Detailed information for compound 19565

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 200.238 | Formula: C8H16N4O2
  • H donors: 2 H acceptors: 2 LogP: -0.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1NN(C(NN1C(=O)C)C)C(=O)C
  • InChi: 1S/C8H16N4O2/c1-5-9-12(8(4)14)6(2)10-11(5)7(3)13/h5-6,9-10H,1-4H3
  • InChiKey: AJNKAYNNVNLIDB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0003 0.0028
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0004 0.0053
Echinococcus multilocularis expressed conserved protein 0.0091 0.0877 0.0875
Plasmodium vivax importin-beta 2, putative 0.0028 0.0069 0.0257
Loa Loa (eye worm) hypothetical protein 0.0042 0.024 0.0656
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0032 0.0115 0.0432
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0004 0.0005
Brugia malayi TAR-binding protein 0.0063 0.0507 0.1867
Trypanosoma cruzi p450 reductase, putative 0.0084 0.0779 1
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0074 0.0657 0.843
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0003 0.0035
Leishmania major cysteine peptidase A (CPA) 0.0023 0.0003 0.0035
Plasmodium falciparum importin beta, putative 0.0028 0.0069 0.0257
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0084 0.0779 1
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0115 0.1203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Entamoeba histolytica hypothetical protein 0.0036 0.016 0.1678
Plasmodium vivax unspecified product 0.0225 0.2597 1
Echinococcus multilocularis methionine synthase reductase 0.0052 0.0368 0.0365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0084 0.0779 1
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0003 0.0035
Entamoeba histolytica hypothetical protein 0.0036 0.016 0.1678
Entamoeba histolytica cysteine proteinase 2 0.0023 0.0003 0.0028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0003 0.0035
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.3612 1
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.149 0.1487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0507 0.0596
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0004 0.5
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0234 0.2706 0.749
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0115 0.1203
Leishmania major cathepsin L-like protease 0.0023 0.0003 0.0035
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0069 0.0857
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0507 0.0596
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0084 0.0779 0.0917
Echinococcus multilocularis protein patched 0.0042 0.024 0.0237
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0507 0.0596
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.016 0.0186
Brugia malayi FAD binding domain containing protein 0.0084 0.0779 0.2872
Loa Loa (eye worm) FAD binding domain-containing protein 0.0052 0.0368 0.1011
Brugia malayi hypothetical protein 0.0036 0.016 0.0582
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.016 0.0157
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0507 0.0505
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0003 0.0028
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.0003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0028 0.0069 0.0184
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0032 0.0115 0.1472
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0507 0.1867
Giardia lamblia Nitric oxide synthase, inducible 0.0074 0.0657 0.5
Leishmania major cathepsin L-like protease 0.0023 0.0003 0.0035
Brugia malayi Importin beta-1 subunit 0.0028 0.0069 0.0246
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.1201 0.1198
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.024 0.0237
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.0003 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.0003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0099 0.0969 0.2678
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0115 0.0432
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0003 0.0035
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Toxoplasma gondii flavodoxin domain-containing protein 0.0042 0.0237 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0003 0.0035
Echinococcus multilocularis GPCR, family 2 0.0031 0.0104 0.0101
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0104 0.0119
Loa Loa (eye worm) hypothetical protein 0.0051 0.036 0.0991
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0969 0.3575
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0003 0.0028
Giardia lamblia Hypothetical protein 0.0074 0.0657 0.5
Echinococcus granulosus microtubule associated protein 2 0.0682 0.8466 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0023 0.0003 0.0035
Toxoplasma gondii flavodoxin domain-containing protein 0.0042 0.0237 1
Schistosoma mansoni hypothetical protein 0.004 0.022 0.0257
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0973 0.1146
Loa Loa (eye worm) hypothetical protein 0.0097 0.0953 0.2634
Trichomonas vaginalis sulfite reductase, putative 0.0084 0.0779 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0104 0.0119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0004 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Schistosoma mansoni hypothetical protein 0.004 0.022 0.0257
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Plasmodium vivax vivapain-1 0.0225 0.2597 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0023 0.0003 0.0028
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Schistosoma mansoni hypothetical protein 0.0031 0.0104 0.0119
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0004 0.5
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Schistosoma mansoni lipoxygenase 0.0081 0.075 0.0883
