Detailed information for compound 1944984

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 449.542 | Formula: C24H19NO4S2
  • H donors: 2 H acceptors: 4 LogP: 5.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cccc(c1)C(=O)c1ccc(s1)c1cccc(c1)NS(=O)(=O)c1cccc(c1)C
  • InChi: 1S/C24H19NO4S2/c1-16-5-2-10-21(13-16)31(28,29)25-19-8-3-6-17(14-19)22-11-12-23(30-22)24(27)18-7-4-9-20(26)15-18/h2-15,25-26H,1H3
  • InChiKey: RMRIFXKPKUCHRY-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 1 Starlite/ChEMBL References
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis Dehydrogenase:reductase SDR family hydroxysteroid (17-beta) dehydrogenase 2 387 aa 359 aa 24.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein hydroxysteroid (17-beta) dehydrogenase 1 328 aa 265 aa 27.2 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.1548 0.2371
Leishmania major potassium channel subunit-like protein 0.0021 0.0135 0.0295
Echinococcus granulosus potassium channel subfamily K 8 0.0021 0.0135 0.0127
Echinococcus multilocularis isocitrate dehydrogenase 0.0022 0.0156 0.0149
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0095 0.063
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0021 0.0135 0.0127
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0021 0.0135 0.0147
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0095 0.063
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0393 0.0386
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0022 0.0155 0.0148
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0028 0.0021
Loa Loa (eye worm) hypothetical protein 0.0068 0.0858 0.1347
Plasmodium vivax potassium channel, putative 0.0021 0.0135 0.0295
Brugia malayi Isocitrate dehydrogenase 0.0022 0.0156 0.0253
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0604 0.1505
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0095 0.0122
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0021 0.0135 0.0217
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0013 0.002 0.0033
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.021 0.0488
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0095 0.063
Echinococcus granulosus peroxisome assembly protein 26 0.0192 0.2763 0.2758
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0078 0.0071
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0071 0.0907 0.0901
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0078 0.015
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.004 0.0424 0.1042
Loa Loa (eye worm) transcription factor SMAD2 0.0167 0.239 0.3756
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0051 0.0604 0.0589
Echinococcus granulosus tubulin beta 1 chain 0.0265 0.3899 0.3894
Loa Loa (eye worm) solute carrier family 6 member 4 0.0063 0.0782 0.1229
Echinococcus multilocularis tubulin alpha 1C chain 0.0192 0.2763 0.2758
Echinococcus granulosus alpha tubulin 0.0192 0.2763 0.2758
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.008 0.1041 0.1775
Loa Loa (eye worm) hypothetical protein 0.0063 0.0782 0.1229
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0907 0.0893
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0026 0.021 0.0329
Loa Loa (eye worm) cytochrome P450 0.0018 0.0095 0.0149
Loa Loa (eye worm) hypothetical protein 0.0063 0.0782 0.1229
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.021 0.0499
Onchocerca volvulus 0.0026 0.0213 0.0886
Schistosoma mansoni hypothetical protein 0.0038 0.0401 0.0386
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0021 0.0135 0.0295
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0051 0.0604 0.1514
Echinococcus multilocularis lamin 0.0026 0.0213 0.0206
Schistosoma mansoni tubulin subunit beta 0.0265 0.3899 0.3889
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0135 0.0305
Echinococcus granulosus inositol monophosphatase 1 0.0026 0.0209 0.0202
Echinococcus granulosus Tubulin alpha 1 chain 0.0192 0.2763 0.2758
Onchocerca volvulus 0.0021 0.0135 0.0533
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0187
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0365 0.075
Echinococcus granulosus para nitrobenzyl esterase 0.0013 0.0016 0.0009
Echinococcus granulosus potassium channel subfamily K 0.0021 0.0135 0.0127
Brugia malayi Thioredoxin reductase 0.0049 0.0575 0.0973
Trichomonas vaginalis tubulin epsilon chain, putative 0.0061 0.075 0.1892
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0051 0.0604 0.1375
Trichomonas vaginalis bromodomain-containing protein, putative 0.0073 0.0933 0.2363
Loa Loa (eye worm) hypothetical protein 0.0027 0.0236 0.037
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0365 0.2788
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0078 0.0097
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0575 0.0568
Onchocerca volvulus 0.0067 0.0843 0.3716
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0095 0.0122
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0022 0.0155 0.0253
Mycobacterium ulcerans ion transport protein 0.0021 0.0135 0.0948
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0708 0.1112
Trypanosoma brucei tubulin delta chain 0.0061 0.075 0.1883
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.1548 0.2371
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0078 0.012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0068 0.0858 0.0843
Echinococcus multilocularis L aminoadipate semialdehyde 0.0047 0.0544 0.0537
Echinococcus multilocularis tubulin alpha 3 chain 0.0192 0.2763 0.2758
Brugia malayi hypothetical protein 0.0038 0.0393 0.0661
Giardia lamblia Alpha-tubulin 0.0192 0.2763 0.7028
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0078 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.1034 0.2622
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0026 0.0014
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Leishmania major beta tubulin 0.0265 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0104
Onchocerca volvulus 0.0026 0.0213 0.0886
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trichomonas vaginalis penicillin-binding protein, putative 0.0068 0.0858 0.2168
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3899 0.3894
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0078 0.0071
Schistosoma mansoni tubulin subunit beta 0.0265 0.3899 0.3889
Plasmodium falciparum ataxin-2 like protein, putative 0.0085 0.1121 0.284
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0073 0.0933 0.2363
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0575 0.0903
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0068 0.0858 0.1347
Echinococcus granulosus neutral alpha glucosidase AB 0.0026 0.021 0.0202
Loa Loa (eye worm) latrophilin receptor protein 2 0.0022 0.0155 0.0244
Echinococcus multilocularis musashi 0.0026 0.0213 0.0206
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0095 0.0122
Trichomonas vaginalis tubulin, putative 0.0061 0.075 0.1892
Brugia malayi Carboxylesterase family protein 0.0013 0.0016 0.0013
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0094 0.1267 0.7249
Echinococcus granulosus tubulin alpha chain 0.0192 0.2763 0.2758
Loa Loa (eye worm) hypothetical protein 0.0047 0.0544 0.0854
