Detailed information for compound 19355

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 348.44 | Formula: C16H16N2O3S2
  • H donors: 1 H acceptors: 3 LogP: 3.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCS(=O)(=O)Nc1cccc(c1)OCc1nc2c(s1)cccc2
  • InChi: 1S/C16H16N2O3S2/c1-2-23(19,20)18-12-6-5-7-13(10-12)21-11-16-17-14-8-3-4-9-15(14)22-16/h3-10,18H,2,11H2,1H3
  • InChiKey: LKOUOYVSCGNMKT-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0101 0.1112 0.3282
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0018 0.0075 0.0085
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0082 0.0885 0.2756
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0404 0.1227
Trypanosoma brucei acetyl-CoA carboxylase 0.0742 0.9129 1
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0026 0.018 0.0115
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Trichomonas vaginalis pten, drome, putative 0.0018 0.0075 0.0182
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0083 0.0126
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0404 0.0442
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0369 0.0404
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Trypanosoma brucei unspecified product 0.0186 0.2177 0.2385
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0348 0.053
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0369 0.0659
Echinococcus multilocularis Protein lozenge 0.0054 0.0528 0.0456
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0369 0.0659
Mycobacterium ulcerans hypothetical protein 0.0026 0.018 0.0531
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.1722 0.1886
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0235 0.2788 0.2733
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.1722 0.1659
Brugia malayi CXXC zinc finger family protein 0.0032 0.0249 0.0283
Leishmania major phosphoglycerate kinase C, glycosomal 0.0082 0.0885 0.0969
Trypanosoma brucei phosphoglycerate kinase, putative 0.003 0.0233 0.0255
Trypanosoma brucei phosphoglycerate kinase 0.0082 0.0885 0.0969
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0082 0.0885 0.2198
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.3511 0.3846
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0026 0.018 0.0274
Onchocerca volvulus 0.0018 0.0075 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0322 0.0576
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0083 0.0126
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0101 0.1112 0.3282
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0322 0.0249
Trypanosoma brucei phosphoglycerate kinase 0.0082 0.0885 0.0969
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0283 0.3388 0.3711
Leishmania major carboxylase, putative 0.0283 0.3388 0.3711
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Trypanosoma cruzi phosphoglycerate kinase, putative 0.003 0.0233 0.0417
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0026 0.018 0.0197
Loa Loa (eye worm) acetyltransferase 0.0149 0.1722 0.1955
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0293 0.0873
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0018 0.0075 0.0085
Schistosoma mansoni aspartate carbamoyltransferase 0.0064 0.0653 0.0716
Echinococcus multilocularis dna polymerase eta 0.0062 0.0631 0.0559
Treponema pallidum pyruvate carboxylase subunit B 0.0026 0.018 0.1211
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0101 0.1112 0.1218
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0101 0.1112 0.1145
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0101 0.1112 0.3114
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0026 0.018 0.0197
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0075 0.0082
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0083 0.0094
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0026 0.018 0.0204
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0075 0.0082
Schistosoma mansoni loxhd1 0.0039 0.0348 0.0382
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0695 0.8543 0.9704
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0026 0.018 0.0204
Loa Loa (eye worm) hypothetical protein 0.0039 0.0348 0.0396
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0283 0.3388 0.3658
Schistosoma mansoni hypothetical protein 0.0039 0.0348 0.0382
Echinococcus granulosus phosphoglycerate kinase 1 0.0082 0.0885 0.0894
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0322 0.0951
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0742 0.9129 0.9122
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1827 0.1765
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0083 0.0206
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0075 0.0082
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0322 0.0353
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0018 0.0032
Leishmania major DNA polymerase eta, putative 0.0062 0.0631 0.0691
Onchocerca volvulus 0.0429 0.5216 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0695 0.8543 0.8532
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Schistosoma mansoni hypothetical protein 0.0353 0.4263 0.4669
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1827 0.2075
Schistosoma mansoni rab6-interacting 0.0039 0.0348 0.0382
Loa Loa (eye worm) hypothetical protein 0.0062 0.0631 0.0716
Brugia malayi Protein-tyrosine phosphatase 1 0.0018 0.0075 0.0085
Trypanosoma brucei protein tyrosine phosphatase 1 0.0018 0.0075 0.0082
Trypanosoma brucei glucosidase, putative 0.0035 0.0293 0.0321
Mycobacterium ulcerans phosphoglycerate kinase 0.0082 0.0885 0.2613
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0348 0.0275
Schistosoma mansoni acetyl-CoA carboxylase 0.0742 0.9129 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0322 0.0353
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0026 0.018 0.0321
Leishmania major DNA polymerase eta, putative 0.0036 0.0308 0.0338
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0026 0.018 0.0197
Echinococcus multilocularis dnaJ subfamily B 0.045 0.5472 0.5438
