Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetyl-CoA carboxylase beta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Schistosoma mansoni | tubulin subunit beta | 0.0079 | 0.7069 | 0.6452 |
Trichomonas vaginalis | tubulin, putative | 0.0079 | 0.7069 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0079 | 0.7069 | 0.6452 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0098 | 0.9533 | 1 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0098 | 0.9533 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0101 | 1 | 1 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0101 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0079 | 0.7069 | 0.7069 |
Echinococcus multilocularis | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0039 | 0.1741 | 0.5 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0039 | 0.1741 | 0.5 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Toxoplasma gondii | beta-tubulin, putative | 0.0079 | 0.7069 | 0.6452 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0079 | 0.7069 | 0.6452 |
Echinococcus granulosus | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Schistosoma mansoni | tubulin subunit beta | 0.0079 | 0.7069 | 0.6452 |
Schistosoma mansoni | tubulin subunit beta | 0.0079 | 0.7069 | 0.6452 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0079 | 0.7069 | 0.6452 |
Plasmodium vivax | tubulin beta chain, putative | 0.0079 | 0.7069 | 1 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0101 | 1 | 1 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0063 | 0.4918 | 0.5963 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0039 | 0.1741 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0079 | 0.7069 | 0.5 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0079 | 0.7069 | 0.6452 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0079 | 0.7069 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0079 | 0.7069 | 0.6452 |
Giardia lamblia | Beta tubulin | 0.0079 | 0.7069 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0079 | 0.7069 | 0.6452 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0039 | 0.1741 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.1741 | 0.1741 |
Trypanosoma cruzi | beta tubulin, putative | 0.0079 | 0.7069 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0101 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0079 | 0.7069 | 0.5 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Trypanosoma brucei | beta tubulin | 0.0079 | 0.7069 | 0.7069 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0079 | 0.7069 | 0.5 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Toxoplasma gondii | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0101 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0079 | 0.7069 | 0.6452 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0079 | 0.7069 | 0.6452 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0039 | 0.1741 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0039 | 0.1741 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0079 | 0.7069 | 0.6452 |
Entamoeba histolytica | tubulin family protein | 0.0079 | 0.7069 | 0.5 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0079 | 0.7069 | 0.6452 |
Echinococcus multilocularis | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0101 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Echinococcus multilocularis | tubulin subunit beta | 0.0079 | 0.7069 | 0.6452 |
Chlamydia trachomatis | biotin carboxylase | 0.0035 | 0.1274 | 0.5 |
Plasmodium falciparum | tubulin beta chain | 0.0079 | 0.7069 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0079 | 0.7069 | 0.5 |
Echinococcus granulosus | tubulin subunit beta | 0.0079 | 0.7069 | 0.6452 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0039 | 0.1741 | 0.5 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Trypanosoma brucei | beta tubulin | 0.0079 | 0.7069 | 0.7069 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0079 | 0.7069 | 0.6452 |
Trypanosoma brucei | beta tubulin | 0.0079 | 0.7069 | 0.7069 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0079 | 0.7069 | 0.6452 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0039 | 0.1741 | 0.5 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Schistosoma mansoni | tubulin subunit beta | 0.0079 | 0.7069 | 0.6452 |
Schistosoma mansoni | tubulin subunit beta | 0.0079 | 0.7069 | 0.6452 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Giardia lamblia | Beta tubulin | 0.0079 | 0.7069 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0079 | 0.7069 | 0.6452 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0079 | 0.7069 | 0.6452 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0039 | 0.1741 | 0.1741 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0079 | 0.7069 | 0.6452 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0079 | 0.7069 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0079 | 0.7069 | 0.6452 |
Leishmania major | beta tubulin | 0.0079 | 0.7069 | 0.6452 |
Entamoeba histolytica | tubulin family protein | 0.0079 | 0.7069 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 640 nM | BindingDB_Patents: Spectrophotometric 384 Well Assay. Malonyl CoA formation by acetyl CoA carboxylases is stoichometrically linked to the consumption of ATP. ACC2 activity is measured in a NADH-linked kinetic method measuring ADP generated during the ACC reaction using a coupled lactate dehydrogenase/pyruvate kinase reaction.For biological testing, a human ACC2 construct which lacks the 128 amino acids at the N-terminus for increased solubility (nt 385-6966 in Genbank entry AJ575592) is cloned. The protein is then expressed in insect cells using a baculoviral expression system. Protein purification is performed by anion exchange.All compounds are dissolved in dimethyl sulfoxide (DMSO) to a concentration of 10 mM.Assay reactions are then carried out in 384-well plates, with hACC2 in an appropriate dilution and at final assay concentrations (f.c.) of 100 mM Tris (pH 7.5), 10 mM trisodium citrate, 25 mM KHCO3, 10 mM MgCl2, 0.5 mg/mL BSA, 3.75 mM reduced L-glutathione, 15 U/mL lactate dehydrogenase, 0.5 mM phosphoenolpyruvate. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.