Giardia lamblia Beta tubulin 0.0265 0.3899 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0047 0.0544 0.0537
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Echinococcus granulosus tubulin alpha 3 chain 0.0192 0.2763 0.2758
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0021 0.0135 0.0147
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0013 0.0016 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Loa Loa (eye worm) hypothetical protein 0.0025 0.0206 0.0324
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0013 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2763 0.2758
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3899 0.3894
Trypanosoma brucei alpha tubulin 0.0192 0.2763 0.7072
Trypanosoma brucei beta tubulin 0.0265 0.3899 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0575 0.0568
Echinococcus granulosus serotonin transporter 0.0063 0.0782 0.0775
Trypanosoma brucei calcium-activated potassium channel, putative 0.0021 0.0135 0.0295
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2763 0.2758
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0046 0.0519 0.0512
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Schistosoma mansoni calcium-activated potassium channel 0.0426 0.6365 0.6359
Schistosoma mansoni alpha-glucosidase 0.0099 0.1345 0.1331
Trichomonas vaginalis tubulin beta chain, putative 0.0265 0.3899 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0095 0.0122
Trichomonas vaginalis tubulin alpha chain, putative 0.0265 0.3899 1
Echinococcus granulosus tubulin subunit beta 0.0265 0.3899 0.3894
Echinococcus multilocularis 0.0018 0.0095 0.0088
Trypanosoma cruzi PAB1-binding protein , putative 0.0085 0.1121 0.273
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0071 0.0907 0.0901
Leishmania major beta tubulin 0.0265 0.3899 1
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2763 0.2758
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0021 0.0135 0.0217
Trypanosoma brucei alpha tubulin 0.0192 0.2763 0.7072
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0047 0.0543 0.0528
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Treponema pallidum cell division protein FtsZ 0.0061 0.075 0.2638
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0022 0.0156 0.035
Echinococcus multilocularis lamin dm0 0.0026 0.0213 0.0206
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2763 0.7075
Trichomonas vaginalis tubulin epsilon chain, putative 0.0192 0.2763 0.7075
Schistosoma mansoni hypothetical protein 0.0022 0.0155 0.014
Echinococcus granulosus RUN 0.0027 0.0236 0.0229
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0213 0.0352
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.021 0.0343
Schistosoma mansoni hypothetical protein 0.0021 0.0135 0.0119
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0046 0.0519 0.1286
Giardia lamblia Delta tubulin 0.0061 0.075 0.1759
Echinococcus multilocularis inositol monophosphatase 1 0.0026 0.0209 0.0202
Plasmodium falciparum histone acetyltransferase GCN5 0.0067 0.084 0.2114
Echinococcus multilocularis RUN 0.0027 0.0236 0.0229
Echinococcus multilocularis small conductance calcium activated potassium 0.0426 0.6365 0.6362
Loa Loa (eye worm) hypothetical protein 0.0085 0.1121 0.1762
Loa Loa (eye worm) tubulin beta chain 0.0265 0.3899 0.6125
Mycobacterium tuberculosis Conserved protein 0.0068 0.0858 0.1303
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0026 0.0209 0.0487
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0575 0.1299
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0119 0.0112
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0078 0.015
Trypanosoma cruzi epsilon tubulin, putative 0.014 0.1969 0.4949
Schistosoma mansoni tubulin subunit alpha 0.0061 0.075 0.0736
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0026 0.0209 0.2587
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0209 0.0487
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.002 0.0119 0.0103
Brugia malayi Doublecortin family protein 0.0027 0.0236 0.039
Loa Loa (eye worm) tubulin gamma chain 0.014 0.1969 0.3094
Brugia malayi glutathione reductase 0.0049 0.0575 0.0973
Brugia malayi hypothetical protein 0.0021 0.0135 0.0217
Echinococcus multilocularis lysosomal alpha glucosidase 0.0116 0.1592 0.1586
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0265 0.3899 0.3894
Leishmania major hypothetical protein, conserved 0.0085 0.1121 0.284
Trichomonas vaginalis tubulin epsilon chain, putative 0.0265 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3899 0.3894
Echinococcus granulosus carboxylesterase 5A 0.0077 0.1003 0.0996
Leishmania major ion transport protein-like protein 0.0021 0.0135 0.0295
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0907 0.0893
Echinococcus multilocularis para nitrobenzyl esterase 0.0013 0.0016 0.0009
Onchocerca volvulus 0.0027 0.0236 0.0987
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.013 0.0294
Brugia malayi Cell division protein ftsZ 0.0061 0.075 0.1275
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0051 0.0604 0.1023
Mycobacterium tuberculosis Probable hydrolase 0.0068 0.0858 0.1303
Loa Loa (eye worm) inositol-1 0.0026 0.0209 0.0328
Loa Loa (eye worm) acetyltransferase 0.0247 0.3617 0.5683
Brugia malayi Tubulin alpha chain 0.0192 0.2763 0.4735
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0078 0.015
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.1548 0.2371
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.004 0.0424 0.1042
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.021 0.0343
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0021 0.0135 0.0217
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0051 0.0604 0.1505
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0022 0.0156 0.014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0078 0.015
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0095 0.063
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0213 0.0335
Echinococcus granulosus lamin 0.0026 0.0213 0.0206
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0022 0.0156 0.0149
Brugia malayi hypothetical protein 0.0085 0.1121 0.1913
Echinococcus multilocularis tubulin alpha 1C chain 0.0192 0.2763 0.2758
Plasmodium falciparum glutathione reductase 0.0017 0.0078 0.015
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0046 0.0519 0.0877
Echinococcus granulosus acetylcholinesterase 0.0077 0.1003 0.0996
Echinococcus granulosus tubulin alpha chain 0.0192 0.2763 0.2758
Schistosoma mansoni hypothetical protein 0.0018 0.0095 0.0079
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0095 0.063
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0575 0.0865
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0022 0.0156 0.0149
Loa Loa (eye worm) tubulin beta-2A chain 0.0265 0.3899 0.6125
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.1034 0.2622
Plasmodium vivax tubulin beta chain, putative 0.0265 0.3899 1
Trypanosoma cruzi tubulin delta chain 0.0061 0.075 0.1759
Mycobacterium leprae putative cytochrome p450 0.0018 0.0095 0.0434
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0858 0.204
