Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 3 | Starlite/ChEMBL | No references |
Homo sapiens | Janus kinase 2 | Starlite/ChEMBL | No references |
Homo sapiens | Janus kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0013 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0013 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0013 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0013 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0013 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.59 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | = 8.97 nM | BindingDB_Patents: Enzymatic Assay. A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reactions were carried out in a 384-well plate (Matrical MP-101) in a 10 L total volume. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovine serum albumin (BSA), 0.0005% Tween-20, ATP (4 M for JAK2 and JAK3, 40 M for JAK1 and 7 M for Tyk2)), 2% DMSO and 1 M peptide substrate (JAKtide for JAK2 and JAK3 and IRS-1 peptide for JAK1 and Tyk2). Compounds were diluted serially in 100% dimethyl sulfoxide and tested in an 11 point dose response in duplicate or quadruplicate (200 nl of compound/DMSO was added per 10 L reaction). The reactions were initiated by the addition of enzyme to the final concentration of 2 nM JAK2, 1 nM JAK3, 12 nM Tyk2 or 20 nM JAK1. The assay was run for 240 minutes for JAK1, 150 minutes for JAK2, 90 minutes for JAK3 and 70 minutes for Tyk2. | ChEMBL. | No reference |
IC50 (binding) | = 39.6 nM | Enzymatic Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.