Detailed information for compound 1944943

Basic information

Technical information
  • TDR Targets ID: 1944943
  • Name: (5E)-5-[[4-[(4-chlorophenyl)methoxy]phenyl]me thylidene]imidazolidine-2,4-dione
  • MW: 328.75 | Formula: C17H13ClN2O3
  • H donors: 2 H acceptors: 2 LogP: 3.17 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)N/C/1=C/c1ccc(cc1)OCc1ccc(cc1)Cl
  • InChi: 1S/C17H13ClN2O3/c18-13-5-1-12(2-6-13)10-23-14-7-3-11(4-8-14)9-15-16(21)20-17(22)19-15/h1-9H,10H2,(H2,19,20,21,22)/b15-9+
  • InChiKey: OGBLTCFSEOZAMY-OQLLNIDSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5E)-5-[[4-[(4-chlorophenyl)methoxy]phenyl]methylene]imidazolidine-2,4-dione
  • (5E)-5-[4-(4-chlorobenzyl)oxybenzylidene]hydantoin

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.006 0.0066
Trypanosoma cruzi zeta tubulin, putative 0.0191 0.2191 0.2155
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0721 0.0678
Plasmodium vivax tubulin gamma chain, putative 0.044 0.5284 0.5283
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0476 0.0432
Trichomonas vaginalis tubulin epsilon chain, putative 0.0191 0.2191 0.2155
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0721 0.0718
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.006 0.0066
Echinococcus multilocularis tubulin epsilon chain 0.044 0.5284 0.5262
Loa Loa (eye worm) tubulin alpha chain 0.061 0.7397 0.7397
Loa Loa (eye worm) hypothetical protein 0.0169 0.192 0.1918
Brugia malayi hypothetical protein 0.0243 0.2841 0.2839
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0091 0.0045
Mycobacterium tuberculosis Conserved protein 0.0073 0.0721 0.1218
Leishmania major alpha tubulin 0.061 0.7397 0.7385
Treponema pallidum cell division protein FtsZ 0.0191 0.2191 1
Leishmania major zeta tubulin, putative 0.0191 0.2191 0.2155
Schistosoma mansoni hypothetical protein 0.005 0.0434 0.0403
Plasmodium falciparum glutathione reductase 0.0053 0.0476 0.0432
Plasmodium falciparum alpha tubulin 2 0.061 0.7397 0.7385
Entamoeba histolytica tubulin alpha-1 chain 0.061 0.7397 0.7312
Brugia malayi alpha-tubulin 0.061 0.7397 0.7397
Echinococcus multilocularis 0.0019 0.006 0.0014
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.006 0.0014
Schistosoma mansoni tubulin subunit alpha 0.061 0.7397 0.7389
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0721 0.1218
Brugia malayi hypothetical protein 0.0169 0.192 0.1918
Echinococcus granulosus tubulin alpha chain 0.061 0.7397 0.7385
Leishmania major alpha tubulin 0.061 0.7397 0.7385
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.061 0.7397 0.7385
Echinococcus granulosus bloom syndrome protein 0.0022 0.0091 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0721 0.0678
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0046 0.0044
Schistosoma mansoni tubulin subunit beta 0.0191 0.2191 0.2165
Echinococcus multilocularis tubulin alpha chain 0.061 0.7397 0.7385
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0721 0.1218
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.006 0.0026
Leishmania major cytochrome p450-like protein 0.0019 0.006 0.0014
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0476 0.0432
Echinococcus multilocularis tubulin alpha 3 chain 0.061 0.7397 0.7385
Trypanosoma brucei beta tubulin 0.044 0.5284 0.5262
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0721 0.1218
Schistosoma mansoni cytochrome P450 0.0019 0.006 0.0027
Mycobacterium tuberculosis Cell division protein FtsZ 0.0191 0.2191 0.3872
Echinococcus multilocularis tubulin alpha chain 0.061 0.7397 0.7385
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0478 0.0435
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.006 0.0026
Loa Loa (eye worm) hypothetical protein 0.0059 0.0551 0.0548
Echinococcus multilocularis lamin dm0 0.0028 0.0162 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.006 0.0026
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0361 0.4304 0.4278
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.006 0.0066
Brugia malayi tubulin alpha-2 chain 0.061 0.7397 0.7397
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0476 0.0776
Trichomonas vaginalis tubulin beta chain, putative 0.061 0.7397 0.7385
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0162 0.016
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0721 0.1218
