Detailed information for compound 1966101

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.364 | Formula: C17H18N6O2
  • H donors: 2 H acceptors: 4 LogP: 2.23 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1Nc1ncc(c(n1)NC)C#N)C(=O)N1CCC1
  • InChi: 1S/C17H18N6O2/c1-19-15-12(9-18)10-20-17(22-15)21-13-5-4-11(8-14(13)25-2)16(24)23-6-3-7-23/h4-5,8,10H,3,6-7H2,1-2H3,(H2,19,20,21,22)
  • InChiKey: HVGLZKBVIXIPRE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens leucine-rich repeat kinase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis leucine rich repeat serine:threonine protein Get druggable targets OG5_131478 All targets in OG5_131478
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131478 All targets in OG5_131478
Echinococcus granulosus leucine rich repeat serine:threonine protein Get druggable targets OG5_131478 All targets in OG5_131478
Loa Loa (eye worm) TKL/LRRK protein kinase Get druggable targets OG5_131478 All targets in OG5_131478
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0098 0.1013 0.1013
Loa Loa (eye worm) hypothetical protein 0.0054 0.0486 0.0486
Echinococcus granulosus methyl CpG binding domain protein 2 0.0014 0.0015 0.0015
Loa Loa (eye worm) TATA binding protein associated factor 0.0301 0.3418 0.3418
Entamoeba histolytica hypothetical protein 0.0035 0.0263 0.0263
Leishmania major histone deacetylase, putative 0.0024 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0041 0.0335 0.0335
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0426 0.03
Plasmodium vivax histone deacetylase, putative 0.0024 0.0129 0.0379
Trypanosoma cruzi aminopeptidase, putative 0.0857 1 1
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0071 0.0686 0.0686
Echinococcus granulosus histone deacetylase 0.0024 0.0129 0.0129
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0301 0.3418 0.3418
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0045 0.0376 0.0376
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0027 0.0165 0.0165
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0857 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0002 0.0002
Leishmania major cathepsin L-like protease 0.0049 0.0426 0.0426
Echinococcus multilocularis kinesin family 1 0.0339 0.3867 0.3867
Loa Loa (eye worm) hypothetical protein 0.0038 0.0301 0.0301
Echinococcus granulosus jumonji domain containing protein 0.0031 0.0216 0.0216
Brugia malayi Bromodomain containing protein 0.0062 0.058 0.058
Echinococcus multilocularis histone deacetylase 6 0.0024 0.0129 0.0129
Entamoeba histolytica hypothetical protein 0.0035 0.0263 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0426 0.03
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0076 0.0752 0.0752
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0365 0.4173 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0014 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0013 0.0002 0.0002
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0857 1 1
Schistosoma mansoni hypothetical protein 0.0035 0.0263 0.0263
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0057 0.0525 0.0525
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.0199 0.0199
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0054 0.0486 0.0486
Plasmodium falciparum histone deacetylase, putative 0.0024 0.0129 0.0379
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Schistosoma mansoni zinc finger protein 0.0016 0.0039 0.0039
Brugia malayi Peptidase family M1 containing protein 0.0857 1 1
Onchocerca volvulus Alhambra homolog 0.0022 0.0112 0.0112
Trichomonas vaginalis penicillin-binding protein, putative 0.0057 0.0525 0.0525
Plasmodium vivax histone deacetylase 2, putative 0.0024 0.0129 0.0379
Echinococcus granulosus leukotriene A 4 hydrolase 0.0301 0.3418 0.3418
Echinococcus multilocularis histone deacetylase 6 0.0024 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0057 0.0525 0.0525
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0525 0.1537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0426 0.03
Echinococcus granulosus tumor protein p63 0.0278 0.3144 0.3144
Loa Loa (eye worm) hypothetical protein 0.0556 0.6431 0.6431
Echinococcus multilocularis GPCR, family 2 0.0013 0.0002 0.0002
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0301 0.3418 0.3418
Plasmodium falciparum histone deacetylase 2 0.0024 0.0129 0.0379
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0041 0.0335 0.0335
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0002 0.0002
Brugia malayi PHD-finger family protein 0.0022 0.0112 0.0112
Echinococcus granulosus histone deacetylase 6 0.0024 0.0129 0.0129
Echinococcus granulosus histone deacetylase 6 0.0024 0.0129 0.0129
Onchocerca volvulus 0.0057 0.0525 0.0525
Echinococcus multilocularis histone deacetylase 6 0.0024 0.0129 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0525 0.0525
Trypanosoma cruzi Aminopeptidase M1, putative 0.0857 1 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0301 0.3418 0.3418
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0301 0.3418 0.3418
Toxoplasma gondii aminopeptidase N, putative 0.0301 0.3418 1
