TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 503.038 | Formula: C28H31ClN6O
H donors: 1 H acceptors: 4 LogP: 4.17 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: CCc1ncnc(c1C#Cc1ccc(nc1)N)c1ccc(c(c1)Cl)C(=O)N1CCC(CC1)CN(C)C
InChi: 1S/C28H31ClN6O/c1-4-25-23(8-5-19-6-10-26(30)31-16-19)27(33-18-32-25)21-7-9-22(24(29)15-21)28(36)35-13-11-20(12-14-35)17-34(2)3/h6-7,9-10,15-16,18,20H,4,11-14,17H2,1-3H3,(H2,30,31)
InChiKey: ASWXTYJRGSFHAP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	No references
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1068 aa	927 aa	29.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0058	0.0039	0.2533
Brugia malayi	diacylglycerol kinase	0.067	0.1128	0.1562
Entamoeba histolytica	Rap/Ran GTPase activating protein, putative	0.0086	0.0089	0.0183
Loa Loa (eye worm)	hypothetical protein	0.067	0.1128	0.1128
Trypanosoma brucei	predicted C2 domain protein	0.0086	0.0089	0.0471
Echinococcus multilocularis	calpain 5	0.0086	0.0089	0.007
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0948	0.1623	0.1622
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Schistosoma mansoni	fer-1-related	0.0086	0.0089	0.007
Trypanosoma brucei	Coiled-coil and C2 domain-containing protein	0.0086	0.0089	0.0471
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0086	0.0089	0.007
Echinococcus granulosus	synaptotagmin protein 4	0.0086	0.0089	0.007
Loa Loa (eye worm)	hypothetical protein	0.067	0.1128	0.1128
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0226	0.0338	0.042
Trichomonas vaginalis	copine, putative	0.0086	0.0089	0.0545
Echinococcus granulosus	protein piccolo	0.0086	0.0089	0.007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.0039	0.0239
Schistosoma mansoni	synaptotagmin	0.0086	0.0089	0.007
Leishmania major	hypothetical protein, conserved	0.0086	0.0089	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0948	0.1623	0.2225
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0086	0.0089	0.007
Brugia malayi	Protein kinase domain containing protein	0.0691	0.1165	0.1613
Echinococcus granulosus	synaptotagmin	0.0086	0.0089	0.007
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0086	0.0089	0.579
Echinococcus multilocularis	N chimaerin	0.067	0.1128	0.1531
Echinococcus multilocularis	intersectin 2	0.0086	0.0089	0.007
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Entamoeba histolytica	diacylglycerol kinase, putative	0.067	0.1128	0.269
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0948	0.1623	0.2225
Trypanosoma brucei	hypothetical protein, conserved	0.0086	0.0089	0.0471
Schistosoma mansoni	nedd-4-like E3 ubiquitin-protein ligase	0.0086	0.0089	0.007
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0086	0.0089	0.007
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.067	0.1128	0.1128
Schistosoma mansoni	serine/threonine protein kinase	0.0948	0.1623	0.2225
Echinococcus multilocularis	synaptotagmin	0.0086	0.0089	0.007
Loa Loa (eye worm)	hypothetical protein	0.067	0.1128	0.1128
Schistosoma mansoni	synaptic ras gtpase activating protein syngap	0.0086	0.0089	0.007
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0086	0.0089	0.007
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0086	0.0089	0.0106
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0086	0.0089	0.007
Toxoplasma gondii	Elicitor-responsive protein, putative	0.0086	0.0089	0.0462
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0019	0.0118
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0122	0.0153	0.0941
Trichomonas vaginalis	AGC family protein kinase	0.0948	0.1623	1
Loa Loa (eye worm)	C2 domain-containing protein	0.0086	0.0089	0.0088
Trichomonas vaginalis	synaptotagmin, putative	0.0086	0.0089	0.0545
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0086	0.0089	0.007
Trichomonas vaginalis	ion channel nompc, putative	0.0086	0.0089	0.0545
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Plasmodium falciparum	ferlin, putative	0.0086	0.0089	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0948	0.1623	1
