Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cathepsin C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium vivax | dipeptidyl aminopeptidase 3, putative | cathepsin C | 141 aa | 152 aa | 22.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | steroid hormone receptor | 0.0179 | 0.4189 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0179 | 0.4189 | 0.5 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.023 | 1 | 0.5 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.023 | 1 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0179 | 0.4189 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0179 | 0.4189 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0179 | 0.4189 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0179 | 0.4189 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0179 | 0.4189 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0179 | 0.4189 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.4189 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0179 | 0.4189 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0179 | 0.4189 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0179 | 0.4189 | 0.5 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.023 | 1 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.023 | 1 | 1 |
Toxoplasma gondii | cathepsin CPC1 | 0.023 | 1 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.4189 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0179 | 0.4189 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.4189 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0179 | 0.4189 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0143 | 0 | 0.5 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.023 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0179 | 0.4189 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0179 | 0.4189 | 0.5 |
Onchocerca volvulus | 0.0179 | 0.4189 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0179 | 0.4189 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0179 | 0.4189 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0179 | 0.4189 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0179 | 0.4189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.4189 | 0.5 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.023 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0179 | 0.4189 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0179 | 0.4189 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0179 | 0.4189 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.