Detailed information for compound 1964048

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 318.414 | Formula: C17H26N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H](C1CCCCC1)Nc1nccc(n1)N1C(=O)OCC1(C)C
  • InChi: 1S/C17H26N4O2/c1-12(13-7-5-4-6-8-13)19-15-18-10-9-14(20-15)21-16(22)23-11-17(21,2)3/h9-10,12-13H,4-8,11H2,1-3H3,(H,18,19,20)/t12-/m0/s1
  • InChiKey: ZWIYUWPGWIYNMJ-LBPRGKRZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Fyn 0.075 0.1584 0.1572
Trichomonas vaginalis STE family protein kinase 0.0315 0.0394 0.0689
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0315 0.0394 0.046
Echinococcus granulosus tyrosine protein kinase Src42A 0.0463 0.0797 0.0784
Schistosoma mansoni tyrosine kinase 0.075 0.1584 0.2712
Loa Loa (eye worm) hypothetical protein 0.0381 0.0575 0.0608
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0677 0.1384 0.1372
Brugia malayi Temporarily assigned gene name protein 59 0.0331 0.0438 0.0459
Entamoeba histolytica protein kinase, putative 0.0223 0.0142 0.0253
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0223 0.0142 0.0221
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0242 0.0193 0.0217
Loa Loa (eye worm) hypothetical protein 0.0285 0.031 0.0321
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0446 0.0753 0.0895
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1085 0.2501 0.2491
Schistosoma mansoni serine/threonine protein kinase 0.0259 0.0241 0.0392
Leishmania major protein kinase A catalytic subunit isoform 2 0.0381 0.0575 0.2125
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.031 0.0381 0.0435
Echinococcus multilocularis neuroglian 0.0179 0.0022 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0307 0.0371 0.0615
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0298 0.0346 0.0847
Trypanosoma brucei SNF1-related protein kinases, putative 0.0298 0.0346 0.0372
Echinococcus granulosus tyrosine protein kinase Src64B 0.075 0.1584 0.1572
Trypanosoma cruzi casein kinase, putative 0.0367 0.0535 0.143
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0644 0.1293 0.1281
Trypanosoma cruzi casein kinase, putative 0.0367 0.0535 0.143
Entamoeba histolytica protein kinase, putative 0.054 0.1008 0.1793
Echinococcus granulosus STE20 serine:threonine protein kinase 0.1443 0.348 0.3471
Plasmodium falciparum cGMP-dependent protein kinase 0.0408 0.0647 0.175
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0381 0.0575 0.0679
Brugia malayi Serine/threonine-protein kinase SULU 0.066 0.1337 0.1434
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0234 0.0172 0.0158
Giardia lamblia Kinase, CMGC CLK 0.0397 0.0618 0.1354
Echinococcus granulosus serine:threonine protein kinase 0.035 0.0489 0.0475
Entamoeba histolytica protein kinase domain containing protein 0.0433 0.0717 0.1275
Toxoplasma gondii AGC kinase 0.0381 0.0575 0.0835
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.031 0.0381 0.0965
Echinococcus granulosus roundabout 2 0.0179 0.0022 0.0008
Brugia malayi Protein kinase domain containing protein 0.0715 0.1488 0.1598
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0336 0.0451 0.0801
Echinococcus multilocularis ephrin type A receptor 4 A 0.0401 0.0628 0.0744
Trichomonas vaginalis AGC family protein kinase 0.0223 0.0142 0.024
Loa Loa (eye worm) protein kinase domain-containing protein 0.0634 0.1266 0.1358
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.078 0.1667 0.1655
Giardia lamblia Kinase, NEK 0.0504 0.0912 0.2409
Trichomonas vaginalis CMGC family protein kinase 0.0307 0.0371 0.0647
Plasmodium vivax unspecified product 0.0369 0.054 0.1508
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.1626 0.3983 0.4305
Schistosoma mansoni tyrosine kinase 0.2291 0.5802 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.031 0.0381 0.0828
Loa Loa (eye worm) sex muscle abnormal protein 5 0.031 0.0381 0.0397
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.031 0.038 0.0953
Onchocerca volvulus 0.0229 0.0157 0.03
Onchocerca volvulus 0.0546 0.1025 0.2121
Trichomonas vaginalis CAMK family protein kinase 0.0351 0.0493 0.0865
Brugia malayi Egg laying defective protein 4 0.0408 0.0647 0.0686
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Schistosoma mansoni serine/threonine protein kinase 0.078 0.1667 0.2855
Loa Loa (eye worm) TK protein kinase 0.0982 0.222 0.2392
Schistosoma mansoni protein kinase 0.0367 0.0535 0.09
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0408 0.0647 0.0766
Schistosoma mansoni serine/threonine protein kinase 0.054 0.1008 0.1717
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0298 0.0346 0.1001
Entamoeba histolytica hypothetical protein 0.0452 0.0768 0.1366
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0907 0.2015 0.2003
Entamoeba histolytica protein kinase, putative 0.2118 0.5329 0.9474
Entamoeba histolytica protein kinase, putative 0.0292 0.033 0.0586
Onchocerca volvulus 0.0279 0.0294 0.0586
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0229 0.0157 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.042 0.0681 0.1152
Brugia malayi hypothetical protein 0.0183 0.0031 0.0018
Plasmodium vivax tyrosine kinase-like protein, putative 0.0253 0.0225 0.0432
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0223 0.0142 0.0221
Schistosoma mansoni serine/threonine protein kinase 0.0298 0.0346 0.0573
Echinococcus granulosus defective proboscis extension response 0.0298 0.0346 0.0332
Giardia lamblia Kinase, CDC7 0.0279 0.0294 0.0188
Schistosoma mansoni serine/threonine protein kinase 0.0452 0.0768 0.1302
Loa Loa (eye worm) hypothetical protein 0.0242 0.0192 0.0193
Loa Loa (eye worm) TK/FER protein kinase 0.1059 0.2429 0.2619
Echinococcus granulosus Protein kinase C brain isozyme 0.1262 0.2986 0.2976
Echinococcus granulosus calcium dependent protein kinase 0.0195 0.0066 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Trichomonas vaginalis CMGC family protein kinase 0.0279 0.0294 0.051
Brugia malayi Doublecortin family protein 0.0454 0.0774 0.0824
Echinococcus granulosus NDR protein kinase 0.0957 0.215 0.2139
Echinococcus granulosus tyrosine protein kinase Blk 0.0616 0.1218 0.1205
Loa Loa (eye worm) hypothetical protein 0.0183 0.0031 0.0018
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0439 0.0733 0.0779
Schistosoma mansoni serine/threonine protein kinase 0.0603 0.1182 0.2018
Echinococcus multilocularis epidermal growth factor receptor 0.2291 0.5802 0.7013
Echinococcus granulosus calcium activated potassium channel 0.0409 0.0651 0.0638
Plasmodium vivax casein kinase 1, putative 0.0367 0.0535 0.1493
Trypanosoma cruzi polo-like protein kinase, putative 0.0968 0.2179 0.6489
Schistosoma mansoni tyrosine kinase 0.1506 0.3653 0.6286
Onchocerca volvulus 0.0252 0.022 0.0432
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0307 0.0371 0.0924
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0258 0.0237 0.027
Echinococcus multilocularis mitogen activated protein kinase 0.0307 0.0371 0.0432
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0661 0.1341 0.1329
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Echinococcus granulosus serine:threonine kinase SAD 1 0.0298 0.0346 0.0332
Echinococcus granulosus serine:threonine protein kinase N2 0.133 0.3171 0.3161
Schistosoma mansoni tyrosine kinase 0.1506 0.3653 0.6286
Trichomonas vaginalis CAMK family protein kinase 0.031 0.0381 0.0665
Brugia malayi C1-like domain containing protein 0.075 0.1584 0.1703
Brugia malayi Protein kinase domain containing protein 0.0634 0.1266 0.1358
Echinococcus granulosus N chimaerin 0.0328 0.0428 0.0414
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0381 0.0575 0.0608
Giardia lamblia Kinase, CMGC CDK 0.0439 0.0733 0.1766
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0351 0.0493 0.0479
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0223 0.0142 0.0149
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1085 0.2501 0.3014
Echinococcus multilocularis 0.0461 0.0793 0.0943
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0252 0.022 0.0461
Schistosoma mansoni serine/threonine protein kinase 0.0258 0.0237 0.0385
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0381 0.0575 0.0679
Schistosoma mansoni serine/threonine protein kinase 0.0397 0.0618 0.1043
Brugia malayi cyclin-dependent kinase 7 homolog 0.0187 0.0042 0.003
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0437 0.0727 0.0714
Echinococcus multilocularis rho associated protein kinase 0.1217 0.2864 0.3452
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.031 0.0381 0.046
Trichomonas vaginalis CMGC family protein kinase 0.0307 0.0371 0.0647
Echinococcus multilocularis mitogen activated protein kinase 14 0.0591 0.1149 0.1375
Echinococcus granulosus tyrosine protein kinase Src42A 0.075 0.1584 0.1572
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0575 0.1105 0.1183
Echinococcus multilocularis casein kinase I gamma 0.0634 0.1266 0.1517
Loa Loa (eye worm) CAMK/PKD protein kinase 0.075 0.1584 0.1703
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0328 0.0428 0.0501
Plasmodium falciparum serine/threonine protein kinase KIN 0.0298 0.0346 0.0708
Echinococcus multilocularis 0.0282 0.0303 0.035
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.031 0.0381 0.0444
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0179 0.0022 0.0009
Entamoeba histolytica protein kinase, putative 0.0259 0.0241 0.0429
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.047 0.0817 0.1387
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0433 0.0717 0.0704
Brugia malayi serine/threonine-protein kinase PAK 7 0.0866 0.1903 0.2048