Echinococcus multilocularis		0.0086	0.0089	0.007
Echinococcus granulosus	UNCoordinated family member unc 13	0.0086	0.0089	0.007
Echinococcus multilocularis	UNCoordinated family member (unc 13)	0.0086	0.0089	0.007
Echinococcus multilocularis	copine 9	0.0086	0.0089	0.007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.0039	0.0239
Brugia malayi	calpain 5	0.0086	0.0089	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Brugia malayi	Synaptotagmin protein 3	0.0086	0.0089	0.0106
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0166	0.0231	0.0306
Trichomonas vaginalis	synaptotagmin, putative	0.0086	0.0089	0.0545
Echinococcus granulosus	NDR protein kinase	0.0948	0.1623	0.2225
Trypanosoma brucei	C2 domain containing protein, putative	0.0086	0.0089	0.0471
Entamoeba histolytica	hypothetical protein	0.0086	0.0089	0.0183
Brugia malayi	protein kinase C3,putative	0.0691	0.1165	0.1613
Schistosoma mansoni	synaptotagmin	0.0086	0.0089	0.007
Trichomonas vaginalis	synaptotagmin, putative	0.0086	0.0089	0.0545
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.1452	0.2518	0.2518
Entamoeba histolytica	C2 domain protein, putative	0.0086	0.0089	0.0183
Schistosoma mansoni	hypothetical protein	0.0086	0.0089	0.007
Schistosoma mansoni	diacylglycerol kinase theta	0.067	0.1128	0.1531
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0086	0.0089	0.0471
Echinococcus granulosus	copine 9	0.0086	0.0089	0.007
Schistosoma mansoni	protein kinase C mu	0.067	0.1128	0.1531
Schistosoma mansoni	synaptotagmin	0.0086	0.0089	0.007
Entamoeba histolytica	hypothetical protein	0.0086	0.0089	0.0183
Entamoeba histolytica	protein kinase, putative	0.0948	0.1623	0.3881
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0948	0.1623	0.1622
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0122	0.0153	0.0941
Leishmania major	hypothetical protein, conserved	0.0086	0.0089	1
Leishmania major	hypothetical protein, conserved	0.0086	0.0089	1
Schistosoma mansoni	serine/threonine kinase	0.0948	0.1623	0.2225
Brugia malayi	LD23056p	0.0086	0.0089	0.0106
Echinococcus multilocularis	serine threonine protein kinase	0.2379	0.4169	0.5802
Loa Loa (eye worm)	C2 domain-containing protein	0.0086	0.0089	0.0088
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0089	0.579
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0948	0.1623	0.1622
Echinococcus multilocularis	active breakpoint cluster region	0.0086	0.0089	0.007
Echinococcus granulosus	raf serine:threonine protein kinase	0.067	0.1128	0.1531
Brugia malayi	RhoGAP domain containing protein	0.067	0.1128	0.1562
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0007	0.0044
Entamoeba histolytica	C2 domain containing protein	0.0086	0.0089	0.0183
Trichomonas vaginalis	synaptotagmin, putative	0.0086	0.0089	0.0545
Onchocerca volvulus		0.4709	0.8314	1
Echinococcus granulosus	serine:threonine protein kinase N2	0.2375	0.4161	0.5792
Trichomonas vaginalis	vab10 spectraplakin, putative	0.0086	0.0089	0.0545
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.305	0.5361	0.7478
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0115	0.014	0.0307
Trichomonas vaginalis	AGC family protein kinase	0.0948	0.1623	1
Plasmodium vivax	ferlin, putative	0.0086	0.0089	0.5
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0086	0.0089	0.0545
Entamoeba histolytica	hypothetical protein	0.0086	0.0089	0.0183
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0086	0.0089	0.0088
Echinococcus granulosus	intersectin 2	0.0086	0.0089	0.007
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0089	0.579
Entamoeba histolytica	C2 domain containing protein	0.0086	0.0089	0.0183
Entamoeba histolytica	hypothetical protein	0.0086	0.0089	0.0183
Trichomonas vaginalis	Circumsporozoite protein precursor, putative	0.0086	0.0089	0.0545
Toxoplasma gondii	diacylglycerol kinase, putative	0.067	0.1128	0.6928
Loa Loa (eye worm)	C2 domain-containing protein	0.0086	0.0089	0.0088
Brugia malayi	phospholipase C homolog	0.0086	0.0089	0.0106
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0122	0.0153	0.0337
