Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 86 % | Cytotoxicity against human THP1 cells assessed as growth inhibition at 50 uM after 48 hrs by sulforhodamine B assay relative to control | ChEMBL. | 26515041 |
IC50 (functional) | = 4.56 uM | Cytotoxicity against human THP1 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay | ChEMBL. | 26515041 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 26515041 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.