Detailed information for compound 1952226

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 404.505 | Formula: C24H28N4O2
  • H donors: 0 H acceptors: 2 LogP: 3.06 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(nc(n1C)OCCc1ccc(cc1)CN1CCCCC1)c1ccncc1
  • InChi: 1S/C24H28N4O2/c1-27-23(29)17-22(21-9-12-25-13-10-21)26-24(27)30-16-11-19-5-7-20(8-6-19)18-28-14-3-2-4-15-28/h5-10,12-13,17H,2-4,11,14-16,18H2,1H3
  • InChiKey: JRVLXWHZOKVMGQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Glycogen synthase kinase-3 beta splice variant X1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum CMGC kinase, MAPK family, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 375 aa 31.2 %
Leishmania mexicana mitogen-activated protein kinase, putative,kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 353 aa 32.9 %
Leishmania donovani mitogen-activated protein kinase 7, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 356 aa 30.1 %
Toxoplasma gondii AGC kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 341 aa 24.6 %
Onchocerca volvulus EG:103B4.3 protein homolog Glycogen synthase kinase-3 beta splice variant X1   419 aa 337 aa 24.0 %
Entamoeba histolytica serine/threonine-protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 351 aa 28.2 %
Leishmania infantum protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 363 aa 25.1 %
Leishmania major mitogen-activated protein kinase 7, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 356 aa 29.5 %
Echinococcus granulosus glycogen synthase kinase 3 Glycogen synthase kinase-3 beta splice variant X1   419 aa 408 aa 41.2 %
Echinococcus multilocularis beta adrenergic receptor kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 348 aa 25.6 %
Leishmania donovani protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 380 aa 23.9 %
Cryptosporidium hominis mitogen-activated protein kinase 1, serine/threonine protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 346 aa 30.3 %
Candida albicans protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 360 aa 25.6 %
Leishmania donovani protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 348 aa 24.4 %
Leishmania donovani Mitogen-activated protein kinase 8, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 418 aa 22.0 %
Entamoeba histolytica protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 344 aa 27.9 %
Leishmania major protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 339 aa 26.5 %
Leishmania mexicana mitogen-activated protein kinase 7, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 356 aa 28.7 %
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Glycogen synthase kinase-3 beta splice variant X1   419 aa 340 aa 25.6 %
Leishmania mexicana protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 366 aa 25.1 %
Trypanosoma brucei gambiense protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 356 aa 26.1 %
Echinococcus granulosus serine:threonine protein kinase NLK Glycogen synthase kinase-3 beta splice variant X1   419 aa 384 aa 32.0 %
Cryptosporidium hominis mitogen-activated protein kinase 2 Glycogen synthase kinase-3 beta splice variant X1   419 aa 398 aa 28.1 %
Echinococcus granulosus c-Jun N-terminal kinases Glycogen synthase kinase-3 beta splice variant X1   419 aa 355 aa 29.6 %
Candida albicans kinase required for late nuclear division Glycogen synthase kinase-3 beta splice variant X1   419 aa 363 aa 23.4 %
Leishmania mexicana protein kinase, putative,dual-specificity protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 367 aa 28.6 %
Leishmania mexicana zinc finger protein kinase-like Glycogen synthase kinase-3 beta splice variant X1   419 aa 347 aa 26.5 %
Neospora caninum CAM kinase, CDPK family CAM kinase TgTPK5, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 351 aa 24.2 %
Trypanosoma brucei gambiense protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 336 aa 27.7 %
Trypanosoma congolense kinetoplastid kinetochore protein, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 342 aa 22.8 %
Cryptosporidium hominis MAPK Glycogen synthase kinase-3 beta splice variant X1   419 aa 384 aa 30.2 %
Onchocerca volvulus G protein-coupled receptor kinase 2 homolog Glycogen synthase kinase-3 beta splice variant X1   419 aa 362 aa 23.2 %
Leishmania infantum protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 362 aa 24.9 %
Babesia bovis mitogen-activated protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 396 aa 28.8 %
Cryptosporidium hominis calmodulin-domain protein kinase 1 Glycogen synthase kinase-3 beta splice variant X1   419 aa 364 aa 24.7 %
Babesia bovis protein kinase domain containing protein Glycogen synthase kinase-3 beta splice variant X1   419 aa 352 aa 24.7 %
Trichomonas vaginalis CAMK family protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 365 aa 29.0 %
Leishmania donovani mitogen-activated protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 353 aa 32.3 %
Echinococcus granulosus serine/threonine protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 385 aa 24.9 %
Leishmania infantum protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 341 aa 26.7 %
