plasmepsin II 0.0022 0.0077 0.4793
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0119 0.1857
Echinococcus multilocularis dihydrofolate reductase 0.0011 0.002 0.0031
Echinococcus granulosus orexin receptor type 2 0.003 0.0119 0.0198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0119 0.1857
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0119 0.1855
Echinococcus granulosus g protein coupled receptor 0.003 0.0119 0.0198
Schistosoma mansoni hypothetical protein 0.003 0.0119 0.1857
Echinococcus granulosus Tubulin beta 2C chain 0.0016 0.0047 0.0078
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0119 0.1857
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0037 0.0156 0.2392
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0119 0.1857
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0007 0.0001 0.0003
Loa Loa (eye worm) tubulin beta-4 chain 0.0016 0.0047 0.0718
Leishmania major beta tubulin 0.0016 0.0047 0.068
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0018
Echinococcus granulosus beta tubulin 0.0016 0.0047 0.0078
Leishmania major beta tubulin 0.0016 0.0047 0.068
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0119 0.0196
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0119 0.0198
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0119 0.0198
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0119 0.0196
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0132 0.0638 1
Brugia malayi hypothetical protein 0.003 0.0119 0.1855
Schistosoma mansoni amine GPCR 0.003 0.0119 0.1857
Schistosoma mansoni neuropeptide receptor 0.003 0.0119 0.1857
Loa Loa (eye worm) tubulin beta chain 0.0016 0.0047 0.0718
Trypanosoma cruzi beta tubulin, putative 0.0016 0.0047 0.068
Onchocerca volvulus 0.003 0.0119 0.4632
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0119 0.0198
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0119 0.1857
Loa Loa (eye worm) hypothetical protein 0.0037 0.0155 0.242
Brugia malayi hypothetical protein 0.0013 0.0029 0.0436
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0119 0.1855
Brugia malayi Serotonin receptor 0.003 0.0119 0.1855
Onchocerca volvulus 0.003 0.0119 0.4632
Loa Loa (eye worm) thioredoxin reductase 0.0011 0.0023 0.0337
Entamoeba histolytica tubulin family protein 0.0016 0.0047 0.4029
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Schistosoma mansoni adenoreceptor 0.003 0.0119 0.1857
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0119 0.0196
Onchocerca volvulus 0.003 0.0119 0.4632
Trypanosoma brucei beta tubulin 0.0016 0.0047 0.068
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0119 0.0196
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0026 0.0097 0.0087
Plasmodium vivax plasmepsin IV, putative 0.0022 0.0077 0.488
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0016 0.0047 0.0076
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Echinococcus multilocularis serotonin receptor 0.003 0.0119 0.0196
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0008 0.0004 0.004
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0037 0.0156 1
Echinococcus granulosus tm gpcr rhodopsin 0.1188 0.6018 1
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0022 0.0077 0.488
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0037 0.0156 1
Echinococcus multilocularis g protein coupled receptor 0.003 0.0119 0.0196
Echinococcus granulosus neuropeptide receptor 0.003 0.0119 0.0198
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1188 0.6018 1
Onchocerca volvulus 0.003 0.0119 0.4632
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0119 0.0196
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0119 0.1855
Echinococcus granulosus Tubulin beta 2C chain 0.0016 0.0047 0.0078
Brugia malayi beta-tubulin, identical 0.0016 0.0047 0.0718
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0007 0.0002 0.0018
Brugia malayi hypothetical protein 0.003 0.0119 0.1855
Brugia malayi neuropeptide F receptor 0.003 0.0119 0.1855
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0008 0.0004 0.0043
Plasmodium falciparum glutathione reductase 0.0011 0.0023 0.1246
Echinococcus granulosus g-protein coupled receptor 0.003 0.0119 0.0198
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Trypanosoma brucei beta tubulin 0.0016 0.0047 0.068
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0119 0.0198
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0119 0.0198
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0119 0.0196
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0002 0.0018
Schistosoma mansoni amine GPCR 0.003 0.0119 0.1857
Brugia malayi Dopamine receptor 0.003 0.0119 0.1855
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0119 0.0198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0119 0.1857
Schistosoma mansoni amine GPCR 0.003 0.0119 0.1857
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0119 0.1855
Schistosoma mansoni aldehyde dehydrogenase 0.0015 0.0039 0.06
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0119 0.0196
Trichomonas vaginalis tubulin epsilon chain, putative 0.0016 0.0047 0.068
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0119 0.0196
Loa Loa (eye worm) BEN-1 protein 0.0016 0.0047 0.0718
