Detailed information for compound 1944984

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 449.542 | Formula: C24H19NO4S2
  • H donors: 2 H acceptors: 4 LogP: 5.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cccc(c1)C(=O)c1ccc(s1)c1cccc(c1)NS(=O)(=O)c1cccc(c1)C
  • InChi: 1S/C24H19NO4S2/c1-16-5-2-10-21(13-16)31(28,29)25-19-8-3-6-17(14-19)22-11-12-23(30-22)24(27)18-7-4-9-20(26)15-18/h2-15,25-26H,1H3
  • InChiKey: RMRIFXKPKUCHRY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 1 Starlite/ChEMBL References
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis Dehydrogenase:reductase SDR family hydroxysteroid (17-beta) dehydrogenase 2 387 aa 359 aa 24.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein hydroxysteroid (17-beta) dehydrogenase 1 328 aa 265 aa 27.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Schistosoma mansoni loxhd1 0.0027 0.0236 0.022
Brugia malayi Cytochrome P450 family protein 0.0036 0.0365 0.0612
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0063 0.0782 0.0767
Trichomonas vaginalis maltase-glucoamylase, putative 0.0026 0.021 0.0499
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0078 0.015
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0021 0.0135 0.0217
Giardia lamblia Hypothetical protein 0.0021 0.0135 0.0147
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0068 0.0858 0.1303
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0095 0.0122
Leishmania major potassium channel subunit-like protein 0.0021 0.0135 0.0295
Schistosoma mansoni tubulin subunit delta 0.0061 0.075 0.0736
Brugia malayi hypothetical protein 0.0027 0.0236 0.039
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0095 0.0122
Trypanosoma cruzi epsilon tubulin, putative 0.014 0.1969 0.4949
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.013 0.0294
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0061 0.075 0.1883
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0095 0.063
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0095 0.0122
Echinococcus granulosus carboxylesterase 5A 0.0077 0.1003 0.0996
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.021 0.0499
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0365 0.0573
Brugia malayi alpha-tubulin 0.0192 0.2763 0.4735
Echinococcus multilocularis twik family of potassium channels 0.0021 0.0135 0.0127
Trichomonas vaginalis tubulin beta chain, putative 0.0265 0.3899 1
Plasmodium falciparum potassium channel 0.0021 0.0135 0.0295
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0095 0.0122
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0119 0.0112
Schistosoma mansoni lipoxygenase 0.0163 0.233 0.2318
Loa Loa (eye worm) tubulin beta-4 chain 0.0265 0.3899 0.6125
Mycobacterium tuberculosis Cell division protein FtsZ 0.0061 0.075 0.1137
Brugia malayi Carboxylesterase family protein 0.0077 0.1003 0.1709
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.021 0.0343
Brugia malayi Tubulin beta chain 0.0061 0.075 0.1275
Brugia malayi Doublecortin family protein 0.0027 0.0236 0.039
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0365 0.075
Trichomonas vaginalis D-aminoacylase, putative 0.0068 0.0858 0.2168
Brugia malayi Thioredoxin reductase 0.0049 0.0575 0.0973
Mycobacterium ulcerans cell division protein FtsZ 0.0061 0.075 0.5869
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trypanosoma cruzi tubulin delta chain 0.0061 0.075 0.1759
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0433 0.6474 1
Loa Loa (eye worm) carboxylesterase 0.0013 0.0016 0.0025
Onchocerca volvulus 0.0047 0.0544 0.2371
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3899 0.3894
Echinococcus granulosus tubulin epsilon chain 0.014 0.1969 0.1963
Brugia malayi Cytochrome P450 family protein 0.0018 0.0095 0.0148
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0095 0.063
Loa Loa (eye worm) beta-tubulin 0.0265 0.3899 0.6125
Loa Loa (eye worm) beta-lactamase 0.0068 0.0858 0.1347
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3899 0.3894
Onchocerca volvulus 0.0021 0.0135 0.0533
Schistosoma mansoni lamin 0.0026 0.0213 0.0198
Leishmania major beta tubulin 0.0265 0.3899 1
Brugia malayi beta-lactamase family protein 0.0068 0.0858 0.1459
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0095 0.0043
Toxoplasma gondii beta-tubulin, putative 0.0265 0.3899 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0068 0.0858 0.1303
Echinococcus multilocularis potassium channel subfamily K 8 0.0021 0.0135 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Loa Loa (eye worm) hypothetical protein 0.0026 0.0213 0.0335
Brugia malayi Tubulin gamma chain 0.014 0.1969 0.337
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0023 0.0168 0.0858
Schistosoma mansoni tubulin subunit alpha 0.0192 0.2763 0.2752
Treponema pallidum NADH oxidase 0.0017 0.0078 0.0211
Loa Loa (eye worm) tubulin gamma chain 0.014 0.1969 0.3094
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0013 0.002 0.0033
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0026 0.0209 0.0497
Leishmania major hypothetical protein, conserved 0.0021 0.0135 0.0295
Brugia malayi Tubulin alpha chain 0.0192 0.2763 0.4735
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0135 0.0305
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3899 0.3894
Mycobacterium ulcerans transmembrane cation transporter 0.0021 0.0135 0.0948
Loa Loa (eye worm) tubulin beta chain 0.0061 0.075 0.1179
Trypanosoma brucei PAB1-binding protein , putative 0.0085 0.1121 0.284
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0051 0.0604 0.1375
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3899 0.3894
Schistosoma mansoni hypothetical protein 0.008 0.1041 0.1027
Entamoeba histolytica hypothetical protein 0.0038 0.0393 0.0962
Echinococcus granulosus tubulin alpha chain 0.0192 0.2763 0.2758
Brugia malayi Cytochrome P450 family protein 0.0036 0.0365 0.0612
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0187
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Brugia malayi Tubulin beta-1 chain 0.0265 0.3899 0.6686
Echinococcus multilocularis potassium channel subfamily K 0.0021 0.0135 0.0127
Toxoplasma gondii ABC1 family protein 0.0068 0.0858 0.2159
Loa Loa (eye worm) tubulin beta-1 chain 0.0265 0.3899 0.6125
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0095 0.063
Brugia malayi Glycosyl hydrolases family 31 protein 0.0026 0.021 0.0346
Echinococcus granulosus bloom syndrome protein 0.002 0.013 0.0123
Echinococcus multilocularis serotonin transporter 0.0063 0.0782 0.0775
Plasmodium vivax potassium channel, putative 0.0021 0.0135 0.0295
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Schistosoma mansoni calcium-activated potassium channel 0.0021 0.0135 0.0119
Trichomonas vaginalis tubulin epsilon chain, putative 0.0061 0.075 0.1892
Schistosoma mansoni hypothetical protein 0.04 0.5971 0.5965
Onchocerca volvulus 0.0027 0.0236 0.0987
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0022 0.0156 0.0149
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0051 0.0604 0.0589
Loa Loa (eye worm) hypothetical protein 0.0158 0.2242 0.3523
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.1034 0.2622
