TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 402.385 | Formula: C20H15FN8O
H donors: 2 H acceptors: 5 LogP: 0.94 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc2n(c1)c(=O)c(c(n2)[C@@H](Nc1ncnc2c1nc[nH]2)C)c1ccccn1
InChi: 1S/C20H15FN8O/c1-11(27-19-17-18(24-9-23-17)25-10-26-19)16-15(13-4-2-3-7-22-13)20(30)29-8-12(21)5-6-14(29)28-16/h2-11H,1H3,(H2,23,24,25,26,27)/t11-/m0/s1
InChiKey: GAGFVVAGSUEEKQ-NSHDSACASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0015	0.004	0.0021
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0228	0.0188
Loa Loa (eye worm)	G-protein coupled receptor	0.0618	0.5503	0.5484
Schistosoma mansoni	myosin xvIII	0.0618	0.5503	0.5484
Schistosoma mansoni	tubulin subunit beta	0.1114	1	1
Schistosoma mansoni	amine GPCR	0.0618	0.5503	0.5484
Trypanosoma brucei	beta tubulin	0.1114	1	1
Schistosoma mansoni	biogenic amine receptor	0.0618	0.5503	0.5484
Echinococcus multilocularis	neuropeptide receptor	0.0618	0.5503	0.5494
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Trichomonas vaginalis	tubulin alpha chain, putative	0.1114	1	1
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0015	0.004	0.0021
Trypanosoma brucei	beta tubulin	0.1114	1	1
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0077	0.0595	0.0577
Echinococcus granulosus	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0015	0.004	0.0021
Trichomonas vaginalis	tubulin beta chain, putative	0.1114	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0618	0.5503	0.5484
Schistosoma mansoni	tubulin subunit beta	0.1114	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0618	0.5503	0.5484
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0077	0.0595	0.0557
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0019	0.0019
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0118	0.0972	0.0936
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0618	0.5503	0.5484
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0618	0.5503	0.5484
Schistosoma mansoni	amine GPCR	0.0618	0.5503	0.5484
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0222	0.1916	0.1884
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0618	0.5503	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0618	0.5503	0.5484
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0618	0.5503	0.5484
Echinococcus multilocularis	g-protein coupled receptor	0.0618	0.5503	0.5494
Schistosoma mansoni	tubulin subunit beta	0.1114	1	1
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus granulosus	somatostatin receptor	0.0618	0.5503	0.5494
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Toxoplasma gondii	beta tubulin	0.1114	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0618	0.5503	0.5494
Echinococcus granulosus	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Echinococcus granulosus	g protein coupled receptor	0.0618	0.5503	0.5494
Leishmania major	beta tubulin	0.1114	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1114	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0019	0.0019
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0618	0.5503	0.5484
Brugia malayi	hypothetical protein	0.0618	0.5503	0.5484
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.004	0.0259	0.0259
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0036	0.0228	0.0209
Leishmania major	beta tubulin	0.1114	1	1
Schistosoma mansoni	hypothetical protein	0.0618	0.5503	0.5484
Trichomonas vaginalis	tubulin gamma chain, putative	0.1114	1	1
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus granulosus	Tubulin beta 2C chain	0.1114	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.1114	1	1
Brugia malayi	Dopamine receptor protein 2	0.0618	0.5503	0.5484
Brugia malayi	G protein-coupled receptor	0.0618	0.5503	0.5484
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0618	0.5503	0.5484
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0618	0.5503	0.5484
Echinococcus granulosus	g-protein coupled receptor	0.0618	0.5503	0.5494
Onchocerca volvulus		0.0618	0.5503	0.5
Onchocerca volvulus		0.0618	0.5503	0.5
Entamoeba histolytica	hypothetical protein	0.0094	0.0754	0.0716
Loa Loa (eye worm)	tubulin beta-4 chain	0.1114	1	1
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0618	0.5503	0.5494
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0618	0.5503	0.5494
Onchocerca volvulus		0.0618	0.5503	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0618	0.5503	0.5494
Schistosoma mansoni	histamine h1 receptor	0.0618	0.5503	0.5484
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0618	0.5503	0.5494