Entamoeba histolytica tubulin alpha chain, putative 0.061 0.7397 0.7312
Loa Loa (eye worm) hypothetical protein 0.0073 0.0721 0.0718
Trypanosoma brucei cytochrome P450, putative 0.0038 0.0294 0.0249
Plasmodium vivax tubulin epsilon chain, putative 0.044 0.5284 0.5283
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.006 0.0066
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0476 0.0473
Trichomonas vaginalis tubulin beta chain, putative 0.061 0.7397 0.7385
Brugia malayi Tubulin gamma chain 0.044 0.5284 0.5283
Trypanosoma brucei trypanothione reductase 0.0053 0.0476 0.0432
Echinococcus granulosus tubulin alpha 3 chain 0.061 0.7397 0.7385
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.006 0.0066
Trichomonas vaginalis tubulin beta chain, putative 0.061 0.7397 0.7385
Loa Loa (eye worm) tubulin beta chain 0.0191 0.2191 0.2189
Schistosoma mansoni hypothetical protein 0.0024 0.0114 0.0081
Schistosoma mansoni tubulin subunit alpha 0.061 0.7397 0.7389
Giardia lamblia Gamma tubulin 0.044 0.5284 0.5262
Schistosoma mansoni calcium-activated potassium channel 0.0125 0.1368 0.1339
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0721 0.3146
Trichomonas vaginalis tubulin gamma chain, putative 0.0191 0.2191 0.2155
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0721 0.0678
Echinococcus multilocularis peroxisome assembly protein 26 0.061 0.7397 0.7385
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.006 0.0066
Schistosoma mansoni tubulin subunit epsilon 0.044 0.5284 0.5268
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0361 0.0044
Echinococcus multilocularis tubulin alpha 1C chain 0.061 0.7397 0.7385
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0721 0.1218
Mycobacterium leprae cell division protein FtsZ 0.0191 0.2191 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0478 0.0435
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0066 0.0635 0.0632
Echinococcus granulosus intermediate filament protein 0.0028 0.0162 0.0117
Plasmodium falciparum alpha tubulin 1 0.061 0.7397 0.7385
Trypanosoma brucei zeta tubulin 0.0191 0.2191 0.2155
Echinococcus multilocularis tubulin delta chain 0.0191 0.2191 0.2155
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.006 0.006
Echinococcus granulosus tubulin delta chain 0.0191 0.2191 0.2155
Trypanosoma brucei alpha tubulin 0.061 0.7397 0.7385
Giardia lamblia Epsilon tubulin 0.0191 0.2191 0.2155
Mycobacterium ulcerans cell division protein FtsZ 0.0191 0.2191 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0478 0.0476
Trypanosoma brucei epsilon tubulin 0.044 0.5284 0.5262
Schistosoma mansoni tubulin subunit gamma 0.044 0.5284 0.5268
Plasmodium falciparum tubulin gamma chain 0.044 0.5284 0.5262
Echinococcus granulosus lamin dm0 0.0028 0.0162 0.0117
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0434 0.0432
Leishmania major alpha tubulin 0.061 0.7397 0.7385
Schistosoma mansoni lamin 0.0028 0.0162 0.013
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.1778 0.174
Brugia malayi hypothetical protein 0.0034 0.0244 0.0242
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.006 0.0066
Leishmania major alpha tubulin 0.061 0.7397 0.7385
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0721 0.0678
Echinococcus multilocularis tubulin alpha chain 0.061 0.7397 0.7385
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.1486 0.2599
Loa Loa (eye worm) hypothetical protein 0.0243 0.2841 0.2839
Loa Loa (eye worm) tubulin alpha-2 chain 0.061 0.7397 0.7397
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.1318 0.2297
Echinococcus multilocularis Tubulin alpha 1 chain 0.061 0.7397 0.7385
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0721 0.0678
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0191 0.2191 0.2191
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0046 0.5
Brugia malayi Tubulin alpha chain 0.0191 0.2191 0.2189
Trypanosoma brucei alpha tubulin 0.061 0.7397 0.7385
Echinococcus multilocularis small conductance calcium activated potassium 0.0131 0.1447 0.1408
Echinococcus multilocularis tubulin alpha chain 0.061 0.7397 0.7385
Leishmania major alpha tubulin 0.061 0.7397 0.7385
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0046 0.0044
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.044 0.5284 0.5284
Echinococcus multilocularis geminin 0.0174 0.1984 0.1947