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0957 0.215 0.2588
Trichomonas vaginalis AGC family protein kinase 0.0298 0.0347 0.0605
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.031 0.038 0.0676
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0381 0.0575 0.0789
Echinococcus granulosus tyrosine protein kinase shark 0.0765 0.1626 0.1614
Echinococcus granulosus protein kinase c iota type 0.1421 0.3419 0.341
Brugia malayi MAP kinase sur-1 0.0307 0.0371 0.0386
Loa Loa (eye worm) hypothetical protein 0.0282 0.0303 0.0313
Trichomonas vaginalis CMGC family protein kinase 0.0439 0.0733 0.1292
Trichomonas vaginalis AGC family protein kinase 0.054 0.1008 0.1782
Echinococcus multilocularis serine:threonine protein kinase 0.035 0.0489 0.0575
Echinococcus granulosus expressed protein 0.0259 0.0241 0.0227
Entamoeba histolytica casein kinase, putative 0.0369 0.054 0.0959
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0397 0.0618 0.1686
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0315 0.0394 0.038
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0748 0.1579 0.1567
Loa Loa (eye worm) AUR protein kinase 0.054 0.1008 0.1078
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0307 0.0371 0.0924
Onchocerca volvulus 0.1217 0.2864 0.5982
Echinococcus granulosus cyclin dependent kinase 1 0.0439 0.0733 0.0719
Schistosoma mansoni protein kinase 0.1085 0.2501 0.4297
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.007 0.0096
Entamoeba histolytica protein kinase, putative 0.0298 0.0347 0.0617
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0331 0.0438 0.113
Schistosoma mansoni protein kinase 0.0792 0.1699 0.2911
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0439 0.0733 0.0779
Trypanosoma cruzi cdc2-related kinase 3 0.0439 0.0733 0.2038
Echinococcus granulosus contactin 0.0179 0.0022 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0468 0.0811 0.1431
Schistosoma mansoni serine/threonine protein kinase 0.0381 0.0575 0.0968
Schistosoma mansoni kinase 0.0937 0.2096 0.3596
Entamoeba histolytica protein kinase, putative 0.0233 0.017 0.0302
Entamoeba histolytica protein kinase, putative 0.0433 0.0717 0.1275
Schistosoma mansoni serine/threonine protein kinase 0.0408 0.0647 0.1092
Brugia malayi Protein kinase domain containing protein 0.0641 0.1287 0.138
Onchocerca volvulus 0.0367 0.0535 0.1093
Entamoeba histolytica protein kinase, putative 0.0259 0.0241 0.0429
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0328 0.0428 0.0448
Schistosoma mansoni serine/threonine protein kinase 0.0409 0.0651 0.11
Entamoeba histolytica p21-activated kinase 0.0423 0.069 0.1227
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0179 0.0022 0.0008
Brugia malayi Cam kinase protein 1 0.031 0.0381 0.0397
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0439 0.0733 0.2899
Brugia malayi STE20-like kinase MST 0.096 0.2158 0.2325
Schistosoma mansoni protein kinase 0.0275 0.0282 0.0463
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0748 0.1579 0.1896
Schistosoma mansoni protein kinase 0.0315 0.0394 0.0656
Trichomonas vaginalis AGC family protein kinase 0.0957 0.215 0.3815
Entamoeba histolytica hypothetical protein 0.0242 0.0193 0.0344
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0242 0.0193 0.0309
Loa Loa (eye worm) TK/FER protein kinase 0.0336 0.0451 0.0473
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0042 0.0048
Onchocerca volvulus 0.0279 0.0294 0.0586
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Brugia malayi Immunoglobulin I-set domain containing protein 0.0337 0.0452 0.0475
Trichomonas vaginalis CAMK family protein kinase 0.0968 0.2179 0.3867
Schistosoma mansoni serine/threonine protein kinase 0.0957 0.215 0.369
Echinococcus multilocularis serine:threonine protein kinase N2 0.0957 0.215 0.2588
Schistosoma mansoni serine/threonine protein kinase 0.0634 0.1266 0.2162
Trichomonas vaginalis AGC family protein kinase 0.1124 0.2607 0.4628
Entamoeba histolytica hypothetical protein 0.0223 0.0142 0.0253
Brugia malayi Protein kinase domain containing protein 0.1311 0.3119 0.3368
Schistosoma mansoni tyrosine kinase 0.0589 0.1142 0.1949
Leishmania major protein kinase, putative 0.054 0.1008 0.4252
Brugia malayi Protein kinase domain containing protein 0.1678 0.4124 0.4457
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.031 0.038 0.0953
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Brugia malayi Immunoglobulin I-set domain containing protein 0.0982 0.222 0.2392
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0223 0.0142 0.0221
Schistosoma mansoni serine/threonine kinase 0.0645 0.1298 0.2217
Brugia malayi Immunoglobulin I-set domain containing protein 0.0179 0.0022 0.0008
Echinococcus granulosus protein tyrosine kinase 0.1177 0.2753 0.2743
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.1274 0.3019 0.3259
Loa Loa (eye worm) hypothetical protein 0.0599 0.117 0.1254
Brugia malayi Protein kinase domain 0.0315 0.0394 0.0412
Brugia malayi Protein kinase domain containing protein 0.1016 0.2311 0.2491
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.031 0.0381 0.0397
Loa Loa (eye worm) hypothetical protein 0.0899 0.1993 0.2146
Schistosoma mansoni vesicular amine transporter 0.0298 0.0346 0.0572
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0603 0.1182 0.1267
Toxoplasma gondii CMGC kinase, CK2 family 0.0369 0.054 0.0767
Loa Loa (eye worm) hypothetical protein 0.0179 0.0022 0.0008
Brugia malayi Protein kinase domain containing protein 0.1747 0.4312 0.4661
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0295 0.0337 0.035
Entamoeba histolytica protein kinase domain containing protein 0.0452 0.0768 0.1366
Trichomonas vaginalis CMGC family protein kinase 0.0307 0.0371 0.0647
Schistosoma mansoni hypothetical protein 0.0294 0.0336 0.0555
Echinococcus granulosus protein kinase 0.0461 0.0793 0.0779
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0367 0.0535 0.0565
Echinococcus multilocularis protein kinase shaggy 0.0433 0.0717 0.0852
Trichomonas vaginalis AGC family protein kinase 0.1016 0.2311 0.4101
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.075 0.1584 0.1902
Loa Loa (eye worm) TK/INSR protein kinase 0.1678 0.4124 0.4457
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0439 0.0733 0.1139
Echinococcus multilocularis casein kinase I delta 0.0367 0.0535 0.0631
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0504 0.0912 0.278
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0367 0.0535 0.0565
Brugia malayi Stress-activated protein kinase jnk-1 0.0988 0.2235 0.2409
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0433 0.0717 0.0762
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0958 0.2154 0.2321
Trichomonas vaginalis CMGC family protein kinase 0.042 0.0681 0.12
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Echinococcus multilocularis casein kinase I alpha 0.0367 0.0535 0.0631
Plasmodium falciparum serine/threonine protein kinase 0.0259 0.0241 0.0343
Echinococcus granulosus titin 0.0229 0.0157 0.0143
Brugia malayi map kinase activated protein kinase protein 2 0.1478 0.3577 0.3864
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0331 0.0438 0.0424
Brugia malayi Furin-like cysteine rich region family protein 0.2291 0.5802 0.6278
Loa Loa (eye worm) hypothetical protein 0.0524 0.0964 0.103
Echinococcus multilocularis dual specificity 0.042 0.0681 0.0808
Brugia malayi Protein kinase domain containing protein 0.0336 0.0451 0.0473
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0259 0.0241 0.0486
Echinococcus multilocularis PAK box P21 Rho binding 0.0233 0.017 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Loa Loa (eye worm) hypothetical protein 0.0484 0.0856 0.0913
Entamoeba histolytica protein kinase domain containing protein 0.0433 0.0717 0.1275
Loa Loa (eye worm) hypothetical protein 0.0337 0.0453 0.0476
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0541 0.1011 0.4264
Onchocerca volvulus 0.0242 0.0192 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.0381 0.0575 0.0968
Schistosoma mansoni serine/threonine protein kinase 0.0661 0.1341 0.2293
Echinococcus granulosus CDC7 cell division cycle 7 0.0279 0.0294 0.028
Trichomonas vaginalis CAMK family protein kinase 0.0968 0.2179 0.3867
Trichomonas vaginalis CMGC family protein kinase 0.042 0.0681 0.12
Echinococcus multilocularis calcium activated potassium channel 0.0409 0.0651 0.0771
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0298 0.0346 0.036
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0492 0.0879 0.0938
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0381 0.0575 0.0679
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0328 0.0428 0.0714
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0957 0.215 0.2139
Trypanosoma cruzi NIMA-related kinase, putative 0.0223 0.0142 0.0221
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.054 0.1008 0.1204
Trichomonas vaginalis STE family protein kinase 0.031 0.038 0.0664
Echinococcus multilocularis tyrosine protein kinase Src42A 0.075 0.1584 0.1902
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Brugia malayi putative serine/threonine kinase SADA gamma 0.0298 0.0346 0.036
Trichomonas vaginalis CMGC family protein kinase 0.0279 0.0294 0.051
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.042 0.0681 0.0983
Leishmania major protein kinase, putative 0.0397 0.0618 0.2337
Schistosoma mansoni atypical protein kinase C 0.1444 0.3482 0.5992
Brugia malayi serine/threonine protein kinase 6 0.054 0.1008 0.1078
