Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydroorotate dehydrogenase (quinone) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | dihydroorotate dehydrogenase (quinone) | 395 aa | 361 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0.1492 | 1 | |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0096 | 0.1492 | 0.1492 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1492 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.02 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.02 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.02 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 1 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.02 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.02 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1492 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.02 | 1 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.02 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.02 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 nM | BindingDB_Patents: Inhibition Assay. Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichlorophenol-indophenol). The substrate oxidation (Dihydrooroate, L-DHO), as well as cosubstrate reduction (coenzyme Q, CoQ) is coupled to the chromogen reduction, hence enzymatic activity results in a loss of chromogen absorbance at 600 nm. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.