Echinococcus granulosus cysteinyl tRNA synthetase 0.0029 0.0111 0.0184
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0119 0.1857
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0119 0.0196
Echinococcus granulosus hypothetical protein 0.003 0.0119 0.0198
Leishmania major beta tubulin 0.0016 0.0047 0.068
Echinococcus multilocularis neuropeptide s receptor 0.003 0.0119 0.0196
Loa Loa (eye worm) glutathione reductase 0.0011 0.0023 0.0337
Brugia malayi Serotonin receptor 0.003 0.0119 0.1855
Echinococcus granulosus roundabout 2 0.0007 0.0002 0.0004
Brugia malayi larval opioid receptor 0.003 0.0119 0.1855
Loa Loa (eye worm) hypothetical protein 0.0037 0.0155 0.242
Echinococcus granulosus Tubulin beta 2C chain 0.0016 0.0047 0.0078
Echinococcus granulosus tubulin beta 4A class IVa 0.0016 0.0047 0.0078
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.0119 0.0198
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0119 0.1855
Schistosoma mansoni amine GPCR 0.003 0.0119 0.1857
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0132 0.0638 1
Echinococcus multilocularis inhibitor of apoptosis protein 0.0033 0.0135 0.0222
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Echinococcus multilocularis Tubulin beta 2C chain 0.0016 0.0047 0.0076
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.0008 0.0004 0.0004
Echinococcus granulosus inhibitor of apoptosis protein 0.0033 0.0135 0.0225
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Echinococcus multilocularis Tubulin beta 2C chain 0.0016 0.0047 0.0076
Echinococcus granulosus neuroglian 0.0007 0.0002 0.0004
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.0047 0.068
Plasmodium falciparum plasmepsin IV 0.0022 0.0077 0.4793
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0007 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0018
Echinococcus multilocularis beta tubulin 0.0016 0.0047 0.0076
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0037 0.0155 0.242
Echinococcus granulosus g protein coupled receptor 0.003 0.0119 0.0198
Schistosoma mansoni hypothetical protein 0.003 0.0119 0.1857
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0119 0.0196
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0119 0.1855
Echinococcus granulosus twitchin 0.0008 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Mycobacterium tuberculosis Probable dehydrogenase 0.0026 0.0097 0.0087
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0037 0.0156 0.2392
Loa Loa (eye worm) hypothetical protein 0.0033 0.0135 0.2101
Loa Loa (eye worm) serotonin transporter b 0.0037 0.0155 0.242
Mycobacterium tuberculosis Probable oxidoreductase 0.0029 0.0112 0.0102
Echinococcus granulosus tubulin beta 1 chain 0.0016 0.0047 0.0078
Trichomonas vaginalis set domain proteins, putative 0.0057 0.0256 0.3981
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0029 0.0111 0.1724
Brugia malayi hypothetical protein 0.003 0.0119 0.1855
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0119 0.1857
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0119 0.0198
Toxoplasma gondii beta-1 tubulin, putative 0.0016 0.0047 0.2963
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0397
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0007 0.0002 0.0002
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0119 0.1855
Brugia malayi hypothetical protein 0.003 0.0119 0.1855
Leishmania major trypanothione reductase 0.0011 0.0023 0.0298
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0119 0.0196
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0119 0.1855
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0119 0.0198
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0018
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0007 0.0002 0.0021
Leishmania major beta tubulin 0.0016 0.0047 0.068
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0119 0.1855
Schistosoma mansoni tubulin subunit beta 0.0016 0.0047 0.0721
Onchocerca volvulus 0.0057 0.0256 1
Schistosoma mansoni tubulin subunit beta 0.0016 0.0047 0.0721
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0119 0.1857
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0119 0.1857
Trichomonas vaginalis tubulin, putative 0.0016 0.0047 0.068
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0119 0.1857
Echinococcus granulosus leucyl tRNA synthetase 0.0029 0.0111 0.0184
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0119 0.1857
Plasmodium falciparum thioredoxin reductase 0.0011 0.0023 0.1246
Brugia malayi G-protein coupled receptor 0.003 0.0119 0.1855
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0018
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0029 0.0111 0.1688
Echinococcus multilocularis Tubulin beta 2C chain 0.0016 0.0047 0.0076
Schistosoma mansoni tubulin subunit beta 0.0016 0.0047 0.0721
Onchocerca volvulus 0.003 0.0119 0.4632
Echinococcus multilocularis thioredoxin glutathione reductase 0.0011 0.0023 0.0036
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase 0.0042 0.0181 0.0884
Schistosoma mansoni opsin-like receptor 0.003 0.0119 0.1857
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Onchocerca volvulus 0.0033 0.0135 0.5247
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0119 0.1857
Schistosoma mansoni neuropeptide receptor 0.003 0.0119 0.1857