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.054 0.1008 0.1793
Schistosoma mansoni tyrosine kinase 0.1678 0.4124 0.7099
Echinococcus granulosus tyrosine kinase 0.0616 0.1218 0.1205
Giardia lamblia Kinase, NEK 0.0504 0.0912 0.2409
Brugia malayi SH2 domain containing protein 0.0336 0.0451 0.0473
Trichomonas vaginalis CMGC family protein kinase 0.0433 0.0717 0.1264
Echinococcus granulosus neuroglian 0.0372 0.0551 0.0537
Leishmania major protein kinase, putative 0.031 0.0381 0.1172
Echinococcus multilocularis roundabout 2 0.0179 0.0022 0.0009
Entamoeba histolytica protein kinase domain containing protein 0.0603 0.1182 0.2102
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0381 0.0575 0.1553
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0957 0.215 0.2139
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0298 0.0347 0.0361
Trypanosoma cruzi Protein kinase B 0.1385 0.3321 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.075 0.1584 0.1902
Loa Loa (eye worm) hypothetical protein 0.0524 0.0964 0.103
Echinococcus granulosus cyclin dependent kinase 5 0.0439 0.0733 0.0719
Giardia lamblia Kinase, STE STE20 0.0315 0.0394 0.055
Echinococcus granulosus fibroblast growth factor receptor 4 0.0907 0.2015 0.2003
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0988 0.2235 0.2409
Echinococcus granulosus nervana 2 0.1161 0.271 0.2699
Echinococcus granulosus dual specificity 0.042 0.0681 0.0668
Loa Loa (eye worm) TK/ROR protein kinase 0.0234 0.0172 0.0171
Echinococcus granulosus myotubularin protein 13 0.0259 0.024 0.0226
Loa Loa (eye worm) hypothetical protein 0.0337 0.0452 0.0475
Schistosoma mansoni protein kinase 0.054 0.1008 0.1717
Trichomonas vaginalis CMGC family protein kinase 0.0439 0.0733 0.1292
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.042 0.0681 0.1879
Giardia lamblia Kinase, AGC PKA 0.1276 0.3025 1
Trypanosoma cruzi casein kinase II, putative 0.0369 0.054 0.1444
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0298 0.0347 0.0403
Echinococcus multilocularis tyrosine protein kinase Src64B 0.075 0.1584 0.1902
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0292 0.033 0.0586
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1357 0.3245 0.3235
Loa Loa (eye worm) AGC/PKA protein kinase 0.0381 0.0575 0.0608
Onchocerca volvulus 0.0257 0.0234 0.046
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Trichomonas vaginalis AGC family protein kinase 0.2226 0.5625 1
Echinococcus granulosus dual specificity protein kinase clk2 0.0397 0.0618 0.0605
Loa Loa (eye worm) hypothetical protein 0.0298 0.0346 0.0359
Brugia malayi ephrin receptor 1 precursor 0.0273 0.0279 0.0287
Trypanosoma cruzi casein kinase, putative 0.0367 0.0535 0.143
Trypanosoma cruzi aurora B kinase, putative 0.054 0.1008 0.2886
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0258 0.0237 0.0223
Entamoeba histolytica protein kinase, putative 0.2226 0.5625 1
Schistosoma mansoni serine/threonine protein kinase 0.0408 0.0647 0.1092
Echinococcus granulosus serine:threonine protein kinase 12 B 0.054 0.1008 0.0995
Brugia malayi Protein kinase domain containing protein 0.0397 0.0618 0.0655
Trichomonas vaginalis CMGC family protein kinase 0.042 0.0681 0.12
Brugia malayi Kinase associated domain 1 family protein 0.0294 0.0336 0.0349
Loa Loa (eye worm) hypothetical protein 0.0743 0.1565 0.1682
Echinococcus granulosus serine threonine protein kinase nrc 0.1276 0.3025 0.3015
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0331 0.0438 0.0731
Brugia malayi Immunoglobulin I-set domain containing protein 0.0229 0.0157 0.0155
Entamoeba histolytica protein kinase, putative 0.0342 0.0466 0.0828
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0591 0.1149 0.3319
Echinococcus multilocularis casein kinase i 0.0367 0.0535 0.0631
Schistosoma mansoni protein kinase 0.0233 0.017 0.0269
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1478 0.3577 0.3864
Schistosoma mansoni serine/threonine protein kinase 0.0367 0.0535 0.09
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0223 0.0142 0.0221
Brugia malayi Protein kinase domain containing protein 0.0259 0.0241 0.0246
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0197 0.007 0.006
Plasmodium falciparum protein kinase, putative 0.0275 0.0282 0.0487
Leishmania major protein kinase, putative 0.031 0.038 0.1168
Entamoeba histolytica protein kinase, putative 0.042 0.0681 0.1211
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0363 0.0526 0.0512
Echinococcus granulosus Glutaredoxin protein 5 0.1161 0.271 0.2699
Loa Loa (eye worm) hypothetical protein 0.0337 0.0452 0.0475
Brugia malayi protein kinase C II. 0.1113 0.2576 0.2779
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0307 0.0371 0.0386
Onchocerca volvulus 0.0336 0.0451 0.0916
Echinococcus granulosus tyrosine protein kinase HCK 0.044 0.0734 0.0721
Loa Loa (eye worm) TK/FER protein kinase 0.0336 0.0451 0.0473
Loa Loa (eye worm) hypothetical protein 0.0298 0.0346 0.036
Brugia malayi cell division control protein 2 homolog 0.0439 0.0733 0.0779
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0259 0.0241 0.0181
Brugia malayi Immunoglobulin I-set domain containing protein 0.0179 0.0022 0.0008
Giardia lamblia Kinase, NEK 0.0504 0.0912 0.2409
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0275 0.0282 0.0256
Giardia lamblia Aurora kinase 0.054 0.1008 0.2756
Entamoeba histolytica PH domain containing protein kinase, putative 0.1385 0.3321 0.5904
Echinococcus granulosus roundabout 2 0.0179 0.0022 0.0008
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.031 0.0381 0.0397
Loa Loa (eye worm) thyroid receptor interactor 0.0352 0.0495 0.0521
Loa Loa (eye worm) TK/KIN16 protein kinase 0.2205 0.5567 0.6023
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0381 0.0575 0.1628
Echinococcus granulosus raf serine:threonine protein kinase 0.031 0.038 0.0367
Loa Loa (eye worm) hypothetical protein 0.031 0.0381 0.0397
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.031 0.038 0.0676
Plasmodium vivax calcium-dependent protein kinase, putative 0.031 0.0381 0.0965
Schistosoma mansoni tyrosine kinase 0.047 0.0817 0.1387
Echinococcus multilocularis casein kinase I delta 0.0367 0.0535 0.0631
Brugia malayi Protein kinase domain containing protein 0.0336 0.0451 0.0473
Echinococcus multilocularis dual specificity 0.042 0.0681 0.0808
Trichomonas vaginalis CMGC family protein kinase 0.0307 0.0371 0.0647
Entamoeba histolytica PH domain containing protein kinase, putative 0.0489 0.0871 0.1548
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0397 0.0618 0.1686
Echinococcus granulosus Vam6:Vps39 protein 0.0331 0.0438 0.0424
Brugia malayi phosphoinositide-dependent protein kinase I 0.0298 0.0347 0.0361
Plasmodium falciparum casein kinase 1 0.0367 0.0535 0.1364
Brugia malayi serine/threonine-protein kinase 6 0.054 0.1008 0.1078
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0307 0.0371 0.0417
Trichomonas vaginalis AGC family protein kinase 0.2226 0.5625 1
Echinococcus granulosus casein kinase I alpha 0.0367 0.0535 0.0522
Loa Loa (eye worm) hypothetical protein 0.0524 0.0964 0.103
Entamoeba histolytica PH domain containing protein kinase, putative 0.1385 0.3321 0.5904
Echinococcus granulosus epidermal growth factor receptor 0.1506 0.3653 0.3643
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.031 0.0381 0.0397
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0298 0.0346 0.0401
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0437 0.0727 0.0864
Echinococcus granulosus tyrosine protein kinase Lyn 0.0865 0.1899 0.1888
Schistosoma mansoni serine/threonine protein kinase 0.1274 0.3019 0.519
Entamoeba histolytica PH domain containing protein kinase, putative 0.0223 0.0142 0.0253
Entamoeba histolytica protein kinase, putative 0.0452 0.0768 0.1366
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0197 0.007 0.006
Echinococcus granulosus cyclin dependent kinase 0.0439 0.0733 0.0719
Plasmodium falciparum serine/threonine protein kinase, putative 0.054 0.1008 0.3005
Brugia malayi Temporarily assigned gene name protein 59 0.0487 0.0863 0.0921
Schistosoma mansoni nephrin 0.0411 0.0657 0.111
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.1161 0.271 0.2699
Echinococcus granulosus mitogen activated protein kinase 14 0.0591 0.1149 0.1136
Echinococcus multilocularis tyrosine protein kinase Fyn 0.075 0.1584 0.1902
Loa Loa (eye worm) AGC/NDR protein kinase 0.0957 0.215 0.2316
Onchocerca volvulus 0.0331 0.0438 0.0888
Schistosoma mansoni serine/threonine protein kinase 0.0644 0.1293 0.221
Trichomonas vaginalis CMGC family protein kinase 0.0369 0.054 0.0948
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.031 0.0381 0.0367
Loa Loa (eye worm) SRC-1 0.075 0.1584 0.1703
Trichomonas vaginalis STE family protein kinase 0.0315 0.0394 0.0689
Loa Loa (eye worm) hypothetical protein 0.0449 0.0759 0.0808
Echinococcus multilocularis cyclin dependent kinase 0.0439 0.0733 0.087
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.031 0.0381 0.0633
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.1747 0.4312 0.4661
Trichomonas vaginalis AGC family protein kinase 0.054 0.1008 0.1782
Schistosoma mansoni tyrosine kinase 0.1177 0.2753 0.4732
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0381 0.0575 0.0835
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0958 0.2154 0.2321
Echinococcus granulosus nervana 2 0.1161 0.271 0.2699
Loa Loa (eye worm) hypothetical protein 0.0331 0.0438 0.0459
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0742 0.1562 0.1679
Trichomonas vaginalis AGC family protein kinase 0.0504 0.0912 0.161
