Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.3289 | 0.3289 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.4591 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0075 | 0.4591 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0.0002 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | RNA binding protein | 0.0075 | 0.4591 | 0.4591 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3289 | 0.3289 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1767 | 0.3848 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.091 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.091 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1767 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.091 | 0.091 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Brugia malayi | RNA binding protein | 0.0075 | 0.4591 | 0.4591 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0005 |
Brugia malayi | TAR-binding protein | 0.0075 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.3289 | 0.3289 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0005 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0005 |
Brugia malayi | hypothetical protein | 0.003 | 0.091 | 0.091 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.091 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0075 | 0.4591 | 0.4591 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.4591 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.091 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.4591 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0075 | 0.4591 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0005 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0075 | 0.4591 | 0.4591 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.4591 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1767 | 0.1767 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.091 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0075 | 0.4591 | 0.4591 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.091 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0005 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.091 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.091 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0002 | 0.0005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.