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0119 0.0196
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0022 0.0077 0.1182
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0018
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0119 0.0196
Brugia malayi neuropeptide F receptor 0.003 0.0119 0.1855
Plasmodium falciparum plasmepsin I 0.0022 0.0077 0.4793
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0119 0.0196
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0119 0.0198
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0119 0.1855
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.197 1 1
Entamoeba histolytica tubulin family protein 0.0016 0.0047 0.4029
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0033 0.0135 0.2101
Schistosoma mansoni tubulin subunit beta 0.0016 0.0047 0.0721
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0119 0.0198
Schistosoma mansoni neuropeptide receptor 0.003 0.0119 0.1857
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0119 0.1857
Chlamydia trachomatis cysteine--tRNA ligase 0.0029 0.0111 0.3026
Leishmania major beta tubulin 0.0016 0.0047 0.068
Plasmodium vivax tubulin beta chain, putative 0.0016 0.0047 0.2963
Loa Loa (eye worm) hypothetical protein 0.0022 0.0077 0.1182
Loa Loa (eye worm) tubulin beta-2A chain 0.0016 0.0047 0.0718
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0119 0.0196
Echinococcus multilocularis roundabout 2 0.0007 0.0002 0.0002
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.0119 0.0196
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0132 0.0638 1
Echinococcus granulosus sex peptide receptor 0.003 0.0119 0.0198
Schistosoma mansoni histamine h1 receptor 0.003 0.0119 0.1857
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0119 0.0198
Echinococcus multilocularis Tubulin beta 2C chain 0.0016 0.0047 0.0076
Trypanosoma brucei beta tubulin 0.0016 0.0047 0.068
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0119 0.0198
Schistosoma mansoni opsin-like receptor 0.003 0.0119 0.1857
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0119 0.0198
Echinococcus granulosus tubulin subunit beta 0.0016 0.0047 0.0078
Echinococcus granulosus fmrfamide receptor 0.003 0.0119 0.0198
Echinococcus multilocularis g protein coupled receptor 0.003 0.0119 0.0196
Leishmania major beta tubulin 0.0016 0.0047 0.068
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0119 0.0198
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0119 0.0198
Leishmania major beta tubulin 0.0016 0.0047 0.068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0007 0.0001 0.0003
Onchocerca volvulus 0.003 0.0119 0.4632
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Leishmania major beta tubulin 0.0016 0.0047 0.068
Echinococcus multilocularis somatostatin receptor 0.003 0.0119 0.0196
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0119 0.1855
Schistosoma mansoni amine GPCR 0.003 0.0119 0.1857
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0119 0.1855
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0119 0.0198
Plasmodium falciparum cysteine--tRNA ligase 0.0029 0.0111 0.7057
Echinococcus granulosus allatostatin A receptor 0.003 0.0119 0.0198
Echinococcus multilocularis beta tubulin 0.0016 0.0047 0.0076
Brugia malayi RE15519p 0.003 0.0119 0.1855
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0119 0.0196
Brugia malayi hypothetical protein 0.0007 0.0002 0.0018
Schistosoma mansoni opsin-like receptor 0.003 0.0119 0.1857
Brugia malayi Dopamine receptor protein 2 0.003 0.0119 0.1855
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0022 0.0077 0.0127
Echinococcus multilocularis allatostatin A receptor 0.003 0.0119 0.0196
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0184 0.0902 1
Schistosoma mansoni dihydrofolate reductase 0.0011 0.002 0.0294
Trichomonas vaginalis STE family protein kinase 0.0132 0.0638 1
Loa Loa (eye worm) dihydrofolate reductase 0.0011 0.002 0.0291
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.1855
Onchocerca volvulus 0.003 0.0119 0.4632
Echinococcus multilocularis serotonin transporter 0.0037 0.0155 0.0256
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0119 0.0196
Onchocerca volvulus 0.003 0.0119 0.4632
Brugia malayi thymidylate synthase 0.0027 0.01 0.1553
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.0119 0.0198
Echinococcus granulosus thymidylate synthase 0.0027 0.01 0.0167
Mycobacterium leprae ProbableUPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG 0.0031 0.0123 0.0113
Onchocerca volvulus 0.003 0.0119 0.4632
Echinococcus granulosus defective proboscis extension response 0.0007 0.0002 0.0004
Echinococcus multilocularis thymidylate synthase 0.0027 0.01 0.0164
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.007 0.0321 1
Mycobacterium ulcerans thymidylate synthase 0.0027 0.01 0.0096
Brugia malayi G-protein coupled receptor 0.003 0.0119 0.1855
Leishmania major beta tubulin 0.0016 0.0047 0.068

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 667.25 uM Cytotoxicity against human HepG2.2.15 cells assessed as cell death after 9 days by MTT assay ChEMBL. 25847765

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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