Loa Loa (eye worm) alpha-tubulin 0.061 0.7397 0.7397
Trypanosoma brucei tubulin delta chain 0.0191 0.2191 0.2155
Brugia malayi cytochrome P450 0.0019 0.006 0.0057
Loa Loa (eye worm) hypothetical protein 0.0027 0.0156 0.0154
Trichomonas vaginalis tubulin, putative 0.0249 0.291 0.2878
Plasmodium falciparum tubulin delta chain, putative 0.0191 0.2191 0.2155
Schistosoma mansoni microtubule-associated protein tau 0.071 0.864 0.8636
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.1834 0.1807
Brugia malayi Tubulin beta chain 0.0191 0.2191 0.2189
Schistosoma mansoni hypothetical protein 0.0174 0.1984 0.1957
Onchocerca volvulus 0.005 0.0434 0.0989
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.006 0.0066
Echinococcus granulosus geminin 0.0174 0.1984 0.1947
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0478 0.0435
Trichomonas vaginalis tubulin beta chain, putative 0.0249 0.291 0.2878
Giardia lamblia Alpha-tubulin 0.061 0.7397 0.7385
Plasmodium vivax tubulin alpha chain, putative 0.061 0.7397 0.7397
Leishmania major hypothetical protein, conserved 0.0053 0.0478 0.0435
Trichomonas vaginalis tubulin beta chain, putative 0.061 0.7397 0.7385
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.006 0.0014
Echinococcus granulosus tubulin alpha 1C chain 0.061 0.7397 0.7385
Brugia malayi hypothetical protein 0.004 0.0318 0.0316
Trichomonas vaginalis tubulin alpha chain, putative 0.0249 0.291 0.2878
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0419 0.5024 0.5001
Echinococcus multilocularis hypothetical protein 0.061 0.7397 0.7385
Loa Loa (eye worm) hypothetical protein 0.0361 0.4304 0.4303
Echinococcus granulosus Tubulin alpha 1 chain 0.061 0.7397 0.7385
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0721 0.0678
Echinococcus granulosus tubulin gamma 1 chain 0.044 0.5284 0.5262
Loa Loa (eye worm) hypothetical protein 0.0073 0.0721 0.0718
Echinococcus granulosus tubulin subunit TubB 0.061 0.7397 0.7385
Loa Loa (eye worm) RecQ helicase 0.0022 0.0091 0.0088
Brugia malayi glutathione reductase 0.0053 0.0476 0.0473
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.006 0.0026
Brugia malayi Tubulin beta chain 0.0249 0.291 0.2909
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0411 0.0367
Echinococcus multilocularis tubulin subunit TubB 0.061 0.7397 0.7385
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.006 0.0066
Brugia malayi Cytochrome P450 family protein 0.0019 0.006 0.0057
Trypanosoma brucei alpha tubulin 0.061 0.7397 0.7385
Echinococcus multilocularis tubulin alpha 0.044 0.5284 0.5262
Brugia malayi beta-lactamase family protein 0.0073 0.0721 0.0718
Plasmodium vivax delta tubulin, putative 0.0191 0.2191 0.2189
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0318 0.0274
Trichomonas vaginalis tubulin alpha chain, putative 0.044 0.5284 0.5262
Echinococcus multilocularis Tubulin alpha 1 chain 0.061 0.7397 0.7385
Trypanosoma cruzi tubulin delta chain 0.0191 0.2191 0.2155
Loa Loa (eye worm) CYP4Cod1 0.0038 0.0294 0.0291
Onchocerca volvulus 0.0073 0.0721 0.2031
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0478 0.0476
Schistosoma mansoni hypothetical protein 0.0174 0.1984 0.1957
Echinococcus granulosus tubulin alpha chain 0.061 0.7397 0.7385
Loa Loa (eye worm) acetyltransferase 0.0162 0.1834 0.1832
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0591 0.0589
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.006 0.0014
Schistosoma mansoni lamin 0.0028 0.0162 0.013
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0721 0.0718
Echinococcus granulosus microtubule associated protein 2 0.071 0.864 0.8634
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.1318 0.5905
Trypanosoma cruzi tubulin gamma chain 0.044 0.5284 0.5262
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0721 0.3146
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0046 0.0013
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0019 0.006 0.0066
Leishmania major alpha tubulin 0.061 0.7397 0.7385
Brugia malayi intermediate filament protein 0.0028 0.0162 0.016
Brugia malayi beta-lactamase 0.0073 0.0721 0.0718
Entamoeba histolytica tubulin gamma chain 0.044 0.5284 0.5129
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0294 0.0291
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.1834 0.1832
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0411 0.0411
