TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 389.836 | Formula: C18H20ClN5O3
H donors: 2 H acceptors: 3 LogP: 1.97 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1Nc1ncc(c(n1)NC)Cl)C(=O)N1CC2(C1)COC2
InChi: 1S/C18H20ClN5O3/c1-20-15-12(19)6-21-17(23-15)22-13-4-3-11(5-14(13)26-2)16(25)24-7-18(8-24)9-27-10-18/h3-6H,7-10H2,1-2H3,(H2,20,21,22,23)
InChiKey: BHJVCEUMPVQICF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	leucine-rich repeat kinase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	Get druggable targets OG5_131478	All targets in OG5_131478
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_131478	All targets in OG5_131478
Loa Loa (eye worm)	TKL/LRRK protein kinase	Get druggable targets OG5_131478	All targets in OG5_131478
Echinococcus granulosus	leucine rich repeat serine:threonine protein	Get druggable targets OG5_131478	All targets in OG5_131478

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.003	0.1102	0.1102
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.003	0.1102	0.1102
Echinococcus granulosus	proteasome subunit alpha type 6	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.003	0.1102	0.1102
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0245	1	1
Leishmania major	proteasome beta-1 subunit, putative	0.003	0.1102	0.1102
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.003	0.1102	0.1102
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.003	0.1102	0.1102
Plasmodium vivax	proteasome subunit beta type-1, putative	0.003	0.1102	0.1102
Trypanosoma brucei	proteasome beta 6 subunit	0.003	0.1102	0.1102
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.003	0.1102	0.1102
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.003	0.1102	0.1102
Leishmania major	proteasome alpha 7 subunit, putative	0.003	0.1102	0.1102
Brugia malayi	Protein kinase domain containing protein	0.007	0.2784	0.2784
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0245	1	1
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.003	0.1102	0.1102
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.003	0.1102	0.1102
Brugia malayi	Proteasome A-type and B-type family protein	0.017	0.6904	0.6904
Brugia malayi	20S proteasome alpha5 subunit	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.003	0.1102	0.1102
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.003	0.1102	0.1102
Onchocerca volvulus	Notchless protein homolog	0.003	0.1102	1
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0245	1	1
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.003	0.1102	0.1102
Echinococcus multilocularis	proteasome subunit alpha type 6	0.003	0.1102	0.1102
Leishmania major	proteasome alpha 1 subunit, putative	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.003	0.1102	0.1102
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.003	0.1102	0.1102
Toxoplasma gondii	proteasome subunit beta type, putative	0.0245	1	1
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.003	0.1102	0.1102
Leishmania major	proteasome alpha 1 subunit, putative	0.003	0.1102	0.1102
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.003	0.1102	0.1102
Echinococcus multilocularis	proteasome subunit beta type 6	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.003	0.1102	0.1102
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.003	0.1102	0.1102
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.003	0.1102	0.1102
Leishmania major	proteasome beta 2 subunit, putative	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.003	0.1102	0.1102
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.003	0.1102	0.1102
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.003	0.1102	0.1102
Mycobacterium ulcerans	proteasome PrcB	0.0245	1	1
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.003	0.1102	0.1102
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.003	0.1102	0.1102
Leishmania major	proteasome alpha 7 subunit, putative	0.003	0.1102	0.1102
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.003	0.1102	0.1102
Brugia malayi	Proteasome A-type and B-type family protein	0.003	0.1102	0.1102
Plasmodium vivax	proteasome subunit beta type-4, putative	0.003	0.1102	0.1102
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.003	0.1102	0.1102
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.003	0.1102	0.1102
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.003	0.1102	0.1102
Loa Loa (eye worm)	proteasome subunit beta type 2	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.003	0.1102	0.1102
Plasmodium vivax	proteasome subunit beta type-2, putative	0.003	0.1102	0.1102
Plasmodium falciparum	proteasome subunit beta type-5	0.0245	1	1
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.003	0.1102	0.1102
Brugia malayi	proteasome subunit alpha type 3	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.003	0.1102	0.1102
Loa Loa (eye worm)	proteasome subunit beta type 1	0.003	0.1102	0.1102
Loa Loa (eye worm)	proteasome subunit beta type 3	0.003	0.1102	0.1102
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.003	0.1102	0.1102
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.003	0.1102	0.1102
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0245	1	1
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0245	1	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.003	0.1102	0.1102
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.003	0.1102	0.1102
Echinococcus granulosus	Proteasome subunit alpha type 7	0.003	0.1102	0.1102
Trypanosoma brucei	proteasome beta 7 subunit	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0245	1	1
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.003	0.1102	0.1102
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.003	0.1102	0.1102
Plasmodium falciparum	proteasome subunit beta type-4	0.003	0.1102	0.1102
Brugia malayi	proteasome subunit beta type 2	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.003	0.1102	0.1102
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.003	0.1102	0.1102
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.003	0.1102	0.1102
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0245	1	1
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.003	0.1102	0.1102
Brugia malayi	proteasome subunit alpha type 6	0.003	0.1102	0.1102
Trypanosoma cruzi	20S proteasome subunit	0.003	0.1102	0.1102
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.003	0.1102	0.1102
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0071	0.2804	0.2804
Echinococcus multilocularis	proteasome subunit alpha type 2	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.003	0.1102	0.1102
Echinococcus granulosus	Proteasome subunit alpha beta	0.003	0.1102	0.1102
Echinococcus granulosus	proteasome prosome macropain	0.0245	1	1
Echinococcus granulosus	proteasome subunit beta type 6	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0245	1	1
