Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetyl-CoA carboxylase beta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0048 | 0.3125 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.003 | 0.0752 | 0.0752 |
Toxoplasma gondii | pyruvate carboxylase | 0.0039 | 0.1903 | 0.1903 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0098 | 0.9542 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0048 | 0.3125 | 0.3923 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0048 | 0.3125 | 0.2987 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0048 | 0.3125 | 0.1778 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0048 | 0.3125 | 0.27 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0098 | 0.9542 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0039 | 0.1903 | 0.1245 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0048 | 0.3125 | 0.3923 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0048 | 0.3125 | 0.2987 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0063 | 0.5018 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0048 | 0.3125 | 0.1509 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0039 | 0.1903 | 0.1903 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0048 | 0.3125 | 0.3923 |
Chlamydia trachomatis | biotin carboxylase | 0.0035 | 0.1445 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0101 | 1 | 1 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0073 | 0.6386 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0101 | 1 | 1 |
Schistosoma mansoni | pyruvate carboxylase | 0.0039 | 0.1903 | 0.1903 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0024 | 0.0047 | 0.0047 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0043 | 0.242 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0048 | 0.3125 | 0.2566 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0101 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0048 | 0.3125 | 0.2566 |
Giardia lamblia | Hypothetical protein | 0.0043 | 0.242 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0048 | 0.3125 | 0.27 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0048 | 0.3125 | 0.2566 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0039 | 0.1903 | 0.5 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0039 | 0.1903 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.1903 | 0.1741 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0048 | 0.3125 | 0.3125 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0039 | 0.1903 | 0.1245 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0101 | 1 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0073 | 0.6386 | 1 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0039 | 0.1903 | 0.5 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0101 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0048 | 0.3125 | 0.2987 |
Leishmania major | p450 reductase, putative | 0.0048 | 0.3125 | 0.1509 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0048 | 0.3125 | 0.2566 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3125 | 0.27 |
Leishmania major | cytochrome P450 reductase, putative | 0.0043 | 0.242 | 0.0638 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0101 | 1 | 1 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0039 | 0.1903 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0048 | 0.3125 | 0.3923 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0048 | 0.3125 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0048 | 0.3125 | 0.27 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.1903 | 0.1741 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0039 | 0.1903 | 0.1903 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0048 | 0.3125 | 0.2987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.