Detailed information for compound 19528

Basic information

Technical information
  • TDR Targets ID: 19528
  • Name: 3-(3,5-dihydroxyphenyl)-N-[2-(3,5-dihydroxyph enyl)ethyl]propanamide
  • MW: 317.336 | Formula: C17H19NO5
  • H donors: 5 H acceptors: 5 LogP: 1.97 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CCc1cc(O)cc(c1)O)NCCc1cc(O)cc(c1)O
  • InChi: 1S/C17H19NO5/c19-13-5-11(6-14(20)9-13)1-2-17(23)18-4-3-12-7-15(21)10-16(22)8-12/h5-10,19-22H,1-4H2,(H,18,23)
  • InChiKey: JXQNQSJCCAHWLV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3,5-dihydroxyphenyl)-N-[2-(3,5-dihydroxyphenyl)ethyl]propionamide
  • AIDS050661
  • NSC686578
  • NCI60_031242
  • 3-(3,5-dihydroxyphenyl)-N-(2-(3,5-dihydroxyphenyl)ethyl)propanamide
  • AIDS-050661

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Onchocerca volvulus 0.0022 0.2599 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.2599 0.3773
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.2599 0.4261
Brugia malayi Serotonin receptor 0.0022 0.2599 0.2599
Brugia malayi G-protein coupled receptor 0.0022 0.2599 0.2599
Echinococcus granulosus g protein coupled receptor 0.0022 0.2599 0.4261
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.2599 0.4261
Schistosoma mansoni histamine h1 receptor 0.0022 0.2599 0.3773
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Brugia malayi RE15519p 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.2599 0.4261
Onchocerca volvulus 0.0022 0.2599 0.5
Brugia malayi Dopamine receptor protein 1 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Brugia malayi Cytochrome P450 family protein 0.0017 0.1468 0.1468
Echinococcus granulosus sex peptide receptor 0.0022 0.2599 0.4261
Schistosoma mansoni neuropeptide receptor 0.0022 0.2599 0.3773
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.2599 0.3773
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.2599 0.4261
Brugia malayi Dopamine receptor 0.0022 0.2599 0.2599
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.2599 0.2599
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.2599 0.2599
Echinococcus multilocularis g protein coupled receptor 0.0022 0.2599 0.4261
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.1468 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.2599 0.4261
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.3427 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0017 0.1468 0.5
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0017 0.1468 0.5
Brugia malayi hypothetical protein 0.0022 0.2599 0.2599
Echinococcus granulosus g protein coupled receptor 0.0022 0.2599 0.4261
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.2599 0.4261
Schistosoma mansoni amine GPCR 0.0022 0.2599 0.3773
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.2599 0.4261
Loa Loa (eye worm) cytochrome P450 0.0017 0.1468 0.1468
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.2599 0.4261
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.2599 0.3773
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0017 0.1468 0.5
Echinococcus granulosus neuropeptide receptor 0.0022 0.2599 0.4261
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.2599 0.4261
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.2599 0.3773
Echinococcus multilocularis 0.0017 0.1468 0.2406
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.2599 0.3773
Echinococcus granulosus serotonin receptor 0.0022 0.2599 0.4261
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0017 0.1468 0.5
Brugia malayi AKH receptor 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus multilocularis somatostatin receptor 0.0022 0.2599 0.4261
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.1468 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.3427 0.3427
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.2599 0.4261
Echinococcus multilocularis fmrfamide receptor 0.0022 0.2599 0.4261
Echinococcus granulosus neuropeptide receptor 0.0022 0.2599 0.4261
Brugia malayi cytochrome P450 0.0017 0.1468 0.1468
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.2599 0.4261
Schistosoma mansoni hypothetical protein 0.0022 0.2599 0.3773
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Schistosoma mansoni opsin-like receptor 0.0022 0.2599 0.3773
Schistosoma mansoni neuropeptide receptor 0.0022 0.2599 0.3773
Schistosoma mansoni cytochrome P450 0.0017 0.1468 0.2131
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.2599 0.4261
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.2599 0.2599
Schistosoma mansoni amine GPCR 0.0022 0.2599 0.3773
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.2599 0.4261
Schistosoma mansoni hypothetical protein 0.0022 0.2599 0.3773
Brugia malayi Cytochrome P450 family protein 0.0026 0.3427 0.3427
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Brugia malayi ORL1-like opioid receptor 0.0022 0.2599 0.2599
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0017 0.1468 0.5
Onchocerca volvulus 0.0022 0.2599 0.5
Onchocerca volvulus 0.0022 0.2599 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus granulosus allatostatin A receptor 0.0022 0.2599 0.4261
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.61 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.2599 0.4261
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Trypanosoma brucei cytochrome P450, putative 0.0026 0.3427 1
Echinococcus granulosus somatostatin receptor 0.0022 0.2599 0.4261
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.2599 0.4261
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0017 0.1468 0.5
Schistosoma mansoni adenoreceptor 0.0022 0.2599 0.3773
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.2599 0.3773