Entamoeba histolytica hypothetical protein 0.0036 0.016 0.1678
Schistosoma mansoni lipoxygenase 0.0117 0.1201 0.1416
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0032 0.0115 0.1472
Leishmania major cathepsin L-like protease 0.0023 0.0003 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Plasmodium vivax flavodoxin domain containing protein 0.0074 0.0657 0.2521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0104 0.028
Treponema pallidum flavodoxin 0.0032 0.0115 0.5
Trypanosoma cruzi cysteine protease, putative 0.0023 0.0003 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0004 0.0005
Leishmania major cytochrome P450 reductase, putative 0.0074 0.0657 0.843
Schistosoma mansoni survival motor neuron protein 0.0048 0.0316 0.037
Schistosoma mansoni cytochrome P450 reductase 0.0084 0.0779 0.0917
Onchocerca volvulus 0.0048 0.0316 1
Plasmodium vivax unspecified product 0.021 0.2405 0.9259
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2706 0.3194
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.8466 0.8465
Leishmania major hypothetical protein, conserved 0.0032 0.0115 0.1472
Plasmodium falciparum nitric oxide synthase, putative 0.0084 0.0779 0.2993
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.024 0.0656
Onchocerca volvulus 0.0023 0.0004 0.0046
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0115 0.1203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.028
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.8466 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0004 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.024 0.3075
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0032 0.0115 0.0432
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0003 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Plasmodium falciparum cysteine proteinase falcipain 1 0.0225 0.2597 1
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0003 0.0028
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0004 0.0053
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0104 0.0101
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0104 0.0374
Schistosoma mansoni hypothetical protein 0.0036 0.016 0.0186
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0084 0.0779 1
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0569 0.2093
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0003 0.0035
Leishmania major p450 reductase, putative 0.0084 0.0779 1
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.024 0.028
Leishmania major cathepsin L-like protease 0.0023 0.0003 0.0035
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0969 0.3575
Brugia malayi CHE-14 protein 0.0042 0.024 0.0876
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0032 0.0115 0.1472
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0953 0.1123
Schistosoma mansoni hypothetical protein 0.004 0.022 0.0257
Echinococcus granulosus tar DNA binding protein 0.0063 0.0507 0.0596
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0069 0.0857
Echinococcus granulosus methionine synthase reductase 0.0052 0.0368 0.0431
Echinococcus multilocularis protein dispatched 1 0.0048 0.0315 0.0313
Brugia malayi flavodoxin family protein 0.0032 0.0115 0.0414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0115 0.1203
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0084 0.0779 0.0917
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0084 0.0779 1
Chlamydia trachomatis sulfite reductase 0.0052 0.0368 0.5
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0084 0.0779 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Leishmania major cathepsin L-like protease 0.0023 0.0003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0004
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0507 0.1399
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0084 0.0779 1
Schistosoma mansoni hypothetical protein 0.0067 0.0569 0.0669
Brugia malayi RNA, U transporter 1 0.0081 0.0744 0.2744
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0003 0.0035
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0104 0.0101
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0084 0.0779 1
Schistosoma mansoni hypothetical protein 0.0031 0.0104 0.0119
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0003 0.0035
Brugia malayi hypothetical protein 0.0234 0.2706 1
Loa Loa (eye worm) flavodoxin family protein 0.0032 0.0115 0.031
Schistosoma mansoni patched 1 0.0042 0.024 0.028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0003 0.0035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0969 0.2678
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0032 0.0115 0.1472
Brugia malayi RNA binding protein 0.0063 0.0507 0.1867
Echinococcus granulosus expressed conserved protein 0.0091 0.0877 0.1034
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0507 0.0596
Leishmania major cathepsin L-like protease 0.0023 0.0003 0.0035
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0084 0.0779 0.2993
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0069 0.0067
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0003 0.0035
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0069 0.284
Leishmania major cathepsin L-like protease 0.0023 0.0003 0.0035
Leishmania major cathepsin L-like protease 0.0023 0.0003 0.0035
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2706 0.2704
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0507 0.0596
Loa Loa (eye worm) RNA binding protein 0.0063 0.0507 0.1399
Echinococcus granulosus importin subunit beta 1 0.0028 0.0069 0.0079
Echinococcus multilocularis snurportin 1 0.0304 0.3612 0.361
Loa Loa (eye worm) hypothetical protein 0.0067 0.0569 0.1568
Schistosoma mansoni hypothetical protein 0.004 0.022 0.0257