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0026 0.018 0.0197
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0082 0.0885 0.1581
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0348 0.0275
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0026 0.018 0.0274
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0101 0.1112 0.3282
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0293 0.0873
Trypanosoma brucei unspecified product 0.0026 0.0177 0.0194
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0075 0.0134
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0082 0.0885 0.2756
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0322 0.0353
Echinococcus granulosus dna polymerase kappa 0.0037 0.0322 0.0273
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.003 0.0233 0.0417
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0018 0.0075 0.0404
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3511 0.6273
Leishmania major phosphoglycerate kinase B, cytosolic 0.0082 0.0885 0.0969
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0018 0.0032
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0101 0.1112 0.1044
Entamoeba histolytica phosphoglycerate kinase, putative 0.0082 0.0885 0.6112
Onchocerca volvulus 0.0039 0.0348 0.0635
Echinococcus granulosus dnaJ subfamily B 0.045 0.5472 0.5961
Trypanosoma brucei unspecified product 0.0026 0.0177 0.0194
Giardia lamblia Protein tyrosine phosphatase 0.0018 0.0075 0.0524
Schistosoma mansoni pcd6 interacting protein-related 0.0018 0.0075 0.0082
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0018 0.0075 0.0082
Plasmodium falciparum phosphoglycerate kinase 0.0082 0.0885 0.1348
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1827 0.1935
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0018 0.0075 0.0085
Onchocerca volvulus 0.0018 0.0075 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0235 0.2788 0.3054
Loa Loa (eye worm) hypothetical protein 0.0026 0.018 0.0204
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0293 0.0873
Loa Loa (eye worm) protein tyrosine phosphatase 0.0018 0.0075 0.0085
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0101 0.1112 0.1986
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0026 0.018 0.0274
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0404 0.0363
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0101 0.1112 0.3233
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0404 0.0615
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0283 0.3388 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0293 0.0873
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0322 0.0273
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0026 0.018 0.0197
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0293 0.0332
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0348 0.0302
Echinococcus multilocularis geminin 0.0353 0.4263 0.4219
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0358 0.2493
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.0322 0.0725
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Brugia malayi Stress-activated protein kinase jnk-1 0.0235 0.2788 0.3166
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0716 0.8804 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1827 0.1765
Brugia malayi Doublecortin family protein 0.0039 0.0348 0.0396
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0293 0.0332
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0177 0.0194
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1669 0.1761
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0648 0.071
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0018 0.002
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0018 0.0075 0.0082
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0283 0.3388 0.6053
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.0322 0.0967
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.0322 0.0967
Schistosoma mansoni pyruvate carboxylase 0.0283 0.3388 0.3711
Treponema pallidum phosphoglycerate kinase 0.0082 0.0885 1
Onchocerca volvulus 0.0018 0.0075 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0293 0.0523
Schistosoma mansoni lozenge 0.0054 0.0528 0.0578
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Onchocerca volvulus 0.0018 0.0075 0.011
Schistosoma mansoni hypothetical protein 0.0353 0.4263 0.4669
Onchocerca volvulus 0.0032 0.0249 0.0445
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0322 0.0725
Loa Loa (eye worm) runx1 0.0054 0.0528 0.0599
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0018 0.0075 0.0082
Brugia malayi Phosphoglycerate kinase 0.003 0.0233 0.0265
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0083 0.0008
Schistosoma mansoni lipoxygenase 0.0102 0.1133 0.1241
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0018 0.0075 0.0082
Echinococcus multilocularis dna polymerase kappa 0.0037 0.0322 0.0249
Onchocerca volvulus 0.0018 0.0075 0.011
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0064 0.0653 0.1168
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0083 0.0091
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Brugia malayi Phosphoglycerate kinase 0.0082 0.0885 0.1005
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0358 0.0546
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0101 0.1112 0.3282
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0537 0.6566 1
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0322 0.0353
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0026 0.018 0.0197
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0026 0.018 0.0197
Schistosoma mansoni DNA polymerase eta 0.0062 0.0631 0.0691
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0064 0.0653 0.1727
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0283 0.3388 1
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0018 0.0075 0.0404
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0083 0.0206
Loa Loa (eye worm) glutaminase 2 0.0265 0.3164 0.3594