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.003	0.1102	0.1102
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.003	0.1102	0.1102
Brugia malayi	proteasome subunit alpha type 4	0.003	0.1102	0.1102
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.003	0.1102	0.1102
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.003	0.1102	0.1102
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.003	0.1102	0.1102
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.003	0.1102	0.1102
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.003	0.1102	0.1102
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.003	0.1102	0.1102
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.003	0.1102	0.1102
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.003	0.1102	0.1102
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.003	0.1102	0.1102
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.003	0.1102	0.1102
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.003	0.1102	0.1102
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.003	0.1102	0.1102
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.003	0.1102	0.1102
Echinococcus granulosus	proteasome subunit beta t family	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.003	0.1102	0.1102
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.003	0.1102	0.1102
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.003	0.1102	0.1102
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.003	0.1102	0.1102
Echinococcus granulosus	20S proteasome subunit alpha 6	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.017	0.6904	0.6904
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.003	0.1102	0.1102
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.003	0.1102	0.5
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.003	0.1102	0.1102
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0245	1	1
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.003	0.1102	0.1102
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0245	1	1
Brugia malayi	proteasome subunit alpha type 2	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.003	0.1102	0.1102
Brugia malayi	Proteasome subunit alpha type 1	0.003	0.1102	0.1102
Leishmania major	proteasome beta 7 subunit, putative	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.003	0.1102	0.1102
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.003	0.1102	0.1102
Loa Loa (eye worm)	PAS-3 protein	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.003	0.1102	0.1102
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.003	0.1102	0.1102
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.007	0.2784	0.2784
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.003	0.1102	0.1102
Brugia malayi	proteasome subunit beta type 1	0.003	0.1102	0.1102
Leishmania major	proteasome beta 3 subunit, putative	0.003	0.1102	0.1102
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.003	0.1102	0.1102
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.003	0.1102	0.1102
Plasmodium vivax	proteasome subunit beta type-6, putative	0.003	0.1102	0.1102
Brugia malayi	proteasome subunit alpha type 1	0.003	0.1102	0.1102
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.003	0.1102	0.1102
Trypanosoma brucei	proteasome alpha 7 subunit	0.003	0.1102	0.1102
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.003	0.1102	0.1102
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.003	0.1102	0.1102
Echinococcus granulosus	proteasome subunit beta type 7	0.017	0.6904	0.6904
Leishmania major	proteasome beta 2 subunit, putative	0.003	0.1102	0.1102
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.003	0.1109	0.1109
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.003	0.1102	0.1102
Brugia malayi	Proteasome A-type and B-type family protein	0.003	0.1102	0.1102
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.003	0.1102	0.1102
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.003	0.1102	0.1102
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.003	0.1102	0.1102
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.003	0.1102	0.1102
Brugia malayi	Proteasome subunit alpha type 7-1	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.003	0.1102	0.1102
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.003	0.1102	0.1102
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.007	0.2784	0.2784
Plasmodium vivax	proteasome subunit beta type-3, putative	0.003	0.1102	0.1102
Echinococcus multilocularis	proteasome subunit beta type 7	0.017	0.6904	0.6904
Echinococcus granulosus	proteasome subunit alpha type 2	0.003	0.1102	0.1102
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.003	0.1102	0.1102
Leishmania major	proteasome alpha 2 subunit, putative	0.003	0.1102	0.1102
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.003	0.1102	0.1102
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.003	0.1102	0.1102
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.003	0.1102	0.1102
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.003	0.1102	0.1102
Brugia malayi	proteasome subunit beta type 3	0.003	0.1102	0.1102
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.003	0.1102	0.1102
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.003	0.1102	0.1102
Leishmania major	proteasome alpha 3 subunit, putative	0.003	0.1102	0.1102
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0245	1	1
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.003	0.1102	0.1102
Echinococcus granulosus	subfamily T1A non peptidase ue	0.003	0.1102	0.1102
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0245	1	1
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.003	0.1102	0.1102
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.003	0.1102	0.1102
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.003	0.1102	0.1102
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.003	0.1102	0.1102
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.003	0.1102	0.1102
Leishmania major	proteasome beta 5 subunit, putative	0.0245	1	1
Plasmodium vivax	proteasome subunit beta type-7, putative	0.003	0.1102	0.1102
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.003	0.1102	0.1102

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 6.3 nM	BindingDB_Patents: LabChip Assay. This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In a polypropylene plate, LRRK2, fluorescently-labeled peptide substrate, ATP and test compound were incubated together. Using a LabChip 3000 (Caliper Life Sciences), after the reaction the substrate was separated by capillary electrophoresis into two populations: phosphorylated and unphosphorylated. The relative amounts of each were quantitated by fluorescence intensity.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3641861

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1966086