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Schistosoma mansoni	biogenic amine receptor	0.0618	0.5503	0.5484
Echinococcus granulosus	7TM GPCR rhodopsin	0.0618	0.5503	0.5494
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0019	0.0019
Echinococcus granulosus	G protein coupled receptor 139	0.0618	0.5503	0.5494
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0618	0.5503	0.5484
Echinococcus granulosus	neuropeptide Y receptor	0.0618	0.5503	0.5494
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.004	0.0259	0.022
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0618	0.5503	0.5484
Brugia malayi	hypothetical protein	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus granulosus	g protein coupled receptor	0.0618	0.5503	0.5494
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0618	0.5503	0.5494
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Leishmania major	beta tubulin	0.1114	1	1
Entamoeba histolytica	tubulin family protein	0.1114	1	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0278	0.0239
Echinococcus granulosus	hypothetical protein	0.0618	0.5503	0.5494
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0618	0.5503	0.5484
Echinococcus granulosus	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Echinococcus multilocularis	somatostatin receptor	0.0618	0.5503	0.5494
Echinococcus multilocularis	Tubulin beta 2C chain	0.1114	1	1
Loa Loa (eye worm)	beta-tubulin	0.1114	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0618	0.5503	0.5484
Brugia malayi	hypothetical protein	0.0618	0.5503	0.5484
Loa Loa (eye worm)	neuropeptide F receptor	0.0618	0.5503	0.5484
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.004	0.0259	0.022
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0618	0.5503	0.5494
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0595	0.0557
Onchocerca volvulus		0.0618	0.5503	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0618	0.5503	0.5484
Brugia malayi	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0618	0.5503	0.5494
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0115	0.0941	0.0904
Brugia malayi	G-protein coupled receptor	0.0618	0.5503	0.5484
Echinococcus granulosus	tubulin beta 4A class IVa	0.1114	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0618	0.5503	0.5494
Echinococcus multilocularis	g protein coupled receptor	0.0618	0.5503	0.5494
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.004	0.0259	0.0241
Schistosoma mansoni	neuropeptide F-like receptor	0.0618	0.5503	0.5484
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0019	0.0019
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0081	0.0637	0.0619
Echinococcus granulosus	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0618	0.5503	0.5484
Leishmania major	beta tubulin	0.1114	1	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.1114	1	1
Onchocerca volvulus		0.0618	0.5503	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0618	0.5503	0.5494
Trypanosoma cruzi	beta tubulin, putative	0.1114	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.1114	1	1
Onchocerca volvulus		0.0618	0.5503	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0618	0.5503	0.5494
Leishmania major	beta tubulin	0.1114	1	1
Brugia malayi	Melatonin receptor type 1A	0.0618	0.5503	0.5484
Brugia malayi	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1114	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0618	0.5503	0.5494
Leishmania major	beta tubulin	0.1114	1	1
Leishmania major	beta tubulin	0.1114	1	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0618	0.5503	0.5484
Brugia malayi	G protein-coupled receptor F59B2.13	0.0618	0.5503	0.5484
Onchocerca volvulus		0.0618	0.5503	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.004	0.0259	0.0241
Loa Loa (eye worm)	tubulin beta-1 chain	0.1114	1	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0618	0.5503	0.5494
Echinococcus granulosus	g protein coupled receptor	0.0618	0.5503	0.5494
Schistosoma mansoni	neuropeptide receptor	0.0618	0.5503	0.5484
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Schistosoma mansoni	amine GPCR	0.0618	0.5503	0.5484
Leishmania major	beta tubulin	0.1114	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0118	0.0972	0.0955
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0052	0.0376	0.0337
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0118	0.0972	0.0955
Echinococcus granulosus	orexin receptor type 2	0.0618	0.5503	0.5494
Onchocerca volvulus		0.0618	0.5503	0.5