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0249 0.291 0.2878
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.2841 0.2808
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0411 0.0411
Trichomonas vaginalis esterase, putative 0.0073 0.0721 0.0678
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0721 0.0678
Mycobacterium tuberculosis Conserved protein 0.0073 0.0721 0.1218
Plasmodium vivax glutathione reductase, putative 0.0053 0.0476 0.0473
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0419 0.5024 0.5023
Trypanosoma brucei epsilon tubulin 0.044 0.5284 0.5262
Trypanosoma brucei alpha tubulin, putative 0.0249 0.291 0.2878
Trypanosoma cruzi alpha tubulin, putative 0.061 0.7397 0.7385
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.006 0.0066
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0361 0.0317
Leishmania major alpha tubulin 0.061 0.7397 0.7385
Echinococcus granulosus small conductance calcium activated potassium 0.0131 0.1447 0.1408
Toxoplasma gondii ABC1 family protein 0.0073 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0049
Brugia malayi Tubulin alpha-2 chain 0.061 0.7397 0.7397
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.0294 0.0249
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.006 0.0026
Echinococcus multilocularis Tubulin alpha 1 chain 0.061 0.7397 0.7385
Brugia malayi tubulin alpha chain - mouse 0.061 0.7397 0.7397
Plasmodium vivax tubulin alpha chain, putative 0.061 0.7397 0.7397
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.006 0.0066
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.1834 0.1797
Trichomonas vaginalis tubulin, putative 0.0191 0.2191 0.2155
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.1318 0.2297
Echinococcus multilocularis microtubule associated protein 2 0.071 0.864 0.8634
Trichomonas vaginalis tubulin epsilon chain, putative 0.061 0.7397 0.7385
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0721 0.1218
Echinococcus granulosus tubulin epsilon chain 0.044 0.5284 0.5262
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.1318 0.2297
Leishmania major cytochrome p450-like protein 0.0019 0.006 0.0014
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0046 0.0043
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.006 0.0066
Echinococcus granulosus peroxisome assembly protein 26 0.061 0.7397 0.7385
Trichomonas vaginalis tubulin beta chain, putative 0.061 0.7397 0.7385
Schistosoma mansoni intermediate filament proteins 0.0028 0.0162 0.013
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0318 0.0274
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0318 0.0286
Brugia malayi Tubulin alpha-2 chain 0.061 0.7397 0.7397
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0411 0.0367
Loa Loa (eye worm) tubulin alpha 2 0.0419 0.5024 0.5023
Trypanosoma brucei epsilon tubulin 0.044 0.5284 0.5262
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.1318 0.2297
Leishmania major alpha tubulin 0.061 0.7397 0.7385
Onchocerca volvulus 0.0249 0.291 1
Brugia malayi Cytochrome P450 family protein 0.0062 0.0591 0.0589
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0476 0.0432
Trypanosoma brucei zeta tubulin, putative 0.0191 0.2191 0.2155
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0114 0.0069
Brugia malayi beta-lactamase family protein 0.0073 0.0721 0.0718
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0046 0.0046
Onchocerca volvulus 0.0073 0.0721 0.2031
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.0294 0.0249
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.006 0.0014
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.006 0.0066
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.006 0.0026
Loa Loa (eye worm) hypothetical protein 0.0073 0.0721 0.0718
Leishmania major alpha tubulin 0.061 0.7397 0.7385
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.006 0.0066
Onchocerca volvulus 0.0169 0.192 0.6396
Brugia malayi Cytochrome P450 family protein 0.0038 0.0294 0.0291
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0411 0.0367
Giardia lamblia Delta tubulin 0.0191 0.2191 0.2155
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.1486 0.2599
Brugia malayi Thioredoxin reductase 0.0053 0.0476 0.0473
Echinococcus granulosus tubulin alpha 0.044 0.5284 0.5262
Echinococcus granulosus Tubulin alpha 1 chain 0.061 0.7397 0.7385
