Detailed information for compound 1944992

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 475.488 | Formula: C21H15F2N3O4S2
  • H donors: 2 H acceptors: 5 LogP: 3.73 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1cnc(c1)S(=O)(=O)Nc1cccc(c1)c1ccc(s1)C(=O)c1c(F)ccc(c1F)O
  • InChi: 1S/C21H15F2N3O4S2/c1-26-10-18(24-11-26)32(29,30)25-13-4-2-3-12(9-13)16-7-8-17(31-16)21(28)19-14(22)5-6-15(27)20(19)23/h2-11,25,27H,1H3
  • InChiKey: BPWHZPFCTAZPMO-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 2 Starlite/ChEMBL References
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein hydroxysteroid (17-beta) dehydrogenase 1 328 aa 265 aa 27.2 %
Echinococcus multilocularis Dehydrogenase:reductase SDR family hydroxysteroid (17-beta) dehydrogenase 2 387 aa 359 aa 24.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) TWK-7 protein 0.0021 0.0164 0.0243
Schistosoma mansoni polycystin 1-related 0.0027 0.0265 0.0265
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0125 0.0171
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0013 0.0046 0.0046
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0021 0.0164 0.0265
Schistosoma mansoni hypothetical protein 0.0011 0.0014 0.0014
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0014 0.0001
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0013 0.005 0.0056
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0632 0.1584
Brugia malayi cytochrome P450 0.0018 0.0125 0.0197
Plasmodium falciparum potassium channel 0.0021 0.0164 0.0396
Loa Loa (eye worm) serotonin transporter b 0.0063 0.081 0.1257
Echinococcus multilocularis PHD finger protein rhinoceros 0.0022 0.0181 0.0171
Echinococcus granulosus PHD finger protein rhinoceros 0.0022 0.0181 0.0171
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0108 0.0242
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0108 0.0242
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0422 0.0413
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0125 0.0171
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0181 0.0438
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Trypanosoma brucei calcium-activated potassium channel, putative 0.0021 0.0164 0.0386
Trypanosoma cruzi PAB1-binding protein , putative 0.0086 0.1163 0.2946
Leishmania major alpha tubulin 0.0192 0.2785 0.71
Loa Loa (eye worm) hypothetical protein 0.0016 0.0096 0.0136
Brugia malayi Calcitonin receptor-like protein seb-1 0.0035 0.0376 0.0628
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0019 0.0145 0.0336
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Toxoplasma gondii ion channel protein 0.0021 0.0164 0.0419
Onchocerca volvulus 0.0013 0.0046 0.0162
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0051 0.0632 0.1584
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0026 0.0239 0.0576
Toxoplasma gondii beta-1 tubulin, putative 0.0265 0.3917 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0027 0.0265 0.0256
Onchocerca volvulus 0.0021 0.0164 0.0686
Loa Loa (eye worm) tubulin beta chain 0.0061 0.0778 0.1208
Schistosoma mansoni jumonji/arid domain-containing protein 0.0026 0.0251 0.0251
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0125 0.0171
Plasmodium falciparum LCCL domain-containing protein 0.0027 0.0265 0.0654
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0394 0.0974
Echinococcus granulosus inositol monophosphatase 1 0.0026 0.0239 0.0229
Loa Loa (eye worm) tubulin alpha chain 0.0192 0.2785 0.436
Loa Loa (eye worm) hypothetical protein 0.0063 0.081 0.1257
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0071 0.0935 0.0926
Echinococcus multilocularis tubulin delta chain 0.0061 0.0778 0.0769
Echinococcus granulosus beta tubulin 0.0265 0.3917 0.3911
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0051 0.0632 0.0623
Echinococcus granulosus tubulin alpha chain 0.0192 0.2785 0.2778
Trypanosoma brucei alpha tubulin, putative 0.0079 0.1061 0.2683
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2785 0.71
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0108 0.0242
Mycobacterium tuberculosis Conserved protein 0.0068 0.0885 0.1346
Entamoeba histolytica hypothetical protein 0.0038 0.0422 0.1046
Echinococcus granulosus GPCR family 2 0.0011 0.0014 0.0004
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0163 0.2353 0.2346
Echinococcus granulosus Tubulin alpha 1 chain 0.0192 0.2785 0.2778
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0108 0.0253
Echinococcus granulosus twik family of potassium channels 0.0021 0.0164 0.0155
Toxoplasma gondii isocitrate dehydrogenase 0.0011 0.0014 0.0035
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0108 1
Giardia lamblia Alpha-tubulin 0.0192 0.2785 0.7028
Echinococcus multilocularis tubulin alpha 1C chain 0.0192 0.2785 0.2778
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0394 0.0974
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0548 0.1368
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0192 0.2785 0.71
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.1061 0.2683
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0108 0.0099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.281 0.7163
Entamoeba histolytica acetyltransferase, GNAT family 0.0067 0.0868 0.2188
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0094 0.1294 0.7249
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0108 0.0242
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0051 0.0632 0.0623
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Plasmodium falciparum tubulin delta chain, putative 0.0061 0.0778 0.1967
Echinococcus multilocularis jumonji domain containing protein 0.003 0.0312 0.0302
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0125 0.063
Loa Loa (eye worm) hypothetical protein 0.0047 0.0572 0.0883
Loa Loa (eye worm) hypothetical protein 0.0063 0.081 0.1257
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0108 0.0242
Brugia malayi Tubulin beta chain 0.0061 0.0778 0.1319
Echinococcus multilocularis peregrin 0.0028 0.0273 0.0264
Brugia malayi jmjC domain containing protein 0.0071 0.0942 0.16
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0051 0.0632 0.1584
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0603 0.151
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0021 0.0164 0.0386
Schistosoma mansoni calcium-activated potassium channel 0.0021 0.0164 0.0164
Echinococcus multilocularis neuroligin 0.0013 0.0046 0.0037
Brugia malayi tubulin alpha-2 chain 0.0192 0.2785 0.4761
Trichomonas vaginalis tubulin epsilon chain, putative 0.0192 0.2785 0.71
Loa Loa (eye worm) tubulin beta-2A chain 0.0265 0.3917 0.6138
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0548 0.1368
Toxoplasma gondii LsmAD domain-containing protein 0.0086 0.1163 0.297
Echinococcus multilocularis Tubulin alpha 1 chain 0.0192 0.2785 0.2778
Brugia malayi Carboxylesterase family protein 0.0013 0.0046 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0044
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0537 0.0828
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0125 0.063
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0239 0.0576
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Trichomonas vaginalis tubulin gamma chain, putative 0.0061 0.0778 0.1959
Schistosoma mansoni BC026374 protein (S09 family) 0.0013 0.0046 0.0046
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0239 0.0576
Loa Loa (eye worm) hypothetical protein 0.0022 0.0181 0.0269
Plasmodium falciparum tubulin beta chain 0.0265 0.3917 1
Trichomonas vaginalis D-aminoacylase, putative 0.0068 0.0885 0.2232
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0047 0.0572 0.0572
Onchocerca volvulus 0.008 0.1068 0.4693
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0935 0.0935
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0164 0.0386
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0108 0.0242
Brugia malayi Tubulin beta-1 chain 0.0265 0.3917 0.6703
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0068 0.0885 0.1375
