Detailed information for compound 1944114

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 415.12 | Formula: C16H17Br2NO2
  • H donors: 1 H acceptors: 2 LogP: 4.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(C1=CC(=C(Br)Br)N(C1=O)Cc1ccccc1)O
  • InChi: 1S/C16H17Br2NO2/c1-2-6-14(20)12-9-13(15(17)18)19(16(12)21)10-11-7-4-3-5-8-11/h3-5,7-9,14,20H,2,6,10H2,1H3
  • InChiKey: UBEOMGYQLFRWEL-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0076 0.0834 0.2142
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.002 0.0069 0.0211
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.002 0.0069 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0727 0.1759
Trichomonas vaginalis tubulin, putative 0.0089 0.1011 0.2501
Echinococcus granulosus Tubulin alpha 1 chain 0.0215 0.2744 0.2706
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0066 0.0035
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.002 0.0069 0.0211
Schistosoma mansoni tubulin subunit beta 0.0298 0.3883 0.3859
Leishmania major alpha tubulin 0.0215 0.2744 0.7028
Echinococcus granulosus tubulin alpha 0.0157 0.1948 0.1906
Loa Loa (eye worm) tubulin alpha-2 chain 0.0215 0.2744 0.7066
Schistosoma mansoni tubulin subunit alpha 0.0215 0.2744 0.2717
Leishmania major beta tubulin 0.0298 0.3883 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0147 0.1807 0.465
Schistosoma mansoni lamin 0.0029 0.0188 0.015
Loa Loa (eye worm) tubulin alpha 2 0.0058 0.0585 0.1501
Echinococcus granulosus tubulin epsilon chain 0.0157 0.1948 0.1906
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.055 0.05
Leishmania major beta tubulin 0.0298 0.3883 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.002 0.0069 0.0211
Trypanosoma brucei epsilon tubulin 0.0157 0.1948 0.4949
Onchocerca volvulus 0.0076 0.0834 0.3176
Schistosoma mansoni alpha tubulin 0.0215 0.2744 0.2717
Giardia lamblia Epsilon tubulin 0.0068 0.0727 0.1759
Plasmodium falciparum tubulin delta chain, putative 0.0068 0.0727 0.1759
Loa Loa (eye worm) tubulin alpha chain 0.0215 0.2744 0.7066
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.002 0.0069 0.0211
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.002 0.0069 0.0026
Echinococcus granulosus tubulin beta 1 chain 0.0298 0.3883 0.385
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0727 0.1759
Loa Loa (eye worm) hypothetical protein 0.0029 0.0188 0.0477
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0053 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0215 0.2744 0.7028
Trypanosoma brucei alpha tubulin 0.0215 0.2744 0.7028
Brugia malayi Cytochrome P450 family protein 0.004 0.034 0.0869
Trypanosoma cruzi zeta tubulin, putative 0.0068 0.0727 0.1759
Plasmodium falciparum alpha tubulin 2 0.0215 0.2744 0.7028
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0069 0.0043
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.002 0.0069 0.0211
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.0554 0.1426
Loa Loa (eye worm) hypothetical protein 0.0029 0.0181 0.0459
Toxoplasma gondii beta-tubulin, putative 0.0298 0.3883 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0215 0.2744 0.2706
Trypanosoma brucei cytochrome P450, putative 0.004 0.034 0.075
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0475 0.1103
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0105 0.0263
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0147 0.1807 0.458
Trypanosoma brucei alpha tubulin 0.0215 0.2744 0.7028
Brugia malayi Tubulin alpha chain 0.0215 0.2744 0.7066
Leishmania major hypothetical protein, conserved 0.0056 0.0554 0.1307
Mycobacterium tuberculosis Probable reductase 0.0126 0.1526 0.2297
Schistosoma mansoni tubulin subunit beta 0.0068 0.0727 0.0691
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0834 1
