Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 3 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | p2X purinoceptor 4 | purinergic receptor P2X, ligand-gated ion channel, 3 | 397 aa | 383 aa | 37.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.0264 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0264 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0264 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0264 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0264 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0264 | 0.5 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0264 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0264 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0264 | 0.5 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0264 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta chain | 0.0264 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0264 | 0.5 | 0.5 |
Toxoplasma gondii | beta-tubulin, putative | 0.0264 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0264 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0264 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0264 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0264 | 0.5 | 0.5 |
Loa Loa (eye worm) | beta-tubulin | 0.0264 | 0.5 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0264 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0264 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0264 | 0.5 | 0.5 |
Plasmodium falciparum | tubulin beta chain | 0.0264 | 0.5 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0264 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0264 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0264 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0264 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0264 | 0.5 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Brugia malayi | beta-tubulin, identical | 0.0264 | 0.5 | 0.5 |
Toxoplasma gondii | beta tubulin | 0.0264 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0264 | 0.5 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0264 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin subunit beta | 0.0264 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.0264 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0264 | 0.5 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0264 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0264 | 0.5 | 0.5 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0264 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin subunit beta | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0264 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0264 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0264 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0264 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0264 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0264 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 49 nM | BindingDB_Patents: Inhibiton Assay. Inhibition assay using human P2X3 receptor gene (GeneBank accession number Y07683). | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.