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.0153	1
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0691	0.1165	0.1582
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.4059	0.7156	0.7156
Echinococcus granulosus	synaptotagmin 15	0.0086	0.0089	0.007
Toxoplasma gondii	hypothetical protein	0.0086	0.0089	0.0462
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0058	0.0039	0.2838
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0085	0.0087	0.0535
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.0086	0.0089	0.579
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Trypanosoma brucei	cAMP binding protein, putative	0.0086	0.0089	0.0471
Schistosoma mansoni	serine/threonine protein kinase	0.4059	0.7156	1
Echinococcus granulosus	serine:threonine protein kinase N2	0.0948	0.1623	0.2225
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0948	0.1623	0.2225
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0948	0.1623	1
Schistosoma mansoni	synaptotagmin-like protein	0.0086	0.0089	0.007
Schistosoma mansoni	hypothetical protein	0.0086	0.0089	0.007
Echinococcus multilocularis	Rac GTPase activating protein 1	0.067	0.1128	0.1531
Loa Loa (eye worm)	hypothetical protein	0.0756	0.1281	0.1281
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Schistosoma mansoni	unc-13 (munc13)	0.0086	0.0089	0.007
Echinococcus multilocularis	protein piccolo	0.0086	0.0089	0.007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0019	0.0118
Trichomonas vaginalis	AGC family protein kinase	0.0948	0.1623	1
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Brugia malayi	Copine VIII	0.0086	0.0089	0.0106
Entamoeba histolytica	protein kinase, putative	0.0948	0.1623	0.3881
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0756	0.1281	0.1745
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Entamoeba histolytica	hypothetical protein	0.0086	0.0089	0.0183
Echinococcus granulosus	protein kinase c eta type	0.067	0.1128	0.1531
Entamoeba histolytica	DENN domain protein	0.0086	0.0089	0.0183
Echinococcus multilocularis	synaptotagmin 15	0.0086	0.0089	0.007
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Loa Loa (eye worm)	hypothetical protein	0.067	0.1128	0.1128
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0691	0.1165	0.1165
Schistosoma mansoni	rabphilin-3a	0.0086	0.0089	0.007
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Brugia malayi	Copine family protein	0.0086	0.0089	0.0106
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.067	0.1128	0.1531
Toxoplasma gondii	C2 domain-containing protein	0.0086	0.0089	0.0462
Entamoeba histolytica	hypothetical protein	0.067	0.1128	0.269
Toxoplasma gondii	Sma protein	0.0086	0.0089	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Schistosoma mansoni	rac gtpase activating protein	0.067	0.1128	0.1531
Brugia malayi	Variant SH3 domain containing protein	0.067	0.1128	0.1562
Echinococcus granulosus	protein kinase C gamma type	0.2379	0.4169	0.5802
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0086	0.0089	0.007
Leishmania major	phospholipase c-like protein	0.0086	0.0089	1
Echinococcus granulosus	synaptotagmin	0.0086	0.0089	0.007
Echinococcus granulosus	unc 13 munc13	0.0756	0.1281	0.1745
Leishmania major	c2 domain protein, putative	0.0086	0.0089	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0043	0.0013	0.0078
Brugia malayi	diacylglycerol kinase	0.067	0.1128	0.1562
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Toxoplasma gondii	AGC kinase	0.0948	0.1623	1
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0086	0.0089	0.007
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0948	0.1623	0.1622
Trichomonas vaginalis	AGC family protein kinase	0.0948	0.1623	1
Loa Loa (eye worm)	hypothetical protein	0.4709	0.8314	0.8313
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0086	0.0089	0.0545
Leishmania major	hypothetical protein, conserved	0.0086	0.0089	1
Brugia malayi	C1-like domain containing protein	0.0691	0.1165	0.1613
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0014	0.0087
Schistosoma mansoni	synaptotagmin 12	0.0086	0.0089	0.007