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.2599 0.4261
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.2599 0.5
Schistosoma mansoni hypothetical protein 0.0022 0.2599 0.3773
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0017 0.1468 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.2599 0.4261
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Brugia malayi hypothetical protein 0.0022 0.2599 0.2599
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0017 0.1468 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus multilocularis neuropeptide s receptor 0.0022 0.2599 0.4261
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.2599 0.4261
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0017 0.1468 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.2599 0.3773
Schistosoma mansoni amine GPCR 0.0022 0.2599 0.3773
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.2599 0.3773
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.61 0.61
Schistosoma mansoni amine GPCR 0.0022 0.2599 0.3773
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.2599 0.4261
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Brugia malayi hypothetical protein 0.0022 0.2599 0.2599
Brugia malayi Cytochrome P450 family protein 0.0026 0.3427 0.3427
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.2599 0.4261
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.2599 0.2599
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.2599 0.3773
Onchocerca volvulus 0.0022 0.2599 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.2599 0.3773
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.2599 0.4261
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0017 0.1468 0.5
Brugia malayi hypothetical protein 0.0022 0.2599 0.2599
Onchocerca volvulus 0.0022 0.2599 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.2599 0.3773
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Onchocerca volvulus 0.0022 0.2599 0.5
Schistosoma mansoni myosin xvIII 0.0022 0.2599 0.3773
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.2599 0.2599
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.2599 0.4261
Schistosoma mansoni biogenic amine receptor 0.0022 0.2599 0.3773
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0017 0.1468 0.5
Echinococcus multilocularis sex peptide receptor 0.0022 0.2599 0.4261
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.2599 0.4261
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.2599 0.2599
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0017 0.1468 0.5
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0017 0.1468 0.5
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0017 0.1468 0.5
Brugia malayi hypothetical protein 0.0022 0.2599 0.2599
Onchocerca volvulus 0.0022 0.2599 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0022 0.2599 0.4261
Echinococcus granulosus neuropeptide s receptor 0.0022 0.2599 0.4261
Brugia malayi G protein-coupled receptor 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Schistosoma mansoni biogenic amine receptor 0.0022 0.2599 0.3773
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0022 0.2599 0.2599
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.5535 0.5
Brugia malayi neuropeptide F receptor 0.0022 0.2599 0.2599
Brugia malayi larval opioid receptor 0.0022 0.2599 0.2599
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.2599 0.4261
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.2599 0.4261
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Brugia malayi hypothetical protein 0.0022 0.2599 0.2599
Echinococcus multilocularis neuropeptide receptor 0.0022 0.2599 0.4261
Onchocerca volvulus 0.0022 0.2599 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.6889 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.2599 0.3773
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.2599 0.3773
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.2599 0.2599
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.3427 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.2599 0.4261
Brugia malayi GnHR receptor homolog 0.0022 0.2599 0.2599
Brugia malayi sulfakinin receptor protein 0.0022 0.2599 0.2599
Brugia malayi Dopamine receptor protein 2 0.0022 0.2599 0.2599
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0017 0.1468 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.2599 0.4261
Onchocerca volvulus 0.0022 0.2599 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.2599 0.4261
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.2599 0.3773
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.5535 0.5
Leishmania major cytochrome p450-like protein 0.0026 0.3427 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.2599 0.4261
Echinococcus multilocularis fmrfamide receptor 0.0022 0.2599 0.4261
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.6889 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.2599 0.4261
Brugia malayi hypothetical protein 0.0022 0.2599 0.2599
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.2599 0.4261
Echinococcus multilocularis serotonin receptor 0.0022 0.2599 0.4261
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.2599 0.3773
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.2599 0.3773
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.2599 0.3773
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0017 0.1468 0.5
Brugia malayi follicle stimulating hormone receptor 0.0022 0.2599 0.2599
Schistosoma mansoni neuropeptide receptor 0.0022 0.2599 0.3773
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.2599 0.3773
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.2599 0.3773
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.2599 0.4261