Entamoeba histolytica tubulin family protein 0.0265 0.3917 1
Echinococcus granulosus RUN 0.0027 0.0265 0.0256
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0108 0.0253
Loa Loa (eye worm) inositol-1 0.0026 0.0239 0.036
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0029 0.0284 0.0692
Mycobacterium ulcerans ion transport protein 0.0021 0.0164 0.0948
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.004 0.0453 0.1156
Brugia malayi Tubulin alpha chain 0.0061 0.0778 0.1319
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.002 0.0149 0.0139
Loa Loa (eye worm) hypothetical protein 0.0026 0.0243 0.0366
Trypanosoma brucei zeta tubulin, putative 0.0061 0.0778 0.1959
Echinococcus multilocularis lamin dm0 0.0026 0.0243 0.0233
Echinococcus granulosus twik family of potassium channels 0.0021 0.0164 0.0155
Brugia malayi PHD-finger family protein 0.0022 0.0181 0.0293
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2785 0.71
Echinococcus granulosus tubulin subunit TubB 0.0192 0.2785 0.2778
Brugia malayi Tubulin alpha-2 chain 0.0192 0.2785 0.4761
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0046 0.0548 0.0539
Trypanosoma brucei alpha tubulin 0.0192 0.2785 0.71
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0021 0.0164 0.0265
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0125 0.0171
Leishmania major beta tubulin 0.0265 0.3917 1
Mycobacterium tuberculosis Conserved protein 0.0068 0.0885 0.1346
Loa Loa (eye worm) MH2 domain-containing protein 0.0083 0.1115 0.1736
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0125 0.063
Loa Loa (eye worm) tubulin beta-4 chain 0.0265 0.3917 0.6138
Plasmodium vivax tubulin beta chain, putative 0.0265 0.3917 1
Loa Loa (eye worm) tubulin alpha chain 0.0192 0.2785 0.436
Onchocerca volvulus 0.0021 0.0164 0.0686
Schistosoma mansoni sodium/chloride dependent transporter 0.0063 0.081 0.081
Leishmania major beta tubulin 0.0265 0.3917 1
Loa Loa (eye worm) hypothetical protein 0.0426 0.6376 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0086 0.1163 0.2953
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0164 0.0386
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0039 0.0437 0.0428
Schistosoma mansoni tubulin subunit alpha 0.0192 0.2785 0.2785
Loa Loa (eye worm) tubulin beta-1 chain 0.0265 0.3917 0.6138
Schistosoma mansoni alpha tubulin 0.0192 0.2785 0.2785
Schistosoma mansoni tubulin subunit beta 0.0265 0.3917 0.3917
Toxoplasma gondii thioredoxin reductase 0.0049 0.0603 0.1539
Onchocerca volvulus 0.0013 0.0046 0.0162
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0239 0.0576
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.281 0.7163
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0011 0.0014 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0073 0.0961 0.2434
Onchocerca volvulus 0.0027 0.0265 0.1133
Plasmodium vivax flap endonuclease 1, putative 0.0019 0.0145 0.0346
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0071 0.0935 0.0926
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0013 0.0046 0.005
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0021 0.0164 0.0232
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0039 0.005
Leishmania major beta tubulin 0.0265 0.3917 1
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0021 0.0164 0.0386
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0011 0.0014 0.0011
Trichomonas vaginalis tubulin epsilon chain, putative 0.0265 0.3917 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0021 0.0164 0.0265
Schistosoma mansoni lipoxygenase 0.0114 0.1599 0.1599
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0079 0.1061 0.2683
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3917 0.3911
Echinococcus granulosus flap endonuclease 1 0.0019 0.0145 0.0135
Echinococcus multilocularis inositol monophosphatase 1 0.0026 0.0239 0.0229
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0047 0.0572 0.143
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0029 0.0284 0.0692
Leishmania major epsilon tubulin, putative 0.014 0.1993 0.5072
Brugia malayi Cytochrome P450 family protein 0.0058 0.0736 0.1246
Plasmodium vivax tubulin gamma chain, putative 0.014 0.1993 0.5077
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0401
Toxoplasma gondii isocitrate dehydrogenase 0.0011 0.0014 0.0035
Loa Loa (eye worm) glutathione reductase 0.0049 0.0603 0.0932
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0108 0.0242
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0019 0.0145 0.037
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0164 0.0164
Trichomonas vaginalis tubulin beta chain, putative 0.0265 0.3917 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.008 0.1068 0.1816
Brugia malayi hypothetical protein 0.0027 0.0265 0.0438
Trichomonas vaginalis penicillin-binding protein, putative 0.0068 0.0885 0.2232
Echinococcus multilocularis small conductance calcium activated potassium 0.0426 0.6376 0.6372
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0029 0.0284 0.0692
Echinococcus multilocularis transcription factor Dp 1 0.0026 0.0252 0.0243
Onchocerca volvulus 0.0063 0.081 0.3547
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0073 0.0961 0.2426
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.004 0.0453 0.0444
Echinococcus granulosus tubulin alpha 1C chain 0.0192 0.2785 0.2778
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0108 0.0242
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2785 0.71
Loa Loa (eye worm) transcription factor SMAD2 0.0083 0.1115 0.1736
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0239 0.0576
Echinococcus granulosus lamin 0.0026 0.0243 0.0233
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0125 0.0171
Giardia lamblia PHD finger protein 15 0.0022 0.0181 0.019
Echinococcus granulosus bloom syndrome protein 0.002 0.016 0.0151
Loa Loa (eye worm) hypothetical protein 0.0051 0.0632 0.0978
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0108 0.0146
Echinococcus multilocularis Tubulin alpha 1 chain 0.0192 0.2785 0.2778
Loa Loa (eye worm) tubulin alpha-3 chain 0.0112 0.157 0.2451
Schistosoma mansoni hypothetical protein 0.0039 0.0437 0.0437
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0108 0.0253
Brugia malayi Carboxylesterase family protein 0.0013 0.0046 0.0063
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0021 0.0164 0.0386
Echinococcus multilocularis lipoxygenase domain containing protein 0.0027 0.0265 0.0256
Mycobacterium ulcerans beta-lactamase 0.0068 0.0885 0.6725
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0243 0.0366
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0247 0.3636 0.3636
Mycobacterium leprae cell division protein FtsZ 0.0061 0.0778 0.4244
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0051 0.0632 0.1375
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2785 0.71
Loa Loa (eye worm) hypothetical protein 0.0018 0.0115 0.0166
Schistosoma mansoni tubulin subunit beta 0.0265 0.3917 0.3917
Echinococcus granulosus ubiquitin specific protease 41 0.0051 0.0632 0.0623
Mycobacterium ulcerans esterase/lipase LipP 0.0068 0.0885 0.6725
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0047 0.0572 0.0572
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0021 0.0164 0.0386
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0051 0.0632 0.0632
Toxoplasma gondii ABC1 family protein 0.0068 0.0885 0.226
Loa Loa (eye worm) hypothetical protein 0.0391 0.5839 0.9157
Leishmania major beta tubulin 0.0265 0.3917 1
Echinococcus granulosus survival motor neuron protein 1 0.0391 0.5839 0.5835
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0023 0.0197 0.0858
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3917 0.3911
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0039 0.005
Trichomonas vaginalis inositol monophosphatase, putative 0.0026 0.0239 0.0576
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0717 0.0717
Echinococcus multilocularis acetylcholinesterase 0.0077 0.103 0.1022
Trichomonas vaginalis tubulin, putative 0.0265 0.3917 1
