Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetyl-CoA carboxylase beta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxyl transferase domain containing protein | 0.0098 | 0.9491 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0083 | 0.73 | 1 |
Leishmania major | carboxylase, putative | 0.0039 | 0.101 | 0.101 |
Treponema pallidum | flavodoxin | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0051 | 0.2778 | 0.1967 |
Echinococcus granulosus | methionine synthase reductase | 0.0051 | 0.2778 | 0.1967 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0083 | 0.73 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0083 | 0.73 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0051 | 0.2778 | 0.1967 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0101 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0073 | 0.5956 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0051 | 0.2778 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0041 | 0.1344 | 0.0372 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0073 | 0.5987 | 0.8202 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0101 | 1 | 1 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0039 | 0.101 | 0.1383 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0083 | 0.73 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.101 | 0.101 |
Leishmania major | cytochrome P450 reductase, putative | 0.0073 | 0.5956 | 0.5956 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0083 | 0.73 | 0.73 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0063 | 0.4469 | 0.6121 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0083 | 0.73 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0041 | 0.1344 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.73 | 0.7691 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0083 | 0.73 | 0.6997 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0073 | 0.5956 | 0.8159 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0083 | 0.73 | 0.73 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0039 | 0.101 | 0.101 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0083 | 0.73 | 0.6997 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0083 | 0.73 | 0.73 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0098 | 0.9491 | 1 |
Leishmania major | p450 reductase, putative | 0.0083 | 0.73 | 0.73 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0083 | 0.73 | 0.7691 |
Brugia malayi | FAD binding domain containing protein | 0.0083 | 0.73 | 0.7691 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0101 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0039 | 0.101 | 0.5 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0041 | 0.1344 | 0.0372 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0101 | 1 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.101 | 0.101 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0039 | 0.101 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0083 | 0.73 | 0.73 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0051 | 0.2778 | 0.2927 |
Brugia malayi | flavodoxin family protein | 0.0083 | 0.73 | 0.7691 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0083 | 0.73 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0073 | 0.5987 | 0.8202 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0039 | 0.101 | 0.1383 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0083 | 0.73 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0101 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0073 | 0.5956 | 0.8159 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0101 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0083 | 0.73 | 0.6997 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0083 | 0.73 | 0.6997 |
Giardia lamblia | Hypothetical protein | 0.0073 | 0.5956 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0051 | 0.2778 | 0.2927 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0083 | 0.73 | 0.73 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0083 | 0.73 | 0.6997 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0039 | 0.101 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0039 | 0.101 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0042 | 0.1434 | 0.0472 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0083 | 0.73 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.