Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | free fatty acid receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.2503 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0687 | 0.2744 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2332 | 0.2332 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0687 | 0.2744 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0687 | 0.2744 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.2503 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0687 | 0.2744 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.2332 | 0.2332 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.375 | 0.375 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.2503 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0687 | 0.2744 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0687 | 0.0687 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.2503 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.2503 | 0.5 |
Brugia malayi | hypothetical protein | 0.0042 | 0.2503 | 0.2503 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.2332 | 0.9318 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.375 | 0.375 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0687 | 0.2744 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0687 | 0.2744 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0687 | 0.2744 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.375 | 0.375 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0687 | 0.2744 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.2503 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.2503 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.2503 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0687 | 0.2744 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.375 | 0.375 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 58.37 % | Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux at 100 nM by FLIPR assay relative to control | ChEMBL. | 26482570 |
EC50 (binding) | = 49.7 nM | Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay | ChEMBL. | 26482570 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.