Brugia malayi Protein kinase domain containing protein 0.0701 0.145 0.1557
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Schistosoma mansoni tyrosine kinase 0.0762 0.1617 0.277
Loa Loa (eye worm) CDC7 protein kinase 0.0279 0.0294 0.0303
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0433 0.0717 0.1991
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0315 0.0394 0.046
Echinococcus multilocularis death associated protein kinase 1 0.3192 0.8267 1
Echinococcus granulosus mitogen activated protein kinase 11 0.0591 0.1149 0.1136
Loa Loa (eye worm) hypothetical protein 0.0484 0.0856 0.0913
Brugia malayi Tyrosine-protein kinase abl-1 0.0372 0.055 0.0581
Schistosoma mansoni protein kinase 0.1269 0.3004 0.5165
Schistosoma mansoni serine/threonine protein kinase 0.0412 0.0657 0.1111
Entamoeba histolytica PH domain containing protein kinase, putative 0.0489 0.0871 0.1548
Brugia malayi Pleckstrin Homology Domain 0.0259 0.024 0.0245
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0223 0.0142 0.0221
Echinococcus multilocularis myosin iiia 0.031 0.038 0.0443
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0282 0.0303 0.0527
Schistosoma mansoni tyrosine kinase 0.03 0.0352 0.0583
Echinococcus granulosus hypothetical protein 0.0282 0.0303 0.0289
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.1276 0.3025 1
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.1311 0.3119 0.3368
Loa Loa (eye worm) hypothetical protein 0.0675 0.1378 0.1479
Schistosoma mansoni serine/threonine protein kinase 0.0298 0.0346 0.0573
Echinococcus multilocularis expressed conserved protein 0.0408 0.0647 0.0766
Entamoeba histolytica protein kinase, putative 0.0223 0.0142 0.0253
Brugia malayi hypothetical protein 0.0331 0.0438 0.0459
Trypanosoma cruzi cdc2-related kinase 1 0.0439 0.0733 0.2038
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0367 0.0535 0.143
Brugia malayi Protein kinase domain containing protein 0.0336 0.0451 0.0473
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0315 0.0394 0.038
Trypanosoma brucei casein kinase I, isoform 2 0.0367 0.0535 0.0717
Trichomonas vaginalis STE family protein kinase 0.0315 0.0394 0.0689
Brugia malayi protein unc-22 0.0229 0.0157 0.0155
Plasmodium falciparum calcium-dependent protein kinase 3 0.031 0.0381 0.0828
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0315 0.0394 0.038
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0351 0.0493 0.058
Brugia malayi p70 ribosomal S6 kinase beta 0.2118 0.5329 0.5764
Giardia lamblia Kinase, CMGC GSK 0.0433 0.0717 0.1711
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0907 0.2015 0.2424
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.1276 0.3025 0.3015
Loa Loa (eye worm) TK protein kinase 0.0641 0.1287 0.138
Giardia lamblia Kinase, CMGC GSK 0.0433 0.0717 0.1711
Schistosoma mansoni protein kinase 0.1269 0.3004 0.5165
Trichomonas vaginalis CAMK family protein kinase 0.0468 0.0811 0.1431
Echinococcus multilocularis tyrosine protein kinase shark 0.0765 0.1626 0.1953
Brugia malayi RhoGAP domain containing protein 0.0328 0.0428 0.0448
Giardia lamblia Kinase, AGC AKT 0.0432 0.0715 0.1702
Schistosoma mansoni serine/threonine-protein kinase 0.1385 0.3321 0.5712
Schistosoma mansoni ephrin receptor 0.0198 0.0074 0.0102
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Echinococcus granulosus cGMP dependent protein kinase 0.0408 0.0647 0.0633
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Entamoeba histolytica protein kinase, putative 0.0258 0.0237 0.0422
Schistosoma mansoni cell adhesion molecule 0.0179 0.0022 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.031 0.0381 0.0633
Schistosoma mansoni neuroglian 0.0179 0.0022 0.0013
Entamoeba histolytica protein kinase, putative 0.044 0.0734 0.1305
Schistosoma mansoni tyrosine kinase 0.047 0.0817 0.1387
Echinococcus granulosus protein kinase c epsilon type 0.1113 0.2576 0.2566
Echinococcus granulosus serine:threonine protein kinase N2 0.0373 0.0552 0.0538
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0454 0.0774 0.0824
Schistosoma mansoni protein kinase 0.1269 0.3004 0.5165
Schistosoma mansoni serine/threonine protein kinase 0.0298 0.0346 0.0573
Echinococcus multilocularis aurora kinase A 0.054 0.1008 0.1204
Echinococcus granulosus serine:threonine protein kinase 0.035 0.0489 0.0475
Brugia malayi Hr1 repeat family protein 0.133 0.3171 0.3424
Entamoeba histolytica protein kinase domain containing protein 0.0275 0.0282 0.0502
Brugia malayi serine/threonine-protein kinase plk-2 0.0968 0.2179 0.2348
Trypanosoma cruzi rac serine-threonine kinase, putative 0.1276 0.3025 0.909
Brugia malayi protein kinase C3,putative 0.0579 0.1116 0.1195
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.031 0.0381 0.046
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1506 0.3653 0.3643
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0742 0.1562 0.1679
Schistosoma mansoni protein kinase 0.0861 0.1888 0.3237
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.078 0.1667 0.2002
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0381 0.0575 0.1501
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.2118 0.5329 0.5764
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Entamoeba histolytica casein kinase, putative 0.0367 0.0535 0.0951
Schistosoma mansoni serine/threonine protein kinase 0.019 0.0051 0.0063
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.031 0.0381 0.0367
Schistosoma mansoni tyrosine kinase 0.0278 0.0291 0.0478
Echinococcus multilocularis tyrosine protein kinase HCK 0.044 0.0734 0.0872
Echinococcus multilocularis c src tyrosine kinase 0.047 0.0817 0.0973
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.1274 0.3019 0.3009
Mycobacterium ulcerans hypothetical protein 0.0292 0.0331 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0275 0.0282 0.0653
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0307 0.0371 0.0924
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0861 0.1888 0.227
Schistosoma mansoni serine/threonine protein kinase 0.1262 0.2986 0.5134
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0433 0.0717 0.2823
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0988 0.2235 0.2691
Trichomonas vaginalis CAMK family protein kinase 0.0968 0.2179 0.3867
Brugia malayi casein kinase 1, delta 0.0367 0.0535 0.0565
Loa Loa (eye worm) TK/EGFR protein kinase 0.2291 0.5802 0.6278
Echinococcus multilocularis dual specificity 0.0452 0.0768 0.0913
Trichomonas vaginalis STE family protein kinase 0.0233 0.017 0.029
Brugia malayi Variant SH3 domain containing protein 0.031 0.0381 0.0397
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0307 0.0371 0.0924
Echinococcus granulosus NCK adaptor protein 0.031 0.0381 0.0367
Schistosoma mansoni serine/threonine protein kinase 0.1113 0.2576 0.4426
Loa Loa (eye worm) hypothetical protein 0.0298 0.0346 0.0359
Echinococcus multilocularis protein tyrosine kinase 0.1177 0.2753 0.3319
Echinococcus multilocularis epidermal growth factor receptor 0.1506 0.3653 0.4408
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0307 0.0371 0.1122
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0408 0.0647 0.0973
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0381 0.0575 0.1553
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0381 0.0575 0.1553
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0603 0.1182 0.1415
Brugia malayi Protein kinase domain containing protein 0.0336 0.0451 0.0473
Loa Loa (eye worm) TK/FER protein kinase 0.0336 0.0451 0.0473
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0968 0.2179 0.2168
Loa Loa (eye worm) CAMK protein kinase 0.0229 0.0157 0.0155
Loa Loa (eye worm) AGC/PKA protein kinase 0.0381 0.0575 0.0608
Brugia malayi SH2 domain containing protein 0.1059 0.2429 0.2619
Plasmodium falciparum casein kinase 2, alpha subunit 0.0369 0.054 0.1379
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0298 0.0346 0.0572
Echinococcus granulosus casein kinase i 0.0367 0.0535 0.0522
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0603 0.1182 0.1267
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.075 0.1584 0.1572
Loa Loa (eye worm) casein kinase 0.0519 0.0951 0.1016
Entamoeba histolytica protein kinase , putative 0.054 0.1008 0.1793
Loa Loa (eye worm) hypothetical protein 0.0299 0.0349 0.0363
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0259 0.0241 0.0526
Brugia malayi Protein kinase domain containing protein 0.0575 0.1105 0.1183
Schistosoma mansoni serine/threonine protein kinase 0.1262 0.2986 0.5134
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0223 0.0142 0.0221
Echinococcus granulosus tyrosine kinase 0.0336 0.0451 0.0437
Echinococcus multilocularis tyrosine protein kinase Blk 0.0616 0.1218 0.1458
Echinococcus multilocularis tyrosine protein kinase 0.0641 0.1287 0.1542
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0331 0.0438 0.0513
Loa Loa (eye worm) TK/FER protein kinase 0.0336 0.0451 0.0473
Loa Loa (eye worm) hypothetical protein 0.0337 0.0452 0.0475
Echinococcus granulosus serine:threonine protein kinase TAO1 0.066 0.1337 0.1324
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0381 0.0575 0.0789
Echinococcus granulosus ephrin type A receptor 4 A 0.0401 0.0628 0.0615
Echinococcus multilocularis serine threonine protein kinase 0.1111 0.2573 0.31
Echinococcus granulosus neuroglian 0.0179 0.0022 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Echinococcus multilocularis protein kinase c iota type 0.1421 0.3419 0.4126
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0275 0.0282 0.0271
