Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.6792 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.6792 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.203 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.0089 | 0.6792 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.203 | 0.1949 |
Loa Loa (eye worm) | GMP reductase | 0.0037 | 0.1888 | 0.1825 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.1244 | 0.1244 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0428 | 0.0354 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.2896 | 0.4198 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0089 | 0.6792 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.2896 | 0.4198 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2592 | 0.2534 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.1932 | 0.2763 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.6792 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.577 | 0.577 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0428 | 0.0524 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.1244 | 0.1177 |
Trypanosoma cruzi | GMP reductase | 0.0089 | 0.6792 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.2896 | 0.4198 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0089 | 0.6792 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.9704 | 0.9702 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0089 | 0.6792 | 1 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.9704 | 0.9704 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.203 | 0.2909 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.4619 | 0.6764 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0616 | 0.0803 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0037 | 0.1888 | 0.1888 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0878 | 0.0878 |
Brugia malayi | Inositol-1 | 0.0039 | 0.203 | 0.203 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.203 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.2404 | 0.2345 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0089 | 0.6792 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2171 | 0.2111 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.203 | 0.1949 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0089 | 0.6792 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0616 | 0.0803 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.2896 | 0.4198 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0084 | 0.6293 | 0.8954 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.203 | 0.2909 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0037 | 0.1888 | 0.1888 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0089 | 0.6792 | 1 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0325 | 0.0369 |
Mycobacterium leprae | PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) | 0.0042 | 0.2386 | 0.1432 |
Brugia malayi | GMP reductase | 0.0037 | 0.1888 | 0.1888 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0089 | 0.6792 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.203 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.203 | 0.1969 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.2896 | 0.2896 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0084 | 0.6293 | 1 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.2164 | 0.2164 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.2896 | 0.4198 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0878 | 0.0807 |
Toxoplasma gondii | IMP dehydrogenas | 0.0089 | 0.6792 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.4267 | 0.6241 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.535 | 0.5314 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0042 | 0.2386 | 0.0747 |
Leishmania major | guanosine monophosphate reductase | 0.0089 | 0.6792 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.9704 | 0.9702 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.203 | 0.2909 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0325 | 0.0369 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.2896 | 0.2841 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.203 | 0.1949 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.203 | 0.2909 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.2896 | 0.4198 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.203 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0047 | 0.2806 | 0.2249 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.203 | 0.1949 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0089 | 0.6792 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.1932 | 0.2763 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0616 | 0.0803 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.0849 | 0.0849 |
Trypanosoma cruzi | GMP reductase | 0.0089 | 0.6792 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0089 | 0.6792 | 0.6767 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0089 | 0.6792 | 1 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0084 | 0.6293 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0137 | 0.0061 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0089 | 0.6792 | 0.6792 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.203 | 0.1949 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0047 | 0.2806 | 0.2249 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.4267 | 0.6241 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0325 | 0.0369 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.2896 | 0.4198 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dose (functional) | = 26.6 mg kg-1 | Inhibitory effect of the compound on platelet aggregation induced by Collagen in guinea pigs ex vivo at a dose of 1 mg/Kg after 6 hr of oral administration | ChEMBL. | 8164261 |
Dose (functional) | = 60.9 mg kg-1 | Inhibitory effect of the compound on platelet aggregation induced by Arachidonic acid (AA) in guinea pigs ex vivo at a dose of 1 mg/Kg after 6 hr of oral administration | ChEMBL. | 8164261 |
ED50 (functional) | = 8.1 uM | In vitro vasodilatory activity in isolated rat aorta | ChEMBL. | 8164261 |
IC50 (functional) | = 0.015 uM | In vitro antiplatelet activity against arachidonic acid induced malondialdehyde production | ChEMBL. | 8164261 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.