Detailed information for compound 1959378

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.49 | Formula: C25H25FN4O2
  • H donors: 2 H acceptors: 3 LogP: 2.66 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@H](Cc1ccc(cc1F)c1ccc2c(c1)N(C)C(=O)C2)NC(=O)[C@H]1N[C@H]2C[C@@H]1CC2
  • InChi: 1S/C25H25FN4O2/c1-30-22-11-15(3-5-17(22)12-23(30)31)14-2-4-16(21(26)10-14)8-20(13-27)29-25(32)24-18-6-7-19(9-18)28-24/h2-5,10-11,18-20,24,28H,6-9,12H2,1H3,(H,29,32)/t18-,19+,20-,24-/m0/s1
  • InChiKey: MNEOBAAFLAQMKF-VKDGWMQASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva cathepsin C, putative Get druggable targets OG5_130494 All targets in OG5_130494
Cryptosporidium hominis preprocathepsin c precursor Get druggable targets OG5_130494 All targets in OG5_130494
Theileria parva cathepsin C, putative Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium vivax dipeptidyl aminopeptidase 2, putative Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium vivax dipeptidyl aminopeptidase 1, putative Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium berghei dipeptidyl aminopeptidase 1, putative Get druggable targets OG5_130494 All targets in OG5_130494
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium berghei dipeptidyl aminopeptidase 2 Get druggable targets OG5_130494 All targets in OG5_130494
Giardia lamblia Dipeptidyl-peptidase I precursor Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium yoelii cathepsin c precursor Get druggable targets OG5_130494 All targets in OG5_130494
Cryptosporidium parvum preprocathepsin c precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium yoelii Homo sapiens P3ECSL-related Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Get druggable targets OG5_130494 All targets in OG5_130494
Toxoplasma gondii preprocathepsin c precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Toxoplasma gondii cathepsin CPC1 Get druggable targets OG5_130494 All targets in OG5_130494
Babesia bovis cathepsin C precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Neospora caninum hypothetical protein Get druggable targets OG5_130494 All targets in OG5_130494
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) Get druggable targets OG5_130494 All targets in OG5_130494
Schistosoma japonicum Cathepsin C precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium falciparum dipeptidyl aminopeptidase 2 Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium falciparum dipeptidyl aminopeptidase 1 Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium knowlesi dipeptidyl aminopeptidase 2, putative Get druggable targets OG5_130494 All targets in OG5_130494
Schistosoma japonicum ko:K01275 cathepsin C [EC3.4.14.1], putative Get druggable targets OG5_130494 All targets in OG5_130494
Babesia bovis preprocathepsin c precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax dipeptidyl aminopeptidase 3, putative cathepsin C 141 aa 152 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0007 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0071
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0123 0.0087
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0099 0.0096
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0198 0.2483 1
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0076 0.0266
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0032 0.0339 0.0349
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0265 0.0258
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0115 0.141 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0063 0.074 0.0772
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0123 0.0467
Brugia malayi Death domain containing protein 0.0014 0.0098 0.0096
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0265 0.0271
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Brugia malayi hypothetical protein 0.0014 0.0102 0.01
Brugia malayi nuclear receptor NHR-88 0.0027 0.0265 0.0271
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0008 0.0029 0.0022
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0035 0.0378 0.039
Brugia malayi nuclear receptor NHR-67 0.0013 0.0082 0.0079
Schistosoma mansoni nuclear receptor 0.0013 0.0082 0.0079
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0082 0.0075
Giardia lamblia Dipeptidyl-peptidase I precursor 0.023 0.2902 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0123 0.5
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0082 0.0021
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.001 0.0003
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0035 0.0378 0.0371
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.001 0.0003
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0082 0.0079
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.02 0.2514 0.264
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.0963 0.0957
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0298 0.1005
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.001 0.0003
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0298 0.0306
Loa Loa (eye worm) hypothetical protein 0.0029 0.0298 0.0306
Echinococcus multilocularis survival motor neuron protein 1 0.0227 0.2859 0.2854
Leishmania major trypanothione reductase 0.0045 0.0507 0.2018
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0116 0.0115
Brugia malayi bZIP transcription factor family protein 0.0081 0.0963 0.1007
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0032 0.0339 0.0332
Brugia malayi hypothetical protein 0.0227 0.2859 0.3003
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0076 0.0279
Mycobacterium tuberculosis Probable reductase 0.0103 0.126 0.8933
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0.0082 0.0079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0265 0.0271
Loa Loa (eye worm) hypothetical protein 0.0026 0.0254 0.026
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0507 0.0526
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0298 0.0306
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0265 0.0673
Brugia malayi nuclear hormone receptor 0.0013 0.0082 0.0079
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0123 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0076 0.0266
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0029 0.0074
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0265 0.0271
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0271
Schistosoma mansoni microtubule-associated protein tau 0.0662 0.8498 0.8942
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0076 0.0266
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0102 0.01
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0739 0.9503 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Leishmania major cytochrome p450-like protein 0.0015 0.0116 0.044
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0409 0.0403
Brugia malayi hypothetical protein 0.0038 0.0409 0.0424