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0051 0.0604 0.0597
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0021 0.0135 0.0211
Leishmania major hypothetical protein, conserved 0.0085 0.1121 0.284
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0192 0.2763 0.7075
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0135 0.0305
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0095 0.063
Onchocerca volvulus 0.0157 0.2224 0.9921
Echinococcus granulosus geminin 0.04 0.5971 0.5968
Schistosoma mansoni hypothetical protein 0.0027 0.0236 0.022
Leishmania major beta tubulin 0.0265 0.3899 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0051 0.0604 0.0589
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0078 0.015
Mycobacterium tuberculosis Probable lipase LipD 0.0068 0.0858 0.1303
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0021 0.0135 0.0217
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2763 0.2758
Schistosoma mansoni hypothetical protein 0.0022 0.0155 0.014
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0604 0.1375
Trypanosoma brucei beta tubulin 0.0265 0.3899 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0026 0.0209 0.1543
Plasmodium falciparum tubulin delta chain, putative 0.0061 0.075 0.1883
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0013 0.0016 0.0009
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0021 0.0135 0.0217
Brugia malayi hypothetical protein 0.0391 0.5826 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0022 0.0155 0.0148
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0061 0.075 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0026 0.0209 0.0497
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0028 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0092 0.0185
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.004 0.0424 0.0905
Echinococcus granulosus tubulin subunit beta 0.0265 0.3899 0.3894
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0022 0.0156 0.0203
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.1741 1
Brugia malayi Carboxylesterase family protein 0.0013 0.0016 0.0013
Echinococcus granulosus tubulin alpha 1C chain 0.0192 0.2763 0.2758
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0078 0.015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0095 0.0122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.007 0.089 0.1399
Brugia malayi Pre-SET motif family protein 0.0138 0.1932 0.3306
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0021 0.0135 0.0217
Echinococcus granulosus acetylcholinesterase 0.0077 0.1003 0.0996
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0135 0.0305
Mycobacterium tuberculosis Probable lipase LipE 0.0068 0.0858 0.1303
Plasmodium falciparum potassium channel 0.0021 0.0135 0.0295
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0095 0.0122
Brugia malayi isocitrate dehydrogenase 0.0022 0.0156 0.0253
Echinococcus multilocularis lysosomal alpha glucosidase 0.0116 0.1592 0.1586
Echinococcus multilocularis tubulin delta chain 0.0061 0.075 0.0744
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3899 0.3894
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0022 0.0155 0.0148
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0021 0.0135 0.0295
Echinococcus granulosus lysosomal alpha glucosidase 0.0116 0.1592 0.1586
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.021 0.0488
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.1548 0.2371
Echinococcus multilocularis BC026374 protein (S09 family) 0.0013 0.0016 0.0009
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0365 0.0889
Trichomonas vaginalis penicillin-binding protein, putative 0.0068 0.0858 0.2168
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.021 0.0343
Leishmania major beta tubulin 0.0265 0.3899 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0192 0.2763 0.2758
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0078 0.015
Trichomonas vaginalis inositol monophosphatase, putative 0.0026 0.0209 0.0497
Trypanosoma brucei beta tubulin 0.014 0.1969 0.5025
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0028 0.0045
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0073 0.0933 0.2363
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.013 0.0294
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.004 0.0424 0.1042
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0023 0.0168 0.0235
Loa Loa (eye worm) hypothetical protein 0.0047 0.0543 0.0854
Plasmodium falciparum thioredoxin reductase 0.0017 0.0078 0.015
Trichomonas vaginalis tubulin epsilon chain, putative 0.0192 0.2763 0.7075
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0026 0.0209 0.0487
Echinococcus granulosus potassium channel subfamily K 8 0.0021 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus granulosus serotonin transporter 0.0063 0.0782 0.0775
Mycobacterium ulcerans hypothetical protein 0.0068 0.0858 0.6725
Loa Loa (eye worm) carboxylesterase 0.0077 0.1003 0.1576
Leishmania major beta tubulin 0.0265 0.3899 1
Trichomonas vaginalis D-aminoacylase, putative 0.0068 0.0858 0.2168
Echinococcus multilocularis beta LACTamase domain containing family member 0.0068 0.0858 0.0851
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.004 0.0424 0.0905
Echinococcus multilocularis tubulin beta 1 chain 0.0265 0.3899 0.3894
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0365 0.075
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3899 0.3894
Mycobacterium ulcerans esterase/lipase LipP 0.0068 0.0858 0.6725
Schistosoma mansoni hypothetical protein 0.0038 0.0393 0.0378
Brugia malayi glutathione reductase 0.0049 0.0575 0.0973
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0068 0.0858 0.1347
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus granulosus acetylcholinesterase 0.0077 0.1003 0.0996
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0393 0.0386
Echinococcus multilocularis tubulin subunit TubB 0.0192 0.2763 0.2758
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0135 0.0305
Brugia malayi Tubulin alpha-2 chain 0.0192 0.2763 0.4735
Brugia malayi MH2 domain containing protein 0.0167 0.239 0.4094
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0575 0.0568
Schistosoma mansoni hypothetical protein 0.0021 0.0135 0.0119
Loa Loa (eye worm) tubulin alpha 2 0.0131 0.1828 0.2872
Plasmodium vivax hypothetical protein, conserved 0.0068 0.0858 0.2159
Leishmania major beta tubulin 0.0265 0.3899 1
Plasmodium falciparum LCCL domain-containing protein 0.0027 0.0236 0.0556
Schistosoma mansoni cytochrome P450 0.0018 0.0095 0.0079
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0021 0.0135 0.0127
Plasmodium vivax tubulin gamma chain, putative 0.014 0.1969 0.5025
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0209 0.0487
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Echinococcus multilocularis calcium activated potassium channel variant 0.0021 0.0135 0.0127
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0068 0.0858 0.1303
Trypanosoma cruzi ion transport protein, putative 0.0021 0.0135 0.0147