Entamoeba histolytica serine/threonine protein kinase, putative 0.0298 0.0346 0.0615
Giardia lamblia Kinase, PLK 0.0968 0.2179 0.6963
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0907 0.2015 0.2424
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.042 0.0681 0.2646
Trypanosoma brucei protein kinase, putative 0.0307 0.0371 0.0417
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0381 0.0575 0.0679
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.1747 0.4312 0.4661
Loa Loa (eye worm) TK/ABL protein kinase 0.0939 0.2101 0.2263
Trichomonas vaginalis CMGC family protein kinase 0.0369 0.054 0.0948
Echinococcus granulosus tyrosine protein kinase ABL1 0.0939 0.2101 0.2089
Brugia malayi Variant SH3 domain containing protein 0.0289 0.0323 0.0335
Giardia lamblia Kinase, CMGC CDK 0.0439 0.0733 0.1766
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0968 0.2179 0.2348
Brugia malayi Tyrosine-protein kinase abl-1 0.07 0.1448 0.1555
Echinococcus granulosus aurora kinase A 0.054 0.1008 0.0995
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1478 0.3577 0.4317
Leishmania major protein kinase, putative 0.0397 0.0618 0.2337
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0179 0.0022 0.0009
Echinococcus granulosus rho-associated protein kinase 1 0.1217 0.2864 0.2853
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0242 0.0193 0.0179
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0187 0.0042 0.003
Leishmania major protein kinase, putative 0.0275 0.0282 0.0689
Brugia malayi Protein kinase domain containing protein 0.0452 0.0768 0.0818
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.1443 0.348 0.4199
Schistosoma mansoni serine/threonine protein kinase 0.0409 0.0651 0.11
Loa Loa (eye worm) hypothetical protein 0.0438 0.0731 0.0777
Entamoeba histolytica protein kinase, putative 0.031 0.0381 0.0677
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0298 0.0347 0.0361
Trichomonas vaginalis CAMK family protein kinase 0.0351 0.0493 0.0865
Schistosoma mansoni serine/threonine protein kinase 0.0298 0.0346 0.0573
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0452 0.0768 0.2147
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0381 0.0575 0.0561
Entamoeba histolytica protein kinase domain containing protein 0.054 0.1008 0.1793
Schistosoma mansoni serine/threonine protein kinase 0.0748 0.1579 0.2703
Schistosoma mansoni adapter molecule crk 0.031 0.0381 0.0633
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0369 0.054 0.057
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0591 0.1149 0.1837
Onchocerca volvulus 0.0524 0.0964 0.1994
Plasmodium falciparum calcium-dependent protein kinase 1 0.031 0.0381 0.0828
Plasmodium vivax serine/threonine kinase-1, putative 0.0397 0.0618 0.1776
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.031 0.0381 0.046
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.1016 0.2311 0.2491
Echinococcus multilocularis NCK adaptor protein 0.0316 0.0396 0.0463
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.042 0.0681 0.1039
Plasmodium falciparum calcium-dependent protein kinase 5 0.031 0.0381 0.0828
Trypanosoma brucei aurora B kinase 0.054 0.1008 0.158
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.1274 0.3019 0.364
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0591 0.1149 0.1231
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0968 0.2179 1
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Echinococcus granulosus casein kinase I alpha 0.0367 0.0535 0.0522
Echinococcus multilocularis tyrosine protein kinase Abl 0.07 0.1448 0.1737
Echinococcus granulosus cyclin dependent kinase 7 0.0187 0.0042 0.0028
Echinococcus multilocularis tyrosine protein kinase Fyn 0.075 0.1584 0.1902
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.007 0.0096
Schistosoma mansoni tyrosine kinase 0.075 0.1584 0.2712
Entamoeba histolytica protein kinase, putative 0.0258 0.0237 0.0422
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0258 0.0237 0.0223
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.1269 0.3004 0.3622
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.054 0.1008 0.1793
Brugia malayi Protein kinase domain containing protein 0.0298 0.0347 0.0361
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0179 0.0022 0.0009
Schistosoma mansoni tyrosine kinase 0.1678 0.4124 0.7099
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0591 0.1149 0.3319
Trichomonas vaginalis CK1 family protein kinase 0.0367 0.0535 0.094
Trichomonas vaginalis AGC family protein kinase 0.2226 0.5625 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0179 0.0022 0.0013
Trichomonas vaginalis CK1 family protein kinase 0.0367 0.0535 0.094
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0644 0.1293 0.155
Trypanosoma cruzi cdc2-related kinase 1 0.0439 0.0733 0.2038
Loa Loa (eye worm) TK/ALK protein kinase 0.084 0.183 0.1969
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0661 0.1341 0.144
Brugia malayi Protein kinase domain containing protein 0.0742 0.1562 0.1679
Trypanosoma cruzi polo-like protein kinase, putative 0.0968 0.2179 0.6489
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0433 0.0717 0.0762
Toxoplasma gondii AGC kinase 0.2118 0.5329 1
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0504 0.0912 0.1484
Echinococcus multilocularis N chimaerin 0.0328 0.0428 0.0501
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.0157 0.0247
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0298 0.0346 0.0849
Trichomonas vaginalis AGC family protein kinase 0.1016 0.2311 0.4101
Brugia malayi Protein kinase domain containing protein 0.035 0.0489 0.0514
Plasmodium falciparum protein serine/threonine kinase-1 0.0397 0.0618 0.1651
Entamoeba histolytica PH domain containing protein kinase, putative 0.0223 0.0142 0.0253
Echinococcus multilocularis expressed protein 0.0259 0.0241 0.0275
Trichomonas vaginalis AGC family protein kinase 0.2226 0.5625 1
Echinococcus multilocularis cyclin dependent kinase 7 0.0187 0.0042 0.0034
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.031 0.038 0.0434
Plasmodium vivax glycogen synthase kinase 3, putative 0.0433 0.0717 0.2115
Giardia lamblia Kinase, CMGC MAPK 0.0307 0.0371 0.0465
Brugia malayi Protein kinase domain containing protein 0.0439 0.0733 0.0779
Brugia malayi Variant SH3 domain containing protein 0.031 0.0381 0.0397
Echinococcus multilocularis 0.0655 0.1324 0.1587
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0492 0.0879 0.1047
Loa Loa (eye worm) AGC/AKT protein kinase 0.2226 0.5625 0.6085
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.027 0.0269 0.0276
Echinococcus multilocularis casein kinase I alpha 0.0367 0.0535 0.0631
Echinococcus granulosus casein kinase ii subunit alpha 0.0369 0.054 0.0526
Brugia malayi hypothetical protein 0.0336 0.0451 0.0473
Echinococcus multilocularis roundabout 2 0.0179 0.0022 0.0009
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0331 0.0438 0.113
Brugia malayi Protein kinase domain containing protein 0.1085 0.2501 0.2698
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0397 0.0618 0.1686
Schistosoma mansoni serine/threonine-protein kinase 0.1385 0.3321 0.5712
Brugia malayi Fibronectin type III domain containing protein 0.0337 0.0452 0.0475
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0298 0.0346 0.0372
Echinococcus granulosus casein kinase I gamma 0.0634 0.1266 0.1253
Entamoeba histolytica protein kinase domain containing protein 0.042 0.0681 0.1211
Schistosoma mansoni rap gtpase-activating protein 0.0331 0.0438 0.0731
Trypanosoma brucei cdc2-related kinase 1 0.0439 0.0733 0.1077
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.031 0.0381 0.0444
Plasmodium vivax protein kinase Crk2 0.0439 0.0733 0.2168
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Onchocerca volvulus 0.0433 0.0717 0.1476
Echinococcus multilocularis tyrosine protein kinase Srms 0.0616 0.1218 0.1458
Trichomonas vaginalis AGC family protein kinase 0.054 0.1008 0.1782
Brugia malayi Protein kinase domain containing protein 0.0957 0.215 0.2316
Echinococcus multilocularis rac serine:threonine kinase 0.1385 0.3321 0.4006
Entamoeba histolytica hypothetical protein 0.1093 0.2524 0.4488
Schistosoma mansoni serine/threonine protein kinase 0.0439 0.0733 0.1241
Plasmodium falciparum protein kinase 5 0.0439 0.0733 0.2049
Echinococcus multilocularis Immunoglobulin 0.0298 0.0346 0.0401
Brugia malayi Protein kinase domain containing protein 0.1747 0.4312 0.4661
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0328 0.0428 0.0414
Echinococcus multilocularis hypothetical protein 0.0294 0.0336 0.039
Loa Loa (eye worm) hypothetical protein 0.0542 0.1014 0.1084
Echinococcus multilocularis myotubularin protein 13 0.0259 0.024 0.0274
Loa Loa (eye worm) hypothetical protein 0.039 0.0598 0.0633
Echinococcus granulosus casein kinase I delta 0.0367 0.0535 0.0522
Onchocerca volvulus 0.1102 0.2548 0.532
Brugia malayi hypothetical protein 0.066 0.1337 0.1434
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0661 0.1341 0.1608
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.1113 0.2576 0.2779
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1717 0.423 0.4222
Echinococcus granulosus tyrosine protein kinase Fyn 0.075 0.1584 0.1572
Loa Loa (eye worm) TK/FAK protein kinase 0.1189 0.2786 0.3007
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0742 0.1562 0.1679
Echinococcus multilocularis titin 0.0229 0.0157 0.0173
Loa Loa (eye worm) hypothetical protein 0.0331 0.0438 0.0459
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0282 0.0303 0.0527
Schistosoma mansoni serine/threonine protein kinase 0.0439 0.0733 0.1241