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0265 0.0673
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0265 0.0258
Mycobacterium tuberculosis Probable dehydrogenase 0.0103 0.126 0.8933
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.001 0.0003
Schistosoma mansoni DNA helicase recq1 0.0008 0.0029 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0123 0.0467
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0082 0.0021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0198 0.2483 0.8553
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0123 0.04
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0123 0.0467
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0103 0.126 0.8933
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0367 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0087 0.1051 0.3558
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0076 0.0279
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0116 0.044
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0079
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0254 0.026
Loa Loa (eye worm) DR-78 0.0013 0.0082 0.0079
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0079
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0123 0.0467
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0265 0.0258
Schistosoma mansoni zinc finger protein 0.0013 0.0082 0.0079
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0265 0.0673
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0032 0.0339 0.0349
Loa Loa (eye worm) hypothetical protein 0.0014 0.0102 0.01
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0082 0.0075
Plasmodium falciparum phosphodiesterase delta, putative 0.0032 0.0339 0.1079
Plasmodium falciparum glutathione reductase 0.0016 0.0123 0.0328
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0063 0.074 0.0772
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0739 0.9503 0.9502
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0123 0.0122
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0265 0.0271
Loa Loa (eye worm) hypothetical protein 0.001 0.0052 0.0047
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0152 0.043
Toxoplasma gondii preprocathepsin c precursor, putative 0.023 0.2902 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.000000000045153 0.00000000015724
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0394 0.0408
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0082 0.0075
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0079
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0082 0.0079
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0032 0.0339 0.1339
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.000000000045153 0.00000000015724
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0277 0.0284
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0032 0.0339 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0339 0.118
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0076 0.0073
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Echinococcus granulosus voltage gated potassium channel 0.001 0.0052 0.0047
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0045 0.0507 0.3564
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0007 0.001 0.0003
Plasmodium falciparum phosphodiesterase gamma, putative 0.0032 0.0339 0.1079
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0032 0.0339 0.0332
Onchocerca volvulus 0.0063 0.0739 0.2369
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0409 0.0424
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0007 0.001 0.0003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0265 0.0271
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0271
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.042 0.0435
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0079
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0063 0.074 0.2959
Loa Loa (eye worm) hypothetical protein 0.0227 0.2859 0.3003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0271
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.0835 0.0871
Schistosoma mansoni hypothetical protein 0.0065 0.0768 0.0801
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0265 0.0271
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.023 0.2902 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0265 0.0271
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0032 0.0339 0.1339
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0123 0.0428
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0032 0.0339 0.0332
Onchocerca volvulus 0.0035 0.0367 0.1038
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0063 0.074 0.2959
Onchocerca volvulus 0.0028 0.0276 0.0715
Schistosoma mansoni loxhd1 0.0038 0.0409 0.0424
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0265 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0265 0.0271
Echinococcus granulosus RUN 0.0038 0.0409 0.0424
Schistosoma mansoni hypothetical protein 0.0163 0.2026 0.2126
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0063 0.074 0.2959
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0076 0.0266
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0063 0.074 0.0772
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0032 0.0339 0.0332
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0116 0.0115
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.023 0.2902 1
Echinococcus granulosus dnaJ subfamily B 0.0392 0.5004 0.5262
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0063 0.074 0.2959
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.000000000045153 0.00000000015724
Brugia malayi PAS domain containing protein 0.0047 0.0524 0.0544
Loa Loa (eye worm) doublecortin family protein 0.0038 0.0409 0.0424
Echinococcus multilocularis lamin 0.0026 0.0254 0.0247
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0507 0.05
Schistosoma mansoni lipoxygenase 0.0166 0.2072 0.2174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0265 0.0271
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0076 0.0266
Schistosoma mansoni rab6-interacting 0.0038 0.0409 0.0424
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Brugia malayi Pre-SET motif family protein 0.0029 0.0298 0.0306
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0082 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0339 0.1339
Plasmodium vivax SET domain protein, putative 0.0029 0.0298 0.0712
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Echinococcus multilocularis geminin 0.0163 0.2026 0.202
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0082 0.0079
Loa Loa (eye worm) glutathione reductase 0.0045 0.0507 0.0526
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0032 0.0339 0.0349
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0032 0.0339 0.118
Loa Loa (eye worm) hypothetical protein 0.0014 0.0102 0.01