Trichomonas vaginalis	annexin VII, putative	0.0086	0.0089	0.0545
Loa Loa (eye worm)	phosphatidylinositol 3	0.0058	0.0039	0.0039
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0086	0.0089	0.007
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0058	0.0039	0.0163
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Brugia malayi	Protein kinase domain containing protein	0.0948	0.1623	0.2254
Echinococcus granulosus	Immunoglobulin E set	0.0086	0.0089	0.007
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0058	0.0039	0.2838
Trichomonas vaginalis	AGC family protein kinase	0.0948	0.1623	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Echinococcus multilocularis	synaptotagmin protein 4	0.0086	0.0089	0.007
Onchocerca volvulus		0.067	0.1128	0.1264
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0085	0.0087	0.0535
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0019	0.0118
Schistosoma mansoni	atypical protein kinase C	0.1618	0.2815	0.3901
Leishmania major	copine i-like protein	0.0086	0.0089	1
Onchocerca volvulus		0.067	0.1128	0.1264
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Echinococcus granulosus	Protein kinase C brain isozyme	0.305	0.5361	0.7478
Loa Loa (eye worm)	hypothetical protein	0.067	0.1128	0.1128
Trichomonas vaginalis	splicing factor 3A subunit, putative	0.0086	0.0089	0.0545
Brugia malayi	WW domain containing protein	0.0086	0.0089	0.0106
Plasmodium falciparum	double C2-like domain-containing protein	0.0086	0.0089	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0122	0.0153	0.0196
Trichomonas vaginalis	copine, putative	0.0086	0.0089	0.0545
Loa Loa (eye worm)	Nedd4-PD	0.0086	0.0089	0.0088
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Echinococcus granulosus	otoferlin	0.0086	0.0089	0.007
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0086	0.0089	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Schistosoma mansoni	mctp-related	0.0086	0.0089	0.007
Echinococcus granulosus	protein kinase c iota type	0.1618	0.2815	0.3901
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Echinococcus granulosus	myoferlin	0.0086	0.0089	0.007
Trypanosoma brucei	C2 domain containing protein, putative	0.0086	0.0089	0.0471
Loa Loa (eye worm)	hypothetical protein	0.067	0.1128	0.1128
Schistosoma mansoni	E3 ubiquitin-protein ligase nedd-4	0.0086	0.0089	0.007
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0948	0.1623	0.2225
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0086	0.0089	0.007
Schistosoma mansoni	hypothetical protein	0.0086	0.0089	0.007
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0948	0.1623	0.2225
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0086	0.0089	0.007
Entamoeba histolytica	hypothetical protein, conserved	0.0086	0.0089	0.0183
Loa Loa (eye worm)	raf kinase	0.067	0.1128	0.1128
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Leishmania major	hypothetical protein, conserved	0.0086	0.0089	1
Entamoeba histolytica	hypothetical protein	0.0086	0.0089	0.0183
Trichomonas vaginalis	synaptotagmin, putative	0.0086	0.0089	0.0545
Loa Loa (eye worm)	RasGEF domain-containing protein	0.067	0.1128	0.1128
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0058	0.0039	0.2533
Schistosoma mansoni	serine/threonine protein kinase	0.0948	0.1623	0.2225
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Echinococcus multilocularis	neural cell expressed, developmentally	0.0086	0.0089	0.007
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0014	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0019	0.0118
Schistosoma mansoni	hypothetical protein	0.0086	0.0089	0.007
Echinococcus granulosus	RNA directed DNA polymerase	0.1346	0.233	0.3219
Plasmodium falciparum	ferlin, putative	0.0086	0.0089	0.5
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.0079	0.0056
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0089	0.579
Brugia malayi	NEDD4.2	0.0086	0.0089	0.0106
Schistosoma mansoni	copine	0.0086	0.0089	0.007
Leishmania major	c2 domain protein, putative	0.0086	0.0089	1