Giardia lamblia Alpha-tubulin 0.0215 0.2744 0.7028
Trypanosoma brucei beta tubulin 0.0298 0.3883 1
Plasmodium falciparum thioredoxin reductase 0.0055 0.055 0.1299
Trypanosoma cruzi epsilon tubulin, putative 0.0157 0.1948 0.4949
Echinococcus multilocularis beta tubulin 0.0298 0.3883 0.385
Leishmania major beta tubulin 0.0298 0.3883 1
Toxoplasma gondii ABC1 family protein 0.0076 0.0834 0.2148
Giardia lamblia Beta tubulin 0.0298 0.3883 1
Echinococcus multilocularis tubulin delta chain 0.0068 0.0727 0.0677
Echinococcus multilocularis tubulin alpha 1C chain 0.0215 0.2744 0.2706
Plasmodium falciparum alpha tubulin 1 0.0215 0.2744 0.7028
Trypanosoma brucei tubulin delta chain 0.0068 0.0727 0.1759
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0126 0.1526 0.8826
Trichomonas vaginalis tubulin beta chain, putative 0.0089 0.1011 0.2501
Echinococcus granulosus tubulin alpha chain 0.0215 0.2744 0.2706
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0834 0.1218
Trypanosoma cruzi cytochrome P450, putative 0.004 0.034 0.075
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0834 0.0799
Brugia malayi Cytochrome P450 family protein 0.004 0.034 0.0869
Echinococcus granulosus lamin dm0 0.0029 0.0188 0.0136
Onchocerca volvulus 0.0076 0.0834 0.3176
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.002 0.0069 0.0026
Echinococcus granulosus peroxisome assembly protein 26 0.0215 0.2744 0.2706
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0834 0.2142
Loa Loa (eye worm) hypothetical protein 0.0137 0.1675 0.4309
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.002 0.0069 0.0043
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.002 0.0069 0.0026
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.055 0.05
Brugia malayi Tubulin gamma chain 0.0157 0.1948 0.5014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0368 0.0317
Toxoplasma gondii alpha-tubulin I, putative 0.0215 0.2744 0.7068
Leishmania major alpha tubulin 0.0215 0.2744 0.7028
Schistosoma mansoni tubulin subunit gamma 0.0157 0.1948 0.1917
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0418 0.0954
Onchocerca volvulus 0.0076 0.0834 0.3176
Trypanosoma brucei epsilon tubulin 0.0157 0.1948 0.4949
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.002 0.0069 0.0211
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.0684 0.1755
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0554 0.1307
Loa Loa (eye worm) hypothetical protein 0.0062 0.0637 0.1636
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.3288 0.3252
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.002 0.0069 0.0211
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.002 0.0069 0.0211
Echinococcus granulosus tubulin gamma 1 chain 0.0157 0.1948 0.1906
Trichomonas vaginalis tubulin alpha chain, putative 0.0298 0.3883 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0188 0.0477
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.002 0.0069 0.0026
Loa Loa (eye worm) glutathione reductase 0.0055 0.055 0.1411
Echinococcus granulosus Tubulin alpha 1 chain 0.0215 0.2744 0.2706
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0126 0.1526 0.2297
Trypanosoma cruzi beta tubulin, putative 0.0298 0.3883 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0298 0.3883 0.385
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0554 0.1307
Echinococcus multilocularis tubulin alpha 3 chain 0.0215 0.2744 0.2706
Leishmania major beta tubulin 0.0298 0.3883 1
Schistosoma mansoni tubulin subunit beta 0.0298 0.3883 0.3859
Mycobacterium tuberculosis Probable oxidoreductase 0.0141 0.172 0.2599
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0089 0.1011 0.2501
Echinococcus granulosus Tubulin alpha 1 chain 0.0215 0.2744 0.2706