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0953 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0003 0.0035
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0084 0.0779 0.0777
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0032 0.0115 0.1472
Schistosoma mansoni hypothetical protein 0.0048 0.0316 0.037
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0084 0.0779 1
Schistosoma mansoni hypothetical protein 0.0304 0.3612 0.4265
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0507 0.1399
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0004
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0032 0.0115 0.1443
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0953 0.3517
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0953 0.0951
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0003 0.0035
Loa Loa (eye worm) FAD binding domain-containing protein 0.0084 0.0779 0.2151
Schistosoma mansoni hypothetical protein 0.0031 0.0104 0.0119
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.149 0.1757
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0115 0.1203
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0004
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0084 0.0779 1
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0052 0.0368 0.0431
Brugia malayi FAD binding domain containing protein 0.0052 0.0368 0.135
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0004 0.5
Schistosoma mansoni hypothetical protein 0.0031 0.0104 0.0119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0003 0.0035
Schistosoma mansoni NADPH flavin oxidoreductase 0.0042 0.0245 0.0287
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.1201 0.1416
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Entamoeba histolytica cysteine protease, putative 0.0023 0.0003 0.0028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0003 0.0035
Schistosoma mansoni diflavin oxidoreductase 0.0042 0.0237 0.0277
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0032 0.0115 0.1472
Loa Loa (eye worm) hypothetical protein 0.0084 0.0779 0.2151
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0003 0.0028
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0004 0.0005
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0084 0.0779 0.0777
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0004 0.0053
Entamoeba histolytica hypothetical protein 0.0036 0.016 0.1678
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0032 0.0115 0.1472
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.016 0.0186
Brugia malayi flavodoxin family protein 0.0084 0.0779 0.2872
Echinococcus granulosus Protein patched homolog 1 0.0042 0.024 0.028
Echinococcus granulosus GPCR family 2 0.0031 0.0104 0.0119
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0316 0.1157
Schistosoma mansoni importin beta-1 0.0028 0.0069 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0004 0.0044
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0104 0.0374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0003 0.0035
Echinococcus granulosus snurportin 1 0.0304 0.3612 0.4265
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0004 0.0044

Activities

Activity type Activity value Assay description Source Reference
Rate of inhibition (functional) = 0 % In vitro rate of inhibition of P388 tumor cell growth at 10E-7 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 0 % In vitro rate of inhibition of P388 tumor cell growth at 10E-8 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 0 % In vitro rate of inhibition of P388 tumor cell growth at 10E-7 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 0 % In vitro rate of inhibition of P388 tumor cell growth at 10E-8 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 0.1 % In vitro rate of inhibition of P388 tumor cell growth at 10E-5 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 0.1 % In vitro rate of inhibition of P388 tumor cell growth at 10E-5 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 3.2 % In vitro rate of inhibition of A-549 tumor cell growth at 10E-8 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 3.2 % In vitro rate of inhibition of A-549 tumor cell growth at 10E-8 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 3.6 % In vitro rate of inhibition of A-549 tumor cell growth at 10E-6 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 3.6 % In vitro rate of inhibition of A-549 tumor cell growth at 10E-6 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 4.3 % In vitro rate of inhibition of P388 tumor cell growth at 10E-6 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 4.3 % In vitro rate of inhibition of P388 tumor cell growth at 10E-6 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 6 % In vitro rate of inhibition of A-549 tumor cell growth at 10E-5 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 6 % In vitro rate of inhibition of A-549 tumor cell growth at 10E-5 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 7.4 % In vitro rate of inhibition of A-549 tumor cell growth at 10E-7 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 7.4 % In vitro rate of inhibition of A-549 tumor cell growth at 10E-7 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 14.5 % In vitro rate of inhibition of P388 tumor cell growth at 10E-4 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 14.5 % In vitro rate of inhibition of P388 tumor cell growth at 10E-4 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 68.5 % In vitro rate of inhibition of A-549 tumor cell growth at 10E-4 mol/L ChEMBL. 14980660
Rate of inhibition (functional) = 68.5 % In vitro rate of inhibition of A-549 tumor cell growth at 10E-4 mol/L ChEMBL. 14980660

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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