Brugia malayi beta-lactamase 0.0068 0.0885 0.1502
Loa Loa (eye worm) hypothetical protein 0.0068 0.0885 0.1375
Schistosoma mansoni tubulin subunit beta 0.0265 0.3917 0.3917
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0125 0.063
Leishmania major beta tubulin 0.0265 0.3917 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0011 0.001 0.0024
Onchocerca volvulus 0.0047 0.0572 0.2494
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0125 0.0171
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0125 0.0171
Brugia malayi beta-lactamase family protein 0.0068 0.0885 0.1502
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0013 0.005 0.0033
Schistosoma mansoni hypothetical protein 0.0038 0.0422 0.0422
Leishmania major alpha tubulin 0.0192 0.2785 0.71
Mycobacterium tuberculosis Cell division protein FtsZ 0.0061 0.0778 0.1181
Trichomonas vaginalis tubulin epsilon chain, putative 0.0061 0.0778 0.1959
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0013 0.005 0.0128
Brugia malayi hypothetical protein 0.0055 0.0696 0.1178
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.004 0.0453 0.1125
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0019 0.0145 0.0336
Loa Loa (eye worm) alpha-tubulin 0.0192 0.2785 0.436
Brugia malayi tubulin alpha chain - mouse 0.0192 0.2785 0.4761
Mycobacterium tuberculosis Conserved protein 0.0068 0.0885 0.1346
Leishmania major alpha tubulin 0.0192 0.2785 0.71
Echinococcus granulosus serotonin transporter 0.0063 0.081 0.0801
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0021 0.0164 0.0386
Brugia malayi Latrophilin receptor protein 2 0.0011 0.0014 0.0007
Brugia malayi hypothetical protein 0.0158 0.2265 0.387
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0094 0.1294 0.1978
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0125 0.0171
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Mycobacterium leprae putative cytochrome p450 0.0018 0.0125 0.0434
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0013 0.0046 0.0037
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0013 0.005 0.0128
Loa Loa (eye worm) beta-lactamase 0.0068 0.0885 0.1375
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.005 0.0094
Trypanosoma brucei beta tubulin 0.014 0.1993 0.5072
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0021 0.0164 0.0265
Leishmania major beta tubulin 0.0265 0.3917 1
Loa Loa (eye worm) tubulin alpha 2 0.0131 0.1853 0.2895
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0164 0.0164
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0108 0.0169
Schistosoma mansoni hypothetical protein 0.0407 0.6086 0.6086
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0125 0.0171
Schistosoma mansoni tubulin subunit gamma 0.014 0.1993 0.1993
Echinococcus granulosus peroxisome assembly protein 26 0.0192 0.2785 0.2778
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0026 0.0239 0.1543
Trypanosoma brucei epsilon tubulin 0.014 0.1993 0.5072
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Echinococcus granulosus acetylcholinesterase 0.0077 0.103 0.1022
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2785 0.2778
Onchocerca volvulus 0.0013 0.0046 0.0162
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0125 0.0284
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0011 0.0014 0.0007
Brugia malayi Tubulin beta chain 0.0079 0.1061 0.1804
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0125 0.0434
Schistosoma mansoni hypothetical protein 0.0426 0.6376 0.6376
Giardia lamblia Beta tubulin 0.0265 0.3917 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Echinococcus multilocularis acetylcholinesterase 0.0077 0.103 0.1022
Trypanosoma cruzi PAB1-binding protein , putative 0.0086 0.1163 0.2946
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.004 0.0453 0.1156
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Schistosoma mansoni hypothetical protein 0.0011 0.0014 0.0014
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0063 0.081 0.081
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0047 0.0572 0.0572
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0094 0.1294 1
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0029 0.0284 0.0725
Brugia malayi Tubulin gamma chain 0.014 0.1993 0.3403
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0125 0.0171
Schistosoma mansoni tubulin subunit beta 0.0265 0.3917 0.3917
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0011 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0632 0.1584
Echinococcus granulosus tubulin alpha 1C chain 0.0192 0.2785 0.2778
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0058 0.0077
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0935 0.0935
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0603 0.1519
Leishmania major beta tubulin 0.0265 0.3917 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0632 0.1584
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0108 0.0242
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0021 0.0164 0.0265
Brugia malayi intermediate filament protein 0.0026 0.0243 0.04
Echinococcus granulosus potassium channel subfamily K 0.0021 0.0164 0.0155
Plasmodium vivax potassium channel, putative 0.0021 0.0164 0.0396
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0046 0.0548 0.0845
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0021 0.0164 0.0265
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0394 0.0604
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0011 0.001 0.0024
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0548 0.1368
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0885 0.2232
Loa Loa (eye worm) hypothetical protein 0.0025 0.0235 0.0355
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Echinococcus multilocularis tubulin gamma 1 chain 0.014 0.1993 0.1986
Echinococcus granulosus Tubulin alpha 1 chain 0.0192 0.2785 0.2778
Leishmania major hypothetical protein, conserved 0.0068 0.0885 0.2232
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0125 0.063
Loa Loa (eye worm) hypothetical protein 0.0068 0.0885 0.1375
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0164 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0164 0.0386
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0011 0.0014 0.0004
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0013 0.005 0.0104
Brugia malayi Bromodomain containing protein 0.0028 0.0273 0.0453
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0935 0.0935
Plasmodium vivax glutathione reductase, putative 0.0049 0.0603 0.1519
Plasmodium falciparum potassium channel 0.0021 0.0164 0.0396
Plasmodium vivax delta tubulin, putative 0.0061 0.0778 0.1967
Leishmania major beta tubulin 0.0265 0.3917 1
Echinococcus granulosus tubulin alpha chain 0.0192 0.2785 0.2778
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0013 0.005 0.4116
Schistosoma mansoni hypothetical protein 0.0018 0.0125 0.0125
Onchocerca volvulus 0.0079 0.1061 0.4661
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0125 0.063
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0108 0.0499
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0047 0.0572 0.0965
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0108 0.0099
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0603 0.0932
Onchocerca volvulus 0.0021 0.0164 0.0686
Loa Loa (eye worm) uncoordinated protein 58 0.0021 0.0164 0.0243
Trypanosoma brucei beta tubulin 0.0265 0.3917 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0265 0.3917 0.3911
Onchocerca volvulus 0.0068 0.0885 0.3881
Brugia malayi Carboxylesterase family protein 0.0013 0.0046 0.0063
Plasmodium falciparum glutathione reductase 0.0049 0.0603 0.1519
Schistosoma mansoni calcium-activated potassium channel 0.0426 0.6376 0.6376
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.004 0.0453 0.1125
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3917 0.3911
Schistosoma mansoni hypothetical protein 0.0021 0.0164 0.0164
Brugia malayi hypothetical protein 0.0027 0.0265 0.0438
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0125 0.063