Echinococcus multilocularis cpg binding protein 0.0033 0.0272 0.0198
Schistosoma mansoni ap endonuclease 0.0018 0.0083 0.0091
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0742 0.9129 1
Brugia malayi hypothetical protein 0.0429 0.5216 0.5925
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1585 0.1736
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0101 0.1112 0.2905
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0026 0.018 0.0197
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Plasmodium falciparum carbamoyl phosphate synthetase 0.0064 0.0653 0.0995
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0018 0.0075 0.0404
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0293 0.0873
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Echinococcus multilocularis RUN 0.0039 0.0348 0.0275
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0083 0.0007
Schistosoma mansoni alpha glucosidase 0.0035 0.0293 0.0321
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0283 0.3388 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0082 0.0885 0.2428
Leishmania major DNA polymerase kappa, putative 0.0037 0.0322 0.0353
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0075 0.0082
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0283 0.3388 1
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0026 0.018 0.0321
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0018 0.002
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0101 0.1112 0.1218
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0293 0.0523
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0083 0.0456
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0631 0.0716
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0083 0.0244
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.003 0.0233 0.0255
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0404 0.0442
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0083 0.0575
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Echinococcus granulosus c-Jun N-terminal kinases 0.0235 0.2788 0.2996
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0026 0.018 0.0294
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0369 0.0659
Mycobacterium ulcerans hypothetical protein 0.0154 0.1781 0.5256
Toxoplasma gondii carbamoylphosphate synthetase 0.0064 0.0653 0.0716
Onchocerca volvulus 0.0018 0.0075 0.011
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0293 0.1936
Schistosoma mansoni ap endonuclease 0.0018 0.0083 0.0091
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3511 0.6273
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Echinococcus multilocularis phosphoglycerate kinase 1 0.0082 0.0885 0.0816
Onchocerca volvulus 0.0018 0.0075 0.011
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0026 0.018 0.0321
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0026 0.018 0.0105
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0283 0.3388 0.3711
Leishmania major tyrosine specific protein phosphatase, putative 0.0018 0.0075 0.0082
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0026 0.018 0.0197
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0075 0.0082
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0127 0.1437 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0026 0.018 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0322 0.0353
Leishmania major acetyl-CoA carboxylase, putative 0.0742 0.9129 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.0322 0.0353
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1585 0.1736
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0293 0.1936
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0198 0.2334 0.4455
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0283 0.3388 1
Onchocerca volvulus 0.0018 0.0075 0.011
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0293 0.0873
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0101 0.1112 0.1218
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Trichomonas vaginalis glutaminase, putative 0.0265 0.3164 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0101 0.1112 0.1218
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0173 0.2021 0.2149
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0177 0.0194
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0308 0.0338
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.0631 0.0691
Mycobacterium ulcerans pyruvate carboxylase 0.0283 0.3388 1
Brugia malayi hypothetical protein 0.0018 0.0075 0.0085
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.003 0.0233 0.0417
Toxoplasma gondii hypothetical protein 0.0047 0.0445 0.0487
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0537 0.6566 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.003 0.0233 0.0417
Chlamydia trachomatis biotin carboxylase 0.0257 0.3063 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0293 0.0873
Plasmodium vivax phosphoglycerate kinase, putative 0.0082 0.0885 0.1348
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0064 0.0653 0.0995
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0075 0.0134
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.002
Brugia malayi hypothetical protein 0.0039 0.0348 0.0396
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0695 0.8543 0.9358
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0283 0.3388 0.3711
Schistosoma mansoni polycystin 1-related 0.0039 0.0348 0.0382
Echinococcus granulosus dna polymerase eta 0.0062 0.0631 0.0613
Schistosoma mansoni hypothetical protein 0.045 0.5472 0.5994
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0742 0.9129 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0322 0.0353
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0018 0.0075 0.0082
Onchocerca volvulus 4.1 G protein, putative homolog 0.0018 0.0075 0.011
Onchocerca volvulus 0.0018 0.0075 0.011
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0026 0.018 0.0294
Echinococcus granulosus RUN 0.0039 0.0348 0.0302
Onchocerca volvulus 0.0018 0.0075 0.011
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0348 0.0302
