Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | endoplasmic reticulum to nucleus signaling 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0032 | 0.1447 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.5444 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0153 | 0.0153 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.5444 | 0.5444 |
Brugia malayi | RNA binding protein | 0.0072 | 0.5444 | 0.5444 |
Echinococcus multilocularis | musashi | 0.0032 | 0.1447 | 0.1314 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.4091 | 0.4091 |
Echinococcus multilocularis | lamin | 0.0032 | 0.1447 | 0.1314 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.4091 | 0.4091 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.5444 | 0.5374 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.2268 | 0.3997 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.1447 | 0.1314 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.2268 | 0.2268 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.5444 | 1 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.006 | 0.4277 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0118 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.5444 | 0.5444 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.1447 | 0.1447 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.139 | 0.139 |
Loa Loa (eye worm) | IRE protein kinase | 0.0118 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.5444 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0153 | 0.0153 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.5444 | 1 |
Schistosoma mansoni | lamin | 0.0032 | 0.1447 | 0.2445 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0153 | 0.0153 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.1447 | 0.1314 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4091 | 0.4091 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.5444 | 0.5374 |
Onchocerca volvulus | 0.0032 | 0.1447 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0072 | 0.5444 | 0.5444 |
Entamoeba histolytica | protein kinase, putative | 0.0118 | 1 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.1447 | 0.2445 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0118 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.5444 | 0.5444 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.1447 | 0.1447 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0061 | 0.4314 | 0.7863 |
Schistosoma mansoni | lamin | 0.0032 | 0.1447 | 0.2445 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1447 | 0.1447 |
Echinococcus granulosus | lamin | 0.0032 | 0.1447 | 0.1314 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.5444 | 0.5444 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.1447 | 0.1447 |
Entamoeba histolytica | protein kinase, putative | 0.0118 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.5444 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.1447 | 0.1447 |
Trichomonas vaginalis | conserved hypothetical protein | 0.006 | 0.4277 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.4091 | 0.4091 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2268 | 0.2268 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.1447 | 0.1314 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0153 | 0.0153 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 350 nM | BindingDB_Patents: In Vitro Enzyme Assays. IRE-1 alpha, T1 RNase, and RNase A assays carried out in vitro with several o-vanillin derivatives to demonstrate selectivity of the derivatives for IRE-1 alpha. T1 RNase was assayed as follows. Five ul of a reaction mixture comprising 1x reaction buffer (5x reaction buffer is 100 mM Hepes pH 7.5, 250 mM KOAc, 2.5 mM MgCl2), 3 mM DTT, and 0.4% polyethylene glycol water were added to each well of 384 well plates. Twenty-five nanoliters of a 1 mM test compound solution were added to test wells. Three ul of a 1/48,000 dilution of an approximately 200,000 U/ml RNase T1 (Worthington) preparation were added to each test well and to positive control wells (final concentration 49.5 pg/well). Negative control wells contained only reaction mixture and test compound. After spinning the plates at 1200 rpm for 30 seconds, 3 ul of the mini-XBP-1 mRNA stem-loop substrate described in Example 1 were added to each well of a control plate. | ChEMBL. | No reference |
IC50 (binding) | = 350 nM | BindingDB_Patents: In Vitro Enzyme Assays. IRE-1 alpha, T1 RNase, and RNase A assays carried out in vitro with several o-vanillin derivatives to demonstrate selectivity of the derivatives for IRE-1 alpha. T1 RNase was assayed as follows. Five ul of a reaction mixture comprising 1x reaction buffer (5x reaction buffer is 100 mM Hepes pH 7.5, 250 mM KOAc, 2.5 mM MgCl2), 3 mM DTT, and 0.4% polyethylene glycol water were added to each well of 384 well plates. Twenty-five nanoliters of a 1 mM test compound solution were added to test wells. Three ul of a 1/48,000 dilution of an approximately 200,000 U/ml RNase T1 (Worthington) preparation were added to each test well and to positive control wells (final concentration 49.5 pg/well). Negative control wells contained only reaction mixture and test compound. After spinning the plates at 1200 rpm for 30 seconds, 3 ul of the mini-XBP-1 mRNA stem-loop substrate described in Example 1 were added to each well of a control plate. | ChEMBL. | No reference |
IC50 (binding) | = 350 nM | In Vitro Enzyme Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.