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0265 0.0271
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0265 0.0271
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0347 0.121
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Giardia lamblia Encystation-specific protease 0.0087 0.1051 0.3558
Schistosoma mansoni hypothetical protein 0.0163 0.2026 0.2126
Loa Loa (eye worm) hypothetical protein 0.0078 0.0934 0.0977
Leishmania major hypothetical protein, conserved 0.0032 0.0339 0.1339
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0079
Echinococcus multilocularis Polycystic kidney disease protein 0.0038 0.0409 0.0403
Echinococcus granulosus death domain containing protein 0.0014 0.0098 0.0096
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0076 0.0279
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0271
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.000000000045153 0.00000000015724
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0198 0.2483 0.2478
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.001 0.0003
Brugia malayi hypothetical protein 0.0013 0.0082 0.0079
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Echinococcus granulosus microtubule associated protein 2 0.0662 0.8498 0.8942
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0082 0.0079
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0032 0.0339 0.1339
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0265 0.0258
Brugia malayi hypoxia-induced factor 1 0.0144 0.1791 0.1879
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.001 0.0003
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0076 0.0266
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0076 0.0073
Loa Loa (eye worm) PDE1B protein 0.0739 0.9503 1
Echinococcus multilocularis bloom syndrome protein 0.002 0.0184 0.0177
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0123 0.0467
Schistosoma mansoni netrin receptor unc5 0.0014 0.0098 0.0096
Schistosoma mansoni jun-related protein 0.0065 0.0768 0.0801
Echinococcus multilocularis musashi 0.0026 0.0254 0.0247
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0032 0.0339 0.0349
Schistosoma mansoni intermediate filament proteins 0.0026 0.0254 0.026
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0035 0.0378 0.039
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0265 0.0271
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0032 0.0339 0.0349
Plasmodium vivax thioredoxin reductase, putative 0.0045 0.0507 0.1457
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0098 0.0096
Echinococcus granulosus survival motor neuron protein 1 0.0227 0.2859 0.3003
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0061 0.0217
Brugia malayi ecdysteroid receptor 0.0027 0.0265 0.0271
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0076 0.0266
Loa Loa (eye worm) hypothetical protein 0.0157 0.1948 0.2044
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0198 0.2483 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0123 0.0467
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0102 0.01
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0032 0.0339 0.0349
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.001 0.0003
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0098 0.0096
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0409 0.0424
Plasmodium vivax glutathione reductase, putative 0.0045 0.0507 0.1457
Schistosoma mansoni hypothetical protein 0.005 0.0562 0.0584
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.069 0.0719
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0184 0.0642
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0087 0.1051 0.3558
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0042 0.0037
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0082 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0052 0.0047
Schistosoma mansoni coup transcription factor 0.0027 0.0265 0.0271
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.001 0.0003
Echinococcus granulosus lamin 0.0026 0.0254 0.026
Schistosoma mansoni cpg binding protein 0.0029 0.0296 0.0305
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0082 0.0079
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0082 0.0079
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0061 0.0212
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0079
Mycobacterium leprae Possible regulatory protein 0.0012 0.0076 0.0493
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0079
Leishmania major protein kinase, putative 0.0012 0.0076 0.0279
Schistosoma mansoni nuclear receptor 0.0013 0.0082 0.0079
Brugia malayi intermediate filament protein 0.0026 0.0254 0.026
Loa Loa (eye worm) hypothetical protein 0.0031 0.0317 0.0326
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0032 0.0339 0.0349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0265 0.0271
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0265 0.0258
Onchocerca volvulus 0.0026 0.0254 0.0637
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0069 0.0065
Schistosoma mansoni lamin 0.0026 0.0254 0.026
Plasmodium vivax phosphodiesterase gamma, putative 0.0032 0.0339 0.0857
Loa Loa (eye worm) hypoxia-induced factor 1 0.0144 0.1791 0.1879
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.023 0.2902 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0116 0.0115
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0.0082 0.0079
Brugia malayi nuclear receptor RXR 0.0014 0.0102 0.01
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0032 0.0339 0.1339
Trypanosoma cruzi trypanothione reductase, putative 0.0045 0.0507 0.2018
Toxoplasma gondii cathepsin CPC1 0.023 0.2902 1
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0265 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0265 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0265 0.0271
Onchocerca volvulus 0.0029 0.0298 0.0793
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0008 0.0029 0.0023
Brugia malayi Thioredoxin reductase 0.0045 0.0507 0.0526
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0071
Schistosoma mansoni rab6-interacting 0.0038 0.0409 0.0424
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0739 0.9503 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.000000000045153 0.00000000015724
Mycobacterium tuberculosis Probable oxidoreductase 0.0115 0.141 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0265 0.0258
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0123 0.0467
Schistosoma mansoni hypothetical protein 0.0014 0.0098 0.0096
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.0835 0.0828
Brugia malayi Cyclic-nucleotide gated cation channel 0.0007 0.001 0.0003
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0032 0.0339 0.1339
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.023 0.2902 0.3049
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0032 0.0339 0.1339