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.006 0.0026
Schistosoma mansoni tubulin subunit delta 0.0191 0.2191 0.2165
Schistosoma mansoni tubulin subunit alpha 0.0191 0.2191 0.2165
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0114 0.0069
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.1318 0.2297
Echinococcus granulosus lamin 0.0028 0.0162 0.0117
Brugia malayi hypothetical protein 0.0053 0.0478 0.0476
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0478 0.0435
Echinococcus granulosus tubulin alpha chain 0.061 0.7397 0.7385
Echinococcus granulosus Tubulin alpha 1 chain 0.061 0.7397 0.7385
Loa Loa (eye worm) tubulin gamma chain 0.044 0.5284 0.5283
Echinococcus granulosus tubulin alpha chain 0.061 0.7397 0.7385
Echinococcus granulosus tubulin alpha 1C chain 0.061 0.7397 0.7385
Toxoplasma gondii alpha-tubulin I, putative 0.061 0.7397 0.7397
Mycobacterium tuberculosis Conserved protein 0.0073 0.0721 0.1218
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.006 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.006 0.0026
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0721 0.0718
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0721 0.31
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.006 0.0014
Toxoplasma gondii alpha tubulin TUBA1 0.061 0.7397 0.7397
Loa Loa (eye worm) alpha-tubulin 0.061 0.7397 0.7397
Brugia malayi Cell division protein ftsZ 0.0191 0.2191 0.2189
Loa Loa (eye worm) tubulin alpha-3 chain 0.0361 0.4304 0.4303
Schistosoma mansoni survival motor neuron protein 0.005 0.0434 0.0403
Trypanosoma brucei alpha tubulin 0.061 0.7397 0.7385
Trypanosoma cruzi epsilon tubulin, putative 0.044 0.5284 0.5262
Mycobacterium ulcerans beta-lactamase 0.0073 0.0721 0.3146
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0478 0.0478
Schistosoma mansoni alpha tubulin 0.061 0.7397 0.7389
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.006 0.0026
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0419 0.5024 0.5023
Onchocerca volvulus 0.0073 0.0721 0.2031
Trichomonas vaginalis tubulin gamma chain, putative 0.044 0.5284 0.5262
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.006 0.0066
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.2841 0.2808
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0162 0.016
Trypanosoma cruzi epsilon tubulin, putative 0.044 0.5284 0.5262
Loa Loa (eye worm) hypothetical protein 0.0073 0.0721 0.0718
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.006 0.0026
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.1486 0.2599
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.1486 0.6691
Echinococcus multilocularis tubulin alpha 3 chain 0.061 0.7397 0.7385
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.006 0.0026
Mycobacterium ulcerans lipase LipD 0.0073 0.0721 0.3146
Trypanosoma cruzi zeta tubulin, putative 0.0191 0.2191 0.2155
Loa Loa (eye worm) glutathione reductase 0.0053 0.0476 0.0473
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0476 0.0473
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.006 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0191 0.2191 0.2155
Brugia malayi Cytochrome P450 family protein 0.0038 0.0294 0.0291
Mycobacterium ulcerans hypothetical protein 0.0073 0.0721 0.3146
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.006 0.0026
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0046 0.0046
Giardia lamblia Alpha-tubulin 0.061 0.7397 0.7385
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0721 0.1218
Schistosoma mansoni alpha tubulin 0.061 0.7397 0.7389
Loa Loa (eye worm) hypothetical protein 0.0131 0.1447 0.1445
Leishmania major alpha tubulin 0.061 0.7397 0.7385
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0721 0.069
Echinococcus multilocularis tubulin gamma 1 chain 0.044 0.5284 0.5262
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0162 0.016
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.006 0.0026
Leishmania major gamma-tubulin 0.044 0.5284 0.5262
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.006 0.0026
Trichomonas vaginalis tubulin epsilon chain, putative 0.061 0.7397 0.7385
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0191 0.2191 0.2191
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0361 0.0317
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0721 0.0719
