Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MDM2 proto-oncogene, E3 ubiquitin protein ligase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0038 | 0.1071 | 0.1071 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0072 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0072 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0072 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0072 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0038 | 0.1071 | 0.1071 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1071 | 0.1071 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0072 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0072 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0072 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0072 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0072 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0072 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0072 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0072 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0072 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0038 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0072 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0072 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0072 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0072 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0072 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0072 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0038 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0072 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0072 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0072 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0072 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0072 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0072 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1071 | 0.1071 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0038 | 0.1071 | 0.1071 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0072 | 1 | 1 |
Onchocerca volvulus | 0.0072 | 1 | 1 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0072 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0038 | 0.1071 | 0.1071 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0072 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0072 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0072 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0072 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1071 | 0.1071 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0072 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0038 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0072 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0072 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0072 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0072 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0072 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0072 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0072 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0072 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0072 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0072 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0072 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0072 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0072 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0038 | 0.1071 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | < 5000 nM | BindingDB_Patents: Fluorescence-Polarization Binding Assay. The binding affinity of the MDM2 inhibitors was determined using an optimized, sensitive and quantitative fluorescence polarization-based (FP-based) binding assay using a recombinant human His-tagged MDM2 protein (residues 1-118) and a fluorescently tagged p53-based peptide.The design of the fluorescence probe was based upon a previously reported high-affinity p53-based peptidomimetic compound (5-FAM-beta Ala-beta Ala-Phe-Met-Aib-pTyr-(6-Cl-LTrp)-Glu-Ac3c-Leu-Asn-NH2 (SEQ ID NO: 1)) Garcia-Echeverria et al., J. Med. Chem. 43: 3205-3208 (2000)). This tagged peptide is called PMDM6-F. The Kd value of PMDM6-F with the recombinant MDM2 protein was determined from the saturation curve. MDM2 protein was serially double diluted in a Dynex 96-well, black, round-bottom plate, and the PMDM6-F peptide was added at 1 nM concentration. The assay was performed in the buffer: 100 mM potassium phosphate, pH 7.5; 100 ug/mL bovine gamma globulin; 0.02% sodium azide, 0.01% Triton X-100). | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.