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0265 0.0271
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0032 0.0339 0.0332
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Schistosoma mansoni cpg binding protein 0.0029 0.0296 0.0305
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0131 0.013
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0123 0.0825
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0184 0.0642
Loa Loa (eye worm) hypothetical protein 0.0014 0.0102 0.01
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0082 0.0079
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0369 0.125
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0265 0.0271
Brugia malayi hypothetical protein 0.0157 0.1948 0.2044
Loa Loa (eye worm) hypothetical protein 0.0014 0.0102 0.01
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0103 0.126 0.8933
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0032 0.0339 0.0349
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0367 0.0379
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0052 0.0045
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0035 0.0378 0.039
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0123 0.0122
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0007 0.001 0.0003
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0032 0.0339 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0339 0.118
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.0963 0.1007
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0265 0.0271
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0339 0.1339
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0079
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0007 0.001 0.0034
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0063 0.074 0.0772
Brugia malayi Cytochrome P450 family protein 0.0015 0.0116 0.0115
Toxoplasma gondii cathepsin CPC2 0.0087 0.1051 0.3606
Brugia malayi Cytochrome P450 family protein 0.0015 0.0116 0.0115
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0076 0.0266
Onchocerca volvulus 0.0038 0.0409 0.1191
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.1339
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0339 0.1339
Brugia malayi Pre-SET motif family protein 0.02 0.2514 0.264
Toxoplasma gondii thioredoxin reductase 0.0045 0.0507 0.1726
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0021 0.0014
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0082 0.0075
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0012 0.0081 0.0078
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0394 0.0387
Schistosoma mansoni DNA helicase recq5 0.0008 0.0029 0.0023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0102 0.01
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0052 0.0047
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.023 0.2902 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0166 0.2072 0.2066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0265 0.0271
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0022
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0076 0.0266
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0271
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.0857
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0265 0.0271
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0032 0.0339 0.0349
Loa Loa (eye worm) hypothetical protein 0.0032 0.0339 0.0349
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0265 0.0271
Echinococcus granulosus lamin dm0 0.0026 0.0254 0.026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.000000000045153 0.00000000015724
Brugia malayi CXXC zinc finger family protein 0.0028 0.0276 0.0283
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0254 0.026
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0265 0.0258
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0076 0.0279
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0079
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0129 0.0128
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0123 0.0328
Onchocerca volvulus 0.0013 0.0082 0.0021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0021 0.0015
Schistosoma mansoni hypothetical protein 0.0392 0.5004 0.5262
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0265 0.0271
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0265 0.0271
Loa Loa (eye worm) hypothetical protein 0.0038 0.0409 0.0424
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0123 0.0428
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0116 0.044
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.001 0.0003
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0347 0.121
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0076 0.0069
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0123 0.0467
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.001 0.0003
Plasmodium falciparum glutathione reductase 0.0045 0.0507 0.1664
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0248 0.0254
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0007 0.001 0.0034
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0265 0.0271
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0265 0.0271
Onchocerca volvulus 0.0026 0.0254 0.0637
Schistosoma mansoni lamin 0.0026 0.0254 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0298 0.0306
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0069 0.0065
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Treponema pallidum NADH oxidase 0.0016 0.0123 0.5
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0032 0.0339 0.0349
Loa Loa (eye worm) histone methyltransferase 0.001 0.0043 0.0038
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0021 0.0015
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0198 0.2483 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Schistosoma mansoni hypothetical protein 0.0046 0.0519 0.0539
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0265 0.0271
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0123 0.0467
Schistosoma mansoni polycystin 1-related 0.0038 0.0409 0.0424
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0123 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0123 0.3218
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.1079
Schistosoma mansoni hypothetical protein 0.0038 0.0409 0.0424
Loa Loa (eye worm) hypothetical protein 0.0012 0.0081 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0265 0.0271
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0032 0.0339 0.0349
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0061 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0265 0.0271
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0076 0.0073
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0198 0.2483 0.8506
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0123 0.0467
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0032 0.0339 0.0349