Mycobacterium tuberculosis Conserved protein 0.0068 0.0858 0.1303
Schistosoma mansoni tubulin subunit beta 0.0265 0.3899 0.3889
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0213 0.0335
Echinococcus multilocularis survival motor neuron protein 1 0.0391 0.5826 0.5823
Trypanosoma cruzi beta tubulin, putative 0.0265 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0391 0.5826 0.9154
Plasmodium falciparum tubulin beta chain 0.0265 0.3899 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0022 0.0156 0.0203
Trichomonas vaginalis D-aminoacylase, putative 0.0068 0.0858 0.2168
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0604 0.1375
Toxoplasma gondii beta tubulin 0.0265 0.3899 1
Trypanosoma brucei alpha tubulin 0.0192 0.2763 0.7072
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0095 0.063
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0021 0.0135 0.0184
Trichomonas vaginalis esterase, putative 0.0068 0.0858 0.2168
Mycobacterium ulcerans cell division protein FtsZ 0.0061 0.075 0.5869
Brugia malayi latrophilin 2 splice variant baaae 0.0048 0.055 0.0931
Plasmodium falciparum alpha tubulin 1 0.0192 0.2763 0.7072
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0095 0.0122
Echinococcus multilocularis tubulin alpha 0.014 0.1969 0.1963
Brugia malayi hypothetical protein 0.0013 0.0016 0.0013
Schistosoma mansoni hypothetical protein 0.04 0.5971 0.5965
Echinococcus granulosus tubulin beta 4A class IVa 0.0265 0.3899 0.3894
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Brugia malayi Tubulin gamma chain 0.014 0.1969 0.337
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0131 0.1828 0.2872
Onchocerca volvulus 0.0021 0.0135 0.0533
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0095 0.0122
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0095 0.0193
Brugia malayi Calcitonin receptor-like protein seb-1 0.007 0.089 0.1516
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Loa Loa (eye worm) hypothetical protein 0.0068 0.0858 0.1347
Brugia malayi Tubulin alpha-2 chain 0.0192 0.2763 0.4735
Echinococcus multilocularis peroxisome assembly protein 26 0.0192 0.2763 0.2758
Loa Loa (eye worm) hypothetical protein 0.0068 0.0858 0.1347
Loa Loa (eye worm) tubulin alpha chain 0.0192 0.2763 0.4341
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.1548 0.8877
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0163 0.233 0.2325
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trypanosoma cruzi zeta tubulin, putative 0.0061 0.075 0.1759
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0519 0.1153
Onchocerca volvulus 0.002 0.0119 0.0462
Trypanosoma brucei hypothetical protein, conserved 0.0068 0.0858 0.2159
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.004 0.0424 0.0905
Leishmania major delta tubulin, putative 0.0061 0.075 0.1883
Giardia lamblia Epsilon tubulin 0.0061 0.075 0.1759
Schistosoma mansoni tubulin subunit alpha 0.0192 0.2763 0.2752
Trypanosoma brucei trypanothione reductase 0.0049 0.0575 0.143
Mycobacterium tuberculosis Probable reductase 0.0113 0.1548 0.2371
Onchocerca volvulus 0.0027 0.0236 0.0987
Entamoeba histolytica tubulin family protein 0.0265 0.3899 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0095 0.063
Trypanosoma brucei tubulin gamma chain 0.014 0.1969 0.5025
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0519 0.1286
Loa Loa (eye worm) carboxylesterase 0.0013 0.0016 0.0025
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.1548 0.2371
Giardia lamblia Histone acetyltransferase GCN5 0.0067 0.084 0.1994
Onchocerca volvulus 0.0021 0.0135 0.0533
Giardia lamblia Beta tubulin 0.0265 0.3899 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0077 0.1003 0.0989
Loa Loa (eye worm) hypothetical protein 0.0426 0.6365 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0095 0.063
Trypanosoma brucei alpha tubulin, putative 0.0079 0.1034 0.2614
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0095 0.0122
Brugia malayi Tubulin beta chain 0.0079 0.1034 0.1762
Brugia malayi tubulin alpha chain - mouse 0.0192 0.2763 0.4735
Brugia malayi Carboxylesterase family protein 0.0013 0.0016 0.0013
Trypanosoma brucei epsilon tubulin 0.014 0.1969 0.5025
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0026 0.0209 0.0497
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0068 0.0858 0.0843
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0021 0.0135 0.0127
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0021 0.0135 0.0295
Trichomonas vaginalis D-aminoacylase, putative 0.0068 0.0858 0.2168
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0095 0.0088
Trichomonas vaginalis tubulin alpha chain, putative 0.014 0.1969 0.503
Loa Loa (eye worm) tubulin alpha chain 0.0192 0.2763 0.4341
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0068 0.0858 0.1303
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0023 0.0168 0.0858
Onchocerca volvulus 0.0021 0.0135 0.0533
Loa Loa (eye worm) hypothetical protein 0.0047 0.0543 0.0854
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0021 0.0135 0.0217
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0393 0.0378
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0051 0.0604 0.0597
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0078 0.015
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0021 0.0135 0.0217
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0047 0.0543 0.1359
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0135 0.0305
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.021 0.0488
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Loa Loa (eye worm) hypothetical protein 0.0051 0.0604 0.0949
Schistosoma mansoni tubulin subunit beta 0.0265 0.3899 0.3889
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0073 0.0933 0.2354
Plasmodium vivax delta tubulin, putative 0.0061 0.075 0.1883
Schistosoma mansoni alpha tubulin 0.0192 0.2763 0.2752
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Entamoeba histolytica tubulin alpha-1 chain 0.0192 0.2763 0.7072
Schistosoma mansoni loxhd1 0.0027 0.0236 0.022
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Loa Loa (eye worm) hypothetical protein 0.0027 0.0236 0.037
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0092 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0604 0.1514
Echinococcus granulosus small conductance calcium activated potassium 0.0426 0.6365 0.6362
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3899 0.3894
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0046 0.0519 0.1286
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3899 0.3894
Leishmania major beta tubulin 0.0265 0.3899 1
Onchocerca volvulus 0.0068 0.0858 0.378
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0051 0.0604 0.0589
Toxoplasma gondii isocitrate dehydrogenase 0.0022 0.0156 0.035
Echinococcus multilocularis potassium channel subfamily K 8 0.0021 0.0135 0.0127
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0095 0.0193
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0078 0.0798
Schistosoma mansoni hypothetical protein 0.008 0.1041 0.1027
Leishmania major cytochrome p450-like protein 0.0018 0.0095 0.0193