Echinococcus granulosus dual specificity Glycogen synthase kinase-3 beta splice variant X1   419 aa 354 aa 30.5 %
Leishmania braziliensis mitogen-activated protein kinase 7, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 367 aa 27.8 %
Schistosoma japonicum ko:K02211 cyclin-dependent kinase 9, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 337 aa 29.7 %
Trichomonas vaginalis AGC family protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 343 aa 28.0 %
Leishmania donovani protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 354 aa 28.0 %
Onchocerca volvulus Putative nucleotide binding protein 2 Glycogen synthase kinase-3 beta splice variant X1   419 aa 373 aa 29.2 %
Leishmania major protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 341 aa 26.7 %
Trypanosoma brucei gambiense protein kinase,zinc finger protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 341 aa 27.6 %
Echinococcus multilocularis serine:threonine protein kinase Chk2 Glycogen synthase kinase-3 beta splice variant X1   419 aa 382 aa 27.5 %
Theileria parva calmodulin-domain protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 337 aa 27.0 %
Leishmania infantum protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 380 aa 24.2 %
Leishmania infantum mitogen-activated protein kinase, putative,kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 353 aa 32.3 %
Trypanosoma cruzi glycogen synthase kinase-3 alpha, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 446 aa 38.6 %
Entamoeba histolytica protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 393 aa 29.3 %
Entamoeba histolytica protein kinase domain containing protein Glycogen synthase kinase-3 beta splice variant X1   419 aa 339 aa 29.2 %
Plasmodium knowlesi serine/threonine kinase-1, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 341 aa 24.0 %
Trichomonas vaginalis STE family protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 338 aa 24.3 %
Trichomonas vaginalis CAMK family protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 363 aa 26.4 %
Plasmodium berghei mitogen-activated protein kinase 2 Glycogen synthase kinase-3 beta splice variant X1   419 aa 351 aa 30.5 %
Cryptosporidium parvum protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 337 aa 26.4 %
Leishmania donovani mitogen-activated protein kinase 2 Glycogen synthase kinase-3 beta splice variant X1   419 aa 378 aa 31.2 %
Leishmania infantum mitogen-activated protein kinase, putative,map kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 414 aa 21.5 %
Candida albicans probable Ser Thr protein kinase, similar to RCK2 Glycogen synthase kinase-3 beta splice variant X1   419 aa 384 aa 22.7 %
Candida albicans protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 360 aa 25.6 %
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Glycogen synthase kinase-3 beta splice variant X1   419 aa 340 aa 25.6 %
Leishmania braziliensis protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 444 aa 26.1 %
Onchocerca volvulus G protein-coupled receptor kinase 2 homolog Glycogen synthase kinase-3 beta splice variant X1   419 aa 362 aa 23.2 %
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 368 aa 25.3 %
Leishmania mexicana protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 354 aa 28.0 %
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 377 aa 20.4 %
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Glycogen synthase kinase-3 beta splice variant X1   419 aa 364 aa 24.7 %
Leishmania donovani mitogen-activated protein kinase kinase 3, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 349 aa 26.4 %
Leishmania donovani protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 365 aa 23.8 %
Echinococcus granulosus Serine:threonine protein kinase PLK4 Glycogen synthase kinase-3 beta splice variant X1   419 aa 352 aa 25.9 %
Trichomonas vaginalis AGC family protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 350 aa 24.0 %
Schistosoma mansoni protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 365 aa 27.7 %
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 340 aa 27.4 %
Leishmania infantum protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 354 aa 28.0 %
Entamoeba histolytica protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 349 aa 26.9 %
Echinococcus granulosus beta-adrenergic receptor kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 348 aa 25.6 %
Schistosoma mansoni serine/threonine protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 392 aa 22.7 %
Plasmodium falciparum mitogen-activated protein kinase 2 Glycogen synthase kinase-3 beta splice variant X1   419 aa 378 aa 29.4 %
Babesia bovis calcium-dependent protein kinase 4 Glycogen synthase kinase-3 beta splice variant X1   419 aa 373 aa 27.9 %
Leishmania mexicana protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 365 aa 23.8 %
Brugia malayi Protein kinase domain containing protein Glycogen synthase kinase-3 beta splice variant X1   419 aa 336 aa 21.7 %
Entamoeba histolytica serine/threonine-protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 337 aa 26.7 %
Brugia malayi Protein kinase domain containing protein Glycogen synthase kinase-3 beta splice variant X1   419 aa 423 aa 23.4 %
