Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 3-phosphoinositide dependent protein kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 1 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 1 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 1 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0033 | 0.076 | 0.076 |
Echinococcus granulosus | lamin dm0 | 0.0062 | 0.74 | 0.74 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0042 | 0.2881 | 0.2881 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0073 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0059 | 0.6707 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.74 | 0.5 | |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0059 | 0.6707 | 0.6707 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0073 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0062 | 0.74 | 0.74 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.74 | 0.74 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.7139 | 0.7139 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0062 | 0.74 | 0.74 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0059 | 0.6707 | 0.6707 |
Echinococcus multilocularis | musashi | 0.0062 | 0.74 | 0.74 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0042 | 0.2881 | 0.2881 |
Brugia malayi | Protein kinase domain containing protein | 0.0059 | 0.6707 | 0.6437 |
Schistosoma mansoni | lamin | 0.0062 | 0.74 | 0.2104 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0073 | 1 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.74 | 0.5 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0062 | 0.74 | 0.7187 |
Echinococcus multilocularis | lamin dm0 | 0.0062 | 0.74 | 0.74 |
Trichomonas vaginalis | AGC family protein kinase | 0.0059 | 0.6707 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0062 | 0.74 | 0.7187 |
Schistosoma mansoni | lamin | 0.0062 | 0.74 | 0.2104 |
Echinococcus granulosus | intermediate filament protein | 0.0062 | 0.74 | 0.74 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0059 | 0.6707 | 0.6437 |
Echinococcus granulosus | lamin | 0.0062 | 0.74 | 0.74 |
Loa Loa (eye worm) | intermediate filament protein | 0.0062 | 0.74 | 0.74 |
Schistosoma mansoni | intermediate filament proteins | 0.0062 | 0.74 | 0.2104 |
Trichomonas vaginalis | AGC family protein kinase | 0.0059 | 0.6707 | 0.5 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0059 | 0.6707 | 0.6707 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0059 | 0.6707 | 0.6707 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 96 nM | BindingDB_Patents: Kinase Assay. The activity of the compounds according to the invention on the kinase PDK1 which inhibits the signal transduction pathway is determined in an in vitro kinase assay with recombinantly prepared protein. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.