Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | cationic amino acid transporter, putative | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 501 aa | 462 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fk506 binding protein | 0.0095 | 0.3149 | 0.3149 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0014 | 0.0044 | 0.0044 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0095 | 0.3149 | 1 |
Schistosoma mansoni | immunophilin | 0.0083 | 0.2698 | 0.2698 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0095 | 0.3149 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.026 | 0.9487 | 0.9487 |
Loa Loa (eye worm) | FKBP5 protein | 0.0095 | 0.3149 | 0.3149 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0095 | 0.3149 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0095 | 0.3149 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0083 | 0.2698 | 0.2698 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0095 | 0.3149 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0095 | 0.3149 | 0.3149 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0095 | 0.3149 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0095 | 0.3149 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0095 | 0.3149 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0095 | 0.3149 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.0095 | 0.3149 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0095 | 0.3149 | 0.3149 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0095 | 0.3149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.4758 | 0.4758 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2645 | 0.2645 |
Schistosoma mansoni | immunophilin | 0.0097 | 0.3201 | 0.3201 |
Schistosoma mansoni | immunophilin | 0.0097 | 0.3201 | 0.3201 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0097 | 0.3201 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0097 | 0.3201 | 0.3201 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0097 | 0.3201 | 0.3201 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0083 | 0.2698 | 0.2698 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0095 | 0.3149 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0097 | 0.3201 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0095 | 0.3149 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0095 | 0.3149 | 0.3149 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0095 | 0.3149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.4217 | 0.4217 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0095 | 0.3149 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0095 | 0.3149 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0095 | 0.3149 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0095 | 0.3149 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0095 | 0.3149 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0095 | 0.3149 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100 nM | Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometry | ChEMBL. | 26231156 |
T1/2 (ADMET) | > 90 min | Half life in mouse liver microsomes by LC-MS/MS analysis | ChEMBL. | 26231156 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.