Echinococcus multilocularis neuroligin 0.0013 0.0016 0.0009
Echinococcus multilocularis potassium channel subfamily K 8 0.0021 0.0135 0.0127
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0095 0.0193
Toxoplasma gondii beta tubulin 0.0265 0.3899 1
Trypanosoma brucei tubulin gamma chain 0.014 0.1969 0.5025
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0209 0.0487
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0575 0.0568
Echinococcus granulosus tubulin alpha 0.014 0.1969 0.1963
Echinococcus granulosus tubulin alpha chain 0.0192 0.2763 0.2758
Brugia malayi beta-tubulin, identical 0.0265 0.3899 0.6686
Echinococcus multilocularis bloom syndrome protein 0.002 0.013 0.0123
Mycobacterium tuberculosis Probable reductase 0.0113 0.1548 0.2371
Mycobacterium ulcerans lipase LipD 0.0068 0.0858 0.6725
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0022 0.0156 0.035
Schistosoma mansoni tubulin subunit beta 0.0265 0.3899 0.3889
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0095 0.063
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0078 0.015
Onchocerca volvulus 0.0026 0.0213 0.0886
Trichomonas vaginalis tubulin alpha chain, putative 0.014 0.1969 0.503
Onchocerca volvulus 0.0063 0.0782 0.3441
Echinococcus multilocularis musashi 0.0026 0.0213 0.0206
Mycobacterium leprae putative cytochrome p450 0.0018 0.0095 0.0434
Trypanosoma brucei beta tubulin 0.0265 0.3899 1
Brugia malayi hypothetical protein 0.0027 0.0236 0.039
Echinococcus granulosus tubulin alpha chain 0.0192 0.2763 0.2758
Echinococcus multilocularis lipoxygenase domain containing protein 0.0027 0.0236 0.0229
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0022 0.0156 0.0149
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0022 0.0156 0.0217
Onchocerca volvulus 0.002 0.0119 0.0462
Schistosoma mansoni alpha-glucosidase 0.0099 0.1345 0.1331
Schistosoma mansoni calcium-activated potassium channel 0.0426 0.6365 0.6359
Brugia malayi hypothetical protein 0.0055 0.0658 0.1117
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0022 0.0156 0.0149
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.014 0.1969 0.5025
Schistosoma mansoni survival motor neuron protein 0.008 0.1041 0.1027
Echinococcus multilocularis tubulin alpha 3 chain 0.0192 0.2763 0.2758
Schistosoma mansoni alpha tubulin 0.0192 0.2763 0.2752
Schistosoma mansoni tubulin subunit beta 0.0265 0.3899 0.3889
Loa Loa (eye worm) hypothetical protein 0.0068 0.0858 0.1347
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0047 0.0544 0.092
Loa Loa (eye worm) tubulin alpha-2 chain 0.0192 0.2763 0.4341
Schistosoma mansoni hypothetical protein 0.0022 0.0155 0.014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0022 0.0156 0.0149
Plasmodium falciparum glutathione reductase 0.0049 0.0575 0.143
Echinococcus granulosus survival motor neuron protein 1 0.0391 0.5826 0.5823
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Echinococcus granulosus tubulin gamma 1 chain 0.014 0.1969 0.1963
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0095 0.063
Trypanosoma cruzi PAB1-binding protein , putative 0.0085 0.1121 0.273
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0051 0.0604 0.1514
Loa Loa (eye worm) acetyltransferase 0.0247 0.3617 0.5683
Giardia lamblia Delta tubulin 0.0061 0.075 0.1759
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0064 0.0048
Plasmodium falciparum tubulin beta chain 0.0265 0.3899 1
Onchocerca volvulus 0.0021 0.0135 0.0533
Echinococcus multilocularis Polycystic kidney disease protein 0.0027 0.0236 0.0229
Onchocerca volvulus 0.0067 0.0843 0.3716
Toxoplasma gondii LsmAD domain-containing protein 0.0085 0.1121 0.284
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0078 0.0499
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.004 0.0424 0.1042
Loa Loa (eye worm) BEN-1 protein 0.0265 0.3899 0.6125
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0071 0.0907 0.0901
Schistosoma mansoni hypothetical protein 0.0022 0.0155 0.014
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0078 0.0798
Echinococcus granulosus calcium activated potassium channel variant 0.0021 0.0135 0.0127
Treponema pallidum cell division protein FtsZ 0.0061 0.075 0.2638
Entamoeba histolytica tubulin gamma chain 0.014 0.1969 0.5025
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0038 0.0401 0.0394
Trichomonas vaginalis tubulin, putative 0.0079 0.1034 0.2622
Echinococcus granulosus histone acetyltransferase KAT2B 0.024 0.3511 0.3506
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.004 0.0424 0.1042
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0265 0.3899 0.3894
Echinococcus multilocularis Tubulin alpha 1 chain 0.0192 0.2763 0.2758
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0163 0.233 0.2325
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Brugia malayi Carboxylesterase family protein 0.0013 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trypanosoma brucei beta tubulin 0.0265 0.3899 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0095 0.0122
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.1548 0.2371
Echinococcus granulosus tubulin beta 1 chain 0.0265 0.3899 0.3894
Loa Loa (eye worm) hypothetical protein 0.0068 0.0858 0.1347
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0095 0.0122
Giardia lamblia Beta tubulin 0.0265 0.3899 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.1548 0.2371
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0078 0.0161
Loa Loa (eye worm) hypothetical protein 0.0213 0.3099 0.4869
Trichomonas vaginalis tubulin gamma chain, putative 0.0061 0.075 0.1892
Leishmania major zeta tubulin, putative 0.0061 0.075 0.1883
Echinococcus multilocularis acetylcholinesterase 0.0077 0.1003 0.0996
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3899 0.3894
Schistosoma mansoni hypothetical protein 0.0022 0.0155 0.014
Trichomonas vaginalis tubulin gamma chain, putative 0.014 0.1969 0.503
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Schistosoma mansoni tubulin subunit epsilon 0.014 0.1969 0.1956
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0022 0.0156 0.014
Loa Loa (eye worm) hypothetical protein 0.0192 0.2762 0.4339
Echinococcus multilocularis inositol monophosphatase 1 0.0026 0.0209 0.0202
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.007 0.089 0.1516
Mycobacterium leprae Probable lipase LipE 0.0068 0.0858 0.4867
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0907 0.0893
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0061 0.075 0.1883
Echinococcus granulosus lamin dm0 0.0026 0.0213 0.0206
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.1548 0.2371
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0051 0.0604 0.1023
Entamoeba histolytica hypothetical protein 0.0038 0.0393 0.0962
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0095 0.0122
Leishmania major delta tubulin, putative 0.0061 0.075 0.1883
Trypanosoma cruzi tubulin gamma chain 0.014 0.1969 0.4949
Echinococcus granulosus lipoxygenase domain containing protein 0.0027 0.0236 0.0229
Brugia malayi Inositol-1 0.0026 0.0209 0.0345
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0078 0.015