Echinococcus granulosus	NEDD4 E3 ubiquitin protein ligase WWP1	0.0086	0.0089	0.007
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0086	0.0089	0.0545
Loa Loa (eye worm)	hypothetical protein	0.067	0.1128	0.1128
Loa Loa (eye worm)	hypothetical protein	0.538	0.9506	0.9506
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0086	0.0089	0.007
Toxoplasma gondii	hypothetical protein	0.0086	0.0089	0.0462
Echinococcus multilocularis	NEDD4 E3 ubiquitin protein ligase WWP1	0.0086	0.0089	0.007
Entamoeba histolytica	PH domain containing protein kinase, putative	0.2375	0.4161	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0058	0.0039	0.0063
Trypanosoma cruzi	C2 domain/Ankyrin repeats (3 copies), putative	0.0086	0.0089	0.579
Loa Loa (eye worm)	hypothetical protein	0.067	0.1128	0.1128
Schistosoma mansoni	serine/threonine protein kinase	0.067	0.1128	0.1531
Toxoplasma gondii	phosphoinositide phospholipase PIPLC	0.0086	0.0089	0.0462
Trypanosoma cruzi	Coiled-coil and C2 domain-containing protein	0.0086	0.0089	0.579
Echinococcus multilocularis	copine 9	0.0086	0.0089	0.007
Loa Loa (eye worm)	hypothetical protein	0.008	0.0079	0.0078
Echinococcus multilocularis	synaptotagmin	0.0086	0.0089	0.007
Brugia malayi	Ras association domain family 1 isoform A	0.067	0.1128	0.1562
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0043	0.0013	0.0817
Leishmania major	hypothetical protein, conserved	0.0086	0.0089	1
Trypanosoma brucei	C2 domain containing protein, putative	0.0086	0.0089	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Brugia malayi	Variant SH3 domain containing protein	0.0086	0.0089	0.0106
Trichomonas vaginalis	AGC family protein kinase	0.0948	0.1623	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.067	0.1128	0.1531
Brugia malayi	Synapse defective protein 1	0.0086	0.0089	0.0106
Trypanosoma cruzi	target of rapamycin kinase 3	0.0047	0.0019	0.1243
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.067	0.1128	0.1128
Echinococcus granulosus	myotubularin protein 13	0.067	0.1128	0.1531
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Brugia malayi	Protein kinase c protein 2	0.2122	0.3711	0.5177
Entamoeba histolytica	C2 domain containing protein	0.0086	0.0089	0.0183
Entamoeba histolytica	C2 domain containing protein	0.0086	0.0089	0.0183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0025	0.0152
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Echinococcus multilocularis	synaptotagmin	0.0086	0.0089	0.007
Loa Loa (eye worm)	phosphatidylinositol 3	0.0202	0.0295	0.0295
Entamoeba histolytica	protein kinase, putative	0.0106	0.0125	0.027
Entamoeba histolytica	C2 domain containing protein	0.0086	0.0089	0.0183
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0086	0.0089	0.007
Toxoplasma gondii	ferlin family protein	0.0086	0.0089	0.0462
Echinococcus multilocularis	raf serine:threonine protein kinase	0.067	0.1128	0.1531
Entamoeba histolytica	diacylglycerol kinase, putative	0.067	0.1128	0.269
Schistosoma mansoni	protein kinase C mu	0.0691	0.1165	0.1582
Entamoeba histolytica	calcium-binding protein, putative	0.0086	0.0089	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Entamoeba histolytica	C2 domain containing protein	0.0086	0.0089	0.0183
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0061	0.0044	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Echinococcus granulosus	copine 9	0.0086	0.0089	0.007
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Echinococcus granulosus	synaptotagmin 2	0.0086	0.0089	0.007
Schistosoma mansoni	serine/threonine protein kinase	0.305	0.5361	0.7478
Entamoeba histolytica	protein kinase, putative	0.0948	0.1623	0.3881
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0948	0.1623	0.1622
Echinococcus granulosus	protein kinase c epsilon type	0.4059	0.7156	1
Brugia malayi	Pleckstrin Homology Domain	0.067	0.1128	0.1562
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0014	0.0087
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.0153	1
Echinococcus multilocularis	protein kinase c iota type	0.1618	0.2815	0.3901
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0086	0.0089	0.0545
