Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cathepsin b | 0.0173 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0173 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0032 | 0 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0032 | 0 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0032 | 0 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0062 | 0.2134 | 0.2134 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0062 | 0.2134 | 1 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0032 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0062 | 0.2134 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0173 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0032 | 0 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Toxoplasma gondii | cathepsin B | 0.0062 | 0.2134 | 1 |
Plasmodium vivax | vivapain-2 | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0062 | 0.2134 | 0.2134 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0062 | 0.2134 | 1 |
Echinococcus granulosus | cathepsin b | 0.0173 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 1 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0062 | 0.2134 | 0.2134 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0062 | 0.2134 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0173 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0173 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0173 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0173 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0062 | 0.2134 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0032 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0062 | 0.2134 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0173 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0032 | 0 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Onchocerca volvulus | 0.0032 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.