Schistosoma japonicum ko:K06068 novel protein kinase C, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 366 aa 24.0 %
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 Glycogen synthase kinase-3 beta splice variant X1   419 aa 385 aa 27.0 %
Echinococcus granulosus dual specificity Glycogen synthase kinase-3 beta splice variant X1   419 aa 344 aa 29.9 %
Leishmania infantum protein kinase, putative,mitogen-activated protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 378 aa 31.2 %
Cryptosporidium hominis dual-specificity tyrosine-(Y)-phosphorylation regulated kinase TbPK4 Glycogen synthase kinase-3 beta splice variant X1   419 aa 337 aa 26.1 %
Schistosoma mansoni serine/threonine protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 366 aa 24.9 %
Leishmania mexicana protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 390 aa 22.3 %
Leishmania mexicana protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 391 aa 25.8 %
Schistosoma japonicum Serine/threonine-protein kinase Chk1, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 345 aa 25.2 %
Plasmodium vivax mitogen-activated protein kinase 2, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 403 aa 29.0 %
Cryptosporidium parvum mitogen-activated protein kinase 2, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 395 aa 28.4 %
Trypanosoma congolense kinetoplastid kinetochore protein, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 342 aa 23.1 %
Leishmania donovani dual-specificity protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 366 aa 28.4 %
Leishmania infantum protein kinase, putative,dual-specificity protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 366 aa 28.1 %
Candida albicans protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 354 aa 26.0 %
Trypanosoma brucei glycogen synthase kinase-3 alpha, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 420 aa 36.9 %
Leishmania infantum mitogen-activated protein kinase kinase 3, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 349 aa 26.4 %
Schistosoma mansoni ephrin receptor Glycogen synthase kinase-3 beta splice variant X1   419 aa 359 aa 23.4 %
Trypanosoma brucei gambiense protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 385 aa 24.7 %
Candida albicans probable Ser Thr protein kinase, similar to RCK2 Glycogen synthase kinase-3 beta splice variant X1   419 aa 384 aa 22.7 %
Cryptosporidium parvum MAPK, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 384 aa 30.2 %
Leishmania braziliensis mitogen-activated protein kinase, putative,map kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 389 aa 21.9 %
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 356 aa 26.1 %
Trypanosoma brucei differentiation inhibitory kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 341 aa 27.6 %
Leishmania donovani protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 362 aa 24.9 %
Leishmania braziliensis protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 354 aa 28.0 %
Brugia malayi Protein kinase domain containing protein Glycogen synthase kinase-3 beta splice variant X1   419 aa 340 aa 27.4 %
Babesia bovis serine/threonine protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 352 aa 24.1 %
Babesia bovis cGMP dependent protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 351 aa 26.2 %
Trypanosoma congolense Protein kinase domain containing protein, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 346 aa 23.1 %
Toxoplasma gondii protein kinase, other Glycogen synthase kinase-3 beta splice variant X1   419 aa 352 aa 24.7 %
Entamoeba histolytica serine/threonine-protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 349 aa 28.1 %
Schistosoma mansoni serine/threonine protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 340 aa 24.7 %
Echinococcus multilocularis serine:threonine protein kinase NLK Glycogen synthase kinase-3 beta splice variant X1   419 aa 384 aa 32.0 %
Trypanosoma brucei gambiense glycogen synthase kinase-3 alpha, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 420 aa 36.9 %
Onchocerca volvulus Glycogen synthase kinase-3 beta splice variant X1   419 aa 340 aa 27.4 %
Leishmania mexicana protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 361 aa 24.4 %
Echinococcus granulosus dual specificity Glycogen synthase kinase-3 beta splice variant X1   419 aa 367 aa 29.4 %
Leishmania mexicana protein kinase, putative,mitogen-activated protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 379 aa 30.3 %
Leishmania donovani serine/threonine-protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 357 aa 23.5 %
Cryptosporidium hominis cdc2-related protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 390 aa 27.4 %
Trypanosoma cruzi protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 339 aa 23.3 %
Trypanosoma cruzi calcium/calmodulin-dependent protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 346 aa 25.1 %
Leishmania braziliensis protein kinase, putative,serine/threonine protein kinase sos2, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 383 aa 26.1 %