Echinococcus multilocularis serine:threonine protein kinase N2 0.0373 0.0552 0.0652
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0452 0.0768 0.0818
Trichomonas vaginalis AGC family protein kinase 0.0223 0.0142 0.024
Schistosoma mansoni serine/threonine protein kinase 0.0754 0.1595 0.2731
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0042 0.0048
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0328 0.0428 0.0714
Echinococcus multilocularis CDC7 cell division cycle 7 0.0279 0.0294 0.0338
Toxoplasma gondii AGC kinase 0.0381 0.0575 0.0835
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0603 0.1182 0.117
Onchocerca volvulus Serine\/threonine kinase homolog 0.0492 0.0879 0.1815
Trypanosoma cruzi NIMA-related kinase, putative 0.0223 0.0142 0.0221
Schistosoma mansoni tyrosine kinase 0.0907 0.2015 0.3456
Schistosoma mansoni serine/threonine protein kinase 0.0381 0.0575 0.0968
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0452 0.0768 0.3073
Entamoeba histolytica protein kinase, putative 0.0315 0.0394 0.0701
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.075 0.1584 0.1703
Echinococcus multilocularis Immunoglobulin 0.0298 0.0346 0.0401
Echinococcus multilocularis tyrosine kinase 0.0336 0.0451 0.0529
Echinococcus granulosus twitchin 0.0488 0.0866 0.0853
Schistosoma mansoni growth factor receptor-bound protein 0.0316 0.0396 0.066
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0748 0.1579 0.1697
Brugia malayi intracellular kinase 0.0433 0.0717 0.0762
Echinococcus multilocularis Protein kinase C, brain isozyme 0.1262 0.2986 0.3601
Echinococcus multilocularis mitogen activated protein kinase 14 0.0591 0.1149 0.1375
Onchocerca volvulus 0.1682 0.4136 0.8654
Loa Loa (eye worm) AUR protein kinase 0.054 0.1008 0.1078
Echinococcus granulosus serine:threonine protein kinase 3 0.096 0.2158 0.2147
Loa Loa (eye worm) TK/FER protein kinase 0.0336 0.0451 0.0473
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0439 0.0733 0.0779
Echinococcus multilocularis cyclin dependent kinase 1 0.0439 0.0733 0.087
Trichomonas vaginalis CAMK family protein kinase 0.0968 0.2179 0.3867
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.031 0.0381 0.0444
Onchocerca volvulus 0.0743 0.1565 0.3256
Onchocerca volvulus 0.0336 0.0451 0.0916
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Toxoplasma gondii casein kinase I 0.0367 0.0535 0.0758
Schistosoma mansoni titin 0.0229 0.0157 0.0247
Trichomonas vaginalis CMGC family protein kinase 0.0369 0.054 0.0948
Loa Loa (eye worm) TK/FER protein kinase 0.0336 0.0451 0.0473
Brugia malayi Protein kinase domain containing protein 0.0645 0.1298 0.1392
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Entamoeba histolytica cell division protein kinase 2, putative 0.0439 0.0733 0.1303
Echinococcus multilocularis serine:threonine protein kinase 0.035 0.0489 0.0575
Loa Loa (eye worm) hypothetical protein 0.1747 0.4312 0.4661
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0492 0.0879 0.0866
Leishmania major casein kinase II, putative 0.0369 0.054 0.1952
Brugia malayi Protein kinase c protein 2 0.042 0.0682 0.0724
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0381 0.0575 0.0561
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0179 0.0022 0.0008
Entamoeba histolytica protein kinase, putative 0.0342 0.0466 0.0828
Trypanosoma brucei rac serine-threonine kinase, putative 0.2226 0.5625 1
Schistosoma mansoni serine/threonine protein kinase 0.1393 0.3343 0.5751
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0461 0.0793 0.0844
Entamoeba histolytica SH2 domain containing protein 0.0177 0.0014 0.0026
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.075 0.1584 0.1902
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0331 0.0438 0.0731
Toxoplasma gondii histone kinase SNF1, putative 0.0298 0.0346 0.0393
Giardia lamblia Kinase, CAMK CAMKL 0.0298 0.0346 0.0377
Leishmania major protein kinase A catalytic subunit isoform 1 0.0381 0.0575 0.2125
Brugia malayi Protein kinase domain containing protein 0.0336 0.0451 0.0473
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1478 0.3577 0.3568
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.054 0.1008 0.1793
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0331 0.0438 0.0539
Plasmodium vivax serine/threonine protein kinase 6, putative 0.054 0.1008 0.3109
Brugia malayi Fes/CIP4 homology domain containing protein 0.0352 0.0495 0.0521
Trichomonas vaginalis CMGC family protein kinase 0.042 0.0681 0.12
Echinococcus granulosus dual specificity 0.042 0.0681 0.0668
Trichomonas vaginalis CMGC family protein kinase 0.0397 0.0618 0.1088
Trichomonas vaginalis CAMK family protein kinase 0.0968 0.2179 0.3867
Trypanosoma brucei Casein kinase II 0.0369 0.054 0.0725
Echinococcus granulosus casein kinase I delta 0.0367 0.0535 0.0522
Schistosoma mansoni serine/threonine protein kinase 0.031 0.038 0.0632
Loa Loa (eye worm) hypothetical protein 0.0363 0.0526 0.0555
Echinococcus granulosus c-Jun N-terminal kinases 0.0988 0.2235 0.2224
Schistosoma mansoni serine/threonine protein kinase 0.0298 0.0347 0.0575
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0253 0.0225 0.0159
Echinococcus multilocularis mitogen activated protein kinase 11 0.0591 0.1149 0.1375
Plasmodium falciparum glycogen synthase kinase 3 0.0433 0.0717 0.1995
Brugia malayi Immunoglobulin I-set domain containing protein 0.2205 0.5567 0.6023
Trichomonas vaginalis STE family protein kinase 0.0504 0.0912 0.161
Schistosoma mansoni serine/threonine protein kinase 0.0409 0.0651 0.11
Echinococcus multilocularis cyclin dependent kinase 5 0.0439 0.0733 0.087
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0433 0.0717 0.1109
Echinococcus multilocularis calcium dependent protein kinase 0.0195 0.0066 0.0062
Trichomonas vaginalis CMGC family protein kinase 0.0433 0.0717 0.1264
Echinococcus multilocularis mitogen activated protein kinase 11 0.0591 0.1149 0.1375
Trypanosoma brucei protein kinase, putative 0.0275 0.0282 0.0256
Entamoeba histolytica protein kinase, putative 0.0315 0.0394 0.07
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0397 0.0618 0.0868
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0298 0.0346 0.0572
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.1161 0.271 0.3266
Plasmodium falciparum calcium-dependent protein kinase 4 0.031 0.0381 0.0828
Loa Loa (eye worm) hypothetical protein 0.0183 0.0031 0.0018
Echinococcus multilocularis cyclin dependent kinase 1 0.0439 0.0733 0.087
Echinococcus multilocularis twitchin 0.019 0.0051 0.0044
Brugia malayi SRC-1 0.075 0.1584 0.1703
Echinococcus granulosus insulin receptor 0.1678 0.4124 0.4115
Trichomonas vaginalis CK1 family protein kinase 0.0367 0.0535 0.094
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0307 0.0371 0.1122
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0861 0.1888 0.1876
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0397 0.0618 0.0655
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Echinococcus granulosus cGMP dependent protein kinase 1 0.0408 0.0647 0.0633
Loa Loa (eye worm) hypothetical protein 0.0331 0.0438 0.0459
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Onchocerca volvulus 0.0635 0.1269 0.2635
Schistosoma mansoni protein kinase 0.0575 0.1105 0.1884
Schistosoma mansoni tyrosine kinase 0.1346 0.3216 0.5532
Trichomonas vaginalis conserved hypothetical protein 0.02 0.0079 0.0128
Giardia lamblia Kinase, CMGC DYRK 0.042 0.0681 0.1581
Entamoeba histolytica hypothetical protein 0.0223 0.0142 0.0253
Schistosoma mansoni serine/threonine protein kinase 0.0968 0.2179 0.3741
Giardia lamblia Kinase, CK1 Casein kinase 0.0367 0.0535 0.1056
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0432 0.0715 0.076
Loa Loa (eye worm) hypothetical protein 0.031 0.0381 0.0397
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0452 0.0768 0.1142
Trichomonas vaginalis AGC family protein kinase 0.0298 0.0347 0.0605
Schistosoma mansoni serine/threonine protein kinase 0.1217 0.2864 0.4923
Trichomonas vaginalis AGC family protein kinase 0.0223 0.0142 0.024
Trypanosoma cruzi casein kinase, putative 0.0367 0.0535 0.143
Onchocerca volvulus 0.0336 0.0451 0.0916
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0968 0.2179 0.2623
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0253 0.0225 0.0286
Onchocerca volvulus 0.0484 0.0856 0.1767
Echinococcus multilocularis insulin receptor 0.1678 0.4124 0.4979
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0439 0.0733 0.2899
Schistosoma mansoni serine/threonine protein kinase 0.0988 0.2235 0.3836
Loa Loa (eye worm) hypothetical protein 0.0259 0.024 0.0245
Onchocerca volvulus 0.0336 0.0451 0.0916
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0446 0.0753 0.0739
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0298 0.0346 0.1001
Trichomonas vaginalis AGC family protein kinase 0.2226 0.5625 1
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0866 0.1903 0.2048
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0197 0.007 0.0112
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0397 0.0618 0.0868
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0742 0.1562 0.1875
Loa Loa (eye worm) hypothetical protein 0.0337 0.0453 0.0476
Echinococcus granulosus mitogen activated protein kinase 0.0307 0.0371 0.0357
Trichomonas vaginalis CMGC family protein kinase 0.0369 0.054 0.0948
Brugia malayi Protein kinase domain containing protein 0.0748 0.1579 0.1697
Echinococcus granulosus roundabout 2 0.0477 0.0837 0.0824
Brugia malayi casein kinase I 0.0367 0.0535 0.0565