Plasmodium vivax tubulin beta chain, putative 0.0265 0.3899 1
Leishmania major beta tubulin 0.0265 0.3899 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0094 0.1267 0.7249
Echinococcus multilocularis beta tubulin 0.0265 0.3899 0.3894
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0135 0.0147
Brugia malayi tubulin alpha-2 chain 0.0192 0.2763 0.4735
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0095 0.063
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0095 0.063
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0095 0.063
Echinococcus granulosus tubulin delta chain 0.0061 0.075 0.0744
Plasmodium vivax multidomain scavenger receptor, putative 0.0027 0.0236 0.0556
Trichomonas vaginalis tubulin beta chain, putative 0.0079 0.1034 0.2622
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0247 0.3617 0.3613
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0061 0.075 0.1892
Loa Loa (eye worm) hypothetical protein 0.0025 0.0206 0.0324
Schistosoma mansoni hypothetical protein 0.0426 0.6365 0.6359
Trypanosoma brucei alpha tubulin 0.0192 0.2763 0.7072
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0046 0.0519 0.0877
Brugia malayi Calcitonin receptor-like protein seb-1 0.007 0.089 0.1516
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0046 0.0519 0.1286
Echinococcus granulosus L aminoadipate semialdehyde 0.0047 0.0544 0.0537
Loa Loa (eye worm) TWK-7 protein 0.0021 0.0135 0.0211
Brugia malayi Melibiase family protein 0.0047 0.0543 0.0919
Leishmania major beta tubulin 0.0265 0.3899 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0046 0.0519 0.0512
Schistosoma mansoni alpha tubulin 0.0192 0.2763 0.2752
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0051 0.0604 0.1514
Schistosoma mansoni hypothetical protein 0.04 0.5971 0.5965
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0095 0.0122
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0095 0.0193
Schistosoma mansoni tubulin subunit beta 0.0265 0.3899 0.3889
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2763 0.2758
Schistosoma mansoni alpha tubulin 0.0192 0.2763 0.2752
Echinococcus multilocularis survival motor neuron protein 1 0.0391 0.5826 0.5823
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0021 0.0135 0.0217
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3899 0.3894
Echinococcus granulosus tubulin subunit TubB 0.0192 0.2763 0.2758
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0119 0.0112
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0019 0.0108 0.01
Entamoeba histolytica tubulin family protein 0.0265 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0426 0.6365 1
Loa Loa (eye worm) carboxylesterase 0.0013 0.0016 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0022 0.0156 0.0149
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0021 0.0135 0.0217
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Echinococcus granulosus potassium channel subfamily K 0.0021 0.0135 0.0127
Trypanosoma cruzi tubulin delta chain 0.0061 0.075 0.1759
Echinococcus granulosus GPCR family 2 0.0022 0.0155 0.0148
Echinococcus multilocularis peroxisome assembly protein 26 0.0192 0.2763 0.2758
Loa Loa (eye worm) hypothetical protein 0.0051 0.0604 0.0949
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0135 0.0305
Schistosoma mansoni hypothetical protein 0.0048 0.055 0.0535
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0095 0.0122
Loa Loa (eye worm) tubulin alpha 2 0.0052 0.0609 0.0957
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3899 0.3894
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0193 0.2788 0.7137
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0022 0.0156 0.035
Loa Loa (eye worm) alpha-tubulin 0.0192 0.2763 0.4341
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0022 0.0156 0.035
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.1034 0.2622
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0078 0.015
Loa Loa (eye worm) hypothetical protein 0.0131 0.1828 0.2872
Brugia malayi Latrophilin receptor protein 2 0.0022 0.0155 0.0253
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0095 0.0122
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0068 0.0858 0.0843
Brugia malayi cytochrome P450 0.0018 0.0095 0.0148
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.1034 0.2622
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2763 0.2758
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0073 0.0933 0.2354
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.1741 0.2671
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Onchocerca volvulus 0.0079 0.1034 0.4573
Echinococcus granulosus tubulin alpha 3 chain 0.0192 0.2763 0.2758
Trypanosoma brucei zeta tubulin 0.0061 0.075 0.1883
Brugia malayi Tubulin alpha-2 chain 0.0192 0.2763 0.4735
Onchocerca volvulus 0.0158 0.2242 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0562 0.8461 0.846
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0131 0.1828 0.4667
Loa Loa (eye worm) hypothetical protein 0.007 0.089 0.1399
Echinococcus granulosus intermediate filament protein 0.0026 0.0213 0.0206
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.1741 0.2671
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0907 0.0893
Echinococcus granulosus potassium channel subfamily K 8 0.0021 0.0135 0.0127
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.021 0.0499
Loa Loa (eye worm) hypothetical protein 0.0112 0.1544 0.2426
Echinococcus multilocularis tubulin gamma 1 chain 0.014 0.1969 0.1963
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Schistosoma mansoni lipoxygenase 0.0114 0.1573 0.156
Schistosoma mansoni sodium/chloride dependent transporter 0.0063 0.0782 0.0767
Leishmania major beta tubulin 0.0265 0.3899 1
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0047 0.0543 0.1359
Echinococcus multilocularis L aminoadipate semialdehyde 0.0047 0.0544 0.0537
Schistosoma mansoni tubulin subunit alpha 0.0192 0.2763 0.2752
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Loa Loa (eye worm) hypothetical protein 0.0027 0.0236 0.037
Echinococcus granulosus Tubulin alpha 1 chain 0.0192 0.2763 0.2758
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0135 0.0147
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0575 0.143
Toxoplasma gondii beta-1 tubulin, putative 0.0265 0.3899 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.021 0.0499
Echinococcus granulosus peroxisome assembly protein 26 0.0192 0.2763 0.2758
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0051 0.0604 0.1505
Leishmania major hypothetical protein, conserved 0.0021 0.0135 0.0295
Plasmodium falciparum alpha tubulin 2 0.0192 0.2763 0.7072
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3899 0.3894
Loa Loa (eye worm) norepinephrine transporter 0.0063 0.0782 0.1229
Loa Loa (eye worm) hypothetical protein 0.0068 0.0858 0.1347
Plasmodium falciparum histone acetyltransferase GCN5 0.0067 0.084 0.2114
Trypanosoma brucei hypothetical protein, conserved 0.0068 0.0858 0.2159
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.004 0.0424 0.1042
Leishmania major beta tubulin 0.0265 0.3899 1
Schistosoma mansoni tubulin subunit gamma 0.014 0.1969 0.1956
