Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | complement factor D (adipsin) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | complement factor D (adipsin) | 253 aa | 280 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | 0.0026 | 0.2513 | 0.3152 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0031 | 0.385 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2513 | 0.0644 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0026 | 0.2513 | 0.3152 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0026 | 0.2513 | 0.3152 |
Mycobacterium ulcerans | hydrolase | 0.0031 | 0.385 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.1998 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0026 | 0.2513 | 0.0006 |
Onchocerca volvulus | Matrilysin homolog | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0026 | 0.251 | 0.064 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2513 | 0.0644 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0026 | 0.2513 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2513 | 0.0644 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0026 | 0.2513 | 0.0006 |
Loa Loa (eye worm) | matrixin family protein | 0.0026 | 0.251 | 0.064 |
Schistosoma mansoni | thyroid hormone receptor | 0.0026 | 0.2513 | 0.0006 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0026 | 0.2513 | 0.3152 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.1998 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0026 | 0.2513 | 0.0006 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0026 | 0.2513 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2513 | 0.0644 |
Loa Loa (eye worm) | matrixin family protein | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.7975 | 0.747 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.7975 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.7975 | 0.7296 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.7975 | 0.7296 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0026 | 0.2513 | 0.3152 |
Onchocerca volvulus | 0.0026 | 0.2513 | 0.0004 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.1998 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0026 | 0.251 | 0.3147 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.1998 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0026 | 0.2513 | 0.0006 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0026 | 0.2513 | 0.3152 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0026 | 0.2513 | 0.0644 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.7975 | 1 |
Brugia malayi | Matrixin family protein | 0.0026 | 0.251 | 0.3147 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0026 | 0.2513 | 0.3152 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0026 | 0.2513 | 0.0644 |
Brugia malayi | nuclear hormone receptor | 0.0026 | 0.2513 | 0.3152 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0026 | 0.2513 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.251 | 0.064 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0026 | 0.2513 | 0.3152 |
Schistosoma mansoni | coup transcription factor | 0.0026 | 0.2513 | 0.0006 |
Brugia malayi | nuclear receptor NHR-88 | 0.0026 | 0.2513 | 0.3152 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0026 | 0.2513 | 0.0006 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0026 | 0.2513 | 0.0004 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.1998 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0026 | 0.2513 | 0.0006 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0026 | 0.2513 | 0.0006 |
Brugia malayi | Matrixin family protein | 0.0026 | 0.251 | 0.3147 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.385 | 0.2315 |
Brugia malayi | hypothetical protein | 0.0024 | 0.1998 | 0.2505 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.251 | 0.064 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0026 | 0.2513 | 0.0644 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0026 | 0.2513 | 0.3152 |
Schistosoma mansoni | nuclear hormone receptor | 0.0026 | 0.2513 | 0.0006 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0026 | 0.2513 | 0.0644 |
Brugia malayi | Matrixin family protein | 0.0026 | 0.251 | 0.3147 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0026 | 0.2513 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2513 | 0.0644 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.7975 | 0.7296 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0026 | 0.2513 | 0.0006 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0026 | 0.2513 | 0.3152 |
Brugia malayi | steroid hormone receptor | 0.0026 | 0.2513 | 0.3152 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.7975 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.1998 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0026 | 0.2513 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2513 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2513 | 0.0644 |
Brugia malayi | Matrixin family protein | 0.0026 | 0.251 | 0.3147 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0026 | 0.2513 | 0.0644 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0026 | 0.2513 | 0.3152 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0026 | 0.2513 | 0.3152 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0026 | 0.2513 | 0.3152 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0026 | 0.2513 | 0.3152 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0031 | 0.385 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.7975 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0031 | 0.385 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2513 | 0.0644 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0026 | 0.2513 | 0.0006 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.7975 | 0.7296 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0057 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0026 | 0.2513 | 0.0006 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.1998 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.251 | 0.064 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.1998 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0026 | 0.2513 | 0.0004 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0026 | 0.2513 | 0.0644 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0026 | 0.2513 | 0.3152 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1600 nM | BindingDB_Patents: In Vitro Assay. Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at various concentrations for 1 hour at room temperature in 0.1 M Hepes buffer, pH 7.5, containing 1 mM MgCl2, 1 M NaCl and 0.05% CHAPS. A synthetic substrate Z-Lys-thiobenzyl and 2,4-dinitrobenzenesulfonyl-fluoresceine are added to final concentrations of 200 µM and 25 µM, respectively. The increase in fluorescence is recorded at excitation of 485 nm and emission at 535 nm in a microplate spectrofluorimeter. IC50 values are calculated from percentage of inhibition of complement factor D-activity as a function of test compound concentration. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.