Leishmania major mitogen-activated protein kinase, putative,map kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 411 aa 21.4 %
Trypanosoma brucei protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 345 aa 26.1 %
Plasmodium yoelii mitogen-activated protein kinase 2 Glycogen synthase kinase-3 beta splice variant X1   419 aa 361 aa 29.6 %
Toxoplasma gondii calcium-dependent protein kinase CDPK2 Glycogen synthase kinase-3 beta splice variant X1   419 aa 336 aa 29.8 %
Trypanosoma brucei CMGC/DYRK protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 388 aa 27.6 %
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 388 aa 27.6 %
Plasmodium knowlesi serine/threonine protein kinase KIN, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 390 aa 27.2 %
Echinococcus granulosus serine:threonine protein kinase ULK2 Glycogen synthase kinase-3 beta splice variant X1   419 aa 337 aa 24.9 %
Cryptosporidium parvum mitogen-activated protein kinase 1, serine/threonine protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 346 aa 30.3 %
Leishmania mexicana protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 347 aa 25.4 %
Neospora caninum AGC kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 342 aa 24.6 %
Echinococcus multilocularis peripheral plasma membrane protein CASK Glycogen synthase kinase-3 beta splice variant X1   419 aa 386 aa 24.9 %
Candida albicans kinase required for late nuclear division Glycogen synthase kinase-3 beta splice variant X1   419 aa 363 aa 23.4 %
Cryptosporidium parvum cdc2-related protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 390 aa 26.9 %
Leishmania infantum protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 348 aa 24.4 %
Entamoeba histolytica serine/threonine-protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 351 aa 27.6 %
Schistosoma japonicum Glycogen synthase kinase-3 alpha, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 413 aa 39.7 %
Leishmania mexicana protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 370 aa 23.8 %
Echinococcus granulosus peripheral plasma membrane protein CASK Glycogen synthase kinase-3 beta splice variant X1   419 aa 386 aa 25.1 %
Toxoplasma gondii calcium-dependent protein kinase CDPK9 Glycogen synthase kinase-3 beta splice variant X1   419 aa 339 aa 23.9 %
Neospora caninum CAM kinase, CDPK family, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 396 aa 23.5 %
Echinococcus multilocularis Serine:threonine protein kinase PLK4 Glycogen synthase kinase-3 beta splice variant X1   419 aa 352 aa 25.6 %
Trypanosoma cruzi calcium/calmodulin-dependent protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 341 aa 24.0 %
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 Glycogen synthase kinase-3 beta splice variant X1   419 aa 352 aa 26.1 %
Trichomonas vaginalis AGC family protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 352 aa 26.7 %
Leishmania infantum mitogen-activated protein kinase 7, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 356 aa 30.1 %
Schistosoma japonicum ko:K08805 doublecortin and CaM kinase-like 1, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 342 aa 23.1 %
Schistosoma mansoni serine/threonine protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 382 aa 30.4 %
Trypanosoma congolense rac serine-threonine kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 338 aa 29.0 %
Toxoplasma gondii rhoptry protein ROP18 Glycogen synthase kinase-3 beta splice variant X1   419 aa 397 aa 24.2 %
Leishmania donovani protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 341 aa 26.7 %
Leishmania major protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 362 aa 24.6 %
Plasmodium knowlesi mitogen-activated protein kinase 2, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 395 aa 28.6 %
Leishmania braziliensis protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 365 aa 23.8 %
Candida albicans protein threonine/tyrosine kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 348 aa 26.1 %
Leishmania major protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 365 aa 25.2 %
Leishmania infantum protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 365 aa 23.8 %
Leishmania donovani protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 363 aa 25.1 %
Trypanosoma congolense protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 353 aa 21.0 %
Trichomonas vaginalis CAMK family protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 376 aa 26.1 %
Toxoplasma gondii ULK kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 339 aa 27.7 %
Candida albicans protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 354 aa 26.0 %
Trypanosoma cruzi cdc2-related kinase 10, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 381 aa 26.8 %
Onchocerca volvulus Glycogen synthase kinase-3 beta splice variant X1   419 aa 340 aa 26.2 %
Plasmodium vivax calcium-dependent protein kinase 1, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 352 aa 25.9 %
Leishmania braziliensis protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 363 aa 24.2 %
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 375 aa 31.5 %