Mycobacterium tuberculosis Conserved protein 0.0068 0.0858 0.1303
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Loa Loa (eye worm) PDE1B protein 0.0116 0.1599 0.2513
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0094 0.1267 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0095 0.063
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.002 0.0119 0.0112
Plasmodium vivax tubulin epsilon chain, putative 0.014 0.1969 0.5025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Onchocerca volvulus 0.0026 0.0213 0.0886
Echinococcus granulosus lamin 0.0026 0.0213 0.0206
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0079 0.1034 0.2622
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0047 0.0544 0.0529
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0051 0.0604 0.0597
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trypanosoma cruzi alpha tubulin, putative 0.0192 0.2763 0.7028
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.075 0.1892
Loa Loa (eye worm) hypothetical protein 0.0391 0.5826 0.9154
Toxoplasma gondii melibiase subfamily protein 0.0071 0.0907 0.2287
Echinococcus multilocularis twik family of potassium channels 0.0021 0.0135 0.0127
Loa Loa (eye worm) glutathione reductase 0.0049 0.0575 0.0903
Onchocerca volvulus 0.0021 0.0135 0.0533
Giardia lamblia Beta tubulin 0.0265 0.3899 1
Brugia malayi Carboxylesterase family protein 0.0077 0.1003 0.1709
Loa Loa (eye worm) TWK-28 protein 0.0021 0.0135 0.0211
Brugia malayi intermediate filament protein 0.0026 0.0213 0.0352
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0078 1
Trichomonas vaginalis esterase, putative 0.0068 0.0858 0.2168
Leishmania major trypanothione reductase 0.0049 0.0575 0.143
Leishmania major cytochrome p450-like protein 0.0018 0.0095 0.0193
Trichomonas vaginalis tubulin gamma chain, putative 0.0265 0.3899 1
Trypanosoma brucei epsilon tubulin 0.014 0.1969 0.5025
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0095 0.0122
Schistosoma mansoni lamin 0.0026 0.0213 0.0198
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0026 0.0014
Trichomonas vaginalis set domain proteins, putative 0.0157 0.2224 0.5688
Echinococcus granulosus tubulin alpha 1C chain 0.0192 0.2763 0.2758
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0046 0.0519 0.1286
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.021 0.0499
Onchocerca volvulus 0.0021 0.0135 0.0533
Entamoeba histolytica tubulin alpha-1 chain 0.0192 0.2763 0.7072
Brugia malayi Tubulin alpha chain 0.0061 0.075 0.1275
Schistosoma mansoni hypothetical protein 0.0018 0.0095 0.0079
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0078 0.0063
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0021 0.0135 0.0147
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0095 0.063
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0131 0.1828 0.2872
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Loa Loa (eye worm) hypothetical protein 0.0077 0.1003 0.1576
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0119 0.0103
Giardia lamblia Histone acetyltransferase GCN5 0.0067 0.084 0.1994
Echinococcus granulosus inositol monophosphatase 1 0.0026 0.0209 0.0202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0071 0.0907 0.0901
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0095 0.0434
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0022 0.0155 0.0253
Plasmodium falciparum alpha tubulin 1 0.0192 0.2763 0.7072
Schistosoma mansoni tubulin subunit beta 0.0061 0.075 0.0736
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0116 0.1599 0.1593
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0209 0.0342
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0068 0.0858 0.1459
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0078 0.0499
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0078 0.015
Trypanosoma cruzi zeta tubulin, putative 0.0061 0.075 0.1759
Onchocerca volvulus 0.0021 0.0135 0.0533
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0078 0.0071
Brugia malayi Carboxylesterase family protein 0.0013 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0047 0.0544 0.0854
Entamoeba histolytica hypothetical protein 0.0038 0.0393 0.0962
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0095 0.0122
Onchocerca volvulus 0.0027 0.0236 0.0987
Trypanosoma cruzi zeta tubulin, putative 0.0061 0.075 0.1759
Trypanosoma cruzi beta tubulin, putative 0.0265 0.3899 1
Mycobacterium leprae conserved hypothetical protein 0.0068 0.0858 0.4867
Loa Loa (eye worm) BEN-1 protein 0.0265 0.3899 0.6125
Trypanosoma brucei epsilon tubulin 0.014 0.1969 0.5025
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0095 0.0088
Trypanosoma brucei beta tubulin 0.0265 0.3899 1
Treponema pallidum fructose-bisphosphate aldolase 0.0193 0.2788 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0078 0.015
Echinococcus multilocularis tubulin epsilon chain 0.014 0.1969 0.1963
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.1741 0.2671
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Brugia malayi hypothetical protein 0.0085 0.1121 0.1913
Echinococcus multilocularis 0.0018 0.0095 0.0088
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0112 0.1544 0.3937
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0095 0.063
Loa Loa (eye worm) tubulin beta chain 0.0265 0.3899 0.6125
Onchocerca volvulus 0.0021 0.0135 0.0533
Leishmania major hypothetical protein, conserved 0.0068 0.0858 0.2159
Echinococcus multilocularis tubulin alpha 1C chain 0.0192 0.2763 0.2758
Plasmodium vivax tubulin alpha chain, putative 0.0192 0.2763 0.7072
Echinococcus multilocularis RUN 0.0027 0.0236 0.0229
Schistosoma mansoni calcium-activated potassium channel 0.0405 0.6045 0.6039
Mycobacterium tuberculosis Conserved protein 0.0068 0.0858 0.1303
Brugia malayi acetyltransferase, GNAT family protein 0.0247 0.3617 0.6203
Toxoplasma gondii isocitrate dehydrogenase 0.0022 0.0156 0.035
Trypanosoma brucei trypanothione reductase 0.0049 0.0575 0.143
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0073 0.0933 0.2354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0119 0.0103
Schistosoma mansoni hypothetical protein 0.0038 0.0401 0.0386
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trichomonas vaginalis tubulin, putative 0.0061 0.075 0.1892
Echinococcus multilocularis carboxylesterase 5A 0.0077 0.1003 0.0996
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2763 0.7075
Brugia malayi Pre-SET motif family protein 0.002 0.0119 0.019
Entamoeba histolytica hypothetical protein 0.0038 0.0393 0.0962
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0163 0.233 0.2325
Echinococcus granulosus beta tubulin 0.0265 0.3899 0.3894
Loa Loa (eye worm) latrophilin receptor protein 2 0.0022 0.0155 0.0244
Trypanosoma brucei alpha tubulin 0.0192 0.2763 0.7072
Echinococcus granulosus small conductance calcium activated potassium 0.0426 0.6365 0.6362
Plasmodium falciparum tubulin gamma chain 0.014 0.1969 0.5025
Loa Loa (eye worm) hypothetical protein 0.0063 0.0782 0.1229
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0095 0.063
Schistosoma mansoni inositol monophosphatase 0.0026 0.0209 0.0193
