Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.6005 | 0.6005 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0091 | 0.6936 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0091 | 0.6936 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.6936 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0057 | 0.4005 | 0.4005 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0459 | 0.0459 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.2206 | 0.2206 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.1092 | 0.8086 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0.1092 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.2206 | 0.2206 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.6936 | 1 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0015 | 0.0459 | 0.0459 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.2206 | 0.2206 |
Schistosoma mansoni | jumonji domain containing protein | 0.0015 | 0.0459 | 0.0459 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0015 | 0.0459 | 0.0459 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0091 | 0.6936 | 0.6936 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0091 | 0.6936 | 1 |
Echinococcus granulosus | phd:f box containing protein | 0.0015 | 0.0459 | 0.0459 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0507 | 0.0507 |
Trypanosoma brucei | polo-like protein kinase | 0.0091 | 0.6936 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.2206 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0057 | 0.4005 | 0.4005 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 1 | 1 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0015 | 0.0459 | 0.0459 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.2206 | 0.2206 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1242 | 0.1242 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.6936 | 1 |
Echinococcus multilocularis | phd:f box containing protein | 0.0015 | 0.0459 | 0.0459 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0015 | 0.0459 | 0.0459 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0091 | 0.6936 | 0.6936 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0015 | 0.0459 | 0.0459 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.2206 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0459 | 0.0459 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0459 | 0.0459 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0459 | 0.0459 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0459 | 0.0459 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.6936 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0057 | 0.4005 | 0.4005 |
Brugia malayi | jmjC domain containing protein | 0.0057 | 0.4005 | 0.4005 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.2206 | 0.1907 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0459 | 0.0459 |
Brugia malayi | Inositol-1 | 0.0036 | 0.2206 | 0.2206 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0015 | 0.0459 | 0.0459 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0057 | 0.4005 | 0.4005 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0459 | 0.0459 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.0099 | 0.0099 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0057 | 0.4005 | 0.4005 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 1 | 1 |
Giardia lamblia | Kinase, PLK | 0.0091 | 0.6936 | 0.5 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0015 | 0.0459 | 0.0459 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.2206 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.2206 | 0.2698 |
Brugia malayi | jmjC domain containing protein | 0.0057 | 0.4005 | 0.4005 |
Schistosoma mansoni | phd/f-box containing protein | 0.0015 | 0.0459 | 0.0459 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0091 | 0.6936 | 0.6936 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0091 | 0.6936 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.2206 | 0.2698 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.1092 | 0.0977 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0015 | 0.0459 | 0.0459 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0459 | 0.0459 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.6936 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.1888 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0023 | 0.1092 | 0.3623 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0459 | 0.0459 |
Brugia malayi | TAR-binding protein | 0.0127 | 1 | 1 |
Schistosoma mansoni | kinase | 0.0046 | 0.3116 | 0.3116 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0023 | 0.1092 | 0.3623 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0057 | 0.4005 | 0.4005 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.6936 | 1 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0015 | 0.0459 | 0.0459 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0091 | 0.6936 | 1 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.1092 | 0.5 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.008 | 0.6005 | 0.6005 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.2206 | 0.2698 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0099 | 0.0099 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0045 | 0.3014 | 0.1708 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.1092 | 0.8086 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0091 | 0.6936 | 0.6936 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.1242 | 0.4481 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.008 | 0.6005 | 0.6005 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.1242 | 0.1209 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0459 | 0.0459 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0023 | 0.1092 | 0.0977 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.008 | 0.6005 | 0.6005 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.1242 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.1242 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.1242 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.2206 | 0.2206 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0091 | 0.6936 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0057 | 0.4005 | 0.4005 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0091 | 0.6936 | 0.6936 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.1242 | 0.1209 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.1242 | 0.1209 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0045 | 0.3014 | 0.1708 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 1 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.2206 | 0.2698 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.1888 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.1242 | 0.1209 |
Schistosoma mansoni | jumonji domain containing protein | 0.0057 | 0.4005 | 0.4005 |
Onchocerca volvulus | 0.008 | 0.6005 | 0.8658 | |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0015 | 0.0459 | 0.0459 |
Brugia malayi | hypothetical protein | 0.0024 | 0.1242 | 0.1242 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 1 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.0099 | 0.0099 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.008 | 0.6005 | 0.6005 |
Schistosoma mansoni | protein phosphatase 2C | 0.0015 | 0.0459 | 0.0459 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 25 % | Anticonvulsant activity in Swiss mouse assessed as protection against seizures at 300 mg/kg, ip dosed 1 hr before initiation of maximal electroconvulsions by maximal electroshock test | ChEMBL. | 26052884 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.