Detailed information for compound 1955140

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 479.538 | Formula: C24H32F3N5O2
  • H donors: 3 H acceptors: 4 LogP: 4.2 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CN(C1)C1CCC(CC1)C(C(C)C)O)CNc1ncnc2c1cc(cc2)C(F)(F)F
  • InChi: 1S/C24H32F3N5O2/c1-14(2)22(34)15-3-6-18(7-4-15)32-11-17(12-32)31-21(33)10-28-23-19-9-16(24(25,26)27)5-8-20(19)29-13-30-23/h5,8-9,13-15,17-18,22,34H,3-4,6-7,10-12H2,1-2H3,(H,31,33)(H,28,29,30)
  • InChiKey: VDQZYRCKECVTGJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0062 0.2412 0.2412
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.1072 0.1072
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0044 0.1562 0.1562
Leishmania major lanosterol synthase, putative 0.002 0.0416 0.2765
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0053 0.196 0.2037
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0228 0.0183
Echinococcus multilocularis insulin degrading enzyme 0.0027 0.0736 0.0726
Trypanosoma cruzi peptidase, putative 0.0027 0.0736 0.1633
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.1072 0.1072
Echinococcus granulosus Tolloid protein 1 0.0038 0.1288 0.1339
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.196 0.2037
Schistosoma mansoni thyroid hormone receptor 0.0034 0.1072 0.2157
Loa Loa (eye worm) hypothetical protein 0.0018 0.0304 0.0304
Onchocerca volvulus 0.0016 0.0228 0.0422
Giardia lamblia Hypothetical protein 0.0018 0.0304 0.2454
Echinococcus multilocularis nardilysin 0.0016 0.0237 0.0193
Loa Loa (eye worm) hypothetical protein 0.0018 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0018 0.0303 0.0303
Trypanosoma brucei Replication factor A protein 1 0.004 0.1355 1
Onchocerca volvulus 0.0034 0.1072 0.1986
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.1072 0.1072
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.1072 0.1072
Brugia malayi ephrin receptor 1 precursor 0.0038 0.1266 0.1266
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.004 0.1355 0.3398
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.1072 0.2157
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0228 0.0228
Plasmodium vivax replication protein A1, large subunit, putative 0.004 0.1355 1
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0228 0.0228
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0044 0.1562 0.1562
Trypanosoma brucei telomerase reverse transcriptase 0.0034 0.1092 0.7751
Echinococcus granulosus 3'partial|nardilysin 0.0027 0.0736 0.0749
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0024 0.0615 0.1006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0353 0.0353
Echinococcus multilocularis tyrosine protein kinase Blk 0.0048 0.1726 0.1786
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0054 0.2032 0.2134
Loa Loa (eye worm) hypothetical protein 0.0016 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0091 0.3779 0.3779
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0318 0.0318
Plasmodium falciparum cysteine repeat modular protein 3 0.0018 0.0304 0.0008
Toxoplasma gondii PAN domain-containing protein 0.0057 0.2164 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.1072 0.1072
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0018 0.0304 0.0008
Toxoplasma gondii aspartyl protease ASP1 0.0018 0.0303 0.1264
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0228 0.0459
Echinococcus multilocularis 0.0015 0.0178 0.013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0228 0.0183
Brugia malayi SRC-1 0.0053 0.196 0.196
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.196 0.2037
Echinococcus granulosus c src tyrosine kinase 0.0013 0.0098 0.0068
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0026 0.0725 0.5
Schistosoma mansoni tyrosine kinase 0.0013 0.0098 0.0198
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0228 0.0183
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.1072 0.1109
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.1072 0.1072
Echinococcus granulosus epidermal growth factor receptor 0.0054 0.2032 0.2134
Loa Loa (eye worm) hypothetical protein 0.0034 0.1072 0.1072
Brugia malayi nuclear receptor NHR-88 0.0016 0.0228 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.1072 0.1072
Schistosoma mansoni nuclear receptor 0.0016 0.0228 0.0459
Onchocerca volvulus 0.0016 0.0228 0.0422
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0083 0.3398 1
Schistosoma mansoni hypothetical protein 0.0014 0.0135 0.0271
Brugia malayi insulin-degrading enzyme 0.0027 0.0736 0.0736
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0034 0.1072 0.1072
Brugia malayi sulfakinin receptor protein 0.0091 0.3779 0.3779
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.1072 0.2157
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0053 0.196 0.2037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.1072 0.1072
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0053 0.196 0.2037
Onchocerca volvulus 0.0012 0.006 0.011
Schistosoma mansoni tyrosine kinase 0.0013 0.0098 0.0198
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.1072 0.1087
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0318 0.028