Loa Loa (eye worm) acetylcholinesterase 1 0.0077 0.1003 0.1576
Toxoplasma gondii ion channel protein 0.0021 0.0135 0.0295
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0078 0.0097
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.1548 0.2371
Echinococcus granulosus tubulin beta 4A class IVa 0.0265 0.3899 0.3894
Schistosoma mansoni tubulin subunit alpha 0.0192 0.2763 0.2752
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0095 0.0122
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0078 0.015
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0519 0.1153
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.021 0.0499
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0021 0.0135 0.0147
Echinococcus granulosus neutral alpha glucosidase AB 0.0026 0.021 0.0202
Plasmodium falciparum ataxin-2 like protein, putative 0.0085 0.1121 0.284
Loa Loa (eye worm) inositol-1 0.0026 0.0209 0.0328
Trypanosoma brucei glucosidase, putative 0.0026 0.021 0.0488
Loa Loa (eye worm) doublecortin family protein 0.0027 0.0236 0.037
Loa Loa (eye worm) hypothetical protein 0.0085 0.1121 0.1762
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0026 0.021 0.0488
Schistosoma mansoni tubulin subunit beta 0.0265 0.3899 0.3889
Brugia malayi beta-lactamase family protein 0.0068 0.0858 0.1459
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0021 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0021 0.0135 0.0211
Toxoplasma gondii isocitrate dehydrogenase 0.0022 0.0156 0.035
Trichomonas vaginalis tubulin, putative 0.0079 0.1034 0.2622
Brugia malayi Cytochrome P450 family protein 0.0058 0.0708 0.1202
Leishmania major beta tubulin 0.0265 0.3899 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0167 0.239 0.3756
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0078 0.015
Loa Loa (eye worm) hypothetical protein 0.0027 0.0236 0.037
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0858 0.204
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0021 0.0135 0.0147
Trypanosoma brucei alpha tubulin 0.0192 0.2763 0.7072
Trichomonas vaginalis tubulin epsilon chain, putative 0.0265 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trichomonas vaginalis tubulin gamma chain, putative 0.014 0.1969 0.503
Echinococcus granulosus RUN 0.0027 0.0236 0.0229
Brugia malayi Carboxylesterase family protein 0.0013 0.0016 0.0013
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.021 0.0499
Loa Loa (eye worm) hypothetical protein 0.0068 0.0858 0.1347
Onchocerca volvulus 0.0068 0.0858 0.378
Loa Loa (eye worm) tubulin alpha-3 chain 0.0112 0.1544 0.2426
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0575 0.0865
Toxoplasma gondii alpha-tubulin I, putative 0.0192 0.2763 0.7072
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0119 0.0103
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0095 0.063
Echinococcus multilocularis isocitrate dehydrogenase 0.0022 0.0156 0.0149
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Leishmania major beta tubulin 0.0265 0.3899 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0095 0.0122
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0095 0.063
Echinococcus multilocularis transcription factor Dp 1 0.0026 0.0223 0.0215
Schistosoma mansoni calcium-activated potassium channel 0.0021 0.0135 0.0119
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0021 0.0135 0.0217
Echinococcus multilocularis neutral alpha glucosidase AB 0.0026 0.021 0.0202
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0907 0.0893
Schistosoma mansoni intermediate filament proteins 0.0026 0.0213 0.0198
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.021 0.0499
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0021 0.0135 0.0217
Schistosoma mansoni alpha-glucosidase 0.0099 0.1345 0.1331
Echinococcus multilocularis lipoxygenase domain containing protein 0.0027 0.0236 0.0229
Loa Loa (eye worm) cytochrome P450 0.0018 0.0095 0.0149
Echinococcus multilocularis lamin dm0 0.0026 0.0213 0.0206
Leishmania major gamma-tubulin 0.014 0.1969 0.5025
Trichomonas vaginalis tubulin, putative 0.0265 0.3899 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0013 0.0016 0.0009
Echinococcus granulosus tubulin alpha chain 0.0192 0.2763 0.2758
Trypanosoma brucei tubulin delta chain 0.0061 0.075 0.1883
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0095 0.0122
Echinococcus granulosus tubulin alpha 3 chain 0.0192 0.2763 0.2758
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus granulosus twik family of potassium channels 0.0021 0.0135 0.0127
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0095 0.0043
Echinococcus multilocularis tubulin alpha 0.014 0.1969 0.1963
Echinococcus granulosus histone acetyltransferase KAT2B 0.0073 0.0933 0.0927
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0022 0.0155 0.0148
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0021 0.0135 0.0217
Trypanosoma brucei alpha tubulin, putative 0.0079 0.1034 0.2614
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0095 0.063
Plasmodium falciparum tubulin epsilon chain, putative 0.014 0.1969 0.5025
Giardia lamblia Fructose-bisphosphate aldolase 0.0193 0.2788 0.7093
Echinococcus granulosus beta LACTamase domain containing family member 0.0068 0.0858 0.0851
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0095 0.063
Plasmodium falciparum glutathione reductase 0.0017 0.0078 0.015
Trypanosoma brucei epsilon tubulin 0.014 0.1969 0.5025
Entamoeba histolytica acetyltransferase, GNAT family 0.0067 0.084 0.2114
Trichomonas vaginalis D-aminoacylase, putative 0.0068 0.0858 0.2168
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.021 0.0488
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0907 0.0893
Loa Loa (eye worm) RecQ helicase 0.002 0.013 0.0204
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0095 0.0122
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0078 0.015
Trypanosoma brucei calcium-activated potassium channel, putative 0.0021 0.0135 0.0295
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0022 0.0156 0.035
Echinococcus granulosus Tubulin alpha 1 chain 0.0192 0.2763 0.2758
Echinococcus multilocularis ubiquitin specific protease 41 0.0051 0.0604 0.0597
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2763 0.7075
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2763 0.2758
Leishmania major cytochrome p450-like protein 0.0036 0.0365 0.0889
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0365 0.2788
Mycobacterium ulcerans ion transport protein 0.0021 0.0135 0.0948
Mycobacterium tuberculosis Conserved protein 0.0068 0.0858 0.1303
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0094 0.1267 0.1938
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0021 0.0135 0.0217
Echinococcus granulosus transcription factor Dp 1 0.0026 0.0223 0.0215
Trichomonas vaginalis penicillin-binding protein, putative 0.0068 0.0858 0.2168
Trichomonas vaginalis tubulin epsilon chain, putative 0.0265 0.3899 1
Toxoplasma gondii ion channel protein 0.0021 0.0135 0.0295
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0078 0.015
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0078 0.015