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0013 0.005 0.0033
Schistosoma mansoni acetylcholinesterase 0.0013 0.0046 0.0046
Plasmodium vivax multidomain scavenger receptor, putative 0.0027 0.0265 0.0654
Leishmania major alpha tubulin 0.0192 0.2785 0.71
Loa Loa (eye worm) tubulin gamma chain 0.014 0.1993 0.3116
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0125 0.0171
Loa Loa (eye worm) hypothetical protein 0.0068 0.0885 0.1375
Loa Loa (eye worm) tubulin alpha 2 0.0131 0.1853 0.2895
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.004 0.0453 0.1135
Loa Loa (eye worm) hypothetical protein 0.0047 0.0572 0.0884
Schistosoma mansoni sodium-dependent amino acid transporter 0.0011 0.001 0.001
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0094 0.0094
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0061 0.0778 1
Onchocerca volvulus 0.0027 0.0265 0.1133
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0125 0.0115
Leishmania major calcium/potassium channel (CAKC), putative 0.0021 0.0164 0.0386
Brugia malayi Melibiase family protein 0.0047 0.0572 0.0965
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0251 0.0379
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0058 0.0125
Mycobacterium tuberculosis Probable lipase LipE 0.0068 0.0885 0.1346
Loa Loa (eye worm) flap endonuclease-1 0.0019 0.0145 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0778 0.1959
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3917 0.3911
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3917 0.3911
Leishmania major gamma-tubulin 0.014 0.1993 0.5072
Brugia malayi alpha-tubulin 0.0192 0.2785 0.4761
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0149 0.0149
Leishmania major beta tubulin 0.0265 0.3917 1
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0394 0.0604
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0125 0.063
Trypanosoma cruzi alpha tubulin, putative 0.0192 0.2785 0.71
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0011 0.0014 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0208 0.0312
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0125 0.0318
Echinococcus multilocularis lysine specific demethylase 5A 0.0026 0.0251 0.0242
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0029 0.0284 0.0692
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0051 0.0632 0.1584
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0243 0.04
Schistosoma mansoni hypothetical protein 0.0011 0.0014 0.0014
Echinococcus granulosus geminin 0.0407 0.6086 0.6082
Leishmania major beta tubulin 0.0265 0.3917 1
Echinococcus granulosus tubulin alpha 0.014 0.1993 0.1986
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.1573 0.2409
Brugia malayi beta-lactamase family protein 0.0068 0.0885 0.1502
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0006
Leishmania major potassium channel subunit-like protein 0.0021 0.0164 0.0386
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Entamoeba histolytica tubulin gamma chain 0.014 0.1993 0.5072
Trypanosoma brucei beta tubulin 0.0265 0.3917 1
Echinococcus multilocularis RUN 0.0027 0.0265 0.0256
Schistosoma mansoni rab6-interacting 0.0027 0.0265 0.0265
Trypanosoma brucei zeta tubulin 0.0061 0.0778 0.1959
Toxoplasma gondii alpha-tubulin I, putative 0.0192 0.2785 0.711
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Giardia lamblia Gamma tubulin 0.014 0.1993 0.4949
Onchocerca volvulus 0.0021 0.0164 0.0686
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0029 0.0284 0.047
Plasmodium falciparum thioredoxin reductase 0.0049 0.0603 0.1519
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0108 0.0798
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0014 0.0001
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0051 0.0632 0.0623
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0125 0.063
Schistosoma mansoni survival motor neuron protein 0.008 0.1068 0.1068
Leishmania major cytochrome p450-like protein 0.0018 0.0125 0.0284
Toxoplasma gondii beta tubulin 0.0265 0.3917 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.004 0.0453 0.1125
Trypanosoma brucei tubulin delta chain 0.0061 0.0778 0.1959
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0108 0.0242
Echinococcus granulosus Tubulin alpha 1 chain 0.0192 0.2785 0.2778
Schistosoma mansoni rab6-interacting 0.0027 0.0265 0.0265
Leishmania major alpha tubulin 0.0192 0.2785 0.71
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0019 0.0137 0.0128
Schistosoma mansoni hypothetical protein 0.0027 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0022 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0112 0.157 0.2451
Brugia malayi isocitrate dehydrogenase 0.0011 0.0014 0.0007
Schistosoma mansoni tubulin subunit beta 0.0265 0.3917 0.3917
Schistosoma mansoni intermediate filament proteins 0.0026 0.0243 0.0243
Echinococcus granulosus acetylcholinesterase 0.0077 0.103 0.1022
Trypanosoma brucei hypothetical protein, conserved 0.0068 0.0885 0.2232
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0068 0.0885 0.6725
Brugia malayi Inositol-1 0.0026 0.0239 0.0393
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0108 0.0242
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0021 0.0164 0.0265
Plasmodium falciparum histone acetyltransferase GCN5 0.0067 0.0868 0.2196
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0116 0.1625 0.1617
Leishmania major ion transport protein-like protein 0.0021 0.0164 0.0386
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0021 0.0164 0.0155
Brugia malayi Cytochrome P450 family protein 0.0036 0.0394 0.0659
Brugia malayi hypothetical protein 0.0021 0.0164 0.0265
Leishmania major cytochrome p450-like protein 0.0018 0.0125 0.0284
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Mycobacterium ulcerans lipase LipD 0.0068 0.0885 0.6725
Trichomonas vaginalis tubulin epsilon chain, putative 0.0265 0.3917 1
Echinococcus multilocularis beta tubulin 0.0265 0.3917 0.3911
Schistosoma mansoni tubulin subunit beta 0.0265 0.3917 0.3917
Brugia malayi Tubulin alpha chain 0.0192 0.2785 0.4761
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0021 0.0164 0.0265
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0021 0.0164 0.0265
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0108 0.0242
Trichomonas vaginalis tubulin, putative 0.0079 0.1061 0.2683
Echinococcus granulosus tubulin delta chain 0.0061 0.0778 0.0769
Echinococcus multilocularis BC026374 protein (S09 family) 0.0013 0.0046 0.0037
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.016 0.0375
Schistosoma mansoni sodium/chloride dependent transporter 0.0011 0.001 0.001
Trichomonas vaginalis spcc417.12 protein, putative 0.0013 0.0046 0.0083
Schistosoma mansoni alpha tubulin 0.0192 0.2785 0.2785
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0394 0.0974
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0026 0.0239 0.0576
Loa Loa (eye worm) solute carrier family 6 member 4 0.0063 0.081 0.1257
Loa Loa (eye worm) hypothetical protein 0.0131 0.1853 0.2895
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.1766 0.2707
Echinococcus multilocularis lipoxygenase domain containing protein 0.0027 0.0265 0.0256
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0193 0.281 0.7163
Schistosoma mansoni hypothetical protein 0.0011 0.0014 0.0014
Trichomonas vaginalis tubulin gamma chain, putative 0.014 0.1993 0.5072
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0068 0.0885 0.1346
Echinococcus multilocularis lamin 0.0026 0.0243 0.0233
Trypanosoma cruzi ion transport protein, putative 0.0021 0.0164 0.0386
Leishmania major beta tubulin 0.0265 0.3917 1
Leishmania major zeta tubulin, putative 0.0061 0.0778 0.1959
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0014 0.0001
Echinococcus multilocularis tubulin epsilon chain 0.014 0.1993 0.1986
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0046 0.0548 0.1368
Trichomonas vaginalis flap endonuclease-1, putative 0.0019 0.0145 0.0336
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2785 0.71