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.002 0.0069 0.0211
Leishmania major beta tubulin 0.0298 0.3883 1
Schistosoma mansoni survival motor neuron protein 0.0052 0.0503 0.0466
Schistosoma mansoni lamin 0.0029 0.0188 0.015
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0554 0.1307
Leishmania major alpha tubulin 0.0215 0.2744 0.7028
Echinococcus granulosus Tubulin beta 2C chain 0.0298 0.3883 0.385
Echinococcus granulosus tubulin alpha 3 chain 0.0215 0.2744 0.2706
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0188 0.0477
Loa Loa (eye worm) tubulin beta-4 chain 0.0298 0.3883 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0298 0.3883 0.385
Echinococcus granulosus Tubulin beta 2C chain 0.0298 0.3883 0.385
Echinococcus multilocularis Tubulin alpha 1 chain 0.0215 0.2744 0.2706
Brugia malayi beta-lactamase family protein 0.0076 0.0834 0.2142
Brugia malayi beta-lactamase 0.0076 0.0834 0.2142
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0475 0.0425
Trypanosoma brucei epsilon tubulin 0.0157 0.1948 0.4949
Plasmodium vivax delta tubulin, putative 0.0068 0.0727 0.1866
Schistosoma mansoni calcium-activated potassium channel 0.0131 0.1583 0.155
Leishmania major beta tubulin 0.0298 0.3883 1
Leishmania major alpha tubulin 0.0215 0.2744 0.7028
Brugia malayi tubulin alpha-2 chain 0.0215 0.2744 0.7066
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0068 0.0727 0.1871
Echinococcus granulosus bloom syndrome protein 0.0023 0.0105 0.0052
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.034 0.0869
Leishmania major beta tubulin 0.0298 0.3883 1
Brugia malayi Tubulin beta chain 0.0089 0.1011 0.2598
Echinococcus granulosus tubulin alpha chain 0.0215 0.2744 0.2706
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0834 0.204
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0834 0.204
Trichomonas vaginalis esterase, putative 0.0076 0.0834 0.204
Leishmania major beta tubulin 0.0298 0.3883 1
Leishmania major delta tubulin, putative 0.0068 0.0727 0.1759
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0503 0.1288
Echinococcus granulosus tubulin alpha chain 0.0215 0.2744 0.2706
Loa Loa (eye worm) tubulin beta chain 0.0298 0.3883 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0157 0.1948 0.4949
Echinococcus multilocularis tubulin alpha chain 0.0215 0.2744 0.2706
Echinococcus multilocularis Tubulin alpha 1 chain 0.0215 0.2744 0.2706
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0834 0.0785
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0368 0.0317
Trichomonas vaginalis tubulin epsilon chain, putative 0.0068 0.0727 0.1759
Leishmania major alpha tubulin 0.0215 0.2744 0.7028
Echinococcus multilocularis hypothetical protein 0.0215 0.2744 0.2706
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0418 0.0954
Loa Loa (eye worm) hypothetical protein 0.0126 0.1523 0.3917
Toxoplasma gondii thioredoxin reductase 0.0055 0.055 0.1417
Loa Loa (eye worm) beta-lactamase 0.0076 0.0834 0.2142
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0475 0.1224
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.055 0.0776
Echinococcus granulosus small conductance calcium activated potassium 0.0137 0.1675 0.163
Entamoeba histolytica tubulin family protein 0.0298 0.3883 1
Leishmania major gamma-tubulin 0.0157 0.1948 0.4949
Echinococcus granulosus intermediate filament protein 0.0029 0.0188 0.0136
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.1011 0.2501
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.002 0.0069 0.0211
Leishmania major beta tubulin 0.0298 0.3883 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0126 0.1526 0.2297
Leishmania major beta tubulin 0.0298 0.3883 1
Echinococcus granulosus beta tubulin 0.0298 0.3883 0.385
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0834 0.204
