TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 633.132 | Formula: C41H84N4++++
H donors: 0 H acceptors: 0 LogP: 11.77 Rotable bonds: 28
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCCCCCCCC[N+]12CC[N+](CC1)(CC2)CCCCC[N+]12CC[N+](CC1)(CC2)CCCCCCCCCCCC
InChi: 1S/C41H84N4/c1-3-5-7-9-11-13-15-17-19-22-26-42-30-36-44(37-31-42,38-32-42)28-24-21-25-29-45-39-33-43(34-40-45,35-41-45)27-23-20-18-16-14-12-10-8-6-4-2/h3-41H2,1-2H3/q+4
InChiKey: WGDFBXMZAAIPES-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus multilocularis	neuropeptides capa receptor	0.0138	0.9992	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3893	0.3879
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0565	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.9992	1
Brugia malayi	follicle stimulating hormone receptor	0.0138	0.9992	0.9992
Echinococcus granulosus	neuropeptide receptor	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Loa Loa (eye worm)	G-protein coupled receptor	0.0138	0.9992	0.9992
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0138	0.9992	0.9992
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0138	0.9992	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.0565	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0138	0.9992	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0138	0.9992	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0138	0.9992	1
Onchocerca volvulus		0.0138	0.9992	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.2462	0.2444
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0138	0.9992	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.2462	0.2444
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus granulosus	neuropeptides capa receptor	0.0138	0.9992	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.9992	1
Schistosoma mansoni	biogenic amine receptor	0.0138	0.9992	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0138	0.9992	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0138	0.9992	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0138	0.9992	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0565	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0565	0.0539
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0138	0.9992	1
Onchocerca volvulus		0.0138	0.9992	0.5
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Brugia malayi	G-protein coupled receptor	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Brugia malayi	hypothetical protein	0.0138	0.9992	0.9992
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0138	0.9992	0.9992
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0138	0.9992	1
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.3893	0.3879
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3893	0.3879
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0138	0.9992	1
Echinococcus granulosus	tar DNA binding protein	0.0063	0.3893	0.3879
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0565	0.5
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0565	1
Schistosoma mansoni	adenoreceptor	0.0138	0.9992	1
Schistosoma mansoni	hypothetical protein	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Schistosoma mansoni	neuropeptide F-like receptor	0.0138	0.9992	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0138	0.9992	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0138	0.9992	0.9992
Loa Loa (eye worm)	neuropeptide F receptor	0.0138	0.9992	0.9992
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0565	1
Onchocerca volvulus		0.0138	0.9992	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0138	0.9992	1
Echinococcus granulosus	neuropeptide Y receptor	0.0138	0.9992	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0138	0.9992	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0565	1
Echinococcus granulosus	g protein coupled receptor	0.0138	0.9992	1
Onchocerca volvulus		0.0138	0.9992	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0565	1
Echinococcus multilocularis	g-protein coupled receptor	0.0138	0.9992	1
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.0565	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0138	0.9992	1
Brugia malayi	larval opioid receptor	0.0138	0.9992	0.9992
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0138	0.9992	0.9992
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0138	0.9992	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0138	0.9992	1
Echinococcus multilocularis	neuropeptide s receptor	0.0138	0.9992	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0138	0.9992	0.9992
Echinococcus multilocularis	dro:myosuppressin receptor	0.0138	0.9992	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0138	0.9992	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0565	1
Echinococcus granulosus	fmrfamide receptor	0.0138	0.9992	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0138	0.9992	0.9992
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0565	1
Trypanosoma brucei	unspecified product	0.0022	0.0565	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0138	0.9992	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.9992	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.2796	0.2777
Schistosoma mansoni	neuropeptide receptor	0.0138	0.9992	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0138	0.9992	1
Loa Loa (eye worm)	TYRA-2 protein	0.0138	0.9992	0.9992
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0565	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0565	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus granulosus	dna polymerase kappa	0.0022	0.0565	0.0539
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.9992	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0138	0.9992	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0138	0.9992	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0565	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0138	0.9992	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0138	0.9992	1
Brugia malayi	hypothetical protein	0.0138	0.9992	0.9992