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus multilocularis	neuropeptide Y receptor	0.0618	0.5503	0.5494
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0019	0.0019
Schistosoma mansoni	biogenic amine receptor	0.0618	0.5503	0.5484
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.004	0.0259	0.0241
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0618	0.5503	0.5494
Leishmania major	beta tubulin	0.1114	1	1
Schistosoma mansoni	hypothetical protein	0.0618	0.5503	0.5484
Trypanosoma brucei	DNA polymerase IV, putative	0.0013	0.0019	0.0019
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0618	0.5503	0.5484
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0618	0.5503	0.5494
Plasmodium falciparum	tubulin beta chain	0.1114	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0618	0.5503	0.5494
Onchocerca volvulus		0.0618	0.5503	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0618	0.5503	0.5494
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0618	0.5503	0.5484
Echinococcus granulosus	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Brugia malayi	Dopamine receptor protein 1	0.0618	0.5503	0.5484
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0222	0.1916	0.1901
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0618	0.5503	0.5484
Giardia lamblia	Beta tubulin	0.1114	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.1114	1	1
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0077	0.0595	0.0577
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.004	0.0259	0.0241
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0618	0.5503	0.5484
Schistosoma mansoni	hypothetical protein	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Mycobacterium ulcerans	DNA polymerase IV	0.0013	0.0019	0.5
Echinococcus granulosus	Tubulin beta 2C chain	0.1114	1	1
Toxoplasma gondii	beta-tubulin, putative	0.1114	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.1114	1	1
Brugia malayi	GnHR receptor homolog	0.0618	0.5503	0.5484
Echinococcus granulosus	fmrfamide receptor	0.0618	0.5503	0.5494
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0618	0.5503	0.5494
Onchocerca volvulus		0.0618	0.5503	0.5
Giardia lamblia	Beta tubulin	0.1114	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0618	0.5503	0.5484
Loa Loa (eye worm)	phosphatidylinositol 3	0.0198	0.1698	0.1664
Echinococcus multilocularis	neuropeptides capa receptor	0.0618	0.5503	0.5494
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0618	0.5503	0.5494
Echinococcus granulosus	beta tubulin	0.1114	1	1
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0015	0.004	0.0021
Schistosoma mansoni	amine GPCR	0.0618	0.5503	0.5484
Echinococcus multilocularis	Zinc finger, PHD finger	0.0015	0.004	0.0021
Onchocerca volvulus		0.0618	0.5503	0.5
Brugia malayi	neuropeptide F receptor	0.0618	0.5503	0.5484
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0618	0.5503	0.5484
Echinococcus multilocularis	allatostatin A receptor	0.0618	0.5503	0.5494
Schistosoma mansoni	amine GPCR	0.0618	0.5503	0.5484
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0057	0.0418	0.0271
Brugia malayi	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus multilocularis	Tubulin beta 2C chain	0.1114	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0618	0.5503	0.5494
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0118	0.0972	0.0955
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Giardia lamblia	Beta tubulin	0.1114	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0094	0.0754	0.0716
Brugia malayi	Serotonin receptor	0.0618	0.5503	0.5484
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.004	0.0259	0.022
Entamoeba histolytica	tubulin family protein	0.1114	1	1
Schistosoma mansoni	opsin-like receptor	0.0618	0.5503	0.5484
Onchocerca volvulus		0.0618	0.5503	0.5
Brugia malayi	putative neuropeptide receptor	0.0618	0.5503	0.5484
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0118	0.0972	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.1114	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.0618	0.5503	0.5484
Echinococcus multilocularis	neuropeptide s receptor	0.0618	0.5503	0.5494
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0618	0.5503	0.5484
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0019	0.0019
Leishmania major	beta tubulin	0.1114	1	1
Leishmania major	beta tubulin	0.1114	1	1
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0015	0.004	0.0021
Leishmania major	beta tubulin	0.1114	1	1
