Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transmembrane protease, serine 15 | Starlite/ChEMBL | No references |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0222 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0037 | 0.0953 | 0.0892 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0222 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0037 | 0.0953 | 0.0953 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0953 | 0.0953 |
Onchocerca volvulus | 0.0019 | 0.0067 | 0.014 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0037 | 0.0953 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.4801 | 0.4801 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0222 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0953 | 0.0953 |
Brugia malayi | Trypsin family protein | 0.0116 | 0.4801 | 0.4801 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0037 | 0.0953 | 0.0953 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0037 | 0.0953 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0222 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0037 | 0.0953 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0037 | 0.0953 | 0.0953 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0019 | 0.0067 | 0.0067 |
Echinococcus multilocularis | acetylcholinesterase | 0.0222 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0037 | 0.0953 | 0.0953 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0037 | 0.0953 | 0.0953 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0037 | 0.0953 | 0.0892 |
Onchocerca volvulus | 0.0037 | 0.0953 | 0.1984 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0037 | 0.0953 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0037 | 0.0953 | 0.0953 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0037 | 0.0953 | 0.0892 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.5128 | 0.5128 |
Onchocerca volvulus | 0.0037 | 0.0953 | 0.1984 | |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.4801 | 0.4801 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0067 | 0.0067 |
Brugia malayi | Carboxylesterase family protein | 0.0037 | 0.0953 | 0.0953 |
Onchocerca volvulus | 0.0037 | 0.0953 | 0.1984 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0037 | 0.0953 | 0.0953 |
Brugia malayi | Carboxylesterase family protein | 0.0037 | 0.0953 | 0.0953 |
Echinococcus multilocularis | neuroligin | 0.0037 | 0.0953 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0953 | 0.0953 |
Onchocerca volvulus | 0.0106 | 0.4333 | 0.9025 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0037 | 0.0953 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0953 | 0.0953 |
Echinococcus granulosus | neuroligin | 0.0037 | 0.0953 | 0.0892 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0037 | 0.0953 | 0.0892 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0037 | 0.0953 | 0.0953 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0037 | 0.0953 | 0.0953 |
Brugia malayi | Protein kinase domain containing protein | 0.0019 | 0.0067 | 0.0067 |
Onchocerca volvulus | 0.0037 | 0.0953 | 0.1984 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0222 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0222 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0222 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0222 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0037 | 0.0953 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0953 | 0.0953 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0953 | 0.0953 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0067 | 0.0067 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0037 | 0.0953 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0953 | 0.0953 |
Brugia malayi | Carboxylesterase family protein | 0.0222 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 0.0953 | 0.1984 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0037 | 0.0953 | 0.0892 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0037 | 0.0953 | 0.0953 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0953 | 0.0953 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0067 | 0.0067 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0116 | 0.4801 | 0.4801 |
Loa Loa (eye worm) | carboxylesterase | 0.0037 | 0.0953 | 0.0953 |
Onchocerca volvulus | 0.0019 | 0.0067 | 0.014 | |
Onchocerca volvulus | 0.0116 | 0.4801 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0067 | 0.0067 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1 nM | BindingDB_Patents: Inhibition Assay. Inhibition assay using human trysin. | ChEMBL. | No reference |
Ki (binding) | = 1 nM | BindingDB_Patents: Inhibition Assay. Inhibition assay using human trysin. | ChEMBL. | No reference |
Ki (binding) | = 2.2 nM | BindingDB_Patents: Inhibition Assay. Inhibition assay using human enteropeptidase. | ChEMBL. | No reference |
Ki (binding) | = 2.2 nM | BindingDB_Patents: Inhibition Assay. Inhibition assay using human enteropeptidase. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.