Schistosoma mansoni alpha tubulin 0.0192 0.2785 0.2785
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0021 0.0164 0.0265
Leishmania major alpha tubulin 0.0192 0.2785 0.71
Echinococcus multilocularis tubulin beta 1 chain 0.0265 0.3917 0.3911
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0021 0.0164 0.0243
Plasmodium vivax tubulin alpha chain, putative 0.0192 0.2785 0.7103
Trypanosoma brucei epsilon tubulin 0.014 0.1993 0.5072
Echinococcus granulosus tubulin beta 1 chain 0.0265 0.3917 0.3911
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0013 0.0046 0.0083
Trypanosoma brucei tubulin gamma chain 0.014 0.1993 0.5072
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0736 0.1141
Plasmodium falciparum flap endonuclease 1 0.0019 0.0145 0.0346
Schistosoma mansoni jumonji/arid domain-containing protein 0.0026 0.0251 0.0251
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0039 0.0437 0.0428
Leishmania major alpha tubulin 0.0192 0.2785 0.71
Brugia malayi beta-tubulin, identical 0.0265 0.3917 0.6703
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0029 0.0284 0.047
Brugia malayi Tubulin alpha-2 chain 0.0192 0.2785 0.4761
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.1766 0.2707
Treponema pallidum sodium- and chloride- dependent transporter 0.0063 0.081 0.2752
Brugia malayi Bloom's syndrome protein homolog 0.002 0.016 0.0258
Echinococcus granulosus jumonji domain containing protein 0.003 0.0312 0.0302
Brugia malayi Pre-SET motif family protein 0.002 0.0149 0.0239
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0125 0.0171
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0422 0.0413
Leishmania major phosphopantetheinyl transferase-like protein 0.0013 0.005 0.0094
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0011 0.0014 0.0001
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0125 0.0171
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.281 0.7163
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0108 0.0276
Trichomonas vaginalis tubulin beta chain, putative 0.0192 0.2785 0.71
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0265 0.3917 0.3911
Trypanosoma cruzi tubulin delta chain 0.0061 0.0778 0.1959
Echinococcus granulosus transcription factor Dp 1 0.0026 0.0252 0.0243
Onchocerca volvulus 0.0021 0.0164 0.0686
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0164 0.0386
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.004 0.0453 0.1125
Leishmania major alpha tubulin 0.0192 0.2785 0.71
Entamoeba histolytica Flap nuclease, putative 0.0019 0.0145 0.0336
Entamoeba histolytica hypothetical protein 0.0038 0.0422 0.1046
Onchocerca volvulus 0.0026 0.0243 0.1034
Entamoeba histolytica tubulin family protein 0.0265 0.3917 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0014 0.0004
Echinococcus granulosus L aminoadipate semialdehyde 0.0047 0.0572 0.0563
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0108 0.0242
Leishmania major beta tubulin 0.0265 0.3917 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0021 0.0164 0.0265
Trichomonas vaginalis esterase, putative 0.0068 0.0885 0.2232
Echinococcus multilocularis musashi 0.0026 0.0243 0.0233
Loa Loa (eye worm) hypothetical protein 0.0037 0.042 0.0644
Echinococcus multilocularis tubulin alpha 3 chain 0.0192 0.2785 0.2778
Echinococcus multilocularis ubiquitin specific protease 41 0.0051 0.0632 0.0623
Brugia malayi Cytochrome P450 family protein 0.0036 0.0394 0.0659
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0108 0.0242
Leishmania major hypothetical protein, conserved 0.0086 0.1163 0.2946
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0011 0.001 0.0024
Echinococcus multilocularis beta tubulin 0.0265 0.3917 0.3911
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0011 0.0014 0.0004
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0125 0.063
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0122 0.0287
Plasmodium falciparum thioredoxin reductase 0.0017 0.0108 0.0253
Echinococcus granulosus beta tubulin 0.0265 0.3917 0.3911
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3917 0.3911
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0108 0.0798
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.1766 0.2707
Onchocerca volvulus 0.0157 0.2248 0.9922
Loa Loa (eye worm) alpha-tubulin 0.0192 0.2785 0.436
Loa Loa (eye worm) latrophilin receptor protein 2 0.0011 0.0014 0.0006
Mycobacterium ulcerans hypothetical protein 0.0068 0.0885 0.6725
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0942 0.0933
Echinococcus granulosus histone acetyltransferase KAT2B 0.0073 0.0961 0.0952
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.281 0.7163
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0029 0.0284 0.0692
Schistosoma mansoni calcium-activated potassium channel 0.0405 0.6057 0.6057
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0131 0.1853 0.2895
Echinococcus multilocularis hypothetical protein 0.0192 0.2785 0.2778
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0021 0.0164 0.0243
Brugia malayi Flap endonuclease-1 0.0019 0.0145 0.0232
Loa Loa (eye worm) tubulin beta chain 0.0265 0.3917 0.6138
Trichomonas vaginalis tubulin alpha chain, putative 0.0265 0.3917 1
Echinococcus multilocularis tubulin alpha 0.014 0.1993 0.1986
Schistosoma mansoni flap endonuclease-1 0.0018 0.0116 0.0116
Schistosoma mansoni tubulin subunit alpha 0.0192 0.2785 0.2785
Echinococcus granulosus carboxylesterase 5A 0.0077 0.103 0.1022
Onchocerca volvulus 0.0068 0.0885 0.3881
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0058 0.0084
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0077 0.103 0.103
Giardia lamblia Alpha-tubulin 0.0192 0.2785 0.7028
Leishmania major hypothetical protein, conserved 0.0021 0.0164 0.0386
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0218
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0131 0.1853 0.4711
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Mycobacterium tuberculosis Probable hydrolase 0.0068 0.0885 0.1346
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0422 0.0422
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0125 0.0171
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0014 0.0004
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0011 0.001 0.001
Trichomonas vaginalis tubulin beta chain, putative 0.0079 0.1061 0.2683
Loa Loa (eye worm) cytochrome P450 0.0018 0.0125 0.0181
Echinococcus multilocularis 0.0018 0.0125 0.0115
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0021 0.0164 0.0265
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0603 0.091
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0068 0.0885 0.1346
Plasmodium vivax SET domain protein, putative 0.002 0.0149 0.0356
Loa Loa (eye worm) hypothetical protein 0.0063 0.081 0.1257
Echinococcus granulosus tubulin alpha 3 chain 0.0192 0.2785 0.2778
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0021 0.0164 0.0155
Echinococcus multilocularis survival motor neuron protein 1 0.0391 0.5839 0.5835
Schistosoma mansoni lamin 0.0026 0.0243 0.0243
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0112 0.157 0.3987
Onchocerca volvulus 0.0068 0.0885 0.3881
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.1573 0.2409
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0125 0.063
Schistosoma mansoni tubulin subunit alpha 0.0192 0.2785 0.2785
Echinococcus multilocularis peroxisome assembly protein 26 0.0192 0.2785 0.2778
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0073 0.0961 0.2452
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0247 0.3636 0.363
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0029 0.0284 0.0692
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0051 0.0632 0.0623
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0021 0.0164 0.0243
Echinococcus multilocularis tubulin alpha 3 chain 0.0192 0.2785 0.2778
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0011 0.0014 0.0001
Echinococcus granulosus peregrin 0.0028 0.0273 0.0264
Entamoeba histolytica tubulin alpha-1 chain 0.0192 0.2785 0.71