Brugia malayi	hypothetical protein	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Brugia malayi	hypothetical protein	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus granulosus	neuropeptide receptor A26	0.0618	0.5503	0.5494
Trypanosoma brucei	DNA polymerase IV, putative	0.0013	0.0019	0.0019
Schistosoma mansoni	neuropeptide receptor	0.0618	0.5503	0.5484
Loa Loa (eye worm)	BEN-1 protein	0.1114	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0618	0.5503	0.5484
Trypanosoma brucei	beta tubulin	0.1114	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0618	0.5503	0.5494
Echinococcus granulosus	beta tubulin	0.1114	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0618	0.5503	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0618	0.5503	0.5494
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.004	0.0259	0.022
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Onchocerca volvulus		0.0618	0.5503	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Leishmania major	beta tubulin	0.1114	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0618	0.5503	0.5494
Brugia malayi	ORL1-like opioid receptor	0.0618	0.5503	0.5484
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0019	0.0019
Echinococcus granulosus	tm gpcr rhodopsin	0.0618	0.5503	0.5494
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0618	0.5503	0.5494
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0618	0.5503	0.5484
Echinococcus granulosus	tubulin subunit beta	0.1114	1	1
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus granulosus	allatostatin A receptor	0.0618	0.5503	0.5494
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0015	0.004	0.0021
Brugia malayi	neuropeptide F receptor	0.0618	0.5503	0.5484
Echinococcus multilocularis	g protein coupled receptor	0.0618	0.5503	0.5494
Leishmania major	beta tubulin	0.1114	1	1
Brugia malayi	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0618	0.5503	0.5494
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus granulosus	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0222	0.1916	0.1901
Onchocerca volvulus		0.0618	0.5503	0.5
Echinococcus multilocularis	tubulin beta 1 chain	0.1114	1	1
Loa Loa (eye worm)	tubulin beta chain	0.1114	1	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0618	0.5503	0.5494
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Onchocerca volvulus		0.0618	0.5503	0.5
Toxoplasma gondii	beta-1 tubulin, putative	0.1114	1	1
Onchocerca volvulus		0.0618	0.5503	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0618	0.5503	0.5484
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0618	0.5503	0.5484
Trypanosoma brucei	beta tubulin	0.1114	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0618	0.5503	0.5494
Echinococcus multilocularis	neuropeptides capa receptor	0.0618	0.5503	0.5494
Schistosoma mansoni	tubulin subunit beta	0.1114	1	1
Leishmania major	beta tubulin	0.1114	1	1
Schistosoma mansoni	neuropeptide receptor	0.0618	0.5503	0.5484
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0618	0.5503	0.5484
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Schistosoma mansoni	tubulin subunit beta	0.1114	1	1
Schistosoma mansoni	adenoreceptor	0.0618	0.5503	0.5484
Echinococcus granulosus	neuropeptides capa receptor	0.0618	0.5503	0.5494
Echinococcus granulosus	neuropeptide receptor	0.0618	0.5503	0.5494
Loa Loa (eye worm)	melatonin receptor type 1A	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0618	0.5503	0.5484
Brugia malayi	Serotonin receptor	0.0618	0.5503	0.5484
Onchocerca volvulus		0.0618	0.5503	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0618	0.5503	0.5494
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0081	0.0637	0.0619
Brugia malayi	larval opioid receptor	0.0618	0.5503	0.5484
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0118	0.0972	0.0955
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Schistosoma mansoni	hypothetical protein	0.0618	0.5503	0.5484
Brugia malayi	beta-tubulin, identical	0.1114	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0618	0.5503	0.5494
Echinococcus multilocularis	beta tubulin	0.1114	1	1
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus multilocularis	orexin receptor type 2	0.0618	0.5503	0.5494
Loa Loa (eye worm)	BEN-1 protein	0.1114	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0618	0.5503	0.5494
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0104	0.0845	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Brugia malayi	Dopamine receptor	0.0618	0.5503	0.5484
Leishmania major	beta tubulin	0.1114	1	1