Plasmodium vivax tubulin gamma chain, putative 0.0157 0.1948 0.5015
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0475 0.1218
Schistosoma mansoni tubulin subunit beta 0.0298 0.3883 0.3859
Schistosoma mansoni alpha tubulin 0.0215 0.2744 0.2717
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0834 0.1218
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.3288 0.3252
Trichomonas vaginalis tubulin gamma chain, putative 0.0298 0.3883 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.002 0.0069 0.0026
Entamoeba histolytica tubulin family protein 0.0298 0.3883 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0834 0.0785
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.002 0.0069 0.0211
Plasmodium falciparum tubulin epsilon chain, putative 0.0157 0.1948 0.4949
Schistosoma mansoni hypothetical protein 0.002 0.0069 0.0031
Loa Loa (eye worm) hypothetical protein 0.0076 0.0834 0.2142
Leishmania major lanosterol 14-alpha-demethylase, putative 0.002 0.0069 0.0043
Mycobacterium leprae Probable lipase LipE 0.0076 0.0834 0.4634
Echinococcus multilocularis lamin 0.0029 0.0188 0.0136
Trichomonas vaginalis tubulin, putative 0.0089 0.1011 0.2501
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.002 0.0069 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.002 0.0069 0.0026
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0069 0.0043
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.002 0.0069 0.0026
Brugia malayi Cytochrome P450 family protein 0.002 0.0069 0.0171
Mycobacterium leprae cell division protein FtsZ 0.0068 0.0727 0.3983
Loa Loa (eye worm) tubulin alpha 2 0.0147 0.1807 0.465
Leishmania major epsilon tubulin, putative 0.0157 0.1948 0.4949
Brugia malayi beta-lactamase family protein 0.0076 0.0834 0.2142
Echinococcus multilocularis tubulin alpha chain 0.0215 0.2744 0.2706
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.055 0.1412
Echinococcus multilocularis small conductance calcium activated potassium 0.0137 0.1675 0.163
Trypanosoma brucei alpha tubulin 0.0215 0.2744 0.7028
Schistosoma mansoni tubulin subunit beta 0.0298 0.3883 0.3859
Plasmodium vivax tubulin epsilon chain, putative 0.0157 0.1948 0.5015
Leishmania major alpha tubulin 0.0215 0.2744 0.7028
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0053 0.013
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.0554 0.1307
Leishmania major beta tubulin 0.0298 0.3883 1
Echinococcus granulosus tubulin subunit TubB 0.0215 0.2744 0.2706
Trypanosoma brucei beta tubulin 0.0298 0.3883 1
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0105 0.0052
Plasmodium vivax tubulin beta chain, putative 0.0298 0.3883 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0141 0.172 1
Brugia malayi hypothetical protein 0.0177 0.2222 0.572
Toxoplasma gondii beta tubulin 0.0298 0.3883 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0157 0.1948 0.4949
Trichomonas vaginalis tubulin epsilon chain, putative 0.0298 0.3883 1
Mycobacterium tuberculosis Conserved protein 0.0076 0.0834 0.1218
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0053 0.0015
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.002 0.0069 0.0211
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.034 0.3676
Trichomonas vaginalis tubulin gamma chain, putative 0.0068 0.0727 0.1759
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.002 0.0069 0.0026
Trichomonas vaginalis tubulin epsilon chain, putative 0.0215 0.2744 0.7028
Onchocerca volvulus 0.0052 0.0503 0.1547
Echinococcus multilocularis peroxisome assembly protein 26 0.0215 0.2744 0.2706
Mycobacterium ulcerans lipase LipD 0.0076 0.0834 1
Trichomonas vaginalis tubulin beta chain, putative 0.0215 0.2744 0.7028
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0068 0.0727 1
