Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0004 | 0 | 0.5 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 1.0801 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 1.0801 | 1 | 0.5 |
Brugia malayi | olfactory channel protein osm-9 | 0.0004 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20 nM | BindingDB_Patents: Activation Assay. The cDNA for human TRPV1 (hTRPV1) was isolated by reverse transcriptase-polymerase chain reaction (RT-PCR) from human small intestine poly A+ RNA supplied by Clontech (Palo Alto, Calif.) using primers designed surrounding the initiation and termination codons identical to the published sequences (Hayes et al. Pain 2000, 88, 205-215). The resulting cDNA PCR products were subcloned into pCIneo mammalian expression vector (Promega) and fully sequenced using fluorescent dye-terminator reagents (Prism, PerkinElmer Applied Biosystems Division) and a PerkinElmer Applied Biosystems Model 373 DNA sequencer or Model 310 genetic analyzer. Expression plasmids encoding the hTRPV1 cDNA were transfected into HEK293 cells using Lipofectamine. Forty-eight hours after transfection, the neomycin-resistant cells were selected with growth medium containing 800 ug/mL Geneticin (Life Technologies, formerly Gibco BRL). Surviving individual colonies were isolated and screened for TRPV1 activity. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.