Detailed information for compound 1978429

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 321.37 | Formula: C20H19NO3
  • H donors: 1 H acceptors: 1 LogP: 4.02 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)ccc(c2)c1cc(OC)cc(c1)C(=O)NC
  • InChi: 1S/C20H19NO3/c1-21-20(22)17-9-16(11-19(12-17)24-3)14-4-5-15-10-18(23-2)7-6-13(15)8-14/h4-12H,1-3H3,(H,21,22)
  • InChiKey: QIZJAXXOKSWUNN-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 1 Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis Dehydrogenase:reductase SDR family hydroxysteroid (17-beta) dehydrogenase 2 387 aa 359 aa 24.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein hydroxysteroid (17-beta) dehydrogenase 1 328 aa 265 aa 27.2 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus 0.0009 0.5 0.5
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0009 0.5 0.5
Brugia malayi dehydrogenases, short chain protein 9 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0009 0.5 0.5
Leishmania major 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0009 0.5 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0009 0.5 0.5
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0009 0.5 0.5
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0009 0.5 0.5
Trypanosoma brucei oxidoreductase-like protein 0.0009 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0009 0.5 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0009 0.5 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0009 0.5 0.5
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase-like protein 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0009 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0009 0.5 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0009 0.5 0.5
Onchocerca volvulus Sepiapterin reductase homolog 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0009 0.5 0.5
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus granulosus hypothetical protein 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, putative 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0009 0.5 0.5
Echinococcus multilocularis conserved hypothetical protein 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0009 0.5 0.5
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0009 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0009 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Echinococcus granulosus hypothetical protein 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type oxidoreductase 0.0009 0.5 0.5
Giardia lamblia Reductase, putative 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.5 0.5
Brugia malayi Dehydrogenases, short chain protein 2 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0009 0.5 0.5
Plasmodium vivax hypothetical protein, conserved 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis oxidoreductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0009 0.5 0.5
Echinococcus granulosus WW domain containing oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase, putative 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Giardia lamblia Short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans oxidoreductase 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Mycobacterium ulcerans dehydrogenase/reductase 0.0009 0.5 0.5
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase, putative 0.0009 0.5 0.5
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, putative 0.0009 0.5 0.5
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0009 0.5 0.5
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0009 0.5 0.5
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Leishmania major pteridine reductase 1 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0009 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0009 0.5 0.5
Loa Loa (eye worm) dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium leprae Probable oxidoreductase 0.0009 0.5 0.5
Brugia malayi dehydrogenases, short chain protein 2 0.0009 0.5 0.5
Brugia malayi hypothetical protein 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0009 0.5 0.5
Echinococcus granulosus steroid dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Toxoplasma gondii carbonyl reductase 1, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0009 0.5 0.5
Giardia lamblia Hypothetical protein 0.0009 0.5 0.5
Echinococcus granulosus oxidoreductase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0009 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0009 0.5 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0009 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0009 0.5 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 13 0.0009 0.5 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0009 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0009 0.5 0.5
Brugia malayi hypothetical protein 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0009 0.5 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0009 0.5 0.5
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Loa Loa (eye worm) dehydrogenase 0.0009 0.5 0.5
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0009 0.5 0.5
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0009 0.5 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0009 0.5 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0009 0.5 0.5
Leishmania major oxidoreductase-like protein 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Schistosoma mansoni retinal dehydrogenase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0009 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0009 0.5 0.5
Trichomonas vaginalis steroid dehydrogenase, putative 0.0009 0.5 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0009 0.5 0.5
Brugia malayi Retinol dehydrogenase 12 0.0009 0.5 0.5
Plasmodium falciparum steroid dehydrogenase, putative 0.0009 0.5 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0009 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0009 0.5 0.5
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Leishmania major dehydrogenase-like protein 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Brugia malayi Dehydrogenases, short chain protein 30 0.0009 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0009 0.5 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0009 0.5 0.5
Brugia malayi oxidoreductase 0.0009 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0009 0.5 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0009 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans carveol-like dehydrogenase 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0009 0.5 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0009 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0009 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.5 0.5
Mycobacterium ulcerans oxidoreductase 0.0009 0.5 0.5
Onchocerca volvulus 0.0009 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0009 0.5 0.5
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0009 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0009 0.5 0.5
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0009 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.5 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0009 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0009 0.5 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 50 nM BindingDB_Patents: Radioactivity Assay. The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-587 (1995): Sam, K. M. et al., Drug Des Discov., 15:157-180 (1997)). The radioactivity is determined by means of scintillation measurement. ChEMBL. No reference
IC50 (binding) = 1760 nM BindingDB_Patents: Radioactivity Assay. The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-587 (1995): Sam, K. M. et al., Drug Des Discov., 15:157-180 (1997)). The radioactivity is determined by means of scintillation measurement. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.