Schistosoma mansoni hypothetical protein 0.0052 0.0503 0.0466
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.002 0.0069 0.0026
Brugia malayi tubulin alpha chain - mouse 0.0215 0.2744 0.7066
Loa Loa (eye worm) hypothetical protein 0.0255 0.3288 0.8467
Trichomonas vaginalis tubulin beta chain, putative 0.0298 0.3883 1
Echinococcus multilocularis tubulin alpha chain 0.0215 0.2744 0.2706
Loa Loa (eye worm) BEN-1 protein 0.0298 0.3883 1
Entamoeba histolytica tubulin alpha chain, putative 0.0215 0.2744 0.6761
Echinococcus granulosus tubulin delta chain 0.0068 0.0727 0.0677
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0834 0.204
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0834 0.204
Giardia lamblia Delta tubulin 0.0068 0.0727 0.1759
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0834 0.4634
Plasmodium falciparum glutathione reductase 0.0055 0.055 0.1299
Echinococcus multilocularis geminin 0.0183 0.2296 0.2255
Loa Loa (eye worm) alpha-tubulin 0.0215 0.2744 0.7066
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0053 0.0129
Echinococcus granulosus tubulin alpha chain 0.0215 0.2744 0.2706
Schistosoma mansoni tubulin subunit epsilon 0.0157 0.1948 0.1917
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0834 0.1218
Plasmodium falciparum tubulin gamma chain 0.0157 0.1948 0.4949
Brugia malayi hypothetical protein 0.0042 0.0368 0.0942
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.1011 0.2501
Brugia malayi glutathione reductase 0.0055 0.055 0.1411
Leishmania major cytochrome p450-like protein 0.002 0.0069 0.0043
Trypanosoma cruzi cytochrome p450-like protein, putative 0.002 0.0069 0.0043
Onchocerca volvulus 0.0177 0.2222 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0098
Loa Loa (eye worm) hypothetical protein 0.0177 0.2222 0.572
Trichomonas vaginalis tubulin gamma chain, putative 0.0157 0.1948 0.4949
Trypanosoma cruzi alpha tubulin, putative 0.0215 0.2744 0.7028
Loa Loa (eye worm) hypothetical protein 0.0076 0.0834 0.2142
Echinococcus granulosus Tubulin beta 2C chain 0.0298 0.3883 0.385
Echinococcus multilocularis Tubulin beta 2C chain 0.0298 0.3883 0.385
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0105 0.0136
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.002 0.0069 0.0026
Echinococcus granulosus tubulin subunit beta 0.0298 0.3883 0.385
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0141 0.172 0.2599
Treponema pallidum cell division protein FtsZ 0.0068 0.0727 1
Trypanosoma brucei zeta tubulin, putative 0.0068 0.0727 0.1759
Mycobacterium tuberculosis Cell division protein FtsZ 0.0068 0.0727 0.1051
Brugia malayi Tubulin alpha chain 0.0068 0.0727 0.1865
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.002 0.0069 0.0211
Leishmania major alpha tubulin 0.0215 0.2744 0.7028
Trypanosoma brucei alpha tubulin, putative 0.0089 0.1011 0.2501
Echinococcus multilocularis Tubulin alpha 1 chain 0.0215 0.2744 0.2706
Plasmodium vivax tubulin alpha chain, putative 0.0215 0.2744 0.7066
Trichomonas vaginalis tubulin, putative 0.0068 0.0727 0.1759
Trypanosoma cruzi zeta tubulin, putative 0.0068 0.0727 0.1759
Echinococcus granulosus Tubulin beta 2C chain 0.0298 0.3883 0.385
Leishmania major cytochrome p450-like protein 0.004 0.034 0.075
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.002 0.0069 0.0211
Trypanosoma brucei alpha tubulin 0.0215 0.2744 0.7028
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.1011 0.2501
Echinococcus multilocularis tubulin alpha 0.0157 0.1948 0.1906
Echinococcus multilocularis musashi 0.0029 0.0188 0.0136
Giardia lamblia Beta tubulin 0.0298 0.3883 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0157 0.1948 0.5018
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0215 0.2744 0.7028
Echinococcus granulosus alpha tubulin 0.0215 0.2744 0.2706
