Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0267 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0267 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0267 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0267 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0267 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0267 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0267 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0267 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0267 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0267 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 155 uM | Inhibition of DNA synthesis in human MCF7 cells assessed as reduction in [3H]-thymidine incorporation incubated for 24 hrs by liquid scintillation counting method | ChEMBL. | 25921266 |
Ki (binding) | = 28.7 nM | Inhibition of human carbonic anhydrase-9 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method | ChEMBL. | 25921266 |
Ki (binding) | = 77.5 nM | Inhibition of human carbonic anhydrase-12 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method | ChEMBL. | 25921266 |
Ki (binding) | = 4490 nM | Inhibition of human carbonic anhydrase-1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method | ChEMBL. | 25921266 |
Ki (binding) | = 7070 nM | Inhibition of human carbonic anhydrase-2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method | ChEMBL. | 25921266 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.