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Brugia malayi	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Loa Loa (eye worm)	G-protein coupled receptor	0.0618	0.5503	0.5484
Echinococcus granulosus	tm gpcr rhodopsin	0.0618	0.5503	0.5494
Echinococcus multilocularis	serotonin receptor	0.0618	0.5503	0.5494
Echinococcus multilocularis	g protein coupled receptor	0.0618	0.5503	0.5494
Echinococcus granulosus	Tubulin beta 2C chain	0.1114	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0618	0.5503	0.5484
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0618	0.5503	0.5494
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0618	0.5503	0.5494
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0015	0.004	0.004
Echinococcus multilocularis	fmrfamide receptor	0.0618	0.5503	0.5494
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0618	0.5503	0.5484
Trichomonas vaginalis	tubulin, putative	0.1114	1	1
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Echinococcus multilocularis	Tubulin beta 2C chain	0.1114	1	1
Brugia malayi	G-protein coupled receptor	0.0618	0.5503	0.5484
Mycobacterium ulcerans	DNA polymerase IV	0.0013	0.0019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Brugia malayi	AKH receptor	0.0618	0.5503	0.5484
Schistosoma mansoni	opsin-like receptor	0.0618	0.5503	0.5484
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Schistosoma mansoni	tubulin subunit beta	0.1114	1	1
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0618	0.5503	0.5494
Loa Loa (eye worm)	neuropeptide F receptor	0.0618	0.5503	0.5484
Schistosoma mansoni	neuropeptide receptor	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Leishmania major	beta tubulin	0.1114	1	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0015	0.004	0.0021
Leishmania major	beta tubulin	0.1114	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0618	0.5503	0.5494
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0618	0.5503	0.5494
Echinococcus multilocularis	neuropeptide receptor	0.0618	0.5503	0.5494
Echinococcus multilocularis	Tubulin beta 2C chain	0.1114	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0618	0.5503	0.5494
Echinococcus multilocularis	beta tubulin	0.1114	1	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0618	0.5503	0.5494
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0118	0.0972	0.0955
Echinococcus granulosus	neuropeptide receptor	0.0618	0.5503	0.5494
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0618	0.5503	0.5484
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0618	0.5503	0.5484
Brugia malayi	RE15519p	0.0618	0.5503	0.5484
Echinococcus granulosus	serotonin receptor	0.0618	0.5503	0.5494
Echinococcus multilocularis	serotonin receptor	0.0618	0.5503	0.5494
Echinococcus multilocularis	sex peptide receptor	0.0618	0.5503	0.5494
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0618	0.5503	0.5494
Echinococcus multilocularis	G protein coupled receptor 139	0.0618	0.5503	0.5494
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Schistosoma mansoni	opsin-like receptor	0.0618	0.5503	0.5484
Brugia malayi	follicle stimulating hormone receptor	0.0618	0.5503	0.5484
Echinococcus granulosus	dro:myosuppressin receptor	0.0618	0.5503	0.5494
Echinococcus multilocularis	tubulin subunit beta	0.1114	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0015	0.004	0.0021
Plasmodium vivax	tubulin beta chain, putative	0.1114	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0618	0.5503	0.5484
Schistosoma mansoni	neuropeptide F-like receptor	0.0618	0.5503	0.5484
Loa Loa (eye worm)	hypothetical protein	0.0618	0.5503	0.5484
Brugia malayi	sulfakinin receptor protein	0.0618	0.5503	0.5484
Echinococcus granulosus	sex peptide receptor	0.0618	0.5503	0.5494

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 183.7 nM	BindingDB_Patents: Alphascreen Assays. A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Ka, PI3Kß, PI3K¿, and PI3Kd. Enzyme reaction buffer was prepared using sterile water (Baxter, Deerfield, Ill.) and 50 mM Tris HCl pH 7, 14 mM MgCl2, 2 mM sodium cholate, and 100 mM NaCl. 2 mM DTT was added fresh the day of the experiment. The Alphascreen buffer was made using sterile water and 10 mM Tris HCl pH 7.5, 150 mM NaCl, 0.10% Tween 20, and 30 mM EDTA. 1 mM DTT was added fresh the day of the experiment. Compound source plates used for this assay were 384-well Greiner clear polypropylene plates containing test compounds at 5 mM and diluted 1:2 over 22 concentrations.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3680929

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1976727