Mycobacterium tuberculosis Probable esterase LipL 0.0068 0.0858 0.1303
Schistosoma mansoni alpha glucosidase 0.0026 0.021 0.0194
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0116 0.1599 0.1586
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0021 0.0135 0.0217
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0519 0.1286
Trypanosoma brucei zeta tubulin, putative 0.0061 0.075 0.1883
Brugia malayi Cell division protein ftsZ 0.0061 0.075 0.1275
Echinococcus granulosus beta tubulin 0.0265 0.3899 0.3894
Echinococcus multilocularis geminin 0.04 0.5971 0.5968
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0021 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0104
Brugia malayi latrophilin 2 splice variant baaae 0.0048 0.055 0.0931
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0038 0.0401 0.0394
Schistosoma mansoni tubulin subunit beta 0.0265 0.3899 0.3889
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0519 0.1153
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0026 0.0209 0.2587
Loa Loa (eye worm) hypothetical protein 0.0063 0.0782 0.1229
Schistosoma mansoni rab6-interacting 0.0027 0.0236 0.022
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0078 0.0499
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0047 0.0543 0.0528
Echinococcus multilocularis tubulin subunit beta 0.0265 0.3899 0.3894
Mycobacterium ulcerans beta-lactamase 0.0068 0.0858 0.6725
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0095 0.0043
Loa Loa (eye worm) tubulin alpha 2 0.0131 0.1828 0.2872
Loa Loa (eye worm) hypothetical protein 0.0068 0.0858 0.1347
Trypanosoma brucei alpha tubulin 0.0192 0.2763 0.7072
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0078 0.012
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0028 0.0034
Loa Loa (eye worm) isocitrate dehydrogenase 0.0022 0.0156 0.0245
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0021 0.0135 0.0295
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0095 0.0193
Loa Loa (eye worm) uncoordinated protein 58 0.0021 0.0135 0.0211
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0026 0.021 0.0329
Giardia lamblia Alpha-tubulin 0.0192 0.2763 0.7028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Giardia lamblia Alpha-tubulin 0.0192 0.2763 0.7028
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0025
Loa Loa (eye worm) serotonin transporter b 0.0063 0.0782 0.1229
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0213 0.0335
Brugia malayi hypothetical protein 0.0038 0.0393 0.0661
Echinococcus granulosus lipoxygenase domain containing protein 0.0027 0.0236 0.0229
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2763 0.7075
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.004 0.0424 0.0417
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0021 0.0135 0.0217
Echinococcus multilocularis GPCR, family 2 0.0022 0.0155 0.0148
Brugia malayi hypothetical protein 0.0013 0.0016 0.0013
Brugia malayi tubulin alpha chain - mouse 0.0192 0.2763 0.4735
Loa Loa (eye worm) hypothetical protein 0.0018 0.0085 0.0134
Brugia malayi Glycosyl hydrolases family 31 protein 0.0116 0.1592 0.2722
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0047 0.0543 0.0528
Onchocerca volvulus 0.0021 0.0135 0.0533
Entamoeba histolytica tubulin alpha chain, putative 0.0192 0.2763 0.7072
Leishmania major calcium/potassium channel (CAKC), putative 0.0021 0.0135 0.0295
Treponema pallidum sodium- and chloride- dependent transporter 0.0063 0.0782 0.2752
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2763 0.2758
Echinococcus granulosus ubiquitin specific protease 41 0.0051 0.0604 0.0597
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0575 0.0903
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0021 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0068 0.0858 0.1347
Leishmania major beta tubulin 0.0265 0.3899 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0116 0.1592 0.2502
Loa Loa (eye worm) alpha-tubulin 0.0192 0.2763 0.4341
Leishmania major beta tubulin 0.0265 0.3899 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.004 0.0424 0.1042
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0193 0.2788 0.7137
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0021 0.0135 0.0211
Onchocerca volvulus 0.0068 0.0858 0.378
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0013 0.002 0.0033
Giardia lamblia Epsilon tubulin 0.0061 0.075 0.1759
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0046 0.0519 0.0815
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0116 0.1599 0.2734
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Plasmodium vivax delta tubulin, putative 0.0061 0.075 0.1883
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0095 0.0122
Schistosoma mansoni inositol monophosphatase 0.0026 0.0209 0.0193
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0393 0.0378
Echinococcus granulosus twik family of potassium channels 0.0021 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0022 0.0155 0.0244
Brugia malayi beta-lactamase 0.0068 0.0858 0.1459
Echinococcus granulosus Polycystic kidney disease protein 0.0027 0.0236 0.0229
Echinococcus multilocularis small conductance calcium activated potassium 0.0426 0.6365 0.6362
Leishmania major beta tubulin 0.0265 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0782 0.1229
Brugia malayi hypothetical protein 0.0021 0.0135 0.0217
Loa Loa (eye worm) tubulin beta-2A chain 0.0265 0.3899 0.6125
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0021 0.0135 0.0147
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0575 0.1299
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.008 0.1041 0.1775
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0022 0.0155 0.0148
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0365 0.0573
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0078 0.0071
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0138 0.1932 0.3035
Loa Loa (eye worm) hypothetical protein 0.0192 0.2763 0.4341
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2763 0.7075
Giardia lamblia Beta tubulin 0.0265 0.3899 1
Leishmania major beta tubulin 0.0265 0.3899 1
Mycobacterium tuberculosis Probable hydrolase 0.0068 0.0858 0.1303
Plasmodium vivax ataxin-2 like protein, putative 0.0085 0.1121 0.284
Entamoeba histolytica tubulin family protein 0.0265 0.3899 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0068 0.0858 0.6725
Trypanosoma cruzi PAB1-binding protein , putative 0.0085 0.1121 0.273
Leishmania major ion transport protein-like protein 0.0021 0.0135 0.0295
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0209 0.0342
Echinococcus granulosus tubulin alpha chain 0.0192 0.2763 0.2758
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2763 0.7075
Loa Loa (eye worm) hypothetical protein 0.0077 0.1003 0.1576
Leishmania major beta tubulin 0.0265 0.3899 1
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0011
Onchocerca volvulus 0.0068 0.0858 0.378
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0013 0.002 0.0006
Loa Loa (eye worm) tubulin alpha chain 0.0192 0.2763 0.4341
Toxoplasma gondii alpha tubulin TUBA1 0.0192 0.2763 0.7072