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.1346	0.233	0.3219
Brugia malayi	Synaptotagmin I	0.0086	0.0089	0.0106
Echinococcus multilocularis	serine:threonine protein kinase N2	0.3303	0.5811	0.811
Entamoeba histolytica	protein kinase, putative	0.0106	0.0125	0.027
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0756	0.1281	0.1745
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0691	0.1165	0.1165
Entamoeba histolytica	hypothetical protein, conserved	0.0086	0.0089	0.0183
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0058	0.0039	0.0037
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0086	0.0089	0.5
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0086	0.0089	0.007
Loa Loa (eye worm)	hypothetical protein	0.0042	0.001	0.001
Echinococcus granulosus	Diacylglycerol kinase theta	0.067	0.1128	0.1531
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Loa Loa (eye worm)	hypothetical protein	0.4709	0.8314	0.8313
Loa Loa (eye worm)	synaptotagmin-1	0.0086	0.0089	0.0088
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0014	0.0087
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0948	0.1623	0.2225
Schistosoma mansoni	synaptotagmin 12	0.0086	0.0089	0.007
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0043	0.0013	0.0078
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0089	0.579
Trypanosoma cruzi	synaptotagmin, putative	0.0086	0.0089	0.579
Trichomonas vaginalis	copine, putative	0.0086	0.0089	0.0545
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0086	0.0089	0.579
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Entamoeba histolytica	hypothetical protein	0.0098	0.011	0.0234
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0948	0.1623	0.1622
Loa Loa (eye worm)	phosphatidylinositol 3-kinase catalytic subunit gamma	0.0086	0.0089	0.0088
Schistosoma mansoni	unc-13 (munc13)	0.0756	0.1281	0.1745
Schistosoma mansoni	unc-13 (munc13)	0.0756	0.1281	0.1745
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Echinococcus granulosus	Rac GTPase activating protein 1	0.067	0.1128	0.1531
Echinococcus multilocularis	myotubularin protein 13	0.067	0.1128	0.1531
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.067	0.1128	0.1128
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Echinococcus multilocularis	RNA directed DNA polymerase	0.1346	0.233	0.3219
Leishmania major	hypothetical protein, conserved	0.0086	0.0089	1
Echinococcus granulosus	N chimaerin	0.067	0.1128	0.1531
Trichomonas vaginalis	copine, putative	0.0086	0.0089	0.0545
Trypanosoma brucei	C2 domain containing protein, putative	0.0086	0.0089	0.0471
Trichomonas vaginalis	synaptotagmin, putative	0.0086	0.0089	0.0545
Trichomonas vaginalis	AGC family protein kinase	0.0948	0.1623	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.067	0.1128	0.1531
Brugia malayi	Protein kinase domain containing protein	0.0948	0.1623	0.2254
Loa Loa (eye worm)	C2 domain-containing protein	0.0086	0.0089	0.0088
Echinococcus granulosus	calpain 5	0.0086	0.0089	0.007
Schistosoma mansoni	protein kinase C	0.0756	0.1281	0.1745
Echinococcus granulosus	synaptotagmin	0.0086	0.0089	0.007
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0086	0.0089	0.007
Schistosoma mansoni	synaptotagmin	0.0086	0.0089	0.007
Echinococcus multilocularis	protein kinase c eta type	0.067	0.1128	0.1531
Brugia malayi	Hr1 repeat family protein	0.0948	0.1623	0.2254
Schistosoma mansoni	rho gtpase activating protein	0.0086	0.0089	0.007
Echinococcus granulosus	extended synaptotagmin 2	0.0086	0.0089	0.007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.0039	0.0239
Toxoplasma gondii	hypothetical protein	0.0086	0.0089	0.0462
Brugia malayi	Protein kinase domain containing protein	0.0948	0.1623	0.2254
Entamoeba histolytica	C2 domain containing protein	0.0086	0.0089	0.0183
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0089	0.579
Trichomonas vaginalis	calcium-dependent lipid-binding protein, putative	0.0086	0.0089	0.0545
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Echinococcus multilocularis	myoferlin	0.0086	0.0089	0.007