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0096 0.0308
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0061 0.0217
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0265 0.0258
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.000000000045153 0.00000000015724
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0123 0.0467
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0032 0.0339 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0265 0.0271
Leishmania major cAMP-specific phosphodiesterase, putative 0.0032 0.0339 0.1339
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0073
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0265 0.0258
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0298 0.0291
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0082 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0339 0.118
Loa Loa (eye worm) hypothetical protein 0.0014 0.0098 0.0096
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0032 0.0339 0.118
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0123 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0265 0.0271
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0032 0.0339 0.1079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0102 0.01
Leishmania major protein kinase, putative 0.0017 0.0137 0.0524
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0271
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0032 0.0339 0.1339
Plasmodium falciparum thioredoxin reductase 0.0016 0.0123 0.0328
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0043 0.0036
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0123 0.0328
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0123 0.0467
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0339 0.1339
Echinococcus granulosus single minded 2 0.0038 0.0409 0.0423
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Brugia malayi hypothetical protein 0.0038 0.0409 0.0424
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0076 0.0279
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0166 0.2072 0.2174
Trypanosoma brucei trypanothione reductase 0.0045 0.0507 0.2018
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0063 0.074 0.0733
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0198 0.2483 0.2608
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0103 0.126 0.8933
Echinococcus granulosus bloom syndrome protein 0.002 0.0184 0.0187
Echinococcus granulosus Polycystic kidney disease protein 0.0038 0.0409 0.0424
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.000000000045153 0.00000000015724
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0339 0.1339
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0102 0.01
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0012 0.0081 0.0074
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0115 0.141 1
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0098 0.0091
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0265 0.0271
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0254 0.026
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0123 0.0467
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.0857
Echinococcus multilocularis cpg binding protein 0.0029 0.0296 0.029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0298 0.0306
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0063 0.074 1
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0098 0.0096
Schistosoma mansoni cpg binding protein 0.0028 0.0276 0.0283
Echinococcus granulosus intermediate filament protein 0.0026 0.0254 0.026
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0184 0.0187
Brugia malayi nuclear receptor RXR 0.0013 0.0082 0.0079
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Onchocerca volvulus 0.0013 0.0082 0.0021
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0116 0.3029
Loa Loa (eye worm) hypothetical protein 0.0032 0.0339 0.0349
Onchocerca volvulus 0.0046 0.0519 0.1582
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0265 0.0271
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0265 0.0271
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0082 0.0079
Onchocerca volvulus 0.0228 0.2873 1
Brugia malayi Uncoordinated protein 44 0.0014 0.0098 0.0096
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0123 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0032 0.0339 0.1079
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0032 0.0339 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0265 0.0271
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0043 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0339 0.1339
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0098 0.0096
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0098 0.0091
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0102 0.01
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0123 0.3218
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0052 0.0047
Brugia malayi tailless protein 0.0013 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0032 0.0339 0.0349
Brugia malayi conserved hypotetical protein 0.0013 0.0082 0.0079
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0524 0.0544
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Loa Loa (eye worm) hypothetical protein 0.0008 0.0029 0.0023
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.1339
Leishmania major hypothetical protein, conserved 0.0032 0.0339 0.1339
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0265 0.0271
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0123 0.04
Giardia lamblia Hypothetical protein 0.0032 0.0339 0.1079
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0032 0.0339 0.0349
Trichomonas vaginalis set domain proteins, putative 0.0228 0.2872 1
Onchocerca volvulus 0.0027 0.0265 0.0673
Echinococcus multilocularis Ankyrin 0.0014 0.0099 0.0092
Echinococcus granulosus jun protein 0.0081 0.0963 0.1007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0099 0.0097
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0369 0.125
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0339 0.1339
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0265 0.0271
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0007 0.001 0.0003
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.001 0.0003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0298 0.0291
Loa Loa (eye worm) thioredoxin reductase 0.0045 0.0507 0.0526
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0082 0.0075
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0008 0.0029 0.0022
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0099 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0271
Echinococcus multilocularis RUN 0.0038 0.0409 0.0403
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0276 0.0283
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0082 0.0079