Echinococcus multilocularis hypothetical protein 0.0192 0.2763 0.2758
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0604 0.1505
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0021 0.0135 0.0184
Plasmodium vivax glutathione reductase, putative 0.0049 0.0575 0.143
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2763 0.7075
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0858 0.204
Trichomonas vaginalis tubulin alpha chain, putative 0.0265 0.3899 1
Leishmania major alpha tubulin 0.0192 0.2763 0.7072
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0135 0.0119
Mycobacterium leprae cell division protein FtsZ 0.0061 0.075 0.4244
Schistosoma mansoni tubulin subunit alpha 0.0061 0.075 0.0736
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Leishmania major epsilon tubulin, putative 0.014 0.1969 0.5025
Echinococcus multilocularis para nitrobenzyl esterase 0.0013 0.0016 0.0009
Echinococcus granulosus neuroligin 0.0013 0.0016 0.0009
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0022 0.0156 0.0203
Echinococcus multilocularis lamin 0.0026 0.0213 0.0206
Leishmania major beta tubulin 0.0265 0.3899 1
Loa Loa (eye worm) transcription factor SMAD2 0.0167 0.239 0.3756
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0063 0.0782 0.1329
Trichomonas vaginalis bromodomain-containing protein, putative 0.0073 0.0933 0.2363
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0078 0.0161
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0213 0.0335
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0073 0.0933 0.2354
Brugia malayi hypothetical protein 0.0158 0.2242 0.3839
Trypanosoma cruzi ion transport protein, putative 0.0021 0.0135 0.0147
Plasmodium vivax tubulin alpha chain, putative 0.0192 0.2763 0.7072
Trypanosoma cruzi epsilon tubulin, putative 0.014 0.1969 0.4949
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0095 0.063
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0071 0.0907 0.0901
Plasmodium vivax potassium channel, putative 0.0021 0.0135 0.0295
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0247 0.3617 0.3607
Echinococcus granulosus alpha tubulin 0.0192 0.2763 0.2758
Onchocerca volvulus 0.008 0.1041 0.4606
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0708 0.1112
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0213 0.0352
Toxoplasma gondii thioredoxin reductase 0.0049 0.0575 0.143
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0021 0.0135 0.0217
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.1548 0.8877
Echinococcus multilocularis Tubulin alpha 1 chain 0.0192 0.2763 0.2758
Echinococcus granulosus para nitrobenzyl esterase 0.0013 0.0016 0.0009
Echinococcus granulosus BC026374 protein S09 family 0.0013 0.0016 0.0009
Brugia malayi Bloom's syndrome protein homolog 0.002 0.013 0.0209
Trichomonas vaginalis tubulin epsilon chain, putative 0.0192 0.2763 0.7075
Leishmania major alpha glucosidase II subunit, putative 0.0026 0.021 0.0488
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0046 0.0519 0.0504
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0021 0.0135 0.0217
Schistosoma mansoni rab6-interacting 0.0027 0.0236 0.022
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0021 0.0135 0.0217
Echinococcus granulosus Tubulin alpha 1 chain 0.0192 0.2763 0.2758
Leishmania major beta tubulin 0.0265 0.3899 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0022 0.0156 0.035
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.075 0.1892
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0604 0.1514
Trichomonas vaginalis sucrase-isomaltase, putative 0.0026 0.021 0.0499
Loa Loa (eye worm) solute carrier family 6 member 4 0.0063 0.0782 0.1229
Loa Loa (eye worm) hypothetical protein 0.0048 0.055 0.0865
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0021 0.0135 0.0217
Giardia lamblia Gamma tubulin 0.014 0.1969 0.4949
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0078 0.0798
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.002 0.0119 0.0255
Plasmodium falciparum ataxin-2 like protein, putative 0.0085 0.1121 0.284
Loa Loa (eye worm) tubulin alpha chain 0.0192 0.2763 0.4341
Plasmodium falciparum thioredoxin reductase 0.0049 0.0575 0.143
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.2788 0.714
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0095 0.063
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0051 0.0604 0.0597
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0046 0.0519 0.0512
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0095 0.0122
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0068 0.0858 0.0843
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0116 0.1599 0.1593
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0026 0.0209 0.0487
Brugia malayi hypothetical protein 0.0021 0.0135 0.0217
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.002 0.0119 0.0103
Brugia malayi Isocitrate dehydrogenase 0.0022 0.0156 0.0253
Echinococcus multilocularis beta tubulin 0.0265 0.3899 0.3894
Onchocerca volvulus 0.0021 0.0135 0.0533
Echinococcus multilocularis acetylcholinesterase 0.0077 0.1003 0.0996
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.004 0.0424 0.0417
Echinococcus multilocularis tubulin alpha 1C chain 0.0192 0.2763 0.2758
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0051 0.0604 0.0597
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0604 0.1375
Leishmania major cytochrome p450-like protein 0.0018 0.0095 0.0193
Echinococcus multilocularis lysosomal alpha glucosidase 0.0116 0.1592 0.1586
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0021 0.0135 0.0217
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0077 0.1003 0.0989
Echinococcus multilocularis tubulin alpha 3 chain 0.0192 0.2763 0.2758
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0365 0.0573
Plasmodium vivax SET domain protein, putative 0.002 0.0119 0.0255
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0051 0.0604 0.1505
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Schistosoma mansoni polycystin 1-related 0.0027 0.0236 0.022
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0095 0.063
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0393 0.0386
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0211
Schistosoma mansoni tubulin subunit beta 0.0265 0.3899 0.3889
Brugia malayi Tubulin beta chain 0.0079 0.1034 0.1762

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 18 nM Inhibition of human placental cytosolic 17beta HSD1 using unlabeled- and labelled [2,4,6,7-3H]-E1 as substrate incubated for 10 mins by HPLC analysis ChEMBL. 26322835
IC50 (binding) = 99 nM Inhibition of human placental microsomal 17beta HSD2 using unlabeled- and labelled [2,4,6,7-3H]-E2 as substrate incubated for 20 mins by HPLC analysis ChEMBL. 26322835
Inhibition (binding) Inhibition of recombinant mouse 17beta HSD1 expressed in HEK293 cells using unlabeled- and labelled [2,4,6,7-3H]-E1 as substrate at 1 uM incubated for 10 mins by HPLC analysis ChEMBL. 26322835

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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