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0024 0.0615 0.296
Echinococcus granulosus tyrosine protein kinase Lyn 0.0053 0.196 0.2057
Echinococcus multilocularis fibrillin 1 0.0012 0.0059 0.0002
Giardia lamblia Prenyltransferase 0.0024 0.0615 0.5426
Loa Loa (eye worm) hypothetical protein 0.0034 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0037 0.1248 0.1248
Loa Loa (eye worm) hypothetical protein 0.003 0.0901 0.0901
Giardia lamblia CEGP1 protein 0.0018 0.0304 0.2454
Toxoplasma gondii GCC2 and GCC3 domain-containing protein 0.0018 0.0304 0.1268
Brugia malayi Fibulin-1 precursor 0.0012 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.1072 0.1109
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.1072 0.1087
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.1072 0.1072
Brugia malayi nuclear receptor NHR-88 0.0034 0.1072 0.1072
Plasmodium falciparum conserved protein, unknown function 0.0018 0.0304 0.0008
Loa Loa (eye worm) TK/EGFR protein kinase 0.0054 0.2032 0.2032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0318 0.0318
Echinococcus granulosus endonuclease reverse transcriptase 0.0018 0.0304 0.0288
Schistosoma mansoni nardilysin (M16 family) 0.0027 0.0736 0.148
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0048 0.1726 0.1806
Brugia malayi hypothetical protein 0.0016 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0018 0.0318 0.0318
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.1072 0.1986
Leishmania major farnesyltransferase beta subunit 0.0024 0.0615 0.4295
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0228 0.0183
Loa Loa (eye worm) hypothetical protein 0.0018 0.0318 0.0318
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0228 0.0183
Schistosoma mansoni hypothetical protein 0.0015 0.0187 0.0377
Brugia malayi nuclear hormone receptor 0.0034 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0034 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0034 0.1072 0.1072
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.1072 0.2157
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.1072 0.1087
Schistosoma mansoni hypothetical protein 0.003 0.0901 0.1814
Brugia malayi Protein kinase domain containing protein 0.0116 0.4971 0.4971
Brugia malayi GCC2 and GCC3 family protein 0.0018 0.0304 0.0304
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0318 0.064
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.1072 0.2157
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0304 0.0008
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0228 0.0228
Brugia malayi Calcium binding EGF domain containing protein 0.0012 0.0059 0.0059
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.1726 0.1786
Toxoplasma gondii calcium binding egf domain-containing protein 0.0012 0.0059 0.0117
Brugia malayi GCC2 and GCC3 family protein 0.0018 0.0304 0.0304
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0053 0.196 0.2057
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0024 0.0615 0.1006
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0318 0.0318
Echinococcus multilocularis Tolloid protein 1 0.0038 0.1288 0.1318
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0018 0.0305 0.0018
Echinococcus granulosus tyrosine protein kinase Src42A 0.0044 0.1576 0.1647
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0222 1 1
Brugia malayi hypothetical protein 0.0016 0.0228 0.0228
Schistosoma mansoni tyrosine kinase 0.0051 0.1883 0.3787
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0318 0.0318
Toxoplasma gondii PAN domain-containing protein 0.0057 0.2164 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0228 0.0422
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.1072 0.1087
Loa Loa (eye worm) DR-78 0.0016 0.0228 0.0228
Brugia malayi nuclear receptor RXR 0.0018 0.0318 0.0318
Echinococcus multilocularis tyrosine protein kinase Abl 0.0013 0.0098 0.0044
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0135 0.0135
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0125 0.5399 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.021 0.9398 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.1072 0.1072
Brugia malayi Tyrosine-protein kinase abl-1 0.0013 0.0098 0.0098
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0053 0.196 0.2037
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0024 0.0615 0.366
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.1072 0.1109
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.1072 0.1072
Schistosoma mansoni cathepsin D (A01 family) 0.0052 0.1919 0.3862
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0024 0.0615 0.0615
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0034 0.1092 0.6452
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0228 0.0228
Toxoplasma gondii RNA-directed DNA polymerase 0.0034 0.1092 0.4969
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0027 0.0736 0.148
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0012 0.0057 0.0025
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.1072 0.2157
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0135 0.0107
Loa Loa (eye worm) hypothetical protein 0.0037 0.1214 0.1214