Brugia malayi serine/threonine kinase 12 0.054 0.1008 0.1078
Schistosoma mansoni hypothetical protein 0.0331 0.0438 0.0731
Brugia malayi protein-tyrosine kinase 0.0616 0.1218 0.1305
Echinococcus granulosus tyrosine protein kinase Fyn 0.075 0.1584 0.1572
Giardia lamblia Kinase, STE STE20 0.031 0.038 0.0499
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0298 0.0346 0.0849
Echinococcus multilocularis serine:threonine protein kinase 3 0.096 0.2158 0.2598
Echinococcus multilocularis protein kinase c epsilon type 0.1113 0.2576 0.3104
Loa Loa (eye worm) TK protein kinase 0.044 0.0734 0.0781
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0645 0.1298 0.1392
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.042 0.0681 0.0723
Echinococcus multilocularis serine:threonine protein kinase N2 0.133 0.3171 0.3825
Echinococcus granulosus dual specificity 0.0452 0.0768 0.0755
Schistosoma mansoni serine/threonine protein kinase 0.066 0.1337 0.2284
Schistosoma mansoni vam6/vps39 related 0.0331 0.0438 0.0731
Entamoeba histolytica protein kinase 2, putative 0.1276 0.3025 0.5378
Trichomonas vaginalis AGC family protein kinase 0.0298 0.0347 0.0605
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0381 0.0575 0.1553
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Schistosoma mansoni tyrosine kinase 0.0765 0.1626 0.2784
Schistosoma mansoni hypothetical protein 0.0294 0.0336 0.0555
Echinococcus multilocularis neuroglian 0.0372 0.0551 0.065
Schistosoma mansoni serine/threonine protein kinase 0.0397 0.0618 0.1043
Schistosoma mansoni tyrosine kinase 0.1229 0.2894 0.4976
Brugia malayi probable protein kinase 0.0792 0.1699 0.1828
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.066 0.1337 0.1602
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0957 0.215 0.2588
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0367 0.0535 0.0565
Schistosoma mansoni nephrin 0.0179 0.0022 0.0013
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0644 0.1293 0.1281
Loa Loa (eye worm) TK protein kinase 0.0882 0.1945 0.2095
Trypanosoma cruzi casein kinase, putative 0.0367 0.0535 0.143
Brugia malayi Protein kinase domain containing protein 0.2226 0.5625 0.6085
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0408 0.0647 0.0766
Echinococcus granulosus c src tyrosine kinase 0.047 0.0817 0.0804
Trichomonas vaginalis STE family protein kinase 0.0315 0.0394 0.0689
Schistosoma mansoni protein kinase 0.0315 0.0394 0.0656
Brugia malayi Sex muscle abnormal protein 5 0.031 0.0381 0.0397
Trichomonas vaginalis CAMK family protein kinase 0.0298 0.0346 0.0603
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0397 0.0618 0.0918
Echinococcus multilocularis raf serine:threonine protein kinase 0.031 0.038 0.0444
Loa Loa (eye worm) hypothetical protein 0.0635 0.1269 0.1361
Loa Loa (eye worm) TK/EPH protein kinase 0.0467 0.081 0.0863
Echinococcus granulosus activin receptor type 0.0275 0.0282 0.0268
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1357 0.3245 0.3914
Schistosoma mansoni growth factor receptor-bound protein 0.031 0.0381 0.0633
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.09 0.1996 0.354
Echinococcus multilocularis nervana 2 0.1161 0.271 0.3266
Trichomonas vaginalis CAMK family protein kinase 0.035 0.0489 0.0857
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0266 0.026 0.0246
Trichomonas vaginalis CMGC family protein kinase 0.042 0.0681 0.12
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0616 0.1218 0.1205
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0179 0.0022 0.0009
Schistosoma mansoni protein kinase C mu 0.075 0.1584 0.2713
Loa Loa (eye worm) hypothetical protein 0.0482 0.0851 0.0907
Toxoplasma gondii aurora kinase 0.054 0.1008 0.167
Loa Loa (eye worm) TK/FER protein kinase 0.0336 0.0451 0.0473
Trichomonas vaginalis CMGC family protein kinase 0.042 0.0681 0.12
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0259 0.0241 0.0246
Schistosoma mansoni cell adhesion molecule 0.0402 0.0632 0.1067
Loa Loa (eye worm) hypothetical protein 0.0324 0.0418 0.0437
Schistosoma mansoni cell adhesion molecule 0.0179 0.0022 0.0013
Loa Loa (eye worm) hypothetical protein 0.1328 0.3165 0.3417
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Trichomonas vaginalis AGC family protein kinase 0.054 0.1008 0.1782
Echinococcus multilocularis dual specificity protein kinase clk2 0.0397 0.0618 0.0732
Echinococcus multilocularis growth factor receptor bound protein 2 0.031 0.0381 0.0444
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.3545 0.9234 1
Loa Loa (eye worm) TK/FER protein kinase 0.0336 0.0451 0.0473
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0452 0.0768 0.2147
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.042 0.0681 0.0723
Trichomonas vaginalis AGC family protein kinase 0.0381 0.0575 0.1011
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0381 0.0575 0.0789
Trichomonas vaginalis CMGC family protein kinase 0.0279 0.0294 0.051
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.075 0.1584 0.1902
Echinococcus granulosus growth factor receptor bound protein 2 0.0316 0.0396 0.0383
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0234 0.0172 0.0191
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0602 0.1178 0.1263
Brugia malayi Protein kinase domain containing protein 0.3545 0.9234 1
Loa Loa (eye worm) hypothetical protein 0.0899 0.1993 0.2146
Echinococcus multilocularis tyrosine protein kinase Fyn 0.075 0.1584 0.1902
Schistosoma mansoni ephrin receptor 0.0401 0.0628 0.1061
Echinococcus multilocularis roundabout 2 0.0477 0.0837 0.0997
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.1059 0.2429 0.2926
Loa Loa (eye worm) TK/FER protein kinase 0.0336 0.0451 0.0473
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0644 0.1293 0.155
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0616 0.1218 0.1458
Loa Loa (eye worm) hypothetical protein 0.0336 0.0451 0.0473
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0307 0.0371 0.0441
Brugia malayi Protein kinase domain containing protein 0.0546 0.1025 0.1096
Giardia lamblia Kinase, CAMK CAMKL 0.0298 0.0346 0.0377
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.0294 0.0482
Echinococcus granulosus tyrosine protein kinase 0.0641 0.1287 0.1274
Leishmania major casein kinase, putative 0.0367 0.0535 0.1929
Trichomonas vaginalis CMGC family protein kinase 0.0369 0.054 0.0948
Brugia malayi Protein kinase domain containing protein 0.1189 0.2786 0.3007
Echinococcus multilocularis nervana 2 0.1161 0.271 0.3266
Schistosoma mansoni tyrosine kinase 0.1346 0.3216 0.5532
Schistosoma mansoni serine/threonine protein kinase 0.0492 0.0879 0.1494
Echinococcus granulosus casein kinase I alpha 0.0367 0.0535 0.0522
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.1085 0.2501 0.2698
Trypanosoma brucei cdc2-related kinase 3 0.0439 0.0733 0.1077
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0258 0.0237 0.027
Plasmodium vivax serine/threonine protein kinase, putative 0.0259 0.0241 0.0488
Brugia malayi Immunoglobulin I-set domain containing protein 0.0179 0.0022 0.0008
Echinococcus granulosus titin 0.0229 0.0157 0.0143
Trichomonas vaginalis CMGC family protein kinase 0.0439 0.0733 0.1292
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1717 0.423 0.5108
Echinococcus granulosus cGMP dependent protein kinase 1 0.0408 0.0647 0.0633
Entamoeba histolytica casein kinase 1, putative 0.0367 0.0535 0.0951
Schistosoma mansoni serine/threonine protein kinase 0.0957 0.215 0.369
Onchocerca volvulus Tyrosine kinase homolog 0.1917 0.4777 1
Trypanosoma brucei protein kinase, putative 0.0433 0.0717 0.1049
Loa Loa (eye worm) hypothetical protein 0.0438 0.0731 0.0777
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0433 0.0717 0.1214
Onchocerca volvulus Serine\/threonine kinase homolog 0.0968 0.2179 0.4546
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.096 0.2158 0.2325
Echinococcus granulosus protein kinase shaggy 0.0433 0.0717 0.0704
Schistosoma mansoni serine/threonine kinase 0.0957 0.215 0.369
Schistosoma mansoni serine/threonine protein kinase 0.0644 0.1293 0.221
Entamoeba histolytica protein kinase, putative 0.0223 0.0142 0.0253
Brugia malayi Protein kinase domain containing protein 0.0279 0.0294 0.0303
Loa Loa (eye worm) hypothetical protein 0.0301 0.0354 0.0368
Brugia malayi hypothetical protein 0.0337 0.0452 0.0475
Echinococcus granulosus protein kinase C gamma type 0.1111 0.2573 0.2562
Trypanosoma cruzi rac serine-threonine kinase, putative 0.1385 0.3321 1
Giardia lamblia Kinase, AGC PKA 0.0381 0.0575 0.1199
Schistosoma mansoni protein kinase 0.0461 0.0793 0.1345
Schistosoma mansoni ste20-related kinase 0.0765 0.1624 0.2781
Trichomonas vaginalis CAMK family protein kinase 0.0968 0.2179 0.3867
Entamoeba histolytica protein kinase, putative 0.0452 0.0768 0.1366
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.1269 0.3004 0.2994
Loa Loa (eye worm) hypothetical protein 0.0294 0.0336 0.0349
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0939 0.2101 0.2528
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.031 0.0381 0.0965
Echinococcus granulosus epidermal growth factor receptor 0.2291 0.5802 0.5796
Schistosoma mansoni tyrosine kinase 0.1346 0.3216 0.5532
Schistosoma mansoni serine/threonine protein kinase 0.1478 0.3577 0.6155
Onchocerca volvulus 0.0336 0.0451 0.0916
Trichomonas vaginalis AGC family protein kinase 0.2226 0.5625 1
Echinococcus multilocularis serine:threonine protein kinase 38 0.0957 0.215 0.2588
Schistosoma mansoni serine/threonine protein kinase 0.133 0.3171 0.5454
