Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MDM2 proto-oncogene, E3 ubiquitin protein ligase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0676 | 1 | 0.5 |
Onchocerca volvulus | 0.048 | 0.6158 | 1 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0676 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.7019 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.048 | 0.6158 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.048 | 0.6158 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.048 | 0.6158 | 0.8773 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0196 | 0.0578 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0676 | 1 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0228 | 0.1218 | 0.1148 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0228 | 0.1218 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.2211 | 0.3149 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0196 | 0.0578 | 0.0939 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0676 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0196 | 0.0578 | 0.0824 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0355 | 0.3716 | 0.6035 |
Brugia malayi | hypothetical protein | 0.0228 | 0.1218 | 0.1979 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0676 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0196 | 0.0578 | 0.0939 |
Echinococcus multilocularis | thymidylate synthase | 0.048 | 0.6158 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0196 | 0.0578 | 0.0939 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.048 | 0.6158 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.3716 | 0.5294 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.048 | 0.6158 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0196 | 0.0578 | 0.0939 |
Schistosoma mansoni | dihydrofolate reductase | 0.0196 | 0.0578 | 0.0939 |
Brugia malayi | thymidylate synthase | 0.048 | 0.6158 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.048 | 0.6158 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.