Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 3 | Starlite/ChEMBL | No references |
Homo sapiens | Janus kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | Janus kinase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0013 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0013 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0013 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0013 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0013 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 17.4 nM | BindingDB_Patents: Enzymatic Assay. A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reactions were carried out in a 384-well plate (Matrical MP-101) in a 10 L total volume. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovine serum albumin (BSA), 0.0005% Tween-20, ATP (4 M for JAK2 and JAK3, 40 M for JAK1 and 7 M for Tyk2)), 2% DMSO and 1 M peptide substrate (JAKtide for JAK2 and JAK3 and IRS-1 peptide for JAK1 and Tyk2). Compounds were diluted serially in 100% dimethyl sulfoxide and tested in an 11 point dose response in duplicate or quadruplicate (200 nl of compound/DMSO was added per 10 L reaction). The reactions were initiated by the addition of enzyme to the final concentration of 2 nM JAK2, 1 nM JAK3, 12 nM Tyk2 or 20 nM JAK1. The assay was run for 240 minutes for JAK1, 150 minutes for JAK2, 90 minutes for JAK3 and 70 minutes for Tyk2. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.