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0064 0.0048
Leishmania major trypanothione reductase 0.0049 0.0575 0.143
Trypanosoma cruzi ion transport protein, putative 0.0021 0.0135 0.0147
Trichomonas vaginalis tubulin gamma chain, putative 0.0061 0.075 0.1892
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0051 0.0604 0.0597
Plasmodium vivax tubulin alpha chain, putative 0.0192 0.2763 0.7072
Echinococcus granulosus beta tubulin 0.0265 0.3899 0.3894
Schistosoma mansoni rab6-interacting 0.0027 0.0236 0.022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0011
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0907 0.0893
Trichomonas vaginalis tubulin epsilon chain, putative 0.0192 0.2763 0.7075
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0365 0.0573
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0095 0.0122
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0095 0.0122
Loa Loa (eye worm) isocitrate dehydrogenase 0.0022 0.0156 0.0245
Brugia malayi hypothetical protein 0.0021 0.0135 0.0217
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2763 0.7075
Brugia malayi Tubulin beta-1 chain 0.0265 0.3899 0.6686
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.075 0.1892
Echinococcus multilocularis bloom syndrome protein 0.002 0.013 0.0123
Leishmania major beta tubulin 0.0265 0.3899 1
Schistosoma mansoni tubulin subunit epsilon 0.014 0.1969 0.1956
Entamoeba histolytica tubulin family protein 0.0265 0.3899 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0021 0.0135 0.0217
Loa Loa (eye worm) hypothetical protein 0.0048 0.055 0.0865
Mycobacterium ulcerans lipase LipD 0.0068 0.0858 0.6725
Brugia malayi Carboxylesterase family protein 0.0013 0.0016 0.0013
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.021 0.0499
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Leishmania major zeta tubulin, putative 0.0061 0.075 0.1883
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0046 0.0519 0.0504
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0575 0.143
Leishmania major cytochrome p450-like protein 0.0018 0.0095 0.0193
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0026 0.0209 0.0487
Trichomonas vaginalis tubulin gamma chain, putative 0.014 0.1969 0.503
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0095 0.0122
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.014 0.1969 0.5025
Mycobacterium tuberculosis Probable lipase LipE 0.0068 0.0858 0.1303
Schistosoma mansoni cytochrome P450 0.0018 0.0095 0.0079
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0046 0.0519 0.0815
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.075 0.1892
Leishmania major beta tubulin 0.0265 0.3899 1
Trypanosoma brucei PAB1-binding protein , putative 0.0085 0.1121 0.284
Loa Loa (eye worm) tubulin alpha 2 0.0052 0.0609 0.0957
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0095 0.063
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0078 0.0063
Echinococcus granulosus ubiquitin specific protease 41 0.0051 0.0604 0.0597
Echinococcus granulosus tubulin subunit TubB 0.0192 0.2763 0.2758
Loa Loa (eye worm) serotonin transporter b 0.0063 0.0782 0.1229
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0022 0.0156 0.0149
Loa Loa (eye worm) doublecortin family protein 0.0027 0.0236 0.037
Schistosoma mansoni tubulin subunit gamma 0.014 0.1969 0.1956
Echinococcus multilocularis twik family of potassium channels 0.0021 0.0135 0.0127
Echinococcus granulosus twik family of potassium channels 0.0021 0.0135 0.0127
Onchocerca volvulus 0.0068 0.0858 0.378
Leishmania major alpha glucosidase II subunit, putative 0.0026 0.021 0.0488
Leishmania major beta tubulin 0.0265 0.3899 1
Trichomonas vaginalis tubulin gamma chain, putative 0.014 0.1969 0.503
Trichomonas vaginalis maltase-glucoamylase, putative 0.0026 0.021 0.0499
Leishmania major beta tubulin 0.0265 0.3899 1
Echinococcus multilocularis geminin 0.04 0.5971 0.5968
Echinococcus multilocularis tubulin epsilon chain 0.014 0.1969 0.1963
Trichomonas vaginalis sucrase-isomaltase, putative 0.0026 0.021 0.0499
Brugia malayi Glycosyl hydrolases family 31 protein 0.0116 0.1592 0.2722
Echinococcus granulosus transcription factor Dp 1 0.0026 0.0223 0.0215
Loa Loa (eye worm) tubulin beta chain 0.0061 0.075 0.1179
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0365 0.075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0085 0.0134
Mycobacterium ulcerans transmembrane cation transporter 0.0021 0.0135 0.0948
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0858 0.204
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0021 0.0135 0.0217
Loa Loa (eye worm) hypothetical protein 0.0068 0.0858 0.1347
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0116 0.1599 0.1586
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0135 0.0305
Entamoeba histolytica hypothetical protein 0.0038 0.0393 0.0962
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Plasmodium falciparum thioredoxin reductase 0.0017 0.0078 0.015
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0026 0.0209 0.1543
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Mycobacterium tuberculosis Probable esterase LipL 0.0068 0.0858 0.1303
Mycobacterium leprae conserved hypothetical protein 0.0068 0.0858 0.4867
Loa Loa (eye worm) tubulin beta-1 chain 0.0265 0.3899 0.6125
Onchocerca volvulus 0.0079 0.1034 0.4573
Schistosoma mansoni lamin 0.0026 0.0213 0.0198
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.1548 0.2371
Echinococcus granulosus bloom syndrome protein 0.002 0.013 0.0123
Echinococcus multilocularis Polycystic kidney disease protein 0.0027 0.0236 0.0229
Schistosoma mansoni alpha tubulin 0.0192 0.2763 0.2752
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0022 0.0156 0.0149
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0021 0.0135 0.0211
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0013 0.002 0.0006
Loa Loa (eye worm) alpha-tubulin 0.0192 0.2763 0.4341
Echinococcus granulosus intermediate filament protein 0.0026 0.0213 0.0206
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0078 0.0161
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Leishmania major beta tubulin 0.0265 0.3899 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.021 0.0499
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0061 0.075 0.1883
Loa Loa (eye worm) pigment dispersing factor receptor c 0.007 0.089 0.1399
Trypanosoma brucei epsilon tubulin 0.014 0.1969 0.5025
Loa Loa (eye worm) hypothetical protein 0.0131 0.1828 0.2872
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.021 0.0499
Loa Loa (eye worm) tubulin alpha 2 0.0131 0.1828 0.2872
Entamoeba histolytica hypothetical protein 0.0038 0.0393 0.0962
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0209 0.0342
Entamoeba histolytica acetyltransferase, GNAT family 0.0067 0.084 0.2114
Echinococcus multilocularis tubulin alpha 3 chain 0.0192 0.2763 0.2758
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Mycobacterium leprae cell division protein FtsZ 0.0061 0.075 0.4244
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0021 0.0135 0.0127
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0135 0.0305
