Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetyl-CoA carboxylase beta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.0152 | 0.0152 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0893 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0893 | 1 | 1 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0101 | 0.0875 | 0.0734 |
Onchocerca volvulus | 0.0893 | 1 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0425 | 0.4604 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0893 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0893 | 1 | 1 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0101 | 0.0875 | 0.0734 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0063 | 0.0431 | 0.0282 |
Chlamydia trachomatis | biotin carboxylase | 0.0035 | 0.0111 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0893 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0893 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0893 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0425 | 0.4604 | 0.452 |
Echinococcus multilocularis | thymidylate synthase | 0.0893 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0893 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0893 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0893 | 1 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.0152 | 0.0152 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0101 | 0.0875 | 0.0734 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0893 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0425 | 0.4604 | 0.452 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0101 | 0.0875 | 0.0875 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0101 | 0.0875 | 0.0734 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0039 | 0.0152 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0893 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0425 | 0.4604 | 0.4113 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0101 | 0.0875 | 0.0734 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0101 | 0.0875 | 0.0734 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.