Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Homo sapiens | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0445 | 0.0555 | 0.0555 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3502 | 0.5616 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0195 | 0.0195 |
Echinococcus granulosus | dihydrofolate reductase | 0.6151 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3502 | 0.5616 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3502 | 0.5616 | 1 |
Brugia malayi | hypothetical protein | 0.0261 | 0.0251 | 0.0251 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3502 | 0.5616 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.0555 | 0.0555 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3502 | 0.5616 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0549 | 0.0728 | 0.0728 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0261 | 0.0251 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.6151 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0549 | 0.0728 | 0.0728 |
Schistosoma mansoni | dihydrofolate reductase | 0.6151 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.6151 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.6151 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.6151 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.6151 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3502 | 0.5616 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.6151 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 0.0555 | 0.0566 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0549 | 0.0728 | 0.0489 |
Onchocerca volvulus | 0.0549 | 0.0728 | 1 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0549 | 0.0728 | 0.0728 |
Echinococcus multilocularis | thymidylate synthase | 0.0549 | 0.0728 | 0.0728 |
Echinococcus granulosus | thymidylate synthase | 0.0549 | 0.0728 | 0.0728 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0109 | 0 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.6151 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 67 nM | Displacement of [3H]-BTCP (1-[1-(2-benxo[b]thienyl)cyclohexyl]piperidine) from rat forebrain dopamine transporter | ChEMBL. | 8098066 |
IC50 (binding) | = 67 nM | Displacement of [3H]-BTCP (1-[1-(2-benxo[b]thienyl)cyclohexyl]piperidine) from rat forebrain dopamine transporter | ChEMBL. | 8098066 |
IC50 (functional) | = 252 nM | Compound is evaluated for [3H]-dopamine uptake inhibition in rat forebrain | ChEMBL. | 8098066 |
IC50 (binding) | = 386 nM | Inhibition of [3H]-cocaine binding to rat forebrain dopamine receptor | ChEMBL. | 8098066 |
IC50 (binding) | = 386 nM | Inhibition of [3H]-cocaine binding to rat forebrain dopamine receptor | ChEMBL. | 8098066 |
Ki (binding) | = 2710 nM | Inhibition of [3H]-(+)-pentazocine binding to sigma receptor of guinea pig brain homogenates | ChEMBL. | 8098066 |
Ki (binding) | = 2710 nM | Inhibition of [3H]-(+)-pentazocine binding to sigma receptor of guinea pig brain homogenates | ChEMBL. | 8098066 |
Ki (binding) | > 10000 nM | Ability of compound to displace [3H]-TCP from rat brain homogenates | ChEMBL. | 8098066 |
Ki (binding) | > 10000 nM | Ability of compound to displace [3H]-TCP from rat brain homogenates | ChEMBL. | 8098066 |
Ratio (functional) | = 1.5 | Ratio of IC50 of [3H]-cocaine to that of dopamine | ChEMBL. | 8098066 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.