Plasmodium falciparum ataxin-2 like protein, putative 0.0085 0.1121 0.284
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0078 0.015
Echinococcus multilocularis tubulin subunit beta 0.0265 0.3899 0.3894
Loa Loa (eye worm) hypothetical protein 0.0192 0.2763 0.4341
Echinococcus multilocularis beta tubulin 0.0265 0.3899 0.3894
Schistosoma mansoni tubulin subunit beta 0.0265 0.3899 0.3889
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0365 0.0573
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0095 0.063
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Loa Loa (eye worm) carboxylesterase 0.0013 0.0016 0.0025
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.004 0.0424 0.0905
Echinococcus granulosus potassium channel subfamily K 8 0.0021 0.0135 0.0127
Loa Loa (eye worm) beta-lactamase 0.0068 0.0858 0.1347
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0131 0.1828 0.4667
Loa Loa (eye worm) hypothetical protein 0.0192 0.2762 0.4339
Schistosoma mansoni hypothetical protein 0.0027 0.0236 0.022
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0192 0.2763 0.7075
Loa Loa (eye worm) BEN-1 protein 0.0265 0.3899 0.6125
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.021 0.0499
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.004 0.0424 0.1042
Plasmodium vivax SET domain protein, putative 0.002 0.0119 0.0255
Plasmodium vivax tubulin epsilon chain, putative 0.014 0.1969 0.5025
Trypanosoma cruzi zeta tubulin, putative 0.0061 0.075 0.1759
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3899 0.3894
Giardia lamblia Alpha-tubulin 0.0192 0.2763 0.7028
Loa Loa (eye worm) uncoordinated protein 58 0.0021 0.0135 0.0211
Leishmania major beta tubulin 0.0265 0.3899 1
Trypanosoma cruzi epsilon tubulin, putative 0.014 0.1969 0.4949
Onchocerca volvulus 0.0047 0.0544 0.2371
Loa Loa (eye worm) RecQ helicase 0.002 0.013 0.0204
Leishmania major epsilon tubulin, putative 0.014 0.1969 0.5025
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0021 0.0135 0.0217
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Echinococcus granulosus tubulin alpha chain 0.0192 0.2763 0.2758
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2763 0.7075
Loa Loa (eye worm) tubulin alpha-3 chain 0.0112 0.1544 0.2426
Trypanosoma brucei beta tubulin 0.0265 0.3899 1
Brugia malayi Latrophilin receptor protein 2 0.0022 0.0155 0.0253
Brugia malayi Cytochrome P450 family protein 0.0058 0.0708 0.1202
Echinococcus granulosus Tubulin alpha 1 chain 0.0192 0.2763 0.2758
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0078 0.015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0393 0.0386
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.021 0.0499
Echinococcus multilocularis beta LACTamase domain containing family member 0.0068 0.0858 0.0851
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0038 0.0401 0.0394
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0078 0.015
Schistosoma mansoni hypothetical protein 0.0048 0.055 0.0535
Giardia lamblia Hypothetical protein 0.0021 0.0135 0.0147
Loa Loa (eye worm) BEN-1 protein 0.0265 0.3899 0.6125
Echinococcus granulosus lamin dm0 0.0026 0.0213 0.0206
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.004 0.0424 0.1042
Leishmania major beta tubulin 0.0265 0.3899 1
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0046 0.0519 0.0512
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0119 0.0103
Trypanosoma brucei zeta tubulin 0.0061 0.075 0.1883
Trichomonas vaginalis tubulin epsilon chain, putative 0.0265 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0021 0.0135 0.0147
Brugia malayi intermediate filament protein 0.0026 0.0213 0.0352
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0095 0.0122
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus multilocularis Tubulin alpha 1 chain 0.0192 0.2763 0.2758
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0078 0.0798
Giardia lamblia Fructose-bisphosphate aldolase 0.0193 0.2788 0.7093
Loa Loa (eye worm) hypothetical protein 0.0077 0.1003 0.1576
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Toxoplasma gondii melibiase subfamily protein 0.0071 0.0907 0.2287
Loa Loa (eye worm) acetylcholinesterase 1 0.0077 0.1003 0.1576
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0095 0.063
Plasmodium vivax tubulin alpha chain, putative 0.0192 0.2763 0.7072
Brugia malayi Pre-SET motif family protein 0.0138 0.1932 0.3306
Echinococcus granulosus tubulin alpha 1C chain 0.0192 0.2763 0.2758
Plasmodium vivax potassium channel, putative 0.0021 0.0135 0.0295
Toxoplasma gondii ion channel protein 0.0021 0.0135 0.0295
Trichomonas vaginalis tubulin, putative 0.0265 0.3899 1
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0119 0.0112
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3899 0.3894
Giardia lamblia Gamma tubulin 0.014 0.1969 0.4949
Trypanosoma cruzi alpha tubulin, putative 0.0192 0.2763 0.7028
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0138 0.1932 0.3035
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0193 0.2788 0.7137
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0073 0.0933 0.2354
Loa Loa (eye worm) hypothetical protein 0.0077 0.1003 0.1576
Echinococcus granulosus geminin 0.04 0.5971 0.5968
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0365 0.0889
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0068 0.0858 0.1303
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Onchocerca volvulus 0.0158 0.2242 1
Loa Loa (eye worm) tubulin alpha 2 0.0131 0.1828 0.2872
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus multilocularis tubulin beta 1 chain 0.0265 0.3899 0.3894
Echinococcus granulosus beta tubulin 0.0265 0.3899 0.3894
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0078 0.015
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0078 0.015
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0095 0.0193
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0095 0.0122
Schistosoma mansoni tubulin subunit alpha 0.0192 0.2763 0.2752
Plasmodium falciparum LCCL domain-containing protein 0.0027 0.0236 0.0556
Echinococcus multilocularis carboxylesterase 5A 0.0077 0.1003 0.0996
Schistosoma mansoni polycystin 1-related 0.0027 0.0236 0.022
Plasmodium falciparum potassium channel 0.0021 0.0135 0.0295
Trypanosoma cruzi tubulin delta chain 0.0061 0.075 0.1759
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0247 0.3617 0.3613
Echinococcus granulosus lysosomal alpha glucosidase 0.0116 0.1592 0.1586
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0095 0.063
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.007 0.089 0.1516
Schistosoma mansoni lipoxygenase 0.0114 0.1573 0.156
Toxoplasma gondii alpha-tubulin I, putative 0.0192 0.2763 0.7072
Schistosoma mansoni tubulin subunit alpha 0.0192 0.2763 0.2752
Echinococcus granulosus survival motor neuron protein 1 0.0391 0.5826 0.5823
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0022 0.0155 0.0148
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0026 0.021 0.0488
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Plasmodium vivax hypothetical protein, conserved 0.0068 0.0858 0.2159