Schistosoma mansoni tyrosine kinase 0.0051 0.1883 0.3787
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0024 0.0615 0.1006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.1072 0.1109
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.1072 0.1986
Echinococcus multilocularis epidermal growth factor receptor 0.0054 0.2032 0.2114
Schistosoma mansoni tyrosine kinase 0.0054 0.2032 0.4088
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.1072 0.2157
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0024 0.0615 0.0597
Trypanosoma cruzi peptidase, putative 0.0027 0.0736 0.1633
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0135 0.0135
Brugia malayi nuclear receptor NHR-67 0.0016 0.0228 0.0228
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0228 0.0228
Brugia malayi ecdysteroid receptor 0.0034 0.1072 0.1072
Plasmodium vivax telomerase reverse transcriptase, putative 0.0034 0.1092 0.7502
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0318 0.0304
Schistosoma mansoni tyrosine kinase 0.0054 0.2032 0.4088
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0038 0.1288 0.1288
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0018 0.0303 0.0288
Echinococcus multilocularis epidermal growth factor receptor 0.0054 0.2032 0.2114
Toxoplasma gondii hypothetical protein 0.0018 0.0304 0.1268
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.1072 0.1072
Schistosoma mansoni nuclear receptor 0.0016 0.0228 0.0459
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0228 0.0207
Loa Loa (eye worm) hypothetical protein 0.0014 0.0135 0.0135
Toxoplasma gondii insulysin, putative 0.0025 0.0674 0.3003
Brugia malayi latrophilin 2 splice variant baaae 0.003 0.0901 0.0901
Brugia malayi nuclear hormone receptor 0.0016 0.0228 0.0228
Brugia malayi nuclear receptor RXR 0.0016 0.0228 0.0228
Trypanosoma cruzi Replication factor A protein 1 0.004 0.1355 1
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0024 0.0615 0.062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.1072 0.1072
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.1072 0.1072
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.1072 0.1072
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0228 0.0422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.1072 0.1072
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.004 0.1355 0.6203
Loa Loa (eye worm) hypothetical protein 0.0034 0.1072 0.1072
Chlamydia trachomatis insulinase family protease III 0.0027 0.0736 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.1072 0.2157
Loa Loa (eye worm) TK/INSR protein kinase 0.0116 0.4971 0.4971
Toxoplasma gondii sporozoite developmental protein 0.0027 0.0736 0.3294
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0059
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.1072 0.1087
Schistosoma mansoni hypothetical protein 0.0014 0.0135 0.0271
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0024 0.0615 0.1006
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Onchocerca volvulus 0.0074 0.2959 0.5481
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0018 0.0303 0.0303
Brugia malayi replication factor A 73 kDa subunit 0.0083 0.3398 0.3398
Plasmodium falciparum replication protein A1, large subunit 0.004 0.1355 1
Schistosoma mansoni tyrosine kinase 0.0051 0.1883 0.3787
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.1072 0.1072
Toxoplasma gondii peptidase M16 inactive domain-containing protein 0.0016 0.0237 0.0954
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.0027 0.0736 0.3294
Brugia malayi hypothetical protein 0.0091 0.3779 0.3779
Trypanosoma cruzi lanosterol synthase, putative 0.0026 0.0725 0.1497
Trypanosoma brucei lanosterol synthase 0.0026 0.0725 0.4609
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0013 0.0098 0.0068
Echinococcus granulosus tyrosine protein kinase Src64B 0.0053 0.196 0.2057
Echinococcus multilocularis endonuclease reverse transcriptase 0.0018 0.0304 0.0265
Brugia malayi steroid hormone receptor 0.0034 0.1072 0.1072
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0228 0.0207
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0024 0.0615 0.2628
Brugia malayi Telomerase reverse transcriptase 0.0091 0.3781 0.3781
Brugia malayi ecdysone receptor 0.0016 0.0228 0.0228
Brugia malayi hypothetical protein 0.0018 0.0318 0.0318
Echinococcus granulosus FTZ F1 alpha 0.0034 0.1072 0.1109
Echinococcus multilocularis GPCR, family 2 0.0014 0.0135 0.0083
Echinococcus multilocularis nardilysin 0.0027 0.0736 0.0726
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0083 0.3398 0.3398
Loa Loa (eye worm) hypothetical protein 0.0044 0.1562 0.1562
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0304 0.0008
Schistosoma mansoni hypothetical protein 0.0014 0.0135 0.0271
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0024 0.0615 0.1237
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0021 0.046 0.2
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Onchocerca volvulus 0.0019 0.0353 0.0653
Echinococcus granulosus sodium channel protein 0.0012 0.0057 0.0025
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.1072 0.1087