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0089	0.579
Schistosoma mansoni	serine/threonine protein kinase	0.0691	0.1165	0.1582
Trypanosoma brucei	predicted C2 domain protein	0.0086	0.0089	0.0471
Trypanosoma brucei	hypothetical protein, conserved	0.0086	0.0089	0.0471
Loa Loa (eye worm)	hypothetical protein	0.4709	0.8314	0.8313
Trypanosoma brucei	C2 domain/Ankyrin repeats (3 copies), putative	0.0086	0.0089	0.0471
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0691	0.1165	0.1582
Plasmodium vivax	hypothetical protein, conserved	0.0086	0.0089	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0948	0.1623	1
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0948	0.1623	0.1622
Echinococcus multilocularis	Diacylglycerol kinase theta	0.067	0.1128	0.1531
Trypanosoma brucei	synaptotagmin, putative	0.0086	0.0089	0.0471
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0086	0.0089	0.007
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0691	0.1165	0.1613
Schistosoma mansoni	diacylglycerol kinase theta	0.067	0.1128	0.1531
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0129	0.0165	0.0177
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0014	0.0087
Trichomonas vaginalis	synaptotagmin, putative	0.0086	0.0089	0.0545
Entamoeba histolytica	C2 domain containing protein	0.0086	0.0089	0.0183
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0086	0.0089	0.007
Schistosoma mansoni	otoferlin	0.0086	0.0089	0.007
Trichomonas vaginalis	AGC family protein kinase	0.0948	0.1623	1
Brugia malayi	RhoGAP domain containing protein	0.067	0.1128	0.1562
Echinococcus multilocularis	synaptotagmin	0.0086	0.0089	0.007
Trichomonas vaginalis	AGC family protein kinase	0.0948	0.1623	1
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Echinococcus multilocularis	extended synaptotagmin 2	0.0086	0.0089	0.007
Schistosoma mansoni	vav2	0.067	0.1128	0.1531
Trypanosoma brucei	predicted C2 domain protein	0.0086	0.0089	0.0471
Trypanosoma cruzi	synaptotagmin, putative	0.0086	0.0089	0.579
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0098	0.011	0.0234
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0019	0.0118
Plasmodium vivax	double C2-like domain-containing protein, putative	0.0086	0.0089	0.5
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0056	0.0036	0.0055
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.0079	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0086	0.0089	0.007
Schistosoma mansoni	serine/threonine protein kinase	0.0948	0.1623	0.2225
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Echinococcus multilocularis	unc 13 (munc13)	0.0756	0.1281	0.1745
Brugia malayi	RhoGEF domain containing protein	0.067	0.1128	0.1562
Echinococcus granulosus	neural cell expressed developmentally	0.0086	0.0089	0.007
Schistosoma mansoni	glut4 vesicle protein-related	0.0086	0.0089	0.007
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Trypanosoma cruzi	C2 domain containing protein, putative	0.0086	0.0089	0.579
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0086	0.0089	0.0545
Schistosoma mansoni	serine/threonine protein kinase	0.0691	0.1165	0.1582
Trichomonas vaginalis	Proline-rich protein, putative	0.0086	0.0089	0.0545
Loa Loa (eye worm)	C2 domain-containing protein	0.0086	0.0089	0.0088
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0086	0.0089	0.007
Leishmania major	hypothetical protein, conserved	0.0086	0.0089	1
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.0086	0.0089	0.007
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0226	0.0338	0.042
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0014	0.0087
Schistosoma mansoni	hypothetical protein	0.067	0.1128	0.1531
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0058	0.0039	0.0063
Schistosoma mansoni	serine/threonine protein kinase	0.305	0.5361	0.7478
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.067	0.1128	0.1531
Loa Loa (eye worm)	copine family protein	0.0086	0.0089	0.0088
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0104	0.0121	0.0152