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0138	0.9992	0.9992
Echinococcus granulosus	neuropeptides capa receptor	0.0138	0.9992	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.9992	1
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0565	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0138	0.9992	1
Echinococcus granulosus	neuropeptide receptor	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus granulosus	biogenic amine 5HT receptor	0.0138	0.9992	1
Brugia malayi	Dopamine receptor	0.0138	0.9992	0.9992
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0138	0.9992	1
Brugia malayi	putative neuropeptide receptor	0.0138	0.9992	0.9992
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.2462	0.2444
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.9992	1
Echinococcus multilocularis	g protein coupled receptor	0.0138	0.9992	1
Schistosoma mansoni	opsin-like receptor	0.0138	0.9992	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0138	0.9992	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0138	0.9992	1
Onchocerca volvulus		0.0138	0.9992	0.5
Echinococcus granulosus	dna polymerase eta	0.0022	0.0565	0.0539
Echinococcus multilocularis	fmrfamide receptor	0.0138	0.9992	1
Onchocerca volvulus		0.0138	0.9992	0.5
Brugia malayi	sulfakinin receptor protein	0.0138	0.9992	0.9992
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0138	0.9992	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0138	0.9992	1
Echinococcus granulosus	g protein coupled receptor	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1515	0.1492
Echinococcus multilocularis	neuropeptide receptor A26	0.0138	0.9992	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Brugia malayi	RNA binding protein	0.0063	0.3893	0.3876
Loa Loa (eye worm)	hypothetical protein	0.005	0.2796	0.2777
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0138	0.9992	1
Echinococcus granulosus	sex peptide receptor	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Onchocerca volvulus		0.0138	0.9992	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.9992	1
Echinococcus granulosus	somatostatin receptor	0.0138	0.9992	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.9992	1
Brugia malayi	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.2462	0.2444
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0138	0.9992	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0565	0.5
Brugia malayi	Melatonin receptor type 1A	0.0138	0.9992	0.9992
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0565	0.5
Brugia malayi	GnHR receptor homolog	0.0138	0.9992	0.9992
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.0565	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0138	0.9992	1
Schistosoma mansoni	DNA polymerase eta	0.0022	0.0565	0.0539
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0138	0.9992	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0565	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.9992	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.2462	0.2442
Echinococcus multilocularis	orexin receptor type 2	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.3893	0.3876
Echinococcus multilocularis	neuropeptide Y receptor	0.0138	0.9992	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.9992	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.2462	0.2444
Loa Loa (eye worm)	neuropeptide F receptor	0.0138	0.9992	0.9992
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.9992	1
Schistosoma mansoni	hypothetical protein	0.0138	0.9992	1
Onchocerca volvulus		0.0138	0.9992	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0138	0.9992	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.9992	1
Echinococcus granulosus	G protein coupled receptor 139	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Schistosoma mansoni	biogenic amine receptor	0.0138	0.9992	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0565	0.0539
Echinococcus multilocularis	neuropeptide receptor	0.0138	0.9992	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0138	0.9992	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0565	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0138	0.9992	0.9992
Schistosoma mansoni	myosin xvIII	0.0138	0.9992	1
Brugia malayi	neuropeptide F receptor	0.0138	0.9992	0.9992
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0138	0.9992	0.9992
Echinococcus multilocularis	g protein coupled receptor	0.0138	0.9992	1
Schistosoma mansoni	opsin-like receptor	0.0138	0.9992	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Brugia malayi	G protein-coupled receptor	0.0138	0.9992	0.9992
Echinococcus granulosus	orexin receptor type 2	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0565	0.5
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.0565	0.5
Brugia malayi	hypothetical protein	0.0138	0.9992	0.9992
Brugia malayi	ORL1-like opioid receptor	0.0138	0.9992	0.9992
Echinococcus granulosus	serotonin receptor	0.0138	0.9992	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Loa Loa (eye worm)	MH2 domain-containing protein	0.0138	1	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0138	0.9992	1
Schistosoma mansoni	opsin-like receptor	0.0138	0.9992	1
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.3893	0.3876
Schistosoma mansoni	amine GPCR	0.0138	0.9992	1
Echinococcus multilocularis	somatostatin receptor	0.0138	0.9992	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.1515	0.1492
Echinococcus multilocularis	serotonin receptor	0.0138	0.9992	1
Onchocerca volvulus		0.0138	0.9992	0.5
Onchocerca volvulus		0.0138	0.9992	0.5
Echinococcus multilocularis	dna polymerase eta	0.0022	0.0565	0.0539
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.2462	0.2442
Schistosoma mansoni	amine GPCR	0.0138	0.9992	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0138	0.9992	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0565	1