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.3511 0.3846
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0293 0.0321
Onchocerca volvulus 0.0018 0.0075 0.011
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0293 0.0873
Echinococcus granulosus cpg binding protein 0.0033 0.0272 0.0217
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0481 0.086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0026 0.018 0.0294
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0064 0.0653 0.1929
Loa Loa (eye worm) glutaminase 0.0265 0.3164 0.3594
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0322 0.0353
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1585 0.2832
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0293 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0075 0.0082
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0348 0.0302
Echinococcus granulosus geminin 0.0353 0.4263 0.4625
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0018 0.0075 0.0082
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0026 0.018 0.0531
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.0322 0.0353
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0101 0.1112 0.3114
Echinococcus multilocularis Biotin lipoyl attachment 0.0026 0.018 0.0105
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0082 0.0885 0.0969
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0283 0.3388 0.3711
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Onchocerca volvulus 0.0018 0.0075 0.011
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0322 0.0366
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0082 0.0885 0.1581
Giardia lamblia DINP protein human, muc B family 0.0037 0.0322 0.2243
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0283 0.3388 1
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0101 0.1112 0.1986
Onchocerca volvulus 0.0018 0.0075 0.011
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0026 0.018 0.0321
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0018 0.0075 0.0082
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0026 0.018 0.0274
Schistosoma mansoni cpg binding protein 0.0033 0.0272 0.0298
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0083 0.0148
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0018 0.002
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0358 0.2398
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0283 0.3388 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.0631 0.1127
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0026 0.018 0.0274
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0322 0.2144
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Loa Loa (eye worm) hypothetical protein 0.0082 0.0885 0.1005
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0308 0.0551
Onchocerca volvulus 0.0018 0.0075 0.011
Schistosoma mansoni phosphoglycerate kinase 0.0082 0.0885 0.0969
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0235 0.2788 0.3166
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0322 0.0576
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0322 0.0353
Onchocerca volvulus 0.0018 0.0075 0.011
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0026 0.018 0.0197
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0064 0.0653 0.0716
Onchocerca volvulus 0.0091 0.0996 0.1881
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0348 0.0275
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0018 0.0075 0.0085
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0026 0.018 0.0197
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0026 0.018 0.0197
Schistosoma mansoni alpha-glucosidase 0.0136 0.1552 0.1701
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0026 0.018 0.0197
Schistosoma mansoni lipoxygenase 0.0173 0.2021 0.2214
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0026 0.018 0.0105
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0026 0.018 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0322 0.0353
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0101 0.1112 0.3282
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0026 0.018 0.0294
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0173 0.2021 0.1961
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0283 0.3388 0.6053
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0026 0.018 0.0531
Loa Loa (eye worm) hypothetical protein 0.0026 0.018 0.0204
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0101 0.1112 0.3114
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0082 0.0885 0.2428
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0177 0.0194
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Loa Loa (eye worm) hypothetical protein 0.0429 0.5216 0.5925
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0082 0.0885 0.0969
Toxoplasma gondii exonuclease III APE 0.0018 0.0083 0.0091
Brugia malayi hypothetical protein 0.0039 0.0348 0.0396
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0695 0.8543 0.9704
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0018 0.0075 0.0082
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0322 0.0576
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0026 0.018 0.0115
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0293 0.0321
Leishmania major carbamoyl-phosphate synthase, putative 0.0064 0.0653 0.0716
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0075 0.0082
Schistosoma mansoni cpg binding protein 0.0032 0.0249 0.0273
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0026 0.018 0.0294
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0322 0.0353
Onchocerca volvulus 0.0018 0.0075 0.011
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0026 0.018 0.0197
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0075 0.0082
Loa Loa (eye worm) hypothetical protein 0.0429 0.5216 0.5925
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0322 0.0353
Onchocerca volvulus 0.0018 0.0075 0.011
Trypanosoma cruzi acetyl-CoA carboxylase 0.046 0.5597 1