Brugia malayi hypothetical protein 0.0074 0.0724 0.0724
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0301 0.3418 0.3418
Loa Loa (eye worm) hypothetical protein 0.0556 0.6431 0.6431
Echinococcus multilocularis zinc finger protein 0.0016 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.0129
Entamoeba histolytica hypothetical protein 0.0035 0.0263 0.0263
Schistosoma mansoni hypothetical protein 0.0013 0.0002 0.0002
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.0525 0.0401
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0301 0.3418 0.3418
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0857 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0331 0.0331
Echinococcus multilocularis integrin beta 2 0.0251 0.2822 0.2822
Schistosoma mansoni hypothetical protein 0.0295 0.3345 0.3345
Schistosoma mansoni hypothetical protein 0.0017 0.005 0.005
Echinococcus granulosus peregrin 0.0024 0.0135 0.0135
Leishmania major developmentally regulated phosphoprotein-like protein 0.0076 0.0752 0.0752
Trypanosoma brucei Aminopeptidase M1, putative 0.0857 1 1
Schistosoma mansoni hypothetical protein 0.0028 0.0181 0.0181
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0857 1 1
Loa Loa (eye worm) hypothetical protein 0.0301 0.3418 0.3418
Loa Loa (eye worm) TKL/LRRK protein kinase 0.007 0.0681 0.0681
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0301 0.3418 0.3418
Plasmodium falciparum kinesin-5 0.0044 0.0371 0.1084
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0015
Schistosoma mansoni histone deacetylase 4 5 0.0024 0.0129 0.0129
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0015 0.0015
Schistosoma mansoni kinesin eg-5 0.0044 0.0371 0.0371
Schistosoma mansoni integrin beta subunit 0.0197 0.2184 0.2184
Echinococcus granulosus histone deacetylase 6 0.0024 0.0129 0.0129
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0556 0.6431 0.6431
Entamoeba histolytica aminopeptidase, putative 0.0857 1 1
Brugia malayi Peptidase family M1 containing protein 0.0301 0.3418 0.3418
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0076 0.0752 0.0752
Mycobacterium leprae conserved hypothetical protein 0.0057 0.0525 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0186 0.0186
Loa Loa (eye worm) integrin beta-2 0.0343 0.391 0.391
Echinococcus granulosus beta LACTamase domain containing family member 0.0057 0.0525 0.0525
Brugia malayi latrophilin 2 splice variant baaae 0.0028 0.0181 0.0181
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.0112 0.0329
Loa Loa (eye worm) hypothetical protein 0.0057 0.0525 0.0525
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0022 0.0112 0.0112
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0857 1 1
Leishmania major cathepsin L-like protease 0.0049 0.0426 0.0426
Schistosoma mansoni histone deacetylase hda2 0.0024 0.0129 0.0129
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.0112 0.0329
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0019 0.0068 0.0068
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0002 0.0002
Echinococcus multilocularis histone deacetylase 0.0024 0.0129 0.0129
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.005 0.005
Brugia malayi Kelch motif family protein 0.0054 0.0486 0.0486
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0057 0.0525 0.0525
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0301 0.3418 1
Onchocerca volvulus 0.0857 1 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0857 1 1
Echinococcus granulosus integrin beta 2 0.0251 0.2822 0.2822
Leishmania major cathepsin L-like protease 0.0049 0.0426 0.0426
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0019 0.0068 0.0068
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0301 0.3418 0.3418
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0076 0.0752 0.0752
Schistosoma mansoni hypothetical protein 0.0013 0.0002 0.0002
Toxoplasma gondii ABC1 family protein 0.0057 0.0525 0.1537
Echinococcus multilocularis histone deacetylase 7 0.0024 0.0129 0.0129
Loa Loa (eye worm) peptidase family M1 containing protein 0.0301 0.3418 0.3418
Brugia malayi Kinesin motor domain containing protein 0.0044 0.0371 0.0371
Brugia malayi jmjC domain containing protein 0.0073 0.0712 0.0712
Schistosoma mansoni cellular tumor antigen P53 0.0041 0.0331 0.0331
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0014 0.0015 0.0015
Schistosoma mansoni pyruvate dehydrogenase 0.0072 0.0702 0.0702
Echinococcus granulosus PHD finger protein rhinoceros 0.0022 0.0112 0.0112
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0301 0.3418 0.3418
Trypanosoma cruzi histone deacetylase, putative 0.0024 0.0129 0.0129
Schistosoma mansoni hypothetical protein 0.0013 0.0002 0.0002
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0073 0.0712 0.0712
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0426 0.03
Brugia malayi TATA binding protein associated factor 0.0301 0.3418 0.3418
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0014 0.0015 0.0015
Trypanosoma cruzi histone deacetylase, putative 0.0024 0.0129 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0426 0.03