Loa Loa (eye worm)	C2 domain-containing protein	0.0086	0.0089	0.0088
Schistosoma mansoni	serine/threonine protein kinase	0.0948	0.1623	0.2225
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0226	0.0338	0.042
Entamoeba histolytica	protein kinase, putative	0.0948	0.1623	0.3881
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0043	0.0013	0.0078
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0047	0.0019	0.004
Echinococcus multilocularis	synaptotagmin 2	0.0086	0.0089	0.007
Schistosoma mansoni	hypothetical protein	0.0086	0.0089	0.007
Loa Loa (eye worm)	hypothetical protein	0.2016	0.3522	0.3522
Entamoeba histolytica	C2 domain containing protein	0.0086	0.0089	0.0183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0014	0.0087
Brugia malayi	protein kinase C II.	0.4059	0.7156	1
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0089	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0089	0.0088
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0948	0.1623	0.2225
Schistosoma mansoni	synaptotagmin	0.0086	0.0089	0.007
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0928	0.1586	0.9776
Echinococcus multilocularis	protein kinase c epsilon type	0.4059	0.7156	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0089	0.579
Echinococcus granulosus	active breakpoint cluster region	0.0086	0.0089	0.007
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0086	0.0089	0.007
Onchocerca volvulus		0.0756	0.1281	0.145
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0122	0.0153	0.0941
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0005	0.0031
Brugia malayi	Synapse defective protein 1	0.0086	0.0089	0.0106
Schistosoma mansoni	synaptotagmin	0.0086	0.0089	0.007
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0086	0.0089	0.0545
Brugia malayi	p70 ribosomal S6 kinase beta	0.0948	0.1623	0.2254
Trichomonas vaginalis	copine, putative	0.0086	0.0089	0.0545
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0058	0.0039	0.0163
Echinococcus granulosus	synaptotagmin	0.0086	0.0089	0.007
Echinococcus multilocularis	synaptotagmin	0.0086	0.0089	0.007
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0948	0.1623	0.2225
Loa Loa (eye worm)	hypothetical protein	0.067	0.1128	0.1128
Brugia malayi	C2 domain containing protein	0.0086	0.0089	0.0106
Echinococcus granulosus	synaptotagmin	0.0086	0.0089	0.007
Trypanosoma cruzi	cAMP binding protein, putative	0.0086	0.0089	0.579
Loa Loa (eye worm)	hypothetical protein	0.1346	0.233	0.2329
Plasmodium vivax	ferlin, putative	0.0086	0.0089	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 39.77 nM	BindingDB_Patents: mTOR Kinase Activity Assay. The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Fluorescent Protein) and paired with a corresponding Tb-labeled phospho-specific antibody. The assay itself can be divided into two phases: the reaction phase and the detection phase.	ChEMBL.	No reference
IC50 (binding)	= 444.9 nM	BindingDB_Patents: Filter-Binding-Assay. PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3 kinase is expected to be indicative of activity in treating conditions of excessive or anomalous cell proliferation, such as cancers. See also J. A. Engelman, Nature Reviews Cancer, 2009, 9, 550-562; A. Carnero, Expert Opin. Investig. Drugs, 2009, 18, 1265-1277 and P. Liu et al., Nature Reviews Drug Discovery, 2009, 8, 627-64.	ChEMBL.	No reference
IC50 (binding)	= 444.9 nM	BindingDB_Patents: Filter-Binding-Assay. PI3Kalpha assay described herein provides IC50 values indicating the activity of the compounds inhibiting PI3 kinase alpha activity Inhibition of PI3 kinase is expected to be indicative of activity in treating conditions of excessive or anomalous cell proliferation, such as cancers. See also J. A. Engelman, Nature Reviews Cancer, 2009, 9, 550-562; A. Carnero, Expert Opin. Investig. Drugs, 2009, 18, 1265-1277 and P. Liu et al., Nature Reviews Drug Discovery, 2009, 8, 627-64.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3645945

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1966375