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0071 0.0907 0.0901
Echinococcus multilocularis tubulin subunit TubB 0.0192 0.2763 0.2758
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0095 0.0122
Plasmodium falciparum thioredoxin reductase 0.0049 0.0575 0.143
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.004 0.0424 0.1042
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0095 0.0122
Trichomonas vaginalis tubulin beta chain, putative 0.0079 0.1034 0.2622
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0095 0.063
Trichomonas vaginalis D-aminoacylase, putative 0.0068 0.0858 0.2168
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0021 0.0135 0.0211
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Echinococcus granulosus beta LACTamase domain containing family member 0.0068 0.0858 0.0851
Loa Loa (eye worm) norepinephrine transporter 0.0063 0.0782 0.1229
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0051 0.0604 0.0597
Echinococcus multilocularis tubulin delta chain 0.0061 0.075 0.0744
Brugia malayi isocitrate dehydrogenase 0.0022 0.0156 0.0253
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0119 0.0103
Echinococcus multilocularis GPCR, family 2 0.0022 0.0155 0.0148
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.1741 0.2671
Plasmodium falciparum tubulin gamma chain 0.014 0.1969 0.5025
Plasmodium vivax tubulin gamma chain, putative 0.014 0.1969 0.5025
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0116 0.1599 0.2734
Echinococcus granulosus tubulin alpha 1C chain 0.0192 0.2763 0.2758
Echinococcus multilocularis potassium channel subfamily K 0.0021 0.0135 0.0127
Schistosoma mansoni hypothetical protein 0.0022 0.0155 0.014
Echinococcus multilocularis lysosomal alpha glucosidase 0.0116 0.1592 0.1586
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.004 0.0424 0.0417
Loa Loa (eye worm) hypothetical protein 0.0022 0.0155 0.0244
Echinococcus multilocularis calcium activated potassium channel variant 0.0021 0.0135 0.0127
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Trypanosoma brucei alpha tubulin 0.0192 0.2763 0.7072
Leishmania major calcium/potassium channel (CAKC), putative 0.0021 0.0135 0.0295
Echinococcus granulosus lipoxygenase domain containing protein 0.0027 0.0236 0.0229
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0022 0.0156 0.035
Schistosoma mansoni lipoxygenase 0.0163 0.233 0.2318
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.1741 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0095 0.063
Mycobacterium ulcerans esterase/lipase LipP 0.0068 0.0858 0.6725
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0028 0.0045
Echinococcus multilocularis Tubulin alpha 1 chain 0.0192 0.2763 0.2758
Leishmania major beta tubulin 0.0265 0.3899 1
Echinococcus granulosus tubulin gamma 1 chain 0.014 0.1969 0.1963
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2763 0.7075
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0022 0.0156 0.035
Entamoeba histolytica tubulin gamma chain 0.014 0.1969 0.5025
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0022 0.0156 0.0149
Brugia malayi Pre-SET motif family protein 0.002 0.0119 0.019
Brugia malayi hypothetical protein 0.0391 0.5826 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0019 0.0108 0.01
Trypanosoma brucei glucosidase, putative 0.0026 0.021 0.0488
Schistosoma mansoni tubulin subunit beta 0.0061 0.075 0.0736
Loa Loa (eye worm) hypothetical protein 0.0068 0.0858 0.1347
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0193 0.2788 0.7137
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0079 0.1034 0.2622
Entamoeba histolytica hypothetical protein 0.0038 0.0393 0.0962
Echinococcus multilocularis hypothetical protein 0.0192 0.2763 0.2758
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0209 0.0342
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0051 0.0604 0.1505
Trypanosoma brucei beta tubulin 0.014 0.1969 0.5025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0028 0.0034
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0022 0.0156 0.0203
Echinococcus multilocularis twik family of potassium channels 0.0021 0.0135 0.0127
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0063 0.0782 0.1329
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0095 0.0043
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0135 0.0305
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0061 0.075 0.1883
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0562 0.8461 0.846
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2763 0.2758
Leishmania major hypothetical protein, conserved 0.0021 0.0135 0.0295
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus granulosus tubulin alpha chain 0.0192 0.2763 0.2758
Echinococcus multilocularis acetylcholinesterase 0.0077 0.1003 0.0996
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.1741 0.2671
Toxoplasma gondii isocitrate dehydrogenase 0.0022 0.0156 0.035
Leishmania major beta tubulin 0.0265 0.3899 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0073 0.0933 0.2354
Toxoplasma gondii beta-1 tubulin, putative 0.0265 0.3899 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0021 0.0135 0.0217
Mycobacterium ulcerans beta-lactamase 0.0068 0.0858 0.6725
Loa Loa (eye worm) hypothetical protein 0.0213 0.3099 0.4869
Echinococcus multilocularis neutral alpha glucosidase AB 0.0026 0.021 0.0202
Loa Loa (eye worm) hypothetical protein 0.0068 0.0858 0.1347
Echinococcus granulosus calcium activated potassium channel variant 0.0021 0.0135 0.0127
Trypanosoma brucei zeta tubulin, putative 0.0061 0.075 0.1883
Brugia malayi Glycosyl hydrolases family 31 protein 0.0026 0.021 0.0346
Brugia malayi Carboxylesterase family protein 0.0077 0.1003 0.1709
Echinococcus granulosus Tubulin alpha 1 chain 0.0192 0.2763 0.2758
Echinococcus granulosus acetylcholinesterase 0.0077 0.1003 0.0996
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0095 0.063
Trichomonas vaginalis tubulin, putative 0.0079 0.1034 0.2622
Echinococcus multilocularis lipoxygenase domain containing protein 0.0027 0.0236 0.0229
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Loa Loa (eye worm) glutathione reductase 0.0049 0.0575 0.0903
Onchocerca volvulus 0.0021 0.0135 0.0533
Echinococcus granulosus neuroligin 0.0013 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0078 0.0161
Echinococcus granulosus tubulin alpha chain 0.0192 0.2763 0.2758
Toxoplasma gondii ABC1 family protein 0.0068 0.0858 0.2159
Toxoplasma gondii thioredoxin reductase 0.0049 0.0575 0.143
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0116 0.1599 0.1593
Brugia malayi Bloom's syndrome protein homolog 0.002 0.013 0.0209
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0094 0.1267 0.1938
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.1741 0.2671
Mycobacterium tuberculosis Conserved protein 0.0068 0.0858 0.1303
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.013 0.0294
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0095 0.0122
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0022 0.0155 0.0148
Schistosoma mansoni tubulin subunit delta 0.0061 0.075 0.0736
Onchocerca volvulus 0.0157 0.2224 0.9921