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0265 0.0271
Brugia malayi hypothetical protein 0.0063 0.0739 0.0771
Brugia malayi hypothetical protein 0.0013 0.0082 0.0079
Echinococcus granulosus geminin 0.0163 0.2026 0.2126
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0032 0.0339 0.0349
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0116 0.044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0123 0.0467
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.0003
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0052 0.0045
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0076 0.0279
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0032 0.0339 0.0349
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0032 0.0339 0.118
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0052 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0143 0.177 0.6165
Plasmodium vivax multidomain scavenger receptor, putative 0.0038 0.0409 0.1109
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Loa Loa (eye worm) RecQ helicase 0.002 0.0184 0.0187
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0079
Onchocerca volvulus 0.0038 0.0409 0.1191
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0102 0.01
Brugia malayi Doublecortin family protein 0.0038 0.0409 0.0424
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0339 0.1145
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0029 0.0074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0082 0.0079
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0032 0.0339 0.0349
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0409 0.0403
Plasmodium falciparum thioredoxin reductase 0.0045 0.0507 0.1664
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0123 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0265 0.0271
Echinococcus multilocularis dnaJ subfamily B 0.0392 0.5004 0.5
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0087 0.1051 0.3558
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0082 0.0075
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0021 0.0014
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0367 0.036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0079
Brugia malayi nuclear hormone receptor 0.0027 0.0265 0.0271
Echinococcus granulosus Ankyrin 0.0014 0.0099 0.0097
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0123 0.3218
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0099 0.0096
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0102 0.0095
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.1079
Schistosoma mansoni survival motor neuron protein 0.0046 0.0519 0.0539
Echinococcus multilocularis lamin dm0 0.0026 0.0254 0.0247
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0098 0.0096
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0609 0.2079
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0123 0.0116
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0029 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0265 0.0271
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0265 0.0271
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0076 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0076 0.0266
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0.0082 0.0079
Brugia malayi Protein kinase domain containing protein 0.0014 0.0098 0.0096
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0098 0.0077
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0082 0.0079
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0046 0.0519 0.0539
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0123 0.0467
Schistosoma mansoni lipoxygenase 0.0098 0.1189 0.1245
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0198 0.2483 0.8553
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0739 0.9503 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0032 0.0339 0.1079
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0032 0.0339 0.1339
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.001 0.0003
Brugia malayi steroid hormone receptor 0.0027 0.0265 0.0271
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0032 0.0339 0.0349
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0115 0.141 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0032 0.0339 0.1339
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0198 0.2483 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0032 0.0339 0.0349
Brugia malayi glutathione reductase 0.0045 0.0507 0.0526
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.001 0.0003
Plasmodium falciparum LCCL domain-containing protein 0.0038 0.0409 0.1325
Brugia malayi hypothetical protein 0.0014 0.0102 0.01
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0271
Giardia lamblia hypothetical protein 0.0032 0.0339 0.1079
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0103 0.126 0.8933
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0103 0.126 0.8933
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0265 0.0271
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0008 0.0029 0.0023
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.042 0.0435
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0082 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0076 0.0266
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0087 0.1051 0.3397
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0032 0.0339 0.0349
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0079
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0123 0.0122
Loa Loa (eye worm) hypothetical protein 0.0038 0.0409 0.0424
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0008 0.0029 0.0023
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0032 0.0339 0.118
Echinococcus multilocularis jun protein 0.0081 0.0963 0.0957
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0298 0.0306
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0079
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0021 0.0015
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0029 0.0023
Echinococcus granulosus cpg binding protein 0.0029 0.0296 0.0305
Loa Loa (eye worm) hypothetical protein 0.0032 0.0339 0.0349
Brugia malayi ecdysone receptor 0.0013 0.0082 0.0079
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0123 0.0467
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0082 0.0079
Schistosoma mansoni single-minded 0.0047 0.0524 0.0544
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0032 0.0339 0.118
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0076 0.0279
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0265 0.0271
Brugia malayi nuclear receptor NHR-88 0.0013 0.0082 0.0079
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0265 0.0271
Echinococcus multilocularis microtubule associated protein 2 0.0662 0.8498 0.8497

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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