Onchocerca volvulus 0.0018 0.0075 0.011
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0322 0.0366
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.1722 0.1955
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0083 0.0091
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0026 0.018 0.0197
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Loa Loa (eye worm) hypothetical protein 0.0039 0.0348 0.0396
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0692 0.0758
Onchocerca volvulus 0.0039 0.0348 0.0635
Onchocerca volvulus 0.0018 0.0075 0.011
Brugia malayi N-terminal motif family protein 0.0198 0.2334 0.2651
Toxoplasma gondii pyruvate carboxylase 0.0283 0.3388 0.3711
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0083 0.0094
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0742 0.9129 1
Brugia malayi glutaminase DH11.1 0.0265 0.3164 0.3594
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0322 0.0576
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Trypanosoma brucei unspecified product 0.0037 0.0322 0.0353
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0127 0.1437 1
Onchocerca volvulus 0.0018 0.0075 0.011
Brugia malayi hypothetical protein 0.0018 0.0075 0.0085
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0018 0.0075 0.0085
Onchocerca volvulus 0.0018 0.0075 0.011
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Brugia malayi hypothetical protein 0.0018 0.0075 0.0085
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.0075 0.0134
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0404 0.1227
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Schistosoma mansoni glutaminase 0.0265 0.3164 0.3466
Mycobacterium ulcerans glutaminase 0.0265 0.3164 0.934
Brugia malayi hypothetical protein 0.0018 0.0075 0.0085
Loa Loa (eye worm) hypothetical protein 0.0026 0.018 0.0204
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1781 0.5138
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Giardia lamblia Phosphoglycerate kinase 0.0082 0.0885 0.6161
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0075 0.0082
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0293 0.024
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0101 0.1112 0.1986
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Schistosoma mansoni alpha-glucosidase 0.0136 0.1552 0.1701
Trypanosoma brucei phosphoglycerate kinase 0.003 0.0233 0.0255
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0075 0.0085
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0101 0.1112 0.2905
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0322 0.0353
Schistosoma mansoni phosphoglycerate kinase 0.0082 0.0885 0.0969
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0101 0.1112 0.2905
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0322 0.0353
Echinococcus granulosus Biotin lipoyl attachment 0.0026 0.018 0.0115
Chlamydia trachomatis phosphoglycerate kinase 0.0082 0.0885 0.2446
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0026 0.018 0.0321
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0075 0.0082
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0018 0.0075 0.0085
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0348 0.053
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0026 0.018 0.0197
Trypanosoma cruzi phosphoglycerate kinase, putative 0.003 0.0233 0.0417
Schistosoma mansoni rab6-interacting 0.0039 0.0348 0.0382
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0064 0.0653 0.0716
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0026 0.018 0.0321
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0064 0.0653 0.0716
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0064 0.0653 0.1168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Brugia malayi Carboxyl transferase domain containing protein 0.0716 0.8804 1
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0101 0.1112 0.1218
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0083 0.0148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0085
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0026 0.018 0.0197
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0348 0.0396
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0249 0.0283
Schistosoma mansoni cpg binding protein 0.0033 0.0272 0.0298
Brugia malayi hypothetical protein 0.0018 0.0075 0.0085
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0283 0.3388 0.3337
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0695 0.8543 0.9353
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0075 0.0085
Onchocerca volvulus 0.0018 0.0075 0.011
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0322 0.0951
Loa Loa (eye worm) hypothetical protein 0.0198 0.2334 0.2651
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0283 0.3388 0.3711
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1827 0.2075
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0101 0.1112 0.3282
Onchocerca volvulus 0.0018 0.0075 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0322 0.0353
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0293 0.0873

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 13 % Percentage inhibition of Leukotriene D4 when Compound was administered perorally at a dose of 50 mg/kg in guinea pig, ChEMBL. 2498516
Inhibition (functional) = 32 % Inhibition of ovalbumin-induced bronchoconstriction when compound was administered perorally at a dose of 50 mg/kg in guinea pig ChEMBL. 2498516
Inhibition (functional) = 35 % Inhibition of ovalbumin-induced bronchoconstriction when compound was administered intraduodenally at a dose of 50 mg/kg in guinea pig ChEMBL. 2498516
Inhibition (functional) = 41 % Inhibition of Leukotriene D4 induced bronchoconstriction in guinea pig by 50 mg/kg i.d. ChEMBL. 2498516
Inhibition (functional) = 41 % Inhibition of Leukotriene D4 induced bronchoconstriction in guinea pig by 50 mg/kg i.d. ChEMBL. 2498516

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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