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.2599 0.4261
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.2599 0.4261
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0017 0.1468 0.5
Echinococcus granulosus g-protein coupled receptor 0.0022 0.2599 0.4261
Echinococcus granulosus g protein coupled receptor 0.0022 0.2599 0.4261
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.2599 0.2599
Schistosoma mansoni biogenic amine receptor 0.0022 0.2599 0.3773
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.61 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.2599 0.2599
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.2599 0.3773
Onchocerca volvulus 0.0022 0.2599 0.5
Echinococcus granulosus fmrfamide receptor 0.0022 0.2599 0.4261
Schistosoma mansoni neuropeptide receptor 0.0022 0.2599 0.3773
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0032 0.4966 0.4966
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.3427 0.3427
Brugia malayi neuropeptide F receptor 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Brugia malayi putative neuropeptide receptor 0.0022 0.2599 0.2599
Onchocerca volvulus 0.0022 0.2599 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.2599 0.3773
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Brugia malayi hypothetical protein 0.0022 0.2599 0.2599
Onchocerca volvulus 0.0022 0.2599 0.5
Onchocerca volvulus 0.0022 0.2599 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.2599 0.4261
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0017 0.1468 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.2599 0.3773
Echinococcus granulosus hypothetical protein 0.0022 0.2599 0.4261
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Schistosoma mansoni opsin-like receptor 0.0022 0.2599 0.3773
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.2599 0.2599
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.2599 0.3773
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.2599 0.3773
Echinococcus multilocularis serotonin receptor 0.0022 0.2599 0.4261
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.2599 0.2599
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.2599 0.4261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.2599 0.3773
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.2599 0.2599
Echinococcus multilocularis g protein coupled receptor 0.0022 0.2599 0.4261
Loa Loa (eye worm) CYP4Cod1 0.0026 0.3427 0.3427
Onchocerca volvulus 0.0022 0.2599 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.2599 0.4261
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus granulosus orexin receptor type 2 0.0022 0.2599 0.4261
Brugia malayi Melatonin receptor type 1A 0.0022 0.2599 0.2599
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.2599 0.3773
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.2599 0.4261
Schistosoma mansoni amine GPCR 0.0022 0.2599 0.3773
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.2599 0.4261
Onchocerca volvulus 0.0022 0.2599 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.2599 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus multilocularis orexin receptor type 2 0.0022 0.2599 0.4261
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.2599 0.4261
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.2599 0.4261
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.2599 0.3773
Schistosoma mansoni hypothetical protein 0.0022 0.2599 0.3773
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.2599 0.4261
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.1468 0.2406
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.2599 0.4261
Brugia malayi G-protein coupled receptor 0.0022 0.2599 0.2599
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0017 0.1468 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.2599 0.4261
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.2599 0.4261
Echinococcus multilocularis neuropeptide receptor A26 0.0022 0.2599 0.4261
Echinococcus multilocularis allatostatin A receptor 0.0022 0.2599 0.4261
Onchocerca volvulus 0.0022 0.2599 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Brugia malayi Serotonin receptor 0.0022 0.2599 0.2599
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0017 0.1468 0.5
Brugia malayi hypothetical protein 0.0022 0.2599 0.2599
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.2599 0.2599
Echinococcus multilocularis neuropeptide receptor 0.0022 0.2599 0.4261
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.3427 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Echinococcus multilocularis g protein coupled receptor 0.0022 0.2599 0.4261
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.2599 0.2599
Schistosoma mansoni hypothetical protein 0.0017 0.1468 0.2131
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.2599 0.4261
Mycobacterium leprae putative cytochrome p450 0.0017 0.1468 0.5
Schistosoma mansoni opsin-like receptor 0.0022 0.2599 0.3773
Loa Loa (eye worm) hypothetical protein 0.0022 0.2599 0.2599
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.61 0.61
Brugia malayi hypothetical protein 0.0022 0.2599 0.2599
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.2599 0.4261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.2599 0.3773
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.2599 0.3773

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 350 uM Inhibition of HIV-1 integrase-mediated 3'-processing ChEMBL. 9111292
IC50 (binding) > 350 uM Inhibition of HIV-1 integrase-mediated 3'-processing ChEMBL. 9111292

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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