Echinococcus multilocularis tubulin alpha 1C chain 0.061 0.7397 0.7385
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0033
Trichomonas vaginalis tubulin beta chain, putative 0.061 0.7397 0.7385
Toxoplasma gondii thioredoxin reductase 0.0053 0.0476 0.0476
Brugia malayi Tubulin alpha chain 0.061 0.7397 0.7397
Plasmodium falciparum thioredoxin reductase 0.0053 0.0476 0.0432
Trypanosoma cruzi tubulin delta chain 0.0191 0.2191 0.2155
Leishmania major trypanothione reductase 0.0053 0.0476 0.0432
Schistosoma mansoni tubulin subunit alpha 0.061 0.7397 0.7389
Trichomonas vaginalis tubulin alpha chain, putative 0.0249 0.291 0.2878
Trichomonas vaginalis conserved hypothetical protein 0.0191 0.2191 0.2155
Echinococcus multilocularis tubulin alpha chain 0.061 0.7397 0.7385
Echinococcus granulosus alpha tubulin 0.061 0.7397 0.7385
Leishmania major alpha tubulin 0.061 0.7397 0.7385
Schistosoma mansoni hypothetical protein 0.0131 0.1447 0.1419
Leishmania major delta tubulin, putative 0.0191 0.2191 0.2155
Echinococcus granulosus tubulin alpha 3 chain 0.061 0.7397 0.7385
Mycobacterium tuberculosis Probable reductase 0.0121 0.1318 0.2297
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0038 0.0294 0.1157
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.006 0.0026
Loa Loa (eye worm) cytochrome P450 0.0019 0.006 0.0057
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0721 0.0678
Trichomonas vaginalis tubulin alpha chain, putative 0.0249 0.291 0.2878
Trichomonas vaginalis tubulin, putative 0.0249 0.291 0.2878
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.006 0.0066
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0721 0.0678
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0721 0.0678
Schistosoma mansoni alpha tubulin 0.061 0.7397 0.7389
Echinococcus multilocularis musashi 0.0028 0.0162 0.0117
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.006 0.0026
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0721 0.0718
Schistosoma mansoni calcium-activated potassium channel 0.0131 0.1447 0.1419
Trypanosoma brucei tubulin gamma chain 0.044 0.5284 0.5262
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0191 0.2191 0.2155
Schistosoma mansoni hypothetical protein 0.004 0.0318 0.0286
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0091 0.0045
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.006 0.0026
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0091 0.0045
Loa Loa (eye worm) hypothetical protein 0.061 0.7397 0.7397
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0294 0.0291
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0464 0.5586 1
Leishmania major epsilon tubulin, putative 0.044 0.5284 0.5262
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0721 0.069
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0411 0.0409
Loa Loa (eye worm) tubulin alpha 2 0.0419 0.5024 0.5023
Leishmania major cytochrome p450-like protein 0.0038 0.0294 0.0249
Loa Loa (eye worm) beta-lactamase 0.0073 0.0721 0.0718
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.006 0.0026
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0057 0.0012
Loa Loa (eye worm) tubulin alpha chain 0.061 0.7397 0.7397
Echinococcus granulosus tubulin alpha chain 0.061 0.7397 0.7385
Mycobacterium leprae Probable lipase LipE 0.0073 0.0721 0.31
Trichomonas vaginalis tubulin gamma chain, putative 0.044 0.5284 0.5262
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0091 0.0088
Plasmodium falciparum tubulin epsilon chain, putative 0.044 0.5284 0.5262
Schistosoma mansoni hypothetical protein 0.0019 0.006 0.0027
Echinococcus multilocularis lamin 0.0028 0.0162 0.0117
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0478 0.0435
Leishmania major hypothetical protein, conserved 0.0073 0.0721 0.0678
Loa Loa (eye worm) hypothetical protein 0.0028 0.0162 0.016
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0191 0.2191 1
Loa Loa (eye worm) tubulin alpha 2 0.017 0.1931 0.1929
Leishmania major alpha tubulin 0.061 0.7397 0.7385

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 122 uM Inhibition of human recombinant PTP1B expressed in Escherichia coli pre-incubated for 15 mins before pNPP substrate addition by spectrophotometry ChEMBL. 26342135

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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