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.002 0.0069 0.0026
Echinococcus multilocularis Tubulin beta 2C chain 0.0298 0.3883 0.385
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0132 0.0079
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0298 0.3883 0.385
Loa Loa (eye worm) alpha-tubulin 0.0215 0.2744 0.7066
Schistosoma mansoni tubulin subunit delta 0.0068 0.0727 0.0691
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.002 0.0069 0.0211
Trypanosoma cruzi tubulin gamma chain 0.0157 0.1948 0.4949
Echinococcus multilocularis beta tubulin 0.0298 0.3883 0.385
Loa Loa (eye worm) hypothetical protein 0.0076 0.0834 0.2142
Plasmodium vivax tubulin alpha chain, putative 0.0215 0.2744 0.7066
Brugia malayi hypothetical protein 0.0036 0.0283 0.0721
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0053 0.013
Loa Loa (eye worm) acetyltransferase 0.017 0.2123 0.5464
Leishmania major beta tubulin 0.0298 0.3883 1
Schistosoma mansoni tubulin subunit alpha 0.0068 0.0727 0.0691
Leishmania major beta tubulin 0.0298 0.3883 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.002 0.0069 0.0211
Echinococcus multilocularis lamin dm0 0.0029 0.0188 0.0136
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.055 0.1411
Leishmania major alpha tubulin 0.0215 0.2744 0.7028
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0834 0.1218
Brugia malayi alpha-tubulin 0.0215 0.2744 0.7066
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.002 0.0069 0.0026
Echinococcus multilocularis 0.002 0.0069 0.0017
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0141 0.172 0.2599
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0368 0.0331
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0126 0.1526 0.2297
Echinococcus multilocularis tubulin epsilon chain 0.0157 0.1948 0.1906
Leishmania major alpha tubulin 0.0215 0.2744 0.7028
Echinococcus multilocularis tubulin subunit TubB 0.0215 0.2744 0.2706
Schistosoma mansoni tubulin subunit alpha 0.0215 0.2744 0.2717
Leishmania major beta tubulin 0.0298 0.3883 1
Echinococcus granulosus geminin 0.0183 0.2296 0.2255
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0126 0.1526 0.2297
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.034 0.0869
Onchocerca volvulus 0.0089 0.1011 0.4045
Leishmania major alpha tubulin 0.0215 0.2744 0.7028
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0834 0.2143
Echinococcus multilocularis tubulin gamma 1 chain 0.0157 0.1948 0.1906
Schistosoma mansoni tubulin subunit beta 0.0298 0.3883 0.3859
Trypanosoma brucei beta tubulin 0.0298 0.3883 1
Schistosoma mansoni tubulin subunit beta 0.0298 0.3883 0.3859
Echinococcus granulosus lamin 0.0029 0.0188 0.0136
Leishmania major beta tubulin 0.0298 0.3883 1
Brugia malayi hypothetical protein 0.0255 0.3288 0.8467
Echinococcus granulosus beta tubulin 0.0298 0.3883 0.385
Echinococcus multilocularis Tubulin beta 2C chain 0.0298 0.3883 0.385
Brugia malayi Cytochrome P450 family protein 0.0065 0.0684 0.1755
Toxoplasma gondii beta-1 tubulin, putative 0.0298 0.3883 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0298 0.3883 1
Trichomonas vaginalis tubulin beta chain, putative 0.0215 0.2744 0.7028
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.002 0.0069 0.0026
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0053 0.0136
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0418 0.0142
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0475 0.1103
Echinococcus multilocularis tubulin alpha chain 0.0215 0.2744 0.2706
Toxoplasma gondii cytochrome p450 superfamily protein 0.002 0.0069 0.0179
Leishmania major trypanothione reductase 0.0055 0.055 0.1299
Brugia malayi cytochrome P450 0.002 0.0069 0.0171
Brugia malayi Tubulin alpha-2 chain 0.0215 0.2744 0.7066