Loa Loa (eye worm) insulin-degrading enzyme 0.0027 0.0736 0.0736
Leishmania major telomerase reverse transcriptase, putative 0.0034 0.1092 0.7976
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0053 0.196 0.2057
Schistosoma mansoni tyrosine kinase 0.0054 0.2032 0.4088
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0228 0.0207
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0024 0.0615 0.2726
Echinococcus granulosus GPCR family 2 0.0014 0.0135 0.0107
Schistosoma mansoni cathepsin D (A01 family) 0.0052 0.1919 0.3862
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0024 0.0615 0.1006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Loa Loa (eye worm) AStacin protease 0.0024 0.0608 0.0608
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0135 0.0083
Loa Loa (eye worm) hypothetical protein 0.0034 0.1072 0.1072
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.1072 0.1087
Echinococcus granulosus insulin receptor 0.0116 0.4971 0.5272
Loa Loa (eye worm) TK protein kinase 0.0048 0.1726 0.1726
Echinococcus multilocularis tyrosine protein kinase HCK 0.0042 0.1485 0.1529
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.1072 0.1087
Brugia malayi hypothetical protein 0.0018 0.0318 0.0318
Onchocerca volvulus 0.0019 0.0363 0.0673
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0119 0.5102 0.5412
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0024 0.0615 0.1006
Toxoplasma gondii calcium binding egf domain-containing protein 0.0012 0.0059 0.0117
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0303 0.061
Echinococcus granulosus ephrin type A receptor 4 A 0.0094 0.3939 0.417
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.196 0.2037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.1072 0.1109
Loa Loa (eye worm) hypothetical protein 0.0034 0.1072 0.1072
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0228 0.0459
Schistosoma mansoni coup transcription factor 0.0034 0.1072 0.2157
Schistosoma mansoni nuclear hormone receptor 0.0034 0.1072 0.2157
Schistosoma mansoni replication factor A 1 rfa1 0.0083 0.3398 0.6837
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0318 0.064
Echinococcus granulosus epidermal growth factor receptor 0.0054 0.2032 0.2134
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.196 0.2057
Echinococcus multilocularis laminin 0.0012 0.0059 0.0002
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0083 0.3398 0.3577
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0027 0.0736 0.148
Entamoeba histolytica replication factor A protein 1, putative 0.0036 0.1162 0.7259
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.1072 0.2157
Brugia malayi tailless protein 0.0016 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0412
Schistosoma mansoni tyrosine kinase 0.0116 0.4971 1
Schistosoma mansoni ephrin receptor 0.0077 0.3109 0.6255
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.1072 0.1072
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0024 0.0615 0.0615
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0034 0.1092 0.6452
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0044 0.1576 0.1626
Brugia malayi BRCA2 repeat family protein 0.0017 0.0267 0.0267
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0038 0.1288 0.2591
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0083 0.3398 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0018 0.0304 0.0008
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0053 0.196 0.2037
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Schistosoma mansoni tyrosine kinase 0.0053 0.196 0.3943
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0228 0.0228
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0135 0.0083
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0228 0.0207
Plasmodium falciparum cysteine repeat modular protein 2 0.0018 0.0304 0.0008
Plasmodium falciparum cysteine repeat modular protein 4 0.0018 0.0304 0.0008
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0079 0.3205 0.9375
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0228 0.0459
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.1072 0.1109
Loa Loa (eye worm) SRC-1 0.0053 0.196 0.196
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0074 0.2986 0.5531
Schistosoma mansoni nardilysin (M16 family) 0.0027 0.0736 0.148
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0228 0.0183
Echinococcus granulosus laminin 0.0012 0.0059 0.0027
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0012 0.0059 0.0059
Loa Loa (eye worm) TK protein kinase 0.0042 0.1485 0.1485
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0018 0.0303 0.0264
Echinococcus multilocularis insulin receptor 0.0116 0.4971 0.526
Brugia malayi GCC2 and GCC3 family protein 0.002 0.0412 0.0412
Schistosoma mansoni hypothetical protein 0.0018 0.0304 0.0612
Trypanosoma brucei peptidase, putative 0.0027 0.0736 0.4696
Giardia lamblia Telomerase catalytic subunit 0.0034 0.1092 1
Leishmania major phosphoglycan beta 1,3 galactosyltransferase 5 0.0027 0.0736 0.5227
Schistosoma mansoni tyrosine kinase 0.0053 0.196 0.3943
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.1072 0.1109
