Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | glutaminase, putative | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase 2 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Schistosoma mansoni | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Mycobacterium ulcerans | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Brugia malayi | glutaminase DH11.1 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | beta tubulin | 0.0399 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0399 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0399 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0399 | 1 | 1 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0399 | 1 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0399 | 1 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0399 | 1 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0399 | 1 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0399 | 1 | 0.5 |
Toxoplasma gondii | beta-tubulin, putative | 0.0399 | 1 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0399 | 1 | 1 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0399 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0399 | 1 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0399 | 1 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0399 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0399 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0399 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0399 | 1 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0399 | 1 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0399 | 1 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0399 | 1 | 1 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0399 | 1 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0399 | 1 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0399 | 1 | 0.5 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0399 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.0399 | 1 | 1 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0399 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0399 | 1 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0399 | 1 | 0.5 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0399 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0399 | 1 | 1 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0399 | 1 | 0.5 |
Echinococcus multilocularis | tubulin subunit beta | 0.0399 | 1 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0399 | 1 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0399 | 1 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0399 | 1 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.0399 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0399 | 1 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0399 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Echinococcus granulosus | tubulin subunit beta | 0.0399 | 1 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0399 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0399 | 1 | 1 |
Toxoplasma gondii | beta tubulin | 0.0399 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Brugia malayi | beta-tubulin, identical | 0.0399 | 1 | 1 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0399 | 1 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0399 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.0399 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.033 | 0 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0399 | 1 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0399 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0399 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0399 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0399 | 1 | 0.5 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0399 | 1 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0399 | 1 | 0.5 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0399 | 1 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0399 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 nM | BindingDB_Patents: Enzyme Assay-Time Dependence. Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay that couples the production of glutamate (liberated by GAC) to glutamate dehydrogenase (GDH) and measuring the change in absorbance for the reduction of NAD+ to NADH. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.