Brugia malayi	G-protein coupled receptor	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Onchocerca volvulus		0.0138	0.9992	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0138	0.9992	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.9992	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.0565	0.0539
Brugia malayi	Dopamine receptor protein 1	0.0138	0.9992	0.9992
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0138	0.9992	1
Schistosoma mansoni	neuropeptide receptor	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.0565	0.0539
Echinococcus granulosus	g protein coupled receptor	0.0138	0.9992	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.9992	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.9992	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0565	1
Brugia malayi	RE15519p	0.0138	0.9992	0.9992
Onchocerca volvulus		0.0138	0.9992	0.5
Giardia lamblia	DINP protein human, muc B family	0.0022	0.0565	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0565	1
Echinococcus multilocularis	fmrfamide receptor	0.0138	0.9992	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0138	0.9992	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Brugia malayi	hypothetical protein	0.0138	0.9992	0.9992
Schistosoma mansoni	hypothetical protein	0.0138	0.9992	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.0565	0.0539
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.3893	0.3876
Schistosoma mansoni	amine GPCR	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0565	1
Echinococcus granulosus	neuropeptide receptor A26	0.0138	0.9992	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0138	0.9992	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.0565	0.5
Schistosoma mansoni	hypothetical protein	0.0138	0.9992	1
Onchocerca volvulus		0.0138	0.9992	0.5
Schistosoma mansoni	amine GPCR	0.0138	0.9992	1
Echinococcus granulosus	allatostatin A receptor	0.0138	0.9992	1
Echinococcus multilocularis	serotonin receptor	0.0138	0.9992	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3893	0.3879
Brugia malayi	neuropeptide F receptor	0.0138	0.9992	0.9992
Brugia malayi	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus granulosus	tm gpcr rhodopsin	0.0138	0.9992	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.2796	0.2777
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Brugia malayi	hypothetical protein	0.0138	0.9992	0.9992
Brugia malayi	AKH receptor	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus granulosus	hypothetical protein	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Brugia malayi	hypothetical protein	0.0138	0.9992	0.9992
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.9992	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0138	0.9992	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0138	0.9992	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0138	0.9992	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0138	0.9992	1
Schistosoma mansoni	hypothetical protein	0.0034	0.1515	0.1493
Brugia malayi	Serotonin receptor	0.0138	0.9992	0.9992
Brugia malayi	Dopamine receptor protein 2	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3893	0.3879
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.9992	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.2796	0.2777
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.9992	1
Brugia malayi	hypothetical protein	0.0138	0.9992	0.9992
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.9992	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0138	0.9992	1
Onchocerca volvulus		0.0138	0.9992	0.5
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.9992	1
Echinococcus multilocularis	neuropeptide receptor	0.0138	0.9992	1
Echinococcus granulosus	neuropeptide s receptor	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.0565	0.5
Brugia malayi	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.2462	0.2444
Brugia malayi	Serotonin receptor	0.0138	0.9992	0.9992
Schistosoma mansoni	amine GPCR	0.0138	0.9992	1
Echinococcus multilocularis	g protein coupled receptor	0.0138	0.9992	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0138	0.9992	0.5
Schistosoma mansoni	biogenic amine receptor	0.0138	0.9992	1
Schistosoma mansoni	neuropeptide receptor	0.0138	0.9992	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0138	0.9992	0.9992
Loa Loa (eye worm)	transcription factor SMAD2	0.0138	1	1
Onchocerca volvulus		0.0138	0.9992	0.5
Echinococcus multilocularis	sex peptide receptor	0.0138	0.9992	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0565	0.5
Leishmania major	DNA polymerase eta, putative	0.0022	0.0565	0.5
Onchocerca volvulus		0.0138	0.9992	0.5
Schistosoma mansoni	histamine h1 receptor	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Echinococcus granulosus	tm gpcr rhodopsin	0.0138	0.9992	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.9992	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0138	0.9992	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Schistosoma mansoni	neuropeptide receptor	0.0138	0.9992	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0138	0.9992	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0565	0.0539
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.9992	1
Brugia malayi	TAR-binding protein	0.0063	0.3893	0.3876
Onchocerca volvulus		0.0138	0.9992	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0138	0.9992	0.9992
Echinococcus granulosus	neuropeptide FF receptor 2	0.0138	0.9992	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0138	0.9992	1
Loa Loa (eye worm)	RNA binding protein	0.0063	0.3893	0.3876
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3893	0.3879
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.2462	0.2444
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.0565	0.0539
Echinococcus granulosus	biogenic amine 5HT receptor	0.0138	0.9992	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0565	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992
Loa Loa (eye worm)	hypothetical protein	0.0138	0.9992	0.9992

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3558995

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1937919