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0475 0.1224
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0834 0.1218
Schistosoma mansoni cytochrome P450 0.002 0.0069 0.0031
Mycobacterium ulcerans hypothetical protein 0.0076 0.0834 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0834 0.0799
Echinococcus granulosus tubulin alpha chain 0.0215 0.2744 0.2706
Loa Loa (eye worm) hypothetical protein 0.0069 0.0734 0.1885
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.002 0.0069 0.0026
Echinococcus multilocularis tubulin beta 1 chain 0.0298 0.3883 0.385
Brugia malayi hypothetical protein 0.0056 0.0554 0.1419
Trypanosoma brucei trypanothione reductase 0.0055 0.055 0.1299
Loa Loa (eye worm) tubulin beta-1 chain 0.0298 0.3883 1
Plasmodium falciparum tubulin beta chain 0.0298 0.3883 1
Schistosoma mansoni hypothetical protein 0.0025 0.0132 0.0094
Trypanosoma cruzi epsilon tubulin, putative 0.0157 0.1948 0.4949
Mycobacterium tuberculosis Conserved protein 0.0076 0.0834 0.1218
Trypanosoma brucei zeta tubulin 0.0068 0.0727 0.1759
Mycobacterium ulcerans beta-lactamase 0.0076 0.0834 1
Leishmania major zeta tubulin, putative 0.0068 0.0727 0.1759
Loa Loa (eye worm) tubulin gamma chain 0.0157 0.1948 0.5014
Plasmodium vivax glutathione reductase, putative 0.0055 0.055 0.1412
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0068 0.0727 0.1759
Brugia malayi Tubulin alpha-2 chain 0.0215 0.2744 0.7066
Schistosoma mansoni intermediate filament proteins 0.0029 0.0188 0.015
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.002 0.0069 0.0026
Loa Loa (eye worm) tubulin beta chain 0.0068 0.0727 0.1865
Leishmania major alpha tubulin 0.0215 0.2744 0.7028
Echinococcus granulosus tubulin alpha 1C chain 0.0215 0.2744 0.2706
Echinococcus granulosus tubulin alpha 1C chain 0.0215 0.2744 0.2706
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0068 0.0727 0.1871
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0834 0.204
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0834 0.1218
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.002 0.0069 0.0211
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.002 0.0069 0.0026
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.055 0.1299
Giardia lamblia Alpha-tubulin 0.0215 0.2744 0.7028
Loa Loa (eye worm) tubulin alpha chain 0.0215 0.2744 0.7066
Toxoplasma gondii alpha tubulin TUBA1 0.0215 0.2744 0.7068
Echinococcus granulosus cytochrome P450 2K1 0.002 0.0069 0.0017
Loa Loa (eye worm) tubulin beta-2A chain 0.0298 0.3883 1
Echinococcus granulosus Tubulin beta 2C chain 0.0298 0.3883 0.385
Brugia malayi Cell division protein ftsZ 0.0068 0.0727 0.1865
Loa Loa (eye worm) hypothetical protein 0.0056 0.0554 0.1419
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0126 0.1526 0.2297
Leishmania major hypothetical protein, conserved 0.0076 0.0834 0.204
Schistosoma mansoni alpha tubulin 0.0215 0.2744 0.2717
Entamoeba histolytica tubulin alpha-1 chain 0.0215 0.2744 0.6761
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0834 1
Schistosoma mansoni calcium-activated potassium channel 0.0137 0.1675 0.1643
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.002 0.0069 0.0026
Loa Loa (eye worm) RecQ helicase 0.0023 0.0105 0.0263
Entamoeba histolytica tubulin gamma chain 0.0157 0.1948 0.4496
Trypanosoma cruzi tubulin delta chain 0.0068 0.0727 0.1759
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0486 0.6465 1
Trypanosoma cruzi tubulin delta chain 0.0068 0.0727 0.1759
Trypanosoma brucei beta tubulin 0.0157 0.1948 0.4949
Echinococcus multilocularis Tubulin beta 2C chain 0.0298 0.3883 0.385
Trichomonas vaginalis tubulin epsilon chain, putative 0.0215 0.2744 0.7028
Brugia malayi intermediate filament protein 0.0029 0.0188 0.0477