Loa Loa (eye worm) hypothetical protein 0.0192 0.2785 0.436
Plasmodium falciparum tubulin epsilon chain, putative 0.014 0.1993 0.5077
Loa Loa (eye worm) BEN-1 protein 0.0265 0.3917 0.6138
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0108 0.0499
Trichomonas vaginalis penicillin-binding protein, putative 0.0068 0.0885 0.2232
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0125 0.0284
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.1766 1
Loa Loa (eye worm) TWK-28 protein 0.0021 0.0164 0.0243
Brugia malayi Carboxylesterase family protein 0.0013 0.0046 0.0063
Trypanosoma brucei alpha tubulin 0.0192 0.2785 0.71
Entamoeba histolytica tubulin alpha chain, putative 0.0192 0.2785 0.71
Onchocerca volvulus 0.0158 0.2265 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.0181 0.0461
Loa Loa (eye worm) doublecortin family protein 0.0027 0.0265 0.0401
Entamoeba histolytica hypothetical protein 0.0038 0.0422 0.1046
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.1573 0.2409
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Brugia malayi latrophilin 2 splice variant baaae 0.0024 0.0208 0.0341
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.1573 0.8877
Echinococcus granulosus tubulin epsilon chain 0.014 0.1993 0.1986
Trypanosoma cruzi tubulin gamma chain 0.014 0.1993 0.5072
Echinococcus multilocularis twik family of potassium channels 0.0021 0.0164 0.0155
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0022 0.0181 0.0181
Loa Loa (eye worm) tubulin alpha-2 chain 0.0192 0.2785 0.436
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0116 0.1625 0.1617
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.016 0.0375
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Schistosoma mansoni neuroligin 3 (S09 family) 0.0013 0.0046 0.0046
Toxoplasma gondii alpha tubulin TUBA1 0.0192 0.2785 0.711
Brugia malayi glutathione reductase 0.0049 0.0603 0.1018
Trichomonas vaginalis tubulin, putative 0.0061 0.0778 0.1959
Giardia lamblia Delta tubulin 0.0061 0.0778 0.1759
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0068 0.0885 0.1346
Leishmania major alpha tubulin 0.0192 0.2785 0.71
Treponema pallidum cell division protein FtsZ 0.0061 0.0778 0.2638
Leishmania major alpha tubulin 0.0192 0.2785 0.71
Echinococcus granulosus potassium channel subfamily K 8 0.0021 0.0164 0.0155
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0562 0.8466 0.8464
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Plasmodium falciparum phd finger protein, putative 0.0022 0.0181 0.0438
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0125 0.0284
Toxoplasma gondii ion channel protein 0.0021 0.0164 0.0419
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0061 0.0778 0.1959
Trypanosoma brucei epsilon tubulin 0.014 0.1993 0.5072
Treponema pallidum NADH oxidase 0.0017 0.0108 0.0211
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.281 0.7163
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0013 0.0046 0.0046
Plasmodium vivax tubulin alpha chain, putative 0.0192 0.2785 0.7103
Leishmania major cytochrome p450-like protein 0.0036 0.0394 0.0974
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0051 0.0632 0.0632
Echinococcus granulosus lamin dm0 0.0026 0.0243 0.0233
Giardia lamblia Histone acetyltransferase GCN5 0.0067 0.0868 0.1994
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.281 0.7163
Loa Loa (eye worm) hypothetical protein 0.0077 0.103 0.1603
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0125 0.063
Brugia malayi Doublecortin family protein 0.0027 0.0265 0.0438
Loa Loa (eye worm) tubulin alpha 2 0.0052 0.0638 0.0986
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Echinococcus multilocularis flap endonuclease 1 0.0019 0.0145 0.0135
Trypanosoma cruzi epsilon tubulin, putative 0.014 0.1993 0.5072
Schistosoma mansoni hypothetical protein 0.0024 0.0208 0.0208
Brugia malayi hypothetical protein 0.0391 0.5839 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0047 0.0572 0.0563
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0108 0.0242
Loa Loa (eye worm) carboxylesterase 0.0013 0.0046 0.0057
Echinococcus granulosus calcium activated potassium channel variant 0.0021 0.0164 0.0155
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0164 0.0164
Schistosoma mansoni loxhd1 0.0027 0.0265 0.0265
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.281 0.7163
Loa Loa (eye worm) carboxylesterase 0.0077 0.103 0.1603
Schistosoma mansoni cytochrome P450 0.0018 0.0125 0.0125
Loa Loa (eye worm) acetylcholinesterase 1 0.0077 0.103 0.1603
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0164 0.0386
Echinococcus granulosus beta LACTamase domain containing family member 0.0068 0.0885 0.0876
Echinococcus multilocularis tubulin subunit TubB 0.0192 0.2785 0.2778
Trypanosoma cruzi tubulin delta chain 0.0061 0.0778 0.1959
Brugia malayi Carboxylesterase family protein 0.0077 0.103 0.1751
Echinococcus granulosus lipoxygenase domain containing protein 0.0027 0.0265 0.0256
Onchocerca volvulus 0.0013 0.0046 0.0162
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0243 0.0366
Loa Loa (eye worm) hypothetical protein 0.0213 0.3119 0.4885
Giardia lamblia Beta tubulin 0.0265 0.3917 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0068 0.0885 0.0885
Trypanosoma brucei beta tubulin 0.0265 0.3917 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0013 0.0046 0.0037
Schistosoma mansoni calcium-activated potassium channel 0.0021 0.0164 0.0164
Toxoplasma gondii melibiase subfamily protein 0.0071 0.0935 0.2386
Echinococcus multilocularis twik family of potassium channels 0.0021 0.0164 0.0155
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0116 0.1625 0.2771
Echinococcus multilocularis isocitrate dehydrogenase 0.0011 0.0014 0.0004
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0071 0.0935 0.0926
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0021 0.0164 0.0155
Onchocerca volvulus 0.0021 0.0164 0.0686
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0013 0.005 0.0104
Echinococcus granulosus alpha tubulin 0.0192 0.2785 0.2778
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0125 0.063
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0164 0.0164
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0108 0.0276
Entamoeba histolytica hypothetical protein 0.0038 0.0422 0.1046
Plasmodium falciparum alpha tubulin 2 0.0192 0.2785 0.7103
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0164 0.0164
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.0181 0.0461
Giardia lamblia Hypothetical protein 0.0021 0.0164 0.0147
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0061 0.0778 0.1987
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0021 0.0164 0.0265
Echinococcus multilocularis geminin 0.0407 0.6086 0.6082
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3917 0.3911
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0068 0.0885 0.1375
Onchocerca volvulus Alhambra homolog 0.0022 0.0181 0.0758
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0029 0.0284 0.0275
Loa Loa (eye worm) BEN-1 protein 0.0265 0.3917 0.6138
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0149 0.0139
Leishmania major beta tubulin 0.0265 0.3917 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0125 0.0171
Mycobacterium ulcerans transmembrane cation transporter 0.0021 0.0164 0.0948
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0125 0.063
Loa Loa (eye worm) hypothetical protein 0.0086 0.1163 0.1813
Plasmodium falciparum tubulin gamma chain 0.014 0.1993 0.5077
Brugia malayi Cell division protein ftsZ 0.0061 0.0778 0.1319
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0125 0.0284
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0068 0.0885 0.1502
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0012 0.0037 0.0028
Giardia lamblia Flap structure-specific endonuclease 0.0019 0.0145 0.0096
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0603 0.0594
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.1573 0.2409