Echinococcus granulosus nardilysin 0.0027 0.0736 0.0749
Echinococcus granulosus tyrosine kinase 0.0048 0.1726 0.1806
Schistosoma mansoni hypothetical protein 0.0014 0.0135 0.0271
Echinococcus granulosus tyrosine protein kinase Src42A 0.0053 0.196 0.2057
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.1072 0.1986
Echinococcus granulosus insulin degrading enzyme 0.0027 0.0736 0.0749
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0228 0.0207
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.196 0.2057
Brugia malayi GCC2 and GCC3 family protein 0.0018 0.0304 0.0304
Schistosoma mansoni tyrosine kinase 0.0116 0.4971 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.196 0.2057
Echinococcus multilocularis c src tyrosine kinase 0.0013 0.0098 0.0044
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Echinococcus granulosus tyrosine protein kinase HCK 0.0042 0.1485 0.155
Schistosoma mansoni thyroid hormone receptor 0.0034 0.1072 0.2157
Echinococcus multilocularis ephrin type A receptor 4 A 0.0094 0.3939 0.4156
Schistosoma mansoni zinc finger protein 0.0016 0.0228 0.0459
Echinococcus multilocularis nardilysin 0.0027 0.0736 0.0726
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.1072 0.1109
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.1072 0.2157
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.1072 0.1072
Toxoplasma gondii kringle domain-containing protein 0.0018 0.0304 0.1268
Brugia malayi conserved hypotetical protein 0.0016 0.0228 0.0228
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0013 0.0098 0.0044
Plasmodium vivax cysteine repeat modular protein 3, putative 0.0018 0.0304 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.1072 0.1072
Loa Loa (eye worm) BRCA2 repeat family protein 0.0017 0.0267 0.0267
Plasmodium falciparum telomerase reverse transcriptase 0.0034 0.1092 0.7502
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.1072 0.1087
Echinococcus granulosus tm gpcr rhodopsin 0.021 0.9398 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0131 0.0131
Entamoeba histolytica protein kinase, putative 0.0042 0.1485 1
Leishmania major replication factor A, 51kDa subunit, putative 0.004 0.1355 1
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0228 0.0459
Echinococcus granulosus tyrosine protein kinase Blk 0.0048 0.1726 0.1806
Echinococcus multilocularis tyrosine protein kinase Srms 0.0048 0.1726 0.1786
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.1072 0.1072
Brugia malayi Calcitonin receptor-like protein seb-1 0.0044 0.1562 0.1562
Brugia malayi protein-tyrosine kinase 0.0048 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Loa Loa (eye worm) TK/EPH protein kinase 0.0097 0.4064 0.4064
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0053 0.196 0.2037
Loa Loa (eye worm) hypothetical protein 0.0074 0.2959 0.2959
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0083 0.3398 0.3593
Loa Loa (eye worm) hypothetical protein 0.0019 0.0353 0.0353
Plasmodium vivax cysteine repeat modular protein 2, putative 0.0018 0.0304 0.0008
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0018 0.0303 0.1264
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0024 0.0615 0.296
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0013 0.0098 0.0198
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0119 0.5102 0.54
Brugia malayi Protein kinase domain containing protein 0.0065 0.2562 0.2562
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Trypanosoma cruzi lanosterol synthase, putative 0.0026 0.0725 0.1497
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Brugia malayi Furin-like cysteine rich region family protein 0.0054 0.2032 0.2032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0228 0.0207
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0228 0.0228
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0228 0.0228
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0135 0.0107
Schistosoma mansoni insulysin (M16 family) 0.0015 0.0175 0.0353
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0228 0.0459
Loa Loa (eye worm) hypothetical protein 0.0018 0.0318 0.0318

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10 nM BindingDB_Patents: Receptor Binding Assay. Human monocytic cell line THP-1 cells were obtained from American Type Culture Collection (Manassas, Va., USA). The THP-1 cells were grown in RPMI-1640 (RPMI: Roswell Park Memorial Institute Medium-cell culture growth media) supplemented with 10% fetal bovine serum in a humidified 5% CO2 atmosphere at 37° C. The cell density was maintained between 0.5×106 cells/mL. ChEMBL. No reference
IC50 (binding) = 44 nM BindingDB_Patents: Receptor Binding Assay. Human monocytic cell line THP-1 cells were obtained from American Type Culture Collection (Manassas, Va., USA). The THP-1 cells were grown in RPMI-1640 (RPMI: Roswell Park Memorial Institute Medium-cell culture growth media) supplemented with 10% fetal bovine serum in a humidified 5% CO2 atmosphere at 37° C. The cell density was maintained between 0.5×106 cells/mL. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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