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0095 0.0043
Loa Loa (eye worm) hypothetical protein 0.0112 0.1544 0.2426
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3899 0.3894
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0022 0.0156 0.035
Loa Loa (eye worm) hypothetical protein 0.007 0.089 0.1399
Echinococcus granulosus twik family of potassium channels 0.0021 0.0135 0.0127
Brugia malayi beta-tubulin, identical 0.0265 0.3899 0.6686
Brugia malayi hypothetical protein 0.0027 0.0236 0.039
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0061 0.075 0.1892
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0021 0.0135 0.0217
Schistosoma mansoni calcium-activated potassium channel 0.0405 0.6045 0.6039
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3899 0.3894
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0038 0.0401 0.0394
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.002 0.0119 0.0112
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0078 0.015
Leishmania major hypothetical protein, conserved 0.0021 0.0135 0.0295
Loa Loa (eye worm) TWK-28 protein 0.0021 0.0135 0.0211
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0022 0.0156 0.0217
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2763 0.2758
Schistosoma mansoni tubulin subunit beta 0.0265 0.3899 0.3889
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3899 0.3894
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0068 0.0858 0.1303
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0078 0.015
Giardia lamblia Beta tubulin 0.0265 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Toxoplasma gondii ion channel protein 0.0021 0.0135 0.0295
Trichomonas vaginalis inositol monophosphatase, putative 0.0026 0.0209 0.0497
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0061 0.075 1
Brugia malayi acetyltransferase, GNAT family protein 0.0247 0.3617 0.6203
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0051 0.0604 0.0597
Schistosoma mansoni inositol monophosphatase 0.0026 0.0209 0.0193
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0021 0.0135 0.0211
Leishmania major beta tubulin 0.0265 0.3899 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0063 0.0782 0.0767
Onchocerca volvulus 0.0021 0.0135 0.0533
Mycobacterium tuberculosis Probable lipase LipD 0.0068 0.0858 0.1303
Leishmania major hypothetical protein, conserved 0.0068 0.0858 0.2159
Schistosoma mansoni calcium-activated potassium channel 0.0021 0.0135 0.0119
Toxoplasma gondii beta-tubulin, putative 0.0265 0.3899 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0063 0.0782 0.0767
Toxoplasma gondii LsmAD domain-containing protein 0.0085 0.1121 0.284
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0095 0.0122
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0013 0.0016 0.0009
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0078 0.0499
Treponema pallidum sodium- and chloride- dependent transporter 0.0063 0.0782 0.2752
Trichomonas vaginalis penicillin-binding protein, putative 0.0068 0.0858 0.2168
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trichomonas vaginalis set domain proteins, putative 0.0157 0.2224 0.5688
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0604 0.1375
Plasmodium falciparum glutathione reductase 0.0049 0.0575 0.143
Brugia malayi Tubulin alpha-2 chain 0.0192 0.2763 0.4735
Entamoeba histolytica hypothetical protein 0.0038 0.0393 0.0962
Echinococcus granulosus lipoxygenase domain containing protein 0.0027 0.0236 0.0229
Schistosoma mansoni survival motor neuron protein 0.008 0.1041 0.1027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0213 0.0335
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trypanosoma brucei epsilon tubulin 0.014 0.1969 0.5025
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0135 0.0147
Trypanosoma brucei beta tubulin 0.0265 0.3899 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0907 0.0893
Leishmania major gamma-tubulin 0.014 0.1969 0.5025
Brugia malayi Cytochrome P450 family protein 0.0036 0.0365 0.0612
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.002 0.0119 0.0255
Plasmodium vivax ataxin-2 like protein, putative 0.0085 0.1121 0.284
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus multilocularis serotonin transporter 0.0063 0.0782 0.0775
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0021 0.0135 0.0217
Brugia malayi Tubulin alpha chain 0.0061 0.075 0.1275
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0021 0.0135 0.0217
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0078 0.015
Echinococcus multilocularis Tubulin alpha 1 chain 0.0192 0.2763 0.2758
Leishmania major beta tubulin 0.0265 0.3899 1
Brugia malayi hypothetical protein 0.0158 0.2242 0.3839
Echinococcus granulosus Polycystic kidney disease protein 0.0027 0.0236 0.0229
Trichomonas vaginalis tubulin gamma chain, putative 0.0265 0.3899 1
Brugia malayi cytochrome P450 0.0018 0.0095 0.0148
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0095 0.063
Brugia malayi Tubulin beta chain 0.0061 0.075 0.1275
Schistosoma mansoni inositol monophosphatase 0.0026 0.0209 0.0193
Entamoeba histolytica tubulin alpha chain, putative 0.0192 0.2763 0.7072
Schistosoma mansoni intermediate filament proteins 0.0026 0.0213 0.0198
Schistosoma mansoni hypothetical protein 0.0426 0.6365 0.6359
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0051 0.0604 0.1514
Trichomonas vaginalis tubulin, putative 0.0079 0.1034 0.2622
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.021 0.0499
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0068 0.0858 0.6725
Loa Loa (eye worm) hypothetical protein 0.0063 0.0782 0.1229
Brugia malayi alpha-tubulin 0.0192 0.2763 0.4735
Plasmodium falciparum potassium channel 0.0021 0.0135 0.0295
Plasmodium falciparum alpha tubulin 2 0.0192 0.2763 0.7072
Brugia malayi beta-lactamase 0.0068 0.0858 0.1459
Schistosoma mansoni alpha glucosidase 0.0026 0.021 0.0194
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0365 0.0573
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0163 0.233 0.2325
Onchocerca volvulus 0.0068 0.0858 0.378
Brugia malayi hypothetical protein 0.0027 0.0236 0.039
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0095 0.0122
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0078 0.0499
Schistosoma mansoni lamin 0.0026 0.0213 0.0198
Echinococcus granulosus histone acetyltransferase KAT2B 0.0073 0.0933 0.0927
Loa Loa (eye worm) PDE1B protein 0.0116 0.1599 0.2513
Brugia malayi Carboxylesterase family protein 0.0077 0.1003 0.1709
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2763 0.7075
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0021 0.0135 0.0217
Loa Loa (eye worm) tubulin alpha-2 chain 0.0192 0.2763 0.4341
Echinococcus granulosus tubulin alpha 0.014 0.1969 0.1963
Echinococcus granulosus tubulin delta chain 0.0061 0.075 0.0744
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0021 0.0135 0.0217
Schistosoma mansoni alpha tubulin 0.0192 0.2763 0.2752
Leishmania major cytochrome p450-like protein 0.0036 0.0365 0.0889
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0095 0.0122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Plasmodium falciparum tubulin epsilon chain, putative 0.014 0.1969 0.5025
