Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Monoamine oxidase B | Starlite/ChEMBL | References |
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.2604 | 0.4046 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0121 | 0.0987 | 0.1534 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.2604 | 0.4046 |
Brugia malayi | proteasome subunit beta type 2 | 0.0121 | 0.0987 | 0.1534 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0265 | 0.6437 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.2604 | 0.4046 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.2604 | 0.4046 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0265 | 0.6437 | 0.5 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0121 | 0.0987 | 0.1534 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0121 | 0.0987 | 0.1534 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.2604 | 0.4046 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0121 | 0.0987 | 0.1534 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.2604 | 0.4046 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0121 | 0.0987 | 0.1534 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0265 | 0.6437 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0121 | 0.0987 | 0.1534 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.2604 | 0.4046 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.2604 | 0.4046 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.2604 | 0.4046 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.2604 | 0.4046 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0265 | 0.6437 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0121 | 0.0987 | 0.1534 |
Echinococcus granulosus | proteasome prosome macropain | 0.0265 | 0.6437 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.2604 | 0.4046 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0265 | 0.6437 | 1 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0121 | 0.0987 | 0.1534 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0121 | 0.0987 | 0.1534 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0121 | 0.0987 | 0.1534 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0265 | 0.6437 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0121 | 0.0987 | 0.1534 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0265 | 0.6437 | 1 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0121 | 0.0987 | 0.1534 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.2604 | 0.4046 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0265 | 0.6437 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0265 | 0.6437 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0265 | 0.6437 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0265 | 0.6437 | 1 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0121 | 0.0987 | 0.1534 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0265 | 0.6437 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0265 | 0.6437 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0265 | 0.6437 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0121 | 0.0987 | 0.1534 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0333 | 0.9042 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0265 | 0.6437 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0121 | 0.0987 | 0.1534 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0121 | 0.0987 | 0.1534 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.2604 | 0.4046 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of human serum BuChE by spectrophotometric Ellman's method | ChEMBL. | 26107513 | |
IC50 (binding) | Inhibition of human recombinant MAO-A using kynuramine substrate by spectrophotometric assay | ChEMBL. | 26107513 | |
IC50 (binding) | Inhibition of human recombinant MAO-B using kynuramine substrate by spectrophotometric assay | ChEMBL. | 26107513 | |
IC50 (binding) | = 0.12 uM | Inhibition of electric eel AChE by spectrophotometric Ellman's method | ChEMBL. | 26107513 |
IC50 (binding) | = 1 uM | Inhibition of human recombinant AChE by spectrophotometric Ellman's method | ChEMBL. | 26107513 |
IC50 (binding) | = 5 uM | Inhibition of rat brain MAO-B using kynuramine substrate in rat mitochondrial substrate by spectrophotometric assay | ChEMBL. | 26107513 |
Inhibition (binding) | = 0 % | Inhibition of rat brain MAO-A using kynuramine substrate in rat mitochondrial substrate at 10 uM by spectrophotometric assay | ChEMBL. | 26107513 |
Inhibition (binding) | = 47 % | Inhibition of equine serum BuChE at 10 uM by spectrophotometric Ellman's method | ChEMBL. | 26107513 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.