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0263 0.0263
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0857 1 1
Trypanosoma cruzi aminopeptidase, putative 0.0301 0.3418 0.3418
Mycobacterium ulcerans aminopeptidase N PepN 0.0857 1 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0301 0.3418 0.3418
Entamoeba histolytica kinesin, putative 0.0044 0.0371 0.0371
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0556 0.6431 0.6431
Mycobacterium ulcerans aminopeptidase N PepN 0.0301 0.3418 0.3053
Trypanosoma cruzi major cysteine proteinase, putative 0.0038 0.0302 0.0302
Echinococcus granulosus zinc finger protein 0.0016 0.0039 0.0039
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0857 1 1
Loa Loa (eye worm) kinesin-like protein KLP2 0.0044 0.0371 0.0371
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0857 1 1
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.007 0.0681 0.0681
Trypanosoma brucei developmentally regulated phosphoprotein 0.0076 0.0752 0.0631
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0073 0.0712 0.0712
Brugia malayi jmjC domain containing protein 0.0029 0.0186 0.0186
Brugia malayi beta-lactamase 0.0057 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0028 0.0181 0.0181
Echinococcus multilocularis peregrin 0.0024 0.0135 0.0135
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0057 0.0525 0.0525
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0027 0.0165 0.0165
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.0199 0.0199
Echinococcus granulosus lysine specific demethylase 5A 0.0029 0.0186 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0426 0.03
Brugia malayi hypothetical protein 0.0857 1 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0031 0.0215 0.0628
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0857 1 1
Onchocerca volvulus 0.0057 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0301 0.3418 0.3418
Schistosoma mansoni pyruvate dehydrogenase 0.0076 0.0752 0.0752
Onchocerca volvulus 0.0857 1 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0857 1 1
Brugia malayi PHD-finger family protein 0.0021 0.0092 0.0092
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0535 0.0535
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0301 0.3418 1
Giardia lamblia Kinesin-5 0.0044 0.0371 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0724 0.0724
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0057 0.0525 0.0525
Echinococcus granulosus aminopeptidase N 0.0857 1 1
Brugia malayi kinase, mitochondrial precursor 0.0076 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0032 0.0223 0.0223
Brugia malayi beta-lactamase family protein 0.0057 0.0525 0.0525
Brugia malayi Histone deacetylase family protein 0.0024 0.0129 0.0129
Echinococcus granulosus fetal alzheimer antigen falz 0.0019 0.0068 0.0068
Onchocerca volvulus 0.0041 0.0331 0.0331
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0426 0.03
Brugia malayi Histone deacetylase family protein 0.0024 0.0129 0.0129
Echinococcus multilocularis jumonji domain containing protein 0.0031 0.0216 0.0216
Echinococcus granulosus GPCR family 2 0.0013 0.0002 0.0002
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0857 1 1
Brugia malayi sulfakinin receptor protein 0.0074 0.0724 0.0724
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0426 0.03
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0186 0.0186
Loa Loa (eye worm) beta-lactamase 0.0057 0.0525 0.0525
Toxoplasma gondii kinesin motor domain-containing protein 0.0044 0.0371 0.1084
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0857 1 1
Plasmodium vivax kinesin-5 0.0044 0.0371 0.1084
Loa Loa (eye worm) bromodomain containing protein 0.0015 0.0021 0.0021
Brugia malayi hypothetical protein 0.0301 0.3418 0.3418
Toxoplasma gondii histone deacetylase HDAC1 0.0024 0.0129 0.0379
Loa Loa (eye worm) transcription factor SMAD2 0.0098 0.1013 0.1013
Brugia malayi Bromodomain containing protein 0.0024 0.0135 0.0135
Entamoeba histolytica hypothetical protein 0.0035 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0057 0.0525 0.0525
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0426 0.03
Leishmania major hypothetical protein, conserved 0.0057 0.0525 0.0525
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0857 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0265 0.0265
Schistosoma mansoni aminopeptidase A (M01 family) 0.0301 0.3418 0.3418
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0186 0.0186
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0112 0.0329
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0027 0.0165 0.0481
Loa Loa (eye worm) histone deacetylase 0.0024 0.0129 0.0129
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0857 1 1
Schistosoma mansoni histone deacetylase 4 5 0.0024 0.0129 0.0129
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0426 0.03
Trypanosoma brucei aminopeptidase, putative 0.0301 0.3418 0.3331
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0426 0.0426
Trichomonas vaginalis D-aminoacylase, putative 0.0057 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0058 0.0538 0.0538
