Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | No references |
Homo sapiens | transmembrane protease, serine 15 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0024 | 0.0451 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0139 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0019 | 0.0113 | 0.0113 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0451 | 0.0451 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0024 | 0.0451 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.8066 | 0.8066 |
Echinococcus granulosus | acetylcholinesterase | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0451 | 0.0451 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0451 | 0.0451 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0024 | 0.0451 | 0.0343 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0451 | 0.0451 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0451 | 0.0451 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0024 | 0.0451 | 0.5 |
Onchocerca volvulus | 0.0106 | 0.728 | 0.9025 | |
Echinococcus multilocularis | neuroligin | 0.0024 | 0.0451 | 0.0343 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0024 | 0.0451 | 0.0343 |
Onchocerca volvulus | 0.0024 | 0.0451 | 0.056 | |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.8066 | 0.8066 |
Schistosoma mansoni | acetylcholinesterase | 0.0024 | 0.0451 | 0.0451 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0139 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0451 | 0.0451 |
Echinococcus granulosus | acetylcholinesterase | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0451 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0451 | 0.0451 |
Onchocerca volvulus | 0.0024 | 0.0451 | 0.056 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0139 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0113 | 0.0113 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0024 | 0.0451 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0113 | 0.0113 |
Onchocerca volvulus | 0.0024 | 0.0451 | 0.056 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0451 | 0.0451 |
Echinococcus granulosus | carboxylesterase 5A | 0.0139 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0116 | 0.8066 | 0.8066 |
Loa Loa (eye worm) | carboxylesterase | 0.0139 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0451 | 0.0451 |
Onchocerca volvulus | 0.0024 | 0.0451 | 0.056 | |
Onchocerca volvulus | 0.0024 | 0.0451 | 0.056 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0451 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0113 | 0.0113 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0024 | 0.0451 | 0.0343 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0451 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0113 | 0.0113 |
Onchocerca volvulus | 0.0019 | 0.0113 | 0.014 | |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0451 | 0.0451 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0024 | 0.0451 | 0.5 |
Onchocerca volvulus | 0.0116 | 0.8066 | 1 | |
Schistosoma mansoni | gliotactin | 0.0024 | 0.0451 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0113 | 0.0113 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0024 | 0.0451 | 0.0343 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0019 | 0.0113 | 0.0113 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0024 | 0.0451 | 0.0343 |
Echinococcus multilocularis | acetylcholinesterase | 0.0139 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0451 | 0.0451 |
Echinococcus granulosus | neuroligin | 0.0024 | 0.0451 | 0.0343 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0113 | 0.0113 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0451 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0024 | 0.0451 | 0.0451 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0451 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0451 | 0.0451 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.8615 | 0.8615 |
Onchocerca volvulus | 0.0019 | 0.0113 | 0.014 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0451 | 0.0451 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0451 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0116 | 0.8066 | 0.8066 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0024 | 0.0451 | 0.0343 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.33 nM | BindingDB_Patents: Inhibition Assay. Inhibition assay using human trysin. | ChEMBL. | No reference |
Ki (binding) | = 0.33 nM | BindingDB_Patents: Inhibition Assay. Inhibition assay using human trysin. | ChEMBL. | No reference |
Ki (binding) | = 0.52 nM | BindingDB_Patents: Inhibition Assay. Inhibition assay using human enteropeptidase. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.