Leishmania donovani protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 337 aa 22.8 %
Entamoeba histolytica protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 349 aa 31.2 %
Trypanosoma brucei cdc2-related protein kinase 11, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 385 aa 24.9 %
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 342 aa 22.8 %
Leishmania major protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 365 aa 23.3 %
Echinococcus multilocularis dual specificity Glycogen synthase kinase-3 beta splice variant X1   419 aa 367 aa 29.2 %
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 345 aa 26.1 %
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 341 aa 25.5 %
Leishmania major protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 356 aa 27.8 %
Babesia bovis protein serine/threonine kinase 1 Glycogen synthase kinase-3 beta splice variant X1   419 aa 338 aa 23.1 %
Trypanosoma cruzi calcium/calmodulin-dependent protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 346 aa 24.9 %
Trypanosoma brucei gambiense protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 345 aa 26.1 %
Giardia lamblia Kinase, AGC MAST Glycogen synthase kinase-3 beta splice variant X1   419 aa 355 aa 27.6 %
Brugia malayi Protein kinase domain containing protein Glycogen synthase kinase-3 beta splice variant X1   419 aa 338 aa 29.3 %
Leishmania major protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 343 aa 24.5 %
Echinococcus multilocularis dual specificity Glycogen synthase kinase-3 beta splice variant X1   419 aa 354 aa 30.5 %
Schistosoma mansoni serine/threonine protein kinase Glycogen synthase kinase-3 beta splice variant X1   419 aa 349 aa 30.4 %
Echinococcus multilocularis glycogen synthase kinase 3 Glycogen synthase kinase-3 beta splice variant X1   419 aa 408 aa 41.2 %
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Glycogen synthase kinase-3 beta splice variant X1   419 aa 358 aa 23.7 %
Brugia malayi serine/threonine-protein kinase PAK 7 Glycogen synthase kinase-3 beta splice variant X1   419 aa 364 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0058 0 0.5
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0697 1 1
Loa Loa (eye worm) dUTP diphosphatase 0.0697 1 1
Entamoeba histolytica hypothetical protein 0.0697 1 1
Wolbachia endosymbiont of Brugia malayi dUTPase 0.0697 1 1
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0697 1 1
Entamoeba histolytica hypothetical protein 0.0242 0.2879 0.2879
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0242 0.2879 0.2879
Echinococcus multilocularis dUTP pyrophosphatase 0.0697 1 1
Entamoeba histolytica hypothetical protein 0.0455 0.6213 0.6213
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0697 1 1
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0242 0.2879 0.2879
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.0242 0.2879 0.5
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0058 0 0.5
Echinococcus granulosus dUTP pyrophosphatase 0.0697 1 1
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.0697 1 0.5
Giardia lamblia Kinase, CMGC GSK 0.0058 0 0.5
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0697 1 1
Giardia lamblia Kinase, CMGC GSK 0.0058 0 0.5
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0242 0.2879 0.5
Entamoeba histolytica hypothetical protein 0.0455 0.6213 0.6213
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0242 0.2879 0.5
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0058 0 0.5
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0697 1 1
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0697 1 1
Trypanosoma brucei protein kinase, putative 0.0058 0 0.5
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0697 1 1
Entamoeba histolytica hypothetical protein 0.0697 1 1
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0697 1 1
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0697 1 1
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0697 1 1
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0697 1 1
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0697 1 1
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.0242 0.2879 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 110 nM BindingDB_Patents: Inhibition Assay. A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% glycerol, 12 .mu.g/ml P-GS1, 41.7 .mu.M [.gamma.-.sup.32P] ATP (68 kBq/ml), bovine cerebral TPK1 and a compound shown in Table (a final mixture contained 1.7% DMSO deriving from a solution of a test compound prepared in the presence of 10% DMSO) was used as a reaction system. The phosphorylation was started by adding ATP, and the reaction was conducted at 25.degree. C. for 2 hours, and then stopped by adding 21% perchloric acid on ice cooling. The reaction mixture was centrifuged at 12,000 rpm for 5 minutes and adsorbed on P81 paper (Whatmann), and then the paper was washed four times with 75 mM phosphoric acid, three times with water and once with acetone. The paper was dried, and the residual radioactivity was measured using a liquid scintillation counter. The results are shown in the table below. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.