Toxoplasma gondii aminopeptidase N protein 0.0301 0.3418 1
Brugia malayi beta-lactamase family protein 0.0057 0.0525 0.0525
Brugia malayi Integrin beta pat-3 precursor 0.0343 0.391 0.391
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0525 0.0525
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0301 0.3418 0.3418
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0393 0.0393
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0857 1 1
Schistosoma mansoni hypothetical protein 0.0022 0.0112 0.0112
Loa Loa (eye worm) aminopeptidase N 0.0857 1 1
Plasmodium falciparum phd finger protein, putative 0.0022 0.0112 0.0329
Echinococcus multilocularis tumor protein p63 0.0278 0.3144 0.3144
Mycobacterium leprae Probable lipase LipE 0.0057 0.0525 0.5
Echinococcus multilocularis aminopeptidase N 0.0857 1 1
Schistosoma mansoni pyruvate dehydrogenase 0.0072 0.0702 0.0702
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0049 0.0431 0.0431
Echinococcus multilocularis PHD finger protein rhinoceros 0.0022 0.0112 0.0112
Brugia malayi hypothetical protein 0.0054 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0057 0.0525 0.0525
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0263 0.0263
Trichomonas vaginalis D-aminoacylase, putative 0.0057 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0057 0.0525 0.0525
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0057 0.0525 0.0525
Echinococcus multilocularis lysine specific demethylase 5A 0.0027 0.0168 0.0168
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0027 0.0165 0.0035
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0076 0.0752 0.0752
Trypanosoma cruzi cruzipain precursor, putative 0.0049 0.0426 0.0426
Leishmania major histone deacetylase, putative 0.0024 0.0129 0.0129
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0301 0.3418 0.3418
Brugia malayi Calcitonin receptor-like protein seb-1 0.0041 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.0129
Loa Loa (eye worm) histone deacetylase 7A 0.0024 0.0129 0.0129
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0076 0.0752 0.0752
Onchocerca volvulus 0.0057 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0034 0.0246 0.0246
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0014 0.0015 0.0015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0002 0.0002
Echinococcus granulosus histone lysine methyltransferase setb 0.0014 0.0015 0.0015
Trypanosoma cruzi histone deacetylase, putative 0.0024 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0022 0.0112 0.0112
Brugia malayi Protein kinase domain containing protein 0.007 0.0681 0.0681
Trichomonas vaginalis penicillin-binding protein, putative 0.0057 0.0525 0.0525
Toxoplasma gondii aminopeptidase n, putative 0.0301 0.3418 1
Echinococcus granulosus kinesin family 1 0.0339 0.3867 0.3867
Trichomonas vaginalis esterase, putative 0.0057 0.0525 0.0525
Loa Loa (eye worm) MH2 domain-containing protein 0.0098 0.1013 0.1013
Onchocerca volvulus 0.0301 0.3418 0.3418
Trypanosoma brucei Aminopeptidase M1, putative 0.0857 1 1
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0301 0.3418 1
Schistosoma mansoni bromodomain containing protein 0.0052 0.0466 0.0466
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0556 0.6431 0.6431
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0049 0.0431 0.0431
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0857 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0263 0.0263
Echinococcus multilocularis beta LACTamase domain containing family member 0.0057 0.0525 0.0525
Brugia malayi Bromodomain containing protein 0.0032 0.0222 0.0222
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0426 0.0426
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0301 0.3418 0.3418
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0015 0.0015
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0301 0.3418 1
Echinococcus granulosus histone deacetylase 7 0.0024 0.0129 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0426 0.03
Brugia malayi hypothetical protein 0.0035 0.0263 0.0263
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0041 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0301 0.3418 0.3418
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0426 0.0426
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0857 1 1
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0002 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0057 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0556 0.6431 0.6431

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 26.4 nM BindingDB_Patents: LabChip Assay. This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In a polypropylene plate, LRRK2, fluorescently-labeled peptide substrate, ATP and test compound were incubated together. Using a LabChip 3000 (Caliper Life Sciences), after the reaction the substrate was separated by capillary electrophoresis into two populations: phosphorylated and unphosphorylated. The relative amounts of each were quantitated by fluorescence intensity. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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