Echinococcus multilocularis beta LACTamase domain containing family member 0.0068 0.0885 0.0876
Echinococcus granulosus tubulin alpha 3 chain 0.0192 0.2785 0.2778
Loa Loa (eye worm) PDE1B protein 0.0116 0.1625 0.2537
Brugia malayi hypothetical protein 0.0086 0.1163 0.1979
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0164 0.0164
Trichomonas vaginalis D-aminoacylase, putative 0.0068 0.0885 0.2232
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0011 0.0014 0.0004
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0011 0.001 0.001
Leishmania major beta tubulin 0.0265 0.3917 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0013 0.0046 0.005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0011 0.001 0.001
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0061 0.0778 0.1987
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0164 0.0386
Leishmania major beta tubulin 0.0265 0.3917 1
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0885 0.2232
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0011 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0401
Trypanosoma brucei trypanothione reductase 0.0049 0.0603 0.151
Echinococcus granulosus para nitrobenzyl esterase 0.0013 0.0046 0.0037
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0032
Echinococcus granulosus BC026374 protein S09 family 0.0013 0.0046 0.0037
Giardia lamblia Epsilon tubulin 0.0061 0.0778 0.1759
Brugia malayi acetyltransferase, GNAT family protein 0.0247 0.3636 0.6222
Leishmania major hypothetical protein, conserved 0.0021 0.0164 0.0386
Treponema pallidum fructose-bisphosphate aldolase 0.0193 0.281 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0013 0.0046 0.0037
Schistosoma mansoni inositol monophosphatase 0.0026 0.0239 0.0239
Mycobacterium leprae conserved hypothetical protein 0.0068 0.0885 0.4867
Echinococcus granulosus Tubulin beta 2C chain 0.0265 0.3917 0.3911
Giardia lamblia Beta tubulin 0.0265 0.3917 1
Leishmania major beta tubulin 0.0265 0.3917 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0108 0.0253
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0011 0.001 0.001
Echinococcus granulosus Polycystic kidney disease protein 0.0027 0.0265 0.0256
Toxoplasma gondii beta-tubulin, putative 0.0265 0.3917 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Brugia malayi Pre-SET motif family protein 0.0138 0.1956 0.334
Schistosoma mansoni twik family of potassium channels-related 0.0021 0.0164 0.0164
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0029 0.0284 0.0692
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.1061 0.2683
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0394 0.0604
Loa Loa (eye worm) hypothetical protein 0.0192 0.2784 0.4358
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0051 0.0632 0.1584
Leishmania major trypanothione reductase 0.0049 0.0603 0.151
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0164 0.0386
Mycobacterium leprae Probable lipase LipE 0.0068 0.0885 0.4867
Schistosoma mansoni tubulin subunit epsilon 0.014 0.1993 0.1993
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0063 0.081 0.1373
Plasmodium falciparum glutathione reductase 0.0017 0.0108 0.0253
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Trypanosoma cruzi zeta tubulin, putative 0.0061 0.0778 0.1959
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0125 0.063
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.1061 0.2683
Loa Loa (eye worm) norepinephrine transporter 0.0063 0.081 0.1257
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2785 0.2778
Schistosoma mansoni lamin 0.0026 0.0243 0.0243
Leishmania major delta tubulin, putative 0.0061 0.0778 0.1959
Plasmodium vivax hypothetical protein, conserved 0.0068 0.0885 0.2241
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0021 0.0164 0.0386
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2785 0.2778
Echinococcus granulosus small conductance calcium activated potassium 0.0426 0.6376 0.6372
Brugia malayi Thioredoxin reductase 0.0049 0.0603 0.1018
Echinococcus multilocularis Polycystic kidney disease protein 0.0027 0.0265 0.0256
Loa Loa (eye worm) hypothetical protein 0.0077 0.103 0.1603
Echinococcus granulosus intermediate filament protein 0.0026 0.0243 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0778 0.1959
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0125 0.0171
Onchocerca volvulus 0.0026 0.0243 0.1034
Trichomonas vaginalis tubulin epsilon chain, putative 0.0192 0.2785 0.71
Trichomonas vaginalis set domain proteins, putative 0.0157 0.2248 0.5724
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0029 0.0284 0.0702
Brugia malayi Isocitrate dehydrogenase 0.0011 0.0014 0.0007
Echinococcus granulosus tubulin subunit beta 0.0265 0.3917 0.3911
Trypanosoma brucei alpha tubulin 0.0192 0.2785 0.71
Leishmania major beta tubulin 0.0265 0.3917 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0021 0.0164 0.0265
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0125 0.0171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0149 0.0149
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0108 0.0499
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0012 0.0037 0.0028
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0021 0.0164 0.0265
Echinococcus multilocularis serotonin transporter 0.0063 0.081 0.0801
Giardia lamblia Fructose-bisphosphate aldolase 0.0193 0.281 0.7093
Schistosoma mansoni tubulin subunit alpha 0.0061 0.0778 0.0778
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0019 0.0145 0.0336
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.014 0.1993 0.5089
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0942 0.0933
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0575
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Brugia malayi MH2 domain containing protein 0.0083 0.1115 0.1896
Brugia malayi hypothetical protein 0.0013 0.0046 0.0063
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0138 0.1956 0.3058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0193 0.281 0.7163
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0125 0.063
Toxoplasma gondii hypothetical protein 0.0011 0.001 0.0024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0035 0.0376 0.0575
Trichomonas vaginalis tubulin gamma chain, putative 0.014 0.1993 0.5072
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0021 0.0164 0.0265
Echinococcus granulosus tubulin alpha chain 0.0192 0.2785 0.2778
Leishmania major alpha tubulin 0.0192 0.2785 0.71
Plasmodium vivax potassium channel, putative 0.0021 0.0164 0.0396
Schistosoma mansoni tubulin subunit beta 0.0061 0.0778 0.0778
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0108 0.0242
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0029 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0158 0.2265 0.3544
Loa Loa (eye worm) hypothetical protein 0.0068 0.0885 0.1375
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0125 0.063
Echinococcus multilocularis carboxylesterase 5A 0.0077 0.103 0.1022
Echinococcus granulosus tubulin alpha chain 0.0192 0.2785 0.2778
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.1573 0.2409
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0071 0.0935 0.0935
Echinococcus granulosus lysine specific demethylase 5A 0.0026 0.0251 0.0242
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0011 0.0014 0.0014
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0029 0.0284 0.0275
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0073 0.0961 0.2452
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0035 0.0376 0.0628
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0394 0.2788
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0163 0.2353 0.2346
Echinococcus multilocularis GPCR, family 2 0.0011 0.0014 0.0004
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0026 0.0239 0.0609
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0108 0.0242
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2785 0.2778
Trichomonas vaginalis tubulin, putative 0.0079 0.1061 0.2683
Trypanosoma cruzi zeta tubulin, putative 0.0061 0.0778 0.1959