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0834 0.2142
Giardia lamblia Beta tubulin 0.0298 0.3883 1
Brugia malayi Thioredoxin reductase 0.0055 0.055 0.1411
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.002 0.0069 0.0211
Trypanosoma cruzi cytochrome P450, putative 0.004 0.034 0.075
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0126 0.1523 0.3838
Leishmania major beta tubulin 0.0298 0.3883 1
Trypanosoma brucei beta tubulin 0.0298 0.3883 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0126 0.1523 0.3917
Schistosoma mansoni hypothetical protein 0.0183 0.2296 0.2267
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.002 0.0069 0.0026
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0147
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.002 0.0069 0.0026
Echinococcus granulosus tubulin alpha 3 chain 0.0215 0.2744 0.2706
Schistosoma mansoni hypothetical protein 0.0042 0.0368 0.0331
Mycobacterium ulcerans cell division protein FtsZ 0.0068 0.0727 0.8625
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0834 0.204
Trichomonas vaginalis tubulin beta chain, putative 0.0215 0.2744 0.7028
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.017 0.2123 0.2093
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0053 0.0136
Leishmania major alpha tubulin 0.0215 0.2744 0.7028
Trichomonas vaginalis tubulin beta chain, putative 0.0215 0.2744 0.7028
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0834 0.204
Brugia malayi beta-tubulin, identical 0.0298 0.3883 1
Trypanosoma brucei tubulin gamma chain 0.0157 0.1948 0.4949
Brugia malayi Tubulin beta chain 0.0068 0.0727 0.1865
Giardia lamblia Gamma tubulin 0.0157 0.1948 0.4949
Trichomonas vaginalis tubulin, putative 0.0298 0.3883 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.1807 0.465
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0105 0.0136
Echinococcus granulosus histone acetyltransferase KAT2B 0.0165 0.2057 0.2015
Loa Loa (eye worm) cytochrome P450 0.002 0.0069 0.0171
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0554 0.1307
Loa Loa (eye worm) hypothetical protein 0.0215 0.2744 0.7066
Echinococcus multilocularis tubulin alpha chain 0.0215 0.2744 0.2706
Echinococcus multilocularis tubulin subunit beta 0.0298 0.3883 0.385
Schistosoma mansoni hypothetical protein 0.0183 0.2296 0.2267
Trichomonas vaginalis tubulin beta chain, putative 0.0215 0.2744 0.7028
Brugia malayi Tubulin beta-1 chain 0.0298 0.3883 1
Leishmania major cytochrome p450-like protein 0.002 0.0069 0.0043
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0834 0.1218
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.017 0.2123 0.2081
Schistosoma mansoni tubulin subunit alpha 0.0215 0.2744 0.2717
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0188 0.0477
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.0554 0.142
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0132 0.0079
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.002 0.0069 0.0211
Mycobacterium tuberculosis Conserved protein 0.0076 0.0834 0.1218
Loa Loa (eye worm) BEN-1 protein 0.0298 0.3883 1
Loa Loa (eye worm) beta-tubulin 0.0298 0.3883 1
Schistosoma mansoni hypothetical protein 0.0137 0.1675 0.1643
Loa Loa (eye worm) CYP4Cod1 0.004 0.034 0.0869
Loa Loa (eye worm) tubulin alpha 2 0.0147 0.1807 0.465
Brugia malayi acetyltransferase, GNAT family protein 0.017 0.2123 0.5464
Loa Loa (eye worm) hypothetical protein 0.0076 0.0834 0.2142
Echinococcus multilocularis tubulin alpha 1C chain 0.0215 0.2744 0.2706
Leishmania major beta tubulin 0.0298 0.3883 1
Leishmania major beta tubulin 0.0298 0.3883 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0834 0.2142

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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