Trichomonas vaginalis CAMK family protein kinase 0.0968 0.2179 0.3867
Onchocerca volvulus 0.0336 0.0451 0.0916
Trypanosoma cruzi cdc2-related kinase 3 0.0439 0.0733 0.2038
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0289 0.0323 0.0335
Entamoeba histolytica protein kinase, putative 0.2226 0.5625 1
Schistosoma mansoni nck2/grb4 0.031 0.0381 0.0633
Loa Loa (eye worm) variant SH3 domain-containing protein 0.031 0.0381 0.0397
Entamoeba histolytica serine/threonine protein kinase, putative 0.0968 0.2179 0.3875
Schistosoma mansoni vav2 0.0436 0.0724 0.1225
Trypanosoma brucei polo-like protein kinase 0.0968 0.2179 0.3716
Echinococcus multilocularis activin receptor type 0.0275 0.0282 0.0325
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0369 0.054 0.1508
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0298 0.0347 0.0333
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0591 0.1149 0.4943
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0433 0.0717 0.0852
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.066 0.1337 0.1434
Echinococcus multilocularis casein kinase I alpha 0.0367 0.0535 0.0631
Plasmodium falciparum NIMA related kinase 1 0.0504 0.0912 0.267
Loa Loa (eye worm) AGC/PKN protein kinase 0.133 0.3171 0.3424
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0197 0.007 0.006
Echinococcus granulosus dual specificity 0.042 0.0681 0.0668
Schistosoma mansoni serine/threonine protein kinase 0.0742 0.1562 0.2674
Leishmania major protein kinase A catalytic subunit 0.0381 0.0575 0.2125
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0599 0.1171 0.1255
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0259 0.0241 0.0191
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0223 0.0142 0.0221
Entamoeba histolytica protein kinase, putative 0.054 0.1008 0.1793
Brugia malayi P38 map kinase family protein 2 0.0591 0.1149 0.1231
Schistosoma mansoni protein kinase 0.0369 0.054 0.0908
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0315 0.0394 0.046
Schistosoma mansoni serine/threonine protein kinase 0.078 0.1667 0.2855
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.1276 0.3025 0.3648
Loa Loa (eye worm) TK protein kinase 0.0616 0.1218 0.1305
Brugia malayi Casein kinase II, alpha chain 0.0369 0.054 0.057
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.075 0.1584 0.1572
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0463 0.0797 0.0948
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0742 0.1562 0.3249
Echinococcus granulosus serine/threonine protein kinase 0.1385 0.3321 0.3311
Echinococcus granulosus tyrosine protein kinase Srms 0.1509 0.3661 0.3652
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.031 0.0381 0.0965
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.1276 0.3025 1
Brugia malayi Variant SH3 domain containing protein 0.0328 0.0428 0.0448
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0742 0.1562 0.155
Echinococcus granulosus mitogen activated protein kinase 3 0.0307 0.0371 0.0357
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0298 0.0346 0.0402
Loa Loa (eye worm) AGC/PKG protein kinase 0.0408 0.0647 0.0686
Entamoeba histolytica protein kinase, putative 0.0957 0.215 0.3822
Echinococcus multilocularis dual specificity 0.042 0.0681 0.0808
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.031 0.0381 0.0367
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0381 0.0575 0.0561
Brugia malayi Protein kinase domain containing protein 0.0492 0.0879 0.0938
Brugia malayi Protein kinase domain containing protein 0.084 0.183 0.197
Echinococcus granulosus Immunoglobulin 0.0298 0.0346 0.0332
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0397 0.0618 0.1686
Trichomonas vaginalis CMGC family protein kinase 0.0369 0.054 0.0948
Echinococcus multilocularis mitogen activated protein kinase 3 0.0307 0.0371 0.0432
Echinococcus multilocularis Glutaredoxin protein 5 0.1161 0.271 0.3266
Trichomonas vaginalis AGC family protein kinase 0.0282 0.0303 0.0527
Loa Loa (eye worm) hypothetical protein 0.02 0.0079 0.007
Entamoeba histolytica cell division protein kinase 2, putative 0.0439 0.0733 0.1303
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0275 0.0282 0.0653
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.035 0.0489 0.0514
Loa Loa (eye worm) IKK protein kinase 0.0546 0.1025 0.1096
Loa Loa (eye worm) hypothetical protein 0.035 0.0489 0.0514
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0661 0.1341 0.144
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0266 0.026 0.0297
Brugia malayi Protein kinase domain containing protein 0.0198 0.0074 0.0065
Trichomonas vaginalis AGC family protein kinase 0.2226 0.5625 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0439 0.0733 0.0719
Echinococcus granulosus tyrosine protein kinase Fps85D 0.1059 0.2429 0.2418
Trichomonas vaginalis CMGC family protein kinase 0.0369 0.054 0.0948
Echinococcus multilocularis casein kinase ii subunit alpha 0.0369 0.054 0.0637
Loa Loa (eye worm) AUR protein kinase 0.054 0.1008 0.1078
Loa Loa (eye worm) hypothetical protein 0.148 0.3583 0.3871
Trichomonas vaginalis CAMK family protein kinase 0.0645 0.1298 0.2298
Schistosoma mansoni protein kinase 0.0861 0.1888 0.3237
Loa Loa (eye worm) hypothetical protein 0.0677 0.1384 0.1486
Giardia lamblia Kinase, CMGC CK2 0.0369 0.054 0.1073
Entamoeba histolytica protein kinase domain containing protein 0.0369 0.054 0.0959
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0223 0.0142 0.0221

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 697 nM BindingDB_Patents: LC-MS Biochemical Assay. Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a product of the NADPH-dependent alpha-KG reduction reaction.More specifically, the biochemical reactions were performed at room temperature in 384-well Greiner flat-bottom plates (Costar, Cat. No. 781201) using a final reaction volume of 30 uL and the following assay buffer conditions: 50 mM HEPES pH 7.4, 10 mM MgCl2, 50 mM KCl, 1 mM DTT, 0.02% BSA, 5 uM NADPH and 100 uM alpha-KG.The final reaction mixture contained 3.3% DMSO and inhibitors with concentrations ranging 0.02-50 uM. The IDH1 enzyme was used at a final concentration of 0.25 nM. Following 45 minutes incubation, the reaction mixtures were quenched by the addition of 10 uL of 16% formic acid containing 800 nM of 5-carbon labeled 13C-2-HG). The protein was then precipitated by the addition of 2.5 volumes of acetonitrile followed by centrifugation (3000xg, 20 minutes). ChEMBL. No reference
IC50 (binding) = 697 nM BindingDB_Patents: LC-MS Biochemical Assay. Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a product of the NADPH-dependent alpha-KG reduction reaction.More specifically, the biochemical reactions were performed at room temperature in 384-well Greiner flat-bottom plates (Costar, Cat. No. 781201) using a final reaction volume of 30 uL and the following assay buffer conditions: 50 mM HEPES pH 7.4, 10 mM MgCl2, 50 mM KCl, 1 mM DTT, 0.02% BSA, 5 uM NADPH and 100 uM alpha-KG.The final reaction mixture contained 3.3% DMSO and inhibitors with concentrations ranging 0.02-50 uM. The IDH1 enzyme was used at a final concentration of 0.25 nM. Following 45 minutes incubation, the reaction mixtures were quenched by the addition of 10 uL of 16% formic acid containing 800 nM of 5-carbon labeled 13C-2-HG). The protein was then precipitated by the addition of 2.5 volumes of acetonitrile followed by centrifugation (3000xg, 20 minutes). ChEMBL. No reference
IC50 (binding) = 1140 nM BindingDB_Patents: Fluorescence Biochemical Assay. The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and a-ketoglutarate (a-KG) to form nicotinamide adenine dinucleotide phosphate (NADP+) and R (-)-2-hydroxyglutarate (2HG). The reaction can be monitored kinetically by following the oxidation of NADPH to NADP+ which is measured using fluorescence, excitation at 355 nm and emission at 530 nm. Reactions were monitored using the Perkin-Elmer Envision, Model 2101. More specifically, the biochemical reactions were performed at room temperature in 384-well Greiner flat-bottom plates (Cat. No. 781076) using a final reaction volume of 20 µL and the following assay buffer conditions: 50 mM HEPES pH 7.5, 10 mM MgCl2, 1 mM DTT, 0.02% BSA, 0.02% Tween-20, 10 µM NADPH and 100 µM a-KG. The final reaction mixture contained 2.5% DMSO and test compounds with concentrations ranging 0.0000008-25 µM. The IDH1 (R132H) enzyme was used at a final concentration of 10 nM. ChEMBL. No reference
IC50 (binding) = 1140 nM BindingDB_Patents: Fluorescence Biochemical Assay. The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and a-ketoglutarate (a-KG) to form nicotinamide adenine dinucleotide phosphate (NADP+) and R (-)-2-hydroxyglutarate (2HG). The reaction can be monitored kinetically by following the oxidation of NADPH to NADP+ which is measured using fluorescence, excitation at 355 nm and emission at 530 nm. Reactions were monitored using the Perkin-Elmer Envision, Model 2101. More specifically, the biochemical reactions were performed at room temperature in 384-well Greiner flat-bottom plates (Cat. No. 781076) using a final reaction volume of 20 µL and the following assay buffer conditions: 50 mM HEPES pH 7.5, 10 mM MgCl2, 1 mM DTT, 0.02% BSA, 0.02% Tween-20, 10 µM NADPH and 100 µM a-KG. The final reaction mixture contained 2.5% DMSO and test compounds with concentrations ranging 0.0000008-25 µM. The IDH1 (R132H) enzyme was used at a final concentration of 10 nM. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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