Brugia malayi Cytochrome P450 family protein 0.0018 0.0125 0.0197
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0632 0.1584
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0051 0.0632 0.1068
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0108 0.0242
Schistosoma mansoni tubulin subunit delta 0.0061 0.0778 0.0778
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0011 0.0014 0.0004
Brugia malayi hypothetical protein 0.0021 0.0164 0.0265
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0014 0.0004
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0193 0.281 0.7163
Schistosoma mansoni hypothetical protein 0.0407 0.6086 0.6086
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0433 0.6485 1
Trypanosoma brucei alpha tubulin 0.0192 0.2785 0.71
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0125 0.063
Echinococcus granulosus tubulin gamma 1 chain 0.014 0.1993 0.1986
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0108 0.0242
Plasmodium vivax tubulin epsilon chain, putative 0.014 0.1993 0.5077
Entamoeba histolytica hypothetical protein 0.0013 0.005 0.0094
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0046 0.0548 0.1368
Onchocerca volvulus 0.0013 0.0046 0.0162
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0125 0.063
Echinococcus multilocularis potassium channel subfamily K 0.0021 0.0164 0.0155
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0125 0.0284
Echinococcus multilocularis potassium channel subfamily K 8 0.0021 0.0164 0.0155
Loa Loa (eye worm) isocitrate dehydrogenase 0.0011 0.0014 0.0007
Trichomonas vaginalis tubulin alpha chain, putative 0.014 0.1993 0.5072
Trichomonas vaginalis D-aminoacylase, putative 0.0068 0.0885 0.2232
Loa Loa (eye worm) beta-tubulin 0.0265 0.3917 0.6138
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0046 0.0548 0.0539
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0125 0.063
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0026 0.0239 0.0576
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0125 0.0171
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0108 0.0108
Loa Loa (eye worm) RecQ helicase 0.002 0.016 0.0236
Trypanosoma brucei PAB1-binding protein , putative 0.0086 0.1163 0.2946
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0149 0.0139
Schistosoma mansoni lipoxygenase 0.0163 0.2353 0.2353
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0021 0.0164 0.0265
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0603 0.0594
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0029 0.0284 0.0702
Echinococcus multilocularis potassium channel subfamily K 8 0.0021 0.0164 0.0155
Schistosoma mansoni hypothetical protein 0.008 0.1068 0.1068
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.002 0.0149 0.0379
Trypanosoma cruzi beta tubulin, putative 0.0265 0.3917 1
Trypanosoma cruzi ion transport protein, putative 0.0021 0.0164 0.0386
Echinococcus granulosus histone acetyltransferase KAT2B 0.024 0.353 0.3524
Onchocerca volvulus 0.0021 0.0164 0.0686
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0029 0.0284 0.0431
Echinococcus multilocularis tubulin subunit beta 0.0265 0.3917 0.3911
Trichomonas vaginalis tubulin gamma chain, putative 0.0265 0.3917 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0011 0.001 0.001
Plasmodium falciparum ataxin-2 like protein, putative 0.0086 0.1163 0.2953
Leishmania major alpha tubulin 0.0192 0.2785 0.71
Trypanosoma brucei beta tubulin 0.0265 0.3917 1
Schistosoma mansoni inositol monophosphatase 0.0026 0.0239 0.0239
Echinococcus multilocularis calcium activated potassium channel variant 0.0021 0.0164 0.0155
Echinococcus granulosus neuroligin 0.0013 0.0046 0.0037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0046 0.0548 0.0548
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0029 0.0284 0.0431
Toxoplasma gondii hypothetical protein 0.0011 0.001 0.0024
Echinococcus multilocularis bloom syndrome protein 0.002 0.016 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0149 0.0149
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0046 0.0548 0.0923
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0116 0.1625 0.1625
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3917 0.3911
Brugia malayi hypothetical protein 0.0038 0.0422 0.0708
Mycobacterium tuberculosis Probable lipase LipD 0.0068 0.0885 0.1346
Mycobacterium tuberculosis Probable reductase 0.0113 0.1573 0.2409
Trypanosoma cruzi epsilon tubulin, putative 0.014 0.1993 0.5072
Brugia malayi jmjC domain containing protein 0.0026 0.0251 0.0414
Onchocerca volvulus 0.002 0.0149 0.0617
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0026 0.0239 0.2587
Schistosoma mansoni gliotactin 0.0013 0.0046 0.0046
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0021 0.0164 0.0155
Brugia malayi Carboxylesterase family protein 0.0077 0.103 0.1751
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0125 0.0171
Echinococcus multilocularis Tubulin alpha 1 chain 0.0192 0.2785 0.2778
Onchocerca volvulus 0.0021 0.0164 0.0686
Echinococcus granulosus tubulin alpha chain 0.0192 0.2785 0.2778
Echinococcus multilocularis Tubulin beta 2C chain 0.0265 0.3917 0.3911
Mycobacterium ulcerans cell division protein FtsZ 0.0061 0.0778 0.5869
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0125 0.0171
Schistosoma mansoni sodium/chloride dependent transporter 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Echinococcus multilocularis tubulin alpha 1C chain 0.0192 0.2785 0.2778
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0068 0.0885 0.0885
Loa Loa (eye worm) carboxylesterase 0.0013 0.0046 0.0057
Echinococcus granulosus potassium channel subfamily K 8 0.0021 0.0164 0.0155
Mycobacterium tuberculosis Probable esterase LipL 0.0068 0.0885 0.1346
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.002 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0021 0.0164 0.0243
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.004 0.0453 0.0444
Leishmania major beta tubulin 0.0265 0.3917 1
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0181 0.0269
Mycobacterium tuberculosis Carboxylesterase LipT 0.0013 0.0046 0.005
Echinococcus multilocularis tubulin alpha chain 0.0192 0.2785 0.2778
Loa Loa (eye worm) hypothetical protein 0.0068 0.0885 0.1375
Plasmodium vivax ataxin-2 like protein, putative 0.0086 0.1163 0.2953
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0023 0.0197 0.0284
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0056 0.0142
Loa Loa (eye worm) acetyltransferase 0.0247 0.3636 0.5697
Plasmodium falciparum alpha tubulin 1 0.0192 0.2785 0.7103
Trichomonas vaginalis bromodomain-containing protein, putative 0.0073 0.0961 0.2426

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.7 nM Inhibition of human placental microsomal 17beta HSD2 using unlabeled- and labelled [2,4,6,7-3H]-E2 as substrate incubated for 20 mins by HPLC analysis ChEMBL. 26322835
IC50 (binding) = 6 nM Inhibition of human placental cytosolic 17beta HSD1 using unlabeled- and labelled [2,4,6,7-3H]-E1 as substrate incubated for 10 mins by HPLC analysis ChEMBL. 26322835
Inhibition (binding) = 10 % Inhibition of recombinant mouse 17beta HSD1 expressed in HEK293 cells using unlabeled- and labelled [2,4,6,7-3H]-E1 as substrate at 1 uM incubated for 10 mins by HPLC analysis ChEMBL. 26322835
Inhibition (binding) = 29 % Inhibition of recombinant rat 17beta HSD1 expressed in HEK293 cells using unlabeled- and labelled [2,4,6,7-3H]-E1 as substrate at 250 nM incubated for 10 mins by HPLC analysis ChEMBL. 26322835
Inhibition (binding) = 31 % Inhibition of rat liver microsomal 17beta HSD2 using unlabeled- and labelled [2,4,6,7-3H]-E2 as substrate at 250 nM incubated for 20 mins by HPLC analysis ChEMBL. 26322835
Inhibition (binding) = 47 % Inhibition of mouse liver microsomal 17beta HSD2 using unlabeled- and labelled [2,4,6,7-3H]-E2 as substrate at 1 uM incubated for 20 mins by HPLC analysis ChEMBL. 26322835

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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