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0047 0.0544 0.0529
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0095 0.063
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0078 0.0499
Trypanosoma cruzi tubulin gamma chain 0.014 0.1969 0.4949
Loa Loa (eye worm) hypothetical protein 0.0158 0.2242 0.3523
Treponema pallidum fructose-bisphosphate aldolase 0.0193 0.2788 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0433 0.6474 1
Schistosoma mansoni hypothetical protein 0.04 0.5971 0.5965
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0095 0.063
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0021 0.0135 0.0127
Echinococcus granulosus GPCR family 2 0.0022 0.0155 0.0148
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0078 0.015
Echinococcus multilocularis ubiquitin specific protease 41 0.0051 0.0604 0.0597
Mycobacterium tuberculosis Cell division protein FtsZ 0.0061 0.075 0.1137
Onchocerca volvulus 0.0063 0.0782 0.3441
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0095 0.0122
Brugia malayi hypothetical protein 0.0055 0.0658 0.1117
Brugia malayi MH2 domain containing protein 0.0167 0.239 0.4094
Brugia malayi tubulin alpha-2 chain 0.0192 0.2763 0.4735
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0095 0.063
Onchocerca volvulus 0.008 0.1041 0.4606
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0209 0.0487
Loa Loa (eye worm) carboxylesterase 0.0077 0.1003 0.1576
Brugia malayi Cytochrome P450 family protein 0.0036 0.0365 0.0612
Schistosoma mansoni hypothetical protein 0.0038 0.0393 0.0378
Trypanosoma brucei beta tubulin 0.0265 0.3899 1
Leishmania major beta tubulin 0.0265 0.3899 1
Schistosoma mansoni rab6-interacting 0.0027 0.0236 0.022
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0094 0.1267 1
Leishmania major beta tubulin 0.0265 0.3899 1
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0021 0.0135 0.0217
Schistosoma mansoni calcium-activated potassium channel 0.0021 0.0135 0.0119
Echinococcus granulosus histone acetyltransferase KAT2B 0.024 0.3511 0.3506
Onchocerca volvulus 0.0021 0.0135 0.0533
Trypanosoma cruzi PAB1-binding protein , putative 0.0085 0.1121 0.273
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0022 0.0156 0.035
Plasmodium vivax multidomain scavenger receptor, putative 0.0027 0.0236 0.0556
Plasmodium vivax glutathione reductase, putative 0.0049 0.0575 0.143
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0021 0.0135 0.0217
Loa Loa (eye worm) MH2 domain-containing protein 0.0167 0.239 0.3756
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0119 0.0103
Schistosoma mansoni alpha-glucosidase 0.0099 0.1345 0.1331
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Treponema pallidum NADH oxidase 0.0017 0.0078 0.0211
Brugia malayi Melibiase family protein 0.0047 0.0543 0.0919
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0095 0.0434
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0095 0.0043
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0023 0.0168 0.0235
Trypanosoma cruzi ion transport protein, putative 0.0021 0.0135 0.0147
Loa Loa (eye worm) beta-tubulin 0.0265 0.3899 0.6125
Echinococcus granulosus tubulin epsilon chain 0.014 0.1969 0.1963
Brugia malayi beta-lactamase family protein 0.0068 0.0858 0.1459
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0021 0.0135 0.0147
Brugia malayi Cytochrome P450 family protein 0.0018 0.0095 0.0148
Onchocerca volvulus 0.0021 0.0135 0.0533
Echinococcus granulosus tubulin alpha 3 chain 0.0192 0.2763 0.2758
Loa Loa (eye worm) alpha-tubulin 0.0192 0.2763 0.4341
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0095 0.063
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0021 0.0135 0.0217
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.1034 0.2622
Echinococcus multilocularis transcription factor Dp 1 0.0026 0.0223 0.0215
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Brugia malayi Carboxylesterase family protein 0.0013 0.0016 0.0013
Echinococcus multilocularis tubulin gamma 1 chain 0.014 0.1969 0.1963
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0116 0.1599 0.1593
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0026 0.0209 0.0497
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0116 0.1592 0.2502
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.004 0.0424 0.0417
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0068 0.0858 0.1459
Echinococcus multilocularis beta tubulin 0.0265 0.3899 0.3894
Loa Loa (eye worm) TWK-7 protein 0.0021 0.0135 0.0211
Echinococcus multilocularis lipoxygenase domain containing protein 0.0027 0.0236 0.0229
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0047 0.0544 0.092
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0135 0.0147
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0047 0.0543 0.0528
Leishmania major beta tubulin 0.0265 0.3899 1
Toxoplasma gondii alpha tubulin TUBA1 0.0192 0.2763 0.7072
Brugia malayi Inositol-1 0.0026 0.0209 0.0345
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0247 0.3617 0.3607
Echinococcus multilocularis neuroligin 0.0013 0.0016 0.0009
Echinococcus multilocularis acetylcholinesterase 0.0077 0.1003 0.0996
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0112 0.1544 0.3937
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Mycobacterium leprae Probable lipase LipE 0.0068 0.0858 0.4867
Schistosoma mansoni hypothetical protein 0.0022 0.0155 0.014
Echinococcus granulosus BC026374 protein S09 family 0.0013 0.0016 0.0009
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0519 0.1153
Schistosoma mansoni hypothetical protein 0.0022 0.0155 0.014
Leishmania major beta tubulin 0.0265 0.3899 1
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0022 0.0155 0.0148
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus multilocularis BC026374 protein (S09 family) 0.0013 0.0016 0.0009
Brugia malayi beta-lactamase family protein 0.0068 0.0858 0.1459
Mycobacterium ulcerans hypothetical protein 0.0068 0.0858 0.6725
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0095 0.0122
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2763 0.7075
Echinococcus multilocularis potassium channel subfamily K 8 0.0021 0.0135 0.0127
Plasmodium falciparum tubulin delta chain, putative 0.0061 0.075 0.1883
Loa Loa (eye worm) tubulin beta-4 chain 0.0265 0.3899 0.6125

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 18 nM Inhibition of human placental cytosolic 17beta HSD1 using unlabeled- and labelled [2,4,6,7-3H]-E1 as substrate incubated for 10 mins by HPLC analysis ChEMBL. 26322835
IC50 (binding) = 99 nM Inhibition of human placental microsomal 17beta HSD2 using unlabeled- and labelled [2,4,6,7-3H]-E2 as substrate incubated for 20 mins by HPLC analysis ChEMBL. 26322835
Inhibition (binding) Inhibition of recombinant mouse 17beta HSD1 expressed in HEK293 cells using unlabeled- and labelled [2,4,6,7-3H]-E1 as substrate at 